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| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages显示文摘肿瘤微型环境(TME ) 在肿瘤房间的生长起一个突出的作用。作为 TME 的主要煽动性的部件, M2d 巨噬细胞被 TME 教育以便他们采用支持肿瘤转移和前进的一个抑制免疫力的角色。有 6 月的 Fra-1 形式使活跃之物 protein-1 heterodimers 合伙并且驾驶基因抄写。Fra-1 被认为急速地导致 tumorigenesis 和前进。然而,在 M2d 巨噬细胞的产生的 Fra-1 的功能的角色糟糕迄今为止被理解。这里,我们表明那 4T1 乳房的癌房间与 RAW264.7 巨噬细胞房间 co 有教养,扭曲 RAW264.7 巨噬细胞房间区别进 M2d 巨噬细胞。4T1 房间在 RAW264.7 房间,然后 Fra-1 刺激 Fra-1 的 de novo overexpression 绑在 interleukin 6 (IL-6 ) 在 RAW264.7 房间增加 cytokine IL-6 的生产的倡导者。在 autocrine 的 IL-6 幕塑造扭曲 RAW264.7 巨噬细胞房间区别进 M2d 巨噬细胞。这些调查结果开的新卓见进怎么颠倒 M2d 导致巨噬细胞的有免疫力的忍耐改进 immunotherapeutic 途径的功效。 | Qingshan Wang Hong Ni Lan Lan Xiaoli Wei Rong Xiang Yue Wang | 2010 | Cell Research2010，20，6： | 12 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Silver nanocrystals sensitize magnetic-nanoparticle-mediated thermo-induced killing of cancer cells显示文摘磁性的 nanoparticles (MNP ) 能加热肿瘤纸巾起来并且导致在外部交流磁场下面癌症房间杀死。然而,磁性的 nanoparticles 过高热(MNPH ) 要求被注入肿瘤以便因为复杂的热转移,在 vivo 和 MNP 的有限的热质量获得临床上需要的热剂量的 MNP 的高集中。为了切,击倒 MNP 的剂量并且提高这 Nanotherapy 的效果,我们与不同尺寸准备了银 nanoparticles (AgNPs ) 并且在 MNPH 治疗在癌症房间上调查了这些 AgNPs 的效果。AgNPs 能提高 glioma 房间的 thermo 敏感,这效果是尺寸依赖者,这被发现。AgNPs 能导致在 G2/M 阶段逮捕并且在过高热以后提高了癌症房间的 apoptosis 率的房间周期。在适用的老鼠建模的 glioma,与 AgNPs 相结合的 MNPH 能在癌症房间提高 Bax 表示。我们的结果建议 AgNPs 能是潜在的 thermo 敏化并且能进一步为 MNPH 治疗为 Ag 基于 nanostructure 的热种子的设计被开发。 | Lianke Liu Fang Ni Jianchao Zhang Xiaoli Jiang Xiang Lu Zhirui Guo Ruizhi Xu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 4 |
| 5 | Impact of STAT4 gene silencing on the expression profile of proteins in EL-4 cells显示文摘The signal transducers and activators of transcription (STATs) have diverse biological functions and are involved in cell differentiation, proliferation, development, apoptosis and inflammation. Several constitutively activated STATs have been observed in a wide variety of human cancer cell lines and primary tumor cells, including blood malignancies and solid neoplasias. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against selfor nonself-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor im-munity and promote tumor growth. Our previous findings suggest that the supernatant from STAT4silenced tumor cell culture can significantly increase the ratio of CD4+ CD25+ Foxp3+ regulatory T cells among splenic cells in vitro, when compared to that from normal tumor cell culture. In the present study, we identified that the mouse lymphoma cell line EL-4 expressed a high level of STAT4, and silencing of STAT4 by siRNA did not change the expression levels of TGF-β and IL-10 in EL-4 cells. Two-dimensional electrophoresis was conducted to examine the difference of expression profiles of proteins between normal and STAT4-silenced EL4 cells. Some of the protein which has been changed may induce CD4+ CD25+ Foxp3+ regulatory T cells in vitro. | WEI XiaoLi NI Hong WANG QingShan XIANG Rong WANG Yue | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 6 | Understanding the spatial representativeness of air quality monitoring network and its application to PM_(2.5)in the China's Mainland显示文摘Air pollution has seriously endangered human health and the natural ecosystem during the last decades.Air quality monitoring stations(AQMS)have played a critical role in providing valuable data sets for recording regional air pollutants.The spatial representativeness of AQMS is a critical parameter when choosing the location of stations and assessing effects on the population to long-term exposure to air pollution.In this paper,we proposed a methodological framework for assessing the spatial representativeness of the regional air quality monitoring network and applied it to ground-based PM_(2.5)observation in the mainland of China.Weighted multidimensional Euclidean distance between each pixel and the stations was used to determine the representativeness of the existing monitoring network.In addition,the K-means clustering method was adopted to improve the spatial representativeness of the existing AQMS.The results showed that there were obvious differences among the representative area of 1820 