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| 1 | A flexible skin-mounted wireless acoustic device for bowel sounds monitoring and evaluation显示文摘Conventional methods of intestinal inspection play an essential role in the assessment of bowel diseases and other relevant health issues, yet fail to obtain intestinal conditions in real time because of radiation limits and operation inconvenience. Herein, a flexible, skin-mounted device is developed for longterm, real-time monitoring, and for the evaluation of bowel sounds based on the integration of a threedimensional printed elastomeric resonator with flexible electronics. The device is capable of being flexibly attached to abdominal surfaces without performance degradation during breathing. Clinical tests conduct in a normal volunteer and in patients with mechanical intestinal obstruction or paralytic ileus illustrate the usefulness of the device in capturing the characteristics of bowel sounds. Furthermore, a demonstration of collection and classification of bowel sounds by the flexible device based on machine learning methods can serve as a reference for possible applications of the system in the auxiliary diagnosis of bowel problems. | Fengle WANG Dong WU Peng JIN Yingchao ZHANG Yingyun YANG Yinji MA Aiming YANG Ji FU Xue FENG | 2019 | Science China(Information Sciences)2019，62，10： | 5 |
| 2 | DPSIR Model-Based Evaluation Index System for Geographic National Conditions显示文摘Establishing a reasonable evaluation index system is the basis and premise for the scientific evaluation of geographic national conditions. By analyzing the DPSIR model and its correlation and relation with the evaluation index system, the indexes for geographic national conditions were selected from the aspects of resources, ecology, environment, economy, society, etc to build an evaluation index system for geographic national conditions that consists of three hierarchies: index, criterion, and target levels. Furthermore, the index system was analyzed in terms of index integrity, low overlapping of elements, non-existence of isolated indexes, hierarchy of index system, etc., for the purpose of demonstrating that the DPSIR model-based evaluation index system for geographic national conditions meets the principles of index system establishment. | XIE Mingxia WANG Jiayao YANG Aiming CHEN Ke | 2017 | Wuhan University Journal of Natural Sciences2017，22，5： | 3 |
| 3 | Endoscopic characteristics in predicting prognosis of biopsy-diagnosed gastric low-grade intraepithelial neoplasia显示文摘Background: Endoscopic biopsy can underestimate gastric malignancies as low-grade intraepithelial neoplasia (LGIN). Definitively diagnosed LGIN would progress. This study aimed to evaluate predictive factors to identify malignancies misdiagnosed as LGIN by biopsy and LGIN at high risk of progression.Methods: The clinical records of patients diagnosed with gastric LGIN by endoscopic biopsy who underwent at least two endoscopies during the first year of follow-up between 2007 and 2017 were retrospectively collected. Three endoscopists reviewed photographs of the initial endoscopy, described lesion characteristics, and made endoscopic diagnoses. Logistic regression was used to analyze predictors to identify malignancies underestimated as LGIN. A receiver operating characteristic curve was used to evaluate the diagnostic accuracy of these predictors. Patient clinical outcomes of follow-up >1 year were collected. Kaplan-Meier estimates with log-rank tests and Cox proportional hazards regression were used to analyze predictors of progression.Results: Overall, 48 of 182 (26.4%) patients were proven to have malignancies. A single lesion, a large lesion size, and marked intestinal metaplasia (IM) were independent predictors of initially misdiagnosed malignancies. The area under the curve of these predictors was 0.871, with a sensitivity of 68.7% and specificity of 92.5%. Twelve of 98 patients (12.2%) progressed during the 33-month median follow-up period. A whitish appearance, irregular margins, marked IM, and histological diagnosis of LGIN more than twice within the first year were predictors for progression.Conclusions: Lesions diagnosed as LGIN by biopsy with marked IM and other predictors above should be prudently treated for high potential to be malignancies or progress. Endoscopic follow-up with repeated biopsies within the first year is recommended. | Long Zou Qingwei Jiang Tao Guo Xi Wu Qiang Wang Yunlu Feng Shengyu Zhang Weigang Fang Weixun Zhou Aiming Yang | 2022 | Chinese Medical Journal2022，，1： | 3 |
