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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Diagnostic and prognostic bio-markers of sepsis in critical care显示文摘 | Kibe S Adams K Barlow G | 2011 | J Antimicrob Chemoth-er2011，66，2： | 1 |
| 4 | Setup, deposition, and sedimentary characteristics of two storm overwash deposits, Abrahams Bosom Beach, Southeastern Australia显示文摘 | Adam D S Brian G J | 2008 | Journal of Coastal Research2008，，： | 1 |
| 5 | The social and psychological costs of punishing显示文摘 | Adams G S and E Mullen | 2012 | Behavioral and Brain Sciences2012，351，： | 1 |
| 6 | High n-type antimony dopant activation in germanium using laser annealing for n+/p junction diode显示文摘 | THAREJA G CHOPARA S ADAMS B | 2011 | IEEE Electron Device Letters2011，32，7： | 1 |
| 7 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 8 | Tissue Kallikrein Actions at the Rabbit Natural or Recombinant Kinin B2 Receptors显示文摘 | Houle S Molinaro G Adam A | 2003 | Hypertension(S0194- 911X)2003，41，3： | 1 |
| 9 | A marker with high specificity for cardiac injury显示文摘 | Adams J E 3rd Bodor G S Davila-Roman V G | 1993 | Cir-culation1993，88，： | 1 |
| 10 | Neopterin and quinolinic acid are surrogate measures of disease activity in the juvenile idiopathic inflammatory myophathies 显示文摘 | Lisa G Rider Adam S Schiffenbauer Mark Zito | 2002 | Clinical Chemistry2002，48，10： | 1 |
| 11 | CARTpeptides显示文摘 | Kuhar MJ Adams S Dominguez G | 2002 | Neuropeptides2002，36，1： | 1 |
| 12 | Unstiffened steel plate shear wall performance under cyclic loading显示文摘 | ADAM S L HELMUT G L P | 2000 | Journal of Structural Engineering2000，126，4： | 1 |
| 13 | Plasma characterization and room temperature growth of carbon nanotubes and nano-onions by excimer laser ablation 显示文摘 | RADHAKRISHNAN G ADAMS P M BERNSTEIN L S | 2007 | Applied Surface Science2007，253，19： | 1 |
| 14 | Localized infusion of IGF-I resuits in skeletal muscle hypertrophy in rats显示文摘 | Adams G R McCue S A | 1998 | J Appl Physiol1998，84，5： | 1 |
| 15 | Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT显示文摘 | Joslin G Wittwer A Adams S | 1993 | Journal of Biological Chemistry1993，268，3： | 1 |
| 16 | Mitochondrlal potassiual chan- nels: from pharmacology to function显示文摘 | Adam S Jolanta S Marta G | 2006 | Biochimica et Biophysica Acta2006，1757，56： | 1 |
| 17 | Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-l-aspartamide)-acyl conjugate micelles:effects of acyl chain length显示文摘 | ADAMS M L KWON G S | 2003 | Journal of controlled release2003，87，1： | 1 |
| 18 | Pseudobulb injected growth regulators as aids for year around production of Hawaiian Dendrobium orchid cut flowers 显示文摘 | SAKAI W S ADAMS C BRAUN G | 2000 | Acta Horticuhurae2000，514，2： | 1 |
| 19 | Amphiphilic block copolymers for drug delivery显示文摘 | Adams M L Lavasanifar A Kwon G S | 2003 | J Pharm Sci2003，92，： | 1 |
| 20 | Diagnostic and prognostic biomarkers of sepsis in critical care 显示文摘 | Kibe S Adams K Barlow G | 2011 | J Antimicrob Chemother2011，，66： | 1 |
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