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| 1 | Early chronic obstructive pulmonary disease: Beyond spirometry显示文摘The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD) is driving us to improve our understanding of the natural history of this disease. Historically, the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease. However, it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process. As a result, a clearer understanding of the potential benefits of treatment in early COPD is needed. It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives. In this review we discuss the difficulties in diagnosing COPD in its early stages, examine the roleof case-finding and look at the evidence for early intervention with therapeutic agents. There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management. The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease. The mechanistic link is thought to relate to systemic inflammation, causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD. | Judith A Brebner Alice M Turner | 2013 | World Journal of Respirology2013，3，3： | 5 |
| 2 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 3 | 通过模拟学习最大限度地提高物理治疗的临床实习成效(英文)显示文摘本文描述物理治疗专业和物理治疗入门级教育在中国康复医学教育中的演变,提倡以模拟学习技术(simulation-based learning,SBL)为临床实习生积累经验。与医学专业的学生一样,物理治疗专业学生的教育需要一个结构化的临床教育方案,以确保毕业时具备一定的临床专业能力。SBL多年以来一直是医学、工程以及航空专业的首选教学模式。在物理治疗专业培养方案中,SBL培养临床技能的教学模式已经出现。本文亦论述SBL在物理治疗专业入门级教育中的优势,尤其是使用模拟标准化患者作为核心临床教育内容,为学生进入临床实习做好准备。我们建议中国可以将SBL应用在物理治疗专业人才培养方案中,这能够最大限度地提高学生的临床实习经验。 | Alice Y M JONES Margot A SKINNER Elizabeth DEAN | 2015 | 康复学报2015，25，1： | 2 |
| 4 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 5 | Comparing the Effects of Echoic Prompts and Echoic Prompts plus Modeled Prompts on Intraverbal Behavior显示文摘 | Valentino Amber L Shillingsburg M Alice Call Nathan A | 2012 | Journal of Applied Behavior Analysis2012，，45： | 1 |
| 6 | Use of nuclear mutants in the analysis of chloroplast development 显示文摘 | William C T Alice B Robert A M | 1987 | Dev Genet1987，8，： | 1 |
| 7 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 8 | Use of nuclear mutants in the analysis of chloroplast development显示文摘 | WILLIAM C T ALICE B ROBERT A M | 1987 | Development Genetics1987，8，： | 1 |
| 9 | A methodology for intelligent sensor measurement,validation,fusion,and fault detection for equipment monitoring and diagnostics显示文摘 | Satnam A Alice M A Mahesh M | 2001 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2001，15，4： | 1 |
| 10 | Assessment and Evaluation of the Woman With Cardiac Disease During Pregnancy 显示文摘 | Yvonne A Dobbenga-Rhodes Alice M PrivY | 2006 | Journal of Perinatal and Neonatal Nursing2006，20，4： | 1 |
| 11 | The nucleoporin Nup 96 is required for proper expression of interferon-regulated proteins and functions 显示文摘 | Faria A M Levay A Wang Y M Alice O K Rosa M L | 2006 | Immunity2006，24，3： | 1 |
| 12 | New perspectives in diet analysis based on DNA barcoding and parallel pyrosequeneing: the trn- Lapproach 显示文摘 | I Alice V Christian M Muhammad A N | 2009 | Molecular Ecology Resources2009，9，2009： | 1 |
| 13 | Multiple imputation of baseline data in the cardiovascular health study显示文摘 | Arnold Alice M Kxonmal Richard A | 2003 | American Journal of Epidemiology2003，157，1： | 1 |
| 14 | Characterization of the gone encoding manganese peroxidase is ozymc 3 from Phanerochaete chrysosporium显示文摘 | Alic M Lakshmi A Gold MH | 1997 | Biochimica at Biophysica Acta1997，1338，： | 1 |
| 15 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Alexander GG Turpie Michael R Lassen Bruce L Davidson Kenneth A Bauer Michael Gent Louis M Kwong Fred D Cushner Paul A Lotke Scott D Berkowitz Tiemo J Bandel Alice Benson Frank Misselwitz William D Fisher | 2009 | The Lancet2009，，9676： | 1 |
| 16 | A resonant acceleration sensor with two-stage microleverage mechanisms fabricated by SOI-MEMS technology 显示文摘 | SUSAN X P S HENRY S Y ALICE M A | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 17 | Olive oil and lemon salad dressing microencapsulated by freeze-drying显示文摘 | KELLY A SILVA MARIA ALICE Z COELHO VERONICA M A CALADO | 2013 | Food Science and Technology2013，50，2： | 1 |
| 18 | Study of the Aroma Compounds of Rose Apple (Syzygium Jambos Alston) Fruit from Brazil 显示文摘 | Clarissa M Guedes Alice B Pinto Ricardo F A Moreira | 2004 | European Food Research Technology2004，219，： | 1 |
| 19 | Quantum dots to monitor RNAi delivery and improve gene silencing 显示文摘 | Alice A Chen Austin M Derfus Salman R | 2005 | Nucleic Acids Research2005，33，22： | 1 |
| 20 | Plant carbohydrate scavenging through Ton B-dependent recep?tors:A feature shared by phytopathogenic and aquatic bacteria显示文摘 | SERVANE B DAMIEN M ALICE B MARTINE L CATHE?RINE G D JACQUES V EMMANUELLE L MATTHIEU A | 2007 | PLo S One2007，2，2： | 1 |
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