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| 1 | Mechanisms of Huangqi Decoction Granules (黄芪汤颗粒剂) on Hepatitis B Cirrhosis Patients Based on RNA-Sequencing显示文摘Objective: To explore the action mechanisms of Huangqi Decoction Granules(黄芪汤颗粒剂, HQDG) on hepatitis B cirrhosis. Methods: A total of 85 patients with hepatitis B cirrhosis were randomly divided into HQDG group(42 cases) and control group(43 cases) by a random number table and were treated with HQDG or placebo for 48 weeks(6 g per times and orally for 3 times a day), respectively. After RNA-sequencing of serum samples extracted from the patients, the differentially expressed genes(DEGs) in HQDG and control groups before and after treatment were separately screened. The DEGs were then performed pathway enrichment analysis and proteinprotein interaction(PPI) network analysis. The expression levels of key genes were detected by quantitative realtime polymerase chain reaction(qRT-PCR). Results: After the investigation, 4 and 3 cases were respectively excluded from HQD and control groups because of the incomplete data. Additionally, 3 and 5 cases were lost to follow up in HQD and control groups, respectively. Finally, a total of 70 cases with good compliance were included for further DEGs analysis. A total of 1,070 DEGs(including 455 up-regulated genes and 615 down-regulated genes) in HQDG group and 227 DEGs(including 164 up-regulated genes and 63 down-regulated genes) in the control group were identified after treatment. Compared with the control group, 1,043 DEGs were specific in HQDG group. Besides, 1 up-regulated transcription factor(TF, such as GLI family zinc finger 1, GLI1) and 25 down-regulated TFs(such as drosophila mothers against decapentaplegic proteinfamily member 2, SMAD2) were identified. Pathway enrichment analysis showed that down-regulated Ras homolog gene family member A(RHOA) was enriched in pathogenic Escherichia coli infection. In the PPI network, up-regulated epidermal growth factor receptor(EGFR), and down-regulated cell division cycle 42(CDC42) as well as v-akt murine thymoma viral oncogene homolog 1(AKT1) had higher degrees. Moreover, long non-coding RNAs(lncR NA) growth arrest-specific 5(GAS5) was involved in the lncR NA-target regulatory network. Furthermore, qR T-PCR revealed that expression levels of CDC42 and GLI1 had significant differences in HQDG group before and after treatment(P<0.05). Conclusions: CDC42 and GLI1 may be the targets of HQDG in patients with hepatitis B cirrhosis. Additionally, SMAD2, EGFR, AKT1, RHOA and GAS5 might be associated with the curative effect of HQDG on hepatitis B cirrhosis patients. | CHENG Yang LIU Ping HOU Tian-lu Maerbiya Maimaitisidike Reyangguli Ababaikeli Aini Abudureyimu | 2019 | Chinese Journal of Integrative Medicine2019，25，7： | 10 |
| 2 | LPP solution schemes for use with face recognition 显示文摘 | Xu Yong Zhong Aini Yang Jian | 2010 | Pattern Recogni- tion2010，43，12： | 1 |
| 3 | LPP solution schemes for use with face recognition显示文摘 | Xu Yong Zhong Aini Yang Jian | 2010 | Pattern Recognition2010，43，12： | 1 |
| 4 | Bimodal bio-metrics based on a representation and recognition approach显示文摘 | Xu Yong Zhong Aini Yang Jian David Zhang | | 0，，03： | 1 |
| 5 | LPP solution schemes for use with face recognition显示文摘 | Xu Yong Zhong Aini Yang Jian | 2010 | Pattern Recognition2010，43，12： | 1 |
| 6 | LPP solution schemes for use with face recognition显示文摘 | Yong Xu Aini Zhong Jian Yang David Zhang | 2010 | Pattern Recognition2010，，12： | 1 |
| 7 | LPP solution chemes for use with face recognition 显示文摘 | Xu Yong Zhong Aini Yang Jian | 2011 | Pattern Recogni- ion2011，43，12： | 1 |
| 8 | Bimodal Bio- metrics Based on a Representation and Recognition Approach显示文摘 | Xu Yong Zhong Aini Yang Jian | 2011 | Optical Engineering2011，50，37： | 1 |
| 9 | Synthesis of a Kind of Temperature-responsive Cell Culture Surface for Corneal Sheet显示文摘In this study,acrylic acid(AA) and 4-azidoaniline were used to modify poly(N-isopropylacrylamide)(NIPAAm) in order to fabricate temperature-responsive surface for corneal epithelia cell adhesion and detachment.First,NIPAAm was copolymerized with acrylic acid.Then,the copolymer was coupled with azidoaniline to synthesize AzPhPIA,derivative of p(NIPAAm-co-AA),which possesses both thermo-and photo-sensitivities.Second,the synthesized copolymer was characterized by high performance liquid chromatography(HPLC),Fourier transform infrared(FTIR) and a CHN analyzer.The thermo-sensitivity was characterized by temperature reducing experiment,contact angle measurement and low critical solution temperature(LCST) testing.Third,the derivatized copolymer was immobilized by photolithography on a polystyrene plate,and then the surface characterization of AzPhPIA-coated polystyrene plate(PSt) was measured by electron spectroscopy for chemical analysis(ESCA).The thermo-sensitivity and cytocompatibility of the AzPhPIA-coated PSt were investigated by corneal epithelial cells culture.The results revealed that the AzPhPIA-coated PSt exhibited good cytocompatibility and cell detachability when temperature decreased. | Yanqing Guan Zhibin Li Xin Wang Xiaoli Ni Aini Yang Junming Liu | 2010 | Journal of Materials Science & Technology2010，26，12： | 1 |
