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| 1 | 1000 Wh L^(-1)lithium-ion batteries enabled by crosslink-shrunk tough carbon encapsulated silicon microparticle anodes显示文摘Microparticulate silicon(Si),normally shelled with carbons,features higher tap density and less interfacial side reactions compared to its nanosized counterpart,showing great potential to be applied as high-energy lithium-ion battery anodes.However,localized high stress generated during fabrication and particularly,under operating,could induce cracking of carbon shells and release pulverized nanoparticles,significantly deteriorating its electrochemical performance.Here we design a strong yet ductile carbon cage from an easily processing capillary shrinkage of graphene hydrogel followed by precise tailoring of inner voids.Such a structure,analog to the stable structure of plant cells,presents‘imperfection-tolerance’to volume variation of irregular Si microparticles,maintaining the electrode integrity over 1000 cycles with Coulombic efficiency over 99.5%.This design enables the use of a dense and thick(3 m Ah cm^(-2))microparticulate Si anode with an ultra-high volumetric energy density of 1048 Wh L^(-1)achieved at pouch full-cell level coupled with a Li Ni_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode. | Fanqi Chen Junwei Han Debin Kong Yifei Yuan Jing Xiao Shichao Wu Dai-Ming Tang Yaqian Deng Wei Lv Jun Lu Feiyu Kang Quan-Hong Yang | 2021 | National Science Review2021，8，9： | 4 |
| 2 | Construction of Streptomyces lydicus A01 transformant with the chit33 gene from Trichoderma harzianum CECT2413 and its biocontrol effect on Fusaria显示文摘Streptomyces lydicus A01 resists many plant pathogens (including Fusarium spp.) by producing the antifungal agent natamycin, which binds to the ergosterol of fungal cell membranes and inhibits the growth of pathogens. Trichoderma harzianum CECT2413 is a widely-distributed soil fungus that antagonizes several plant fungal pathogens (including Fusarium spp.) by producing chi-tinase and degrading chitin, a major component of the fungal cell wall. This study attempted to enhance the biocontrol effect of S. lydicus A01 on Fusarium spp. by transforming the chitinase gene of Trichoderma. Chitinase and natamycin could act synergisti-cally on both the cell walls and cell membranes of pathogens. The 33-kD chitinase-encoding gene (chit33) was cloned and conju-gal-transformed from T. harzianum CECT2413 to S. lydicus A01, and then confirmed via polymerase chain reaction (PCR) assays. Subsequent analyses using the 3,5-dinitrosalicylic acid (DNS) method and ultraviolet spectrophotometry showed that compared with its wild type strain (WT), the S. lydicus A01 conjugal transformant (CT) with chit33 gene exhibited substantially higher chi-tinase activity and natamycin production. The resistance of S. lydicus A01-chit33 CT and WT to four Fusaria in crops and vegetables was tested via the cup-plate method. Compared with the WT, the conjugal transformant of S. lydicus A01 with chit33 gene from T. harzianum CECT2413 showed greatly increased biocontrol effect on fusarium disease. This study would be beneficial to the development of high-quality antifungal bio-agents for agricultural applications via the synergy between the previously non-existent and pre-existing functions achieved through heterogeneous gene transformation. | WU Qiong BAI LinQuan LIU WeiCheng LI YingYing LU CaiGe LI YaQian LIN ZhenYa WANG Meng XUE ChunSheng CHEN Jie | 2013 | Chinese Science Bulletin2013，58，26： | 1 |
| 3 | Optimising photoelectroncatalytic oxidation of fulvic acid using response surface methodology显示文摘 | FU Jianfeng ZHAO Yaqian WU Qiuli | 2006 | J Hazard Mater2006，144，12： | 1 |
| 4 | Identification of a Novel Fungus, Lepfosphaerulina chartarum SJTU59 and Characterization of Its Xylanolytic Enzymes显示文摘 | Qiong Wu Yaqian Li Yingying Li | 2013 | PLOS ONE2013，8，9： | 1 |
| 5 | A Molecular Foaming and Activation Strategy to Porous N-Doped Carbon Foams for Supercapacitors and CO2 Capture显示文摘Hierarchically porous carbon materials are promising for energy storage,separation and catalysis.It is desirable but fairly challenging to simultaneously create ultrahigh surface areas,large pore volumes and high N contents in these materials.Herein,we demonstrate a facile acid-base enabled in situ molecular foaming and activation strategy for the synthesis of hierarchically macro-/meso-/microporous N-doped carbon foams(HPNCFs).The key design for the synthesis is the selection of histidine(His)and potassium bicarbonate(PBC)to allow the formation of 3D foam structures by in situ foaming,the PBC/His acid-base reaction to enable a molecular mixing and subsequent a uniform chemical activation,and the stable imidazole moiety in