stations in the mainland of China.The monitoring stations could well represent the PM_(2.5)spatial distribution of the entire region,and the effectively represented area(i.e.the area where the Euclidean distance between the pixels and the stations was lower than the average value)accounted for 67.32%of the total area and covered 93.12%of the population.Forty additional stations were identified in the Northwest,North China,and Northeast regions,which could improve the spatial representativeness by 14.31%. | Ling Su Chanchan Gao Xiaoli Ren Fengying Zhang Shanshan Cao Shiqing Zhang Tida Chen Mengqing Liu Bingchuan Ni Min Liu | 2022 | Geoscience Frontiers2022，13，3： | 3 |
| 7 | Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual显示文摘Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology,it is still largely unclear whether virus-specific T cells are sufficient for host protection.Here,we found that in a previously characterized cohort of convalescent subjects,one individual,though lacking detectable anti-viral neutralizing IgG antibodies,showed virus-specific T cell responses,both in CD4^(+)and CD8^(+)T cells.SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months.This study thus further supports a critical role of T cells in host defense against SARS-CoV-2,offering new insights into the design and evaluation of COVID-19 vaccines. | Ling Ni Fang Ye Qin Qiao Yu Feng Yazheng Yang Hui Zhao Li-Nan Zhang Meng-Li Cheng Gengzhen Zhu Xiaoli Li Xuan Zhong Ruifeng Li Cheng-Feng Qin Fang Chen Chen Dong | 2022 | National Science Open2022，1，1： | 1 |
| 8 | Differential gene expression in porcine SK6 cells infected with wild-type and SAP domain-mutant foot-and-mouth disease virus显示文摘Foot-and-mouth disease virus(FMDV) is the causative agent of a highly contagious disease in livestock. The viral proteinaseL^(rop) of FMDV is involved in pathogenicity, and mutation of theL^(rop) SAP domain reduces FMDV pathogenicity in pigs. To determine the gene expression profiles associated with decreased pathogenicity in porcine cells, we performed transcriptome analysis using next-generation sequencing technology and compared differentially expressed genes in SK6 cells infected with FMDV containingL^(rop) with either a wild-type or mutated version of the SAP domain. This analysis yielded 1,853 genes that exhibited a ≥ 2-fold change in expression and was validated by real-time quantitative PCR detection of several differentially expressed genes. Many of the differentially expressed genes correlated with antiviral responses corresponded to genes associated with transcription factors, immune regulation, cytokine production, inflammatory response, and apoptosis. Alterations in gene expression profiles may be responsible for the variations in pathogenicity observed between the two FMDV variants. Our results provided genes of interest for the further study of antiviral pathways and pathogenic mechanisms related to FMDV L^(rop). | Zixin Ni Fan Yang Weijun Cao Xiangle Zhang Ye Jin Ruoqing Mao Xiaoli Du Weiwei Li Jianhong Guo Xiangtao Liu Zixiang Zhu Haixue Zheng | 2016 | Virologica Sinica2016，31，3： | 1 |
| 9 | Efficient renal clearance of DNA tetrahedron nanopartides enables quantitative evaluation of kidney function显示文摘DNA tetrahedro n nano structure (DTN) is one of the simplest DNA nano structures and has bee n successfully applied for biose nsin g, imagi ng, and treatment of can cer. To facilitate its biomedical applications and pote ntial clinical tran slation, fun dame ntal un derstandi ng of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearanee of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide in sight for future optimization of DNA nano structures for biomedical applications. | Dawei Jiang Hyung-Jun lm Madeline E. Boleyn Christopher G. England Dalong Ni Lei Kang Jonathan W. Engle Peng Huang Xiaoli Lan Weibo Cai | 2019 | Nano Research2019，12，3： | 1 |
| 10 | Low prevalence of the metabolic syndrome but high occurrence of various metabolic disorders in Chinese women with polycystic ovary syndrome 显示文摘 | NI Ren - nfin MO Yaqin CHEN Xiaoli | 2009 | Eur J Endocrinol2009，161，3： | 1 |