| 4 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 5 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 6 | Gum Chewing Slightly Enhances Early Recovery from Postoperative Ileus after Cesarean Section: Results of a Prospective, Randomized, Controlled Trial显示文摘 | Hongkai Shang Yang Yang Xiaowen Tong Lijun Zhang Aiming Fang Ling Hong | 2010 | Amer J Perinatol2010，，05： | 1 |
| 7 | Structure and analysing of large bushing显示文摘 | Qu Yang Liu Aiming | 1993 | Glass Fiber1993，，5： | 1 |
| 8 | Multigrid acceleration and chimera technique for viscous flow past a hovering rotor显示文摘 | YANG Aiming YANG Xiaoquan | 2011 | AIAA Journal of Aircraft2011，48，2： | 1 |
| 9 | Singularityanalysis of three-legged parallel robots based onpassive-joint velocities显示文摘 | YANG Guilin CHEN Aiming LIN Wei | 2001 | IEEE Transactions onRobotics and Automation2001，17，4： | 1 |
| 10 | Multigrid acceleration and chi- mera technique for viscous flow past a hovering rotor显示文摘 | Yang Aiming Yang Xiaoquan | 2011 | Jour- nal of aircraft2011，48，2： | 1 |
| 11 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 12 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 13 | Establishment ofScreening Model Based on Study of Clinical Predicting Marker forPancreatic Cancer显示文摘 | Lu Xinghua Wang Li Yang Aiming | 2005 | Bull Med Res2005，34，10： | 1 |
| 14 | How and when did the Yellow River develop its square bend显示文摘 | Lin Aiming Yang Zhenyu Sun Zhiming | 2001 | Geology2001，29，10： | 1 |
| 15 | Membrane Science显示文摘 | Zhao Changsheng Yu Binyu Qian Boshi Wei Qiang Yang Kaiguang Zhang Aiming | 2008 | 310 : 382008，310，： | 1 |
| 16 | Pancreatic carcinoma disguised as type 1 autoimmune pancreatitis with a mass-forming appearance: a clinical dilemma显示文摘In December 2022,a 69-year-old male was presented to the local hospital due to upper abdominal discomfort,gradually developing jaundice with itching,dark urine,and pale-colored stools,with symptoms first appearing ten months prior.Laboratory examinations revealed alanine aminotransferase(ALT)at 507 U/L,aspartate aminotransferase(AST)at 528 U/L,total bilirubin(TBIL)at 226.5μmol/L,and direct bilirubin(DBIL)at 135.2μmol/L. | Zhiyu Yan Xiaoyan Chang Xiaoyin Bai Xianlin Han Yunlu Feng Aiming Yang | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 17 | Parathyroid carcinoma-related severe acute pancreatitis during pregnancy:a case report and literature review显示文摘Introduction Primary hyperparathyroidism(PHPT)is caused by hyperfunctioning parathyroid adenoma,hyperplasia,or carcinoma.Parathyroid carcinoma is a rare disease affecting<1%of PHPT patients and is associated with complications such as acute pancreatitis(AP),which can be complicated by pregnancy[1].Currently,pregnant patients with AP or PHPT can only be treated empirically as there is no consensus approach.Here,we report a rare case of parathyroid carcinoma with adenomarelated AP during pregnancy.The detailed diagnosis and treatment process are described,and clinical features of similar cases are summarized.We hope to improve the diagnosis and treatment of PHPT-related pancreatitis during pregnancy. | Yaxuan Zhou Qiang Wang Long Zou XiWu Aiming Yang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 18 | Risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia显示文摘Objective:To investigate the risk factors for cytomegalovirus(CMV)infection within 100 days and the relationship between early CMV infection and 1-year relapse for patients with acute leukemia following allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods:Three hundred fifty-nine patients with acute leukemia who received allo-HSCT at our center between January 2015 and January 2020 were retrospectively reviewed.Results:Of 359 patients,48.19%(173)patients experienced CMV infection within 100 days posttransplantation.In univariate and multivariate logistic analysis,haploidentical-related donor(HRD)(P<0.001;odds ratio[OR],5.542;95%confidence interval[CI],3.186–9.639),and ratio of CD3^(+)CD8^(+)cells in lymphocytes<14.825%(P<0.001;OR,3.005;95%CI,1.712–5.275)were