His to sustain high N contents after carbonization.The formation mechanism of the HPNCFs is studied in detail.The prepared HPNCFs possess 3D macroporous frameworks with thin well-graphitized carbon walls,ultrahigh surface areas(up to 3200 m^2 g^-1),large pore volumes(up to 2.0 cm^3 g^-1),high micropore volumes(up to 0.67 cm^3 g^-1),narrowly distributed micropores and mesopores and high N contents(up to 14.6 wt%)with pyrrolic N as the predominant N site.The HPNCFs are promising for supercapacitors with high specific capacitances(185-240 F g^-1),good rate capability and excellent stability.They are also excellent for CO2 capture with a high adsorption capacity(~4.13 mmol g^-1),a large isosteric heat of adsorption(26.5 kJ mol^-1)and an excellent CO2/N2 selectivity(~24). | Mengyuan Zhou Yaqian Lin Huayao Xia Xiangru Wei Yan Yao Xiaoning Wang Zhangxiong Wu | 2020 | Nano-Micro Letters2020，12，5： | 1 |
| 6 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 7 | MDL and RMSEP assessment of spectral pretreatments by adding different noises in calibration/validation datasets 显示文摘 | Zhao Na Wu Zhisheng Cheng Yaqian | 2016 | SAA: Mol Bio Spec2016，11，163： | 1 |
| 8 | Optimising photo-electrocatalytic oxidation of fulvic acid using response sur-face methodology显示文摘 | Fu Jianfeng Zhao Yaqian Wu Qiuli | 2006 | Journal of Hazardous Materials2006，144，12： | 1 |
| 9 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global public health threat.Here we use a TRACE-seq-based metatranscriptomic analysis to compare host responses and vaginal microbiome of postmenopausal female patients with underlying severe COVID-19 disease with those of healthy females,thereby providing insights into the changes in the microenvironment of women's reproductive system. | Meng Xiao Bo Lu Rui Ding Xia Liu Xian Wu Yaqian Li Xudong Liu Lin Qiu Zhibo Zhang Jing Xie Yu Chen Dong Zhang Liting Dong Meiling Zhang Jinying Peng Hua Yang Timothy Kudihna Yingchun Xu Taisheng Li Chengqi Yi Lan Zhu | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 10 | Prey decline leads to diet shift in the largest population of Indo-Pacific humpback dolphins?显示文摘The Pearl River Delta(PRD)region on the southeast coast of China has long been known as a highly productive fishing ground.Since the late 1980s,fishing pressure in the PRD has been intense,which warrants concerns of potential fishery-related impacts on the food resources and foraging ecology of apex marine predators in this region,such as the Indo-Pacific humpback dolphin(Sousa chinensis).In this study,we examined 54 stomachs with food remains,collected from beached carcasses of humpback dolphins recovered during fifteen years between 2003 and 2017.The 6043 identified prey items represent 62 teleost taxa,primarily small estuarine fish,but also larger reef fish.The dolphins appear to be opportunistic foragers,hunting across the water-column,with preference for shoaling and meaty fishes(e.g.Collichthys lucidus IRI%=38.6%,Johnius belangerii IRI%=23.1%,Mugil cephalus IRI%=14.0%).Our findings suggest a dietary shift in recent years,from primarily demersal(as previously reported)to greater intake of neritic and pelagic fish.Dolphin foraging group size has decreased in recent years,which corresponds with declining size and numbers of prey items retrieved from dolphin stomachs.We suggest that these are indicators of declining food resources.Faced with a shortage of preferred prey,humpback dolphins may have broadened their dietary spectrum to maintain their daily energy intake,while their foraging group size decreased in response to the altered tradeoff between the costs and benefits of group foraging. | Wenzhi LIN Leszek KARCZMARSKI Ruilian ZHOU Yaqian MO Lang GUO Sam King Fung YIU Xi NING Tak-Cheung WAI Yuping WU | 2021 | Integrative Zoology2021，16，4： | 0 |
| 11 | Cellularmetabolism: A key player in cancer ferroptosis显示文摘Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments. | Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao | 2024 | Cancer Communications2024，44，2： | 0 |
| 12 | Driving force of biomolecular liquid–liquid phase separation probed by nuclear magnetic resonance spectroscopy显示文摘The assembly of biomolecular condensates is driven by liquid–liquid phase separation. To understand the structure and functions of these condensates, it is essential to characterize the underlying driving forces, e.g., protein–protein and protein–RNA interactions. As both structured and low-complexity domains are involved in the phase separation process, NMR is probably the only technique that can be used to depict the binding topology and interaction modes for the structured and nonstructured domains simultaneously. Atomic-resolution analysis for the intramolecular and intermolecular interactions between any pair of components sheds light on the mechanism for phase separation and biomolecular condensate assembly and disassembly. Herein, we describe the procedures used for the most extensively employed NMR techniques to characterize key interactions for biomolecular phase separation. | Hanyu Zhang Weiwei Fan Gilbert Nshogoza Yaqian Liu Jia Gao Jihui Wu Yunyu Shi Xiaoming Tu Jiahai Zhang Ke Ruan | 2022 | Biophysics Reports2022，8，2： | 0 |