| 11 | Synthesis of a Kind of Temperature-responsive Cell Culture Surface for Corneal Sheet显示文摘In this study,acrylic acid(AA) and 4-azidoaniline were used to modify poly(N-isopropylacrylamide)(NIPAAm) in order to fabricate temperature-responsive surface for corneal epithelia cell adhesion and detachment.First,NIPAAm was copolymerized with acrylic acid.Then,the copolymer was coupled with azidoaniline to synthesize AzPhPIA,derivative of p(NIPAAm-co-AA),which possesses both thermo-and photo-sensitivities.Second,the synthesized copolymer was characterized by high performance liquid chromatography(HPLC),Fourier transform infrared(FTIR) and a CHN analyzer.The thermo-sensitivity was characterized by temperature reducing experiment,contact angle measurement and low critical solution temperature(LCST) testing.Third,the derivatized copolymer was immobilized by photolithography on a polystyrene plate,and then the surface characterization of AzPhPIA-coated polystyrene plate(PSt) was measured by electron spectroscopy for chemical analysis(ESCA).The thermo-sensitivity and cytocompatibility of the AzPhPIA-coated PSt were investigated by corneal epithelial cells culture.The results revealed that the AzPhPIA-coated PSt exhibited good cytocompatibility and cell detachability when temperature decreased. | Yanqing Guan Zhibin Li Xin Wang Xiaoli Ni Aini Yang Junming Liu | 2010 | Journal of Materials Science & Technology2010，26，12： | 1 |
| 12 | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury显示文摘Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai | 2023 | Bioactive Materials2023，，1： | 0 |
| 13 | A test of the mycorrhizal-associated nutrient economy framework in two types of tropical rainforests under nutrient enrichments显示文摘Shifts in tree species and their mycorrhizal associations driven by global change play key roles in biogeochemical cycles. In this paper, we proposed a framework of the mycorrhizal-associated nutrient economy(MANE), and tested it using nutrient addition experiments conducted in two tropical rainforests. We selected two tropical rainforests dominated by arbuscular mycorrhizal(AM) and ectomycorrhizal(ECM) trees, and established eighteen20 m×20 m plots in each rainforest. Six nitrogen(N) and phosphorus(P) addition treatments were randomly distributed in each rainforest with three replicates. We examined the differences in soil carbon(C) and nutrient cycling, plant and litter productivity between the two rainforests and their responses to 10-year inorganic N and P additions. We also quantified the P pools of plants, roots, litter, soil and microbes in the two rainforests. Overall,distinct MANE frameworks were applicable for tropical rainforests, in which soil C, N and P were cycled primarily in an inorganic form in the AM-dominated rainforest, whereas they were cycled in an organic form in the ECMdominated rainforest. Notably, the effects of mycorrhizal types on soil P cycling were stronger than those on C and N cycling. The intensified N and P deposition benefited the growth of AM-dominated rainforests instead of ECMdominated rainforests. Our findings underpin the key role of mycorrhizal types in regulating biogeochemical processes, and have important implications for predicting the ecological consequences of global changes. | Qingshui Yu Suhui Ma Xiaofeng Ni Lai Jiang Zhang Zhou Jiangling Zhu Chengjun Ji Zhiyao Tang Xiaoli Cheng Jingyun Fang | 2023 | Forest Ecosystems2023，10，1： | 0 |
| 14 | Proposal of translation of commonly-used acupuncture and moxibustion terminology by Beijing University of Chinese Medicine显示文摘General Secretary Xi Jinping points out“traditional Chinese medicine(TCM)is a treasure of the Chinese nation.We must pro-tect,explore,develop and inherit it well.”According tothe latest in-formation,1 TCM has spread to 196 countries and regions around the world,indicating that it enjoys a good development abroad,especially the development of acupuncture and moxibustion. | Tingyu Fang Shenglou Ni Yanping Wang Xiaoli Li Liangxiao Ma Ochs Shelley | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，2： | 0 |