identified as 2 independent risk factors.One-year relapse rate(RR)between the CMV infection group and the non-CMV infection group was not statistically significant(18.5%vs 19.9%,P=0.688).When we divided the total cohort into AML,ALL,and MAL subgroups,there were no significant differences as well(P=0.138;P=0.588;P=0.117;respectively).Conclusion:In conclusion,donor type(HRD)and the insufficient recovery of CD3^(+)CD8^(+)cells were independent risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia.CMV infection within 100 days did not influence the incidence of relapse in 1 year for patients with acute leukemia. | Juan Chen Aiming Pang Yuanqi Zhao Li Liu Runzhi Ma Jialin Wei Xin Chen Yi He Donglin Yang Rongli Zhang Weihua Zhai Qiaoling Ma Erlie Jiang Mingzhe Han Jiaxi Zhou Sizhou Feng | 2022 | Blood Science2022，4，3： | 0 |
| 19 | Lithium-ion modified cellulose as a water-soluble binder for Li-O2 battery显示文摘An environment-friendly,water-soluble,and cellulose based binder(lithium carboxymethyl cellulose,CMC-Li)was successfully synthesized by using Li+to replace Na+in the commercial sodium carboxymethyl cellulose(CMC-Na).Li-O2 batteries based on the CMC-Li binder present enhanced discharge specific capacities(11151 mAh/g at 100 mA/g)and a superior cycling stability(100 cycles at 200 mA/g)compared with those based on the CMC-Na binder.The enhanced performance may originate from the electrochemical stability of the CMC-Li binder and the ion-conductive nature of CMC-Li,which promotes the diffusion of Li+in the cathode and consequently retards the increase of charge transfer resistance of the cathode during cycling.The results show that the water-soluble CMC-Li binder can be a green substitute for poly(vinylidene fluoride)(PVDF)binder based on organic solvent in the lithium oxygen batteries(LOBs). | Chenyi Hu Aiming Wu Fengjuan Zhu Liuxuan Luo Fan Yang Guofeng Xia Guanghua Wei Shuiyun Shen Junliang Zhang | 2022 | Frontiers in Energy2022，16，3： | 0 |
| 20 | Peripancreatic vascular involvement in patients with type 1 autoimmune pancreatitis显示文摘Background:Type 1 autoimmune pancreatitis(AIP)is the pancreatic manifestation of IgG4-related disease.However,this benign disease can result in the peripancreatic vascular involvement(PVI)on occasion,which increases the difficulty of diagnosis and treatment of this clinical entity as well as for differentiating it from pancreatic malignancies.Methods:We retrospectively reviewed the information on demographics,clinical presentation,laboratory,imaging and endoscopic findings of 101 hospitalized patients with type 1 AIP treated in our department.All the patients were divided into non-PVI and PVI groups according to the first hospitalized medical data.Univariate and multivariate analyses were performed to analyse the potential predictive parameter(s)of PVI in AIP patients.Results:Among the 101 type 1 AIP patients,52(51.5%)exhibited PVI,with a male/female ratio 5.5:1.Their average age was 58.37±8.68 years old.Univariate analysis revealed that the location of pancreatitis lesions,including the pancreatic tail(P=0.010),the presence of splenomegaly(P=0.001)and the white blood cell(WBC)number in peripheral blood(P=0.020),were significantly associated with PVI.The location of pancreatitis lesions,including the pancreatic tail(P=0.023),and the presence of splenomegaly(P=0.010)were found to be independent predictors of the development of PVI by a multivariable regression analysis.A total of 18 out of 25 patients in PVI group who underwent corticosteroid treatment and no less than 6 months radiological follow-up showed improvement in vascular lesions,and no case exhibited exacerbation of PVI lesions during follow-up.Of 36 patients in non-PVI group who were followed up for no less than 6 months,only one case exhibited PVI.Conclusions:This retrospective study demonstrated that type 1 AIP was associated with a high proportion of PVI.Pancreatic tail involvement and splenomegaly may predict the PVI in type 1 AIP.PVI lesions are reversible in a subset of patients. | Meizi Li Xiaoyin Bai Kai Xu Xi Wu Tao Guo Qingwei Jiang Qiang Wang Shengyu Zhang Yingyun Yang Yunlu Feng Aiming Yang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 0 |
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