| 10 | LPP solution schemes for use with face recognition 显示文摘 | XU Yong ZHONG Aini YANG Jian | 2010 | Pattern Recognition(S0031-3203)2010，43，12： | 1 |
| 11 | LPP solution schemes for use with face recognition显示文摘 | XU YONG ZHONG AINI YANG JIAN | 2010 | Pattern Recognition2010，43，12： | 1 |
| 12 | Multiple recurrent cystic echinococcosis with abdominal aortic involvement: A case report显示文摘BACKGROUND Recurrent cystic echinococcosis(CE)with vital organ involvement is a challenge for clinicians.Herein,we report a case of aortic involvement in recurrent retroperitoneal CE lesions following primary splenic CE resection.CASE SUMMARY A 60-year-old male was admitted due to progressive abdominal pain and poor appetite.He was diagnosed with multiple recurrent CE with abdominal aortic involvement according to preoperative evaluation.During surgical resection,major aortic bleeding accidentally occurred while dissecting the cyst,which was firmly attached to the abdominal aortic wall.Hemostasis attempts were conducted to deal with this emergency situation and maintain circulation.Postinterventional recovery was uneventful,and 2-year follow-up showed no sign of recurrence or any other complications.CONCLUSION Radical resection of recurrent complicated CE with aortic involvement should be carefully planned and performed to prevent possible severe adverse complications,thereby improving the postoperative outcome. | Nijiati Taxifulati Xue-An Yang Xin-Feng Zhang Abudusalamu Aini Abuduaini Abulizi Xin Ma Adilai Abulati Fei Wang Ke Xu Tuerganaili Aji Ying-Mei Shao Ayifuhan Ahan | 2020 | World Journal of Clinical Cases2020，8，14： | 0 |
| 13 | Association mapping of lignin response to Verticillium wilt through an eight-way MAGIC population in Upland cotton显示文摘Lignin metabolism plays a pivotal role in plant defense against pathogens and is always positively correlated as a response to pathogen infection. Thus, understanding resistance genes against plant pathogens depends on a genetic analysis of the lignin response. This study used eight Upland cotton lines to construct a multi-parent advanced generation intercross(MAGIC) population(n=280), which exhibited peculiar characteristics from the convergence of various alleles coding for advantageous traits. In order to measure the lignin response to Verticillium wilt(LRVW), the artificial disease nursery(ADN) and rotation nursery(RN) were prepared for MAGIC population planting in four environments. The stem lignin contents were collected, and the LRVW was measured with the lignin value of ADN/RN in each environment, which showed significant variations. We employed 9 323 high-quality single-nucleotide polymorphism(SNP) markers obtained from the Cotton-SNP63K array for genotyping the MAGIC population. The SNPs were distributed through the whole genome with 4.78 SNP/Mb density, ranging from 1.14(ChrA06) to 10.08(ChrD08). In addition, a genome-wide association study was performed using a Mixed Linear Model(MLM) for LRVW. Three stable quantitative trait loci(QTLs), qLRVW-A04, qLRVW-A10, and qLRVW-D05, were identified in more than two environments. Two key candidate genes, Ghi_D05G01046 and Ghi_D05G01221, were selected within the QTLs through the combination of variations in the coding sequence, induced expression patterns, and function annotations. Both genes presented nonsynonymous mutations in coding regions and were strongly induced by Verticillium dahliae. Ghi_D05G01046 encodes a leucine-rich extensin(LRx) protein involved in Arabidopsis cell wall biosynthesis and organization. Ghi_D05G01221 encodes a transcriptional co-repressor novel interactor of novel interactor of jasmonic acid ZIM-domain(JAZ–NINJA), which functions in the jasmonic acid(JA) signaling pathway. In summary, the study creates valuable genetic resources for breeding and QTL mapping and opens up a new perspective to uncover the genetic basis of VW resistance in Upland cotton. | TIAN Xiao-min HAN Peng WANG Jing SHAO Pan-xia AN Qiu-shuang Nurimanguli AINI YANG Qing-yong YOU Chun-yuan LIN Hai-rong ZHU Long-fu PAN Zhen-yuan NIE Xin-hui | 2023 | Journal of Integrative Agriculture2023，22，5： | 0 |
| 14 | Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder显示文摘Major depressive disorder(MDD) is the most common mental disorder. Over 95 million people in China suffer from MDD(Huang et al.,2019). Currently available antidepressants have delayed onset and a low cure rate(Malhi and Mann, 2018). Genetic and psychosocial factors, as well as their interactions, play an important role in the response to antidepressants for MDD patients(Uher, 2011;Gonda et al., 2019;Musci et al., 2019). Understanding the underlying associations and mechanisms may help to improve the first-episode cure rate in MDD patients. | Di Luan Dongfang You Yaqian Wu Fangfang Wu Zhi Xu Ling Li Jiao Jiao Aini Zhang Haixia Feng Yan Kong Yang Zhao Zhijun Zhang | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
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