| 15 | Different Burial-Cooling History of Triassic Strata between the Western Weibei Uplift and the Northwestern Weihe Basin in Northwest China显示文摘Analysis of tectonothermal history of the Yanchang Formation in the western Weibei Uplift and in the northwestern Weihe Basin can reconstruct the cooling history of the southwest most remained Upper Triassic source rock of the North China Plate. Apatite fission-track(AFT) and(U-ThSm)/He(AHe) analysis were used to recover the cooling and uplift history of the Upper Triassic here. Ten sandstones from the Middle–Upper Triassic strata yield AFT ages between 179.8 ± 7.4 and 127.6 ± 8.1 Ma. AHe ages of two sandstones have the value of 37.7 ± 2.3–131.1 ± 8.1 and 45.7 ± 2.8–83.5 ± 5.2 Ma. Time-temperature modeling results showed that tectonothermal history of the Yanchang Formation was initially different in time-space relationships but then became almost identical through time followed by different cooling rate. Modeling results of the Triassic strata in the Qianyang area and the Yaojiagou area revealed three different uplift-cooling stages commencing in the Late Jurassic at ~165 Ma and in Early Cretaceous at ~110 Ma, respectively, both followed by first similar cooling histories to the Early Miocene at ~20 – 23 Ma and then different since the Late Miocene. Uplift-cooling rate since the Late Miocene at ~8 Ma were different between the Western Weibei Uplift and the Northwestern Weihe Basin. The timing, cooling-uplift rates of the Yaojiagou area, which was mainly controlled by movements related to the Liupanshan Mountains, the Qinling Orogens and the Weibei Uplift, had the earliest onset of uplift-cooling for the Upper Triassic series compared to other regions within the Weibei Uplift. Cooling paths for the Upper Triassic series became uniform regionally in the Early Cretaceous marking a key time for the tectonothermal evolutionary history of Upper Triassic series in the southwestern North China Plate. | Qiang Yu Zhanli Ren Rongxi Li Chung Ling Tao Ni Wanshan Lei Baojiang Wang Xiaoli Wu Xiaoli Qin Xianghe Lei | 2023 | Journal of Earth Science2023，34，5： | 0 |
| 16 | A multi-scale 3-D crust velocity model in the Hefei-Chao Lake area around the southern segment of Tanlu Fault Zone显示文摘Regional high-precision velocity models of the crust are an important foundation for examining seismic activity,seismogenic environments,and disaster distribution characteristics.The Hefei-Chao Lake area contains the main geological units of Hefei Basin,with thick sediments and the Chao Lake depression.Several major concealed faults of the southern NNE-trending Tanlu Fault Zone cross this area.To further explore the underground distribution characteristics of the faults and their tectonic evolutionary relationship with adjacent tectonic units,this study used ambient noise data recorded by a seismic array deployed in Hefei City and Chao Lake,constructing a 3-D velocity model at the depth of 1–8 km.Then a multi-scale high-resolution 3-D velocity model of this area was constructed by this new upper crustal velocity model with the previous middle and lower crustal model.The new model reveals that a high-velocity belt is highly consistent with the strike of the Tanlu Fault Zone,and a low-velocity sedimentary characteristic is consistent with the Hefei Basin and Chao Lake depression.The distribution morphology of high and low velocity bodies shows that the sedimentary pattern of Hefei-Chao Lake area is closely related to the tectonic evolution of the Tanlu Fault Zone since the Mesozoic.This study also identifies multiple low-velocity anomalies in the southeastern Hefei City.We speculate that strong ground motion during the 2009 Feidong earthquake(magnitude of 3.5)was related to amplification by the thick sediments in the Hefei Basin.We also discuss further applications of multi-scale high-resolution models of the shallow layer to strong ground motion simulations in cities and for earthquake disaster assessments. | Lingli Li Huajian Yao Song Luo Junhui Li Xiaoli Wang Hongyu Ni Ziwen Bao | 2021 | Earthquake Science2021，34，4： | 0 |
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