| 13 | Ice storm damage to oak forests in subtropical China显示文摘Ice storms,as important sources of frequent and injurious disturbances,drive forest dynamics in the Northern Hemisphere.However,stand-level differential vulnerability to ice storms and the associated factors that predispose forest stands remain unclear.This is particularly concerning in the subtropics where the frequency of ice storms is predicted to increase with global warming.Here we assessed how the impact on three forest stands(early and late secondary-growth forests,and old-growth forests)differed after an extreme ice storm during 20–21 March 2022,and identified the abiotic and biotic factors that determine the damage intensity in the Shennongjia World Natural Heritage Site,a biodiversity conservation hotspot in central China.We found a stand-specific‘middomain effect’where the late secondary-growth forest sustained the most severe damage,the early secondarygrowth forest sustained the least,and the old-growth forest suffered an intermediate amount.‘Crown broken’was the most severe damage type across all three forest stands,although the proportion of‘branch broken’was also high in the old-growth forest.Topography played a significant role in determining the vulnerability of the early secondary-growth forest to severe ice storms whereas the forest structure and composition were important factors in explaining the damage rates in the old-growth forest,although they differed among the damage categories.In contrast,topography,forest structure and composition generally explain the intensity of damage in the late secondary-growth forests.Our results highlight that,in subtropical forests,the intensity of damage caused by severe ice storms and related determining factors are stand-level dependent.We also suggest exploring potential management strategies(e.g.,slow-growing hardwood species that can resist storms should be the main species for reforestation in early secondary-growth forests)to mitigate the risk of future severe ice storms,as well as other wind-related climatic extremes. | Jinyu Guo Jifa Cui Nan Wu Yaqian Zhang Jie Wang Hanyu Xiang Baoshuang Hu Youbing Zhou | 2023 | Forest Ecosystems2023，10，3： | 0 |
| 14 | Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder显示文摘Major depressive disorder(MDD) is the most common mental disorder. Over 95 million people in China suffer from MDD(Huang et al.,2019). Currently available antidepressants have delayed onset and a low cure rate(Malhi and Mann, 2018). Genetic and psychosocial factors, as well as their interactions, play an important role in the response to antidepressants for MDD patients(Uher, 2011;Gonda et al., 2019;Musci et al., 2019). Understanding the underlying associations and mechanisms may help to improve the first-episode cure rate in MDD patients. | Di Luan Dongfang You Yaqian Wu Fangfang Wu Zhi Xu Ling Li Jiao Jiao Aini Zhang Haixia Feng Yan Kong Yang Zhao Zhijun Zhang | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 15 | Gambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer显示文摘Gambogic acid(GA) is a natural product with potent anticancer activity in vitro. However, poor water solubility and systematic toxicity limit the further clinical application of GA. Micellization of hydrophobic molecule could effectively ameliorate aqueous dispersity of GA and induce better blood retention and tumor accumulation, hence lead to improved stability and therapeutic effect of GA. In this study, monomethyl poly(ethylene glycol)-poly(ε-caprolactone)-poly(trimethylene carbonate)(MPEG-P(CL-ran-TMC)) was used to encapsulate GA by a single-step solid dispersion method to form a GA encapsulated MPEG-P(CLran-TMC) micelles(GA micelles). GA micelles were characterized with a small particle size(44 ±1 nm),high drug loading content(26.28% ± 0.12%) and high-efficiency encapsulation(87.59% ± 0.41 %). Compared with free GA, GA micelles showed better dispersion in water, prolonged release behavior in vitro, and enhanced tumor cellular uptake. GA micelles could also effectively induce apoptosis in AsPC-1 cells.Compared with free GA, GA micelles exhibited superior antitumor efficacy and better apoptosis induced effect in a subcutaneous xenograft mouse model of AsPC-1 cells. In conclusion, GA micelles which showed high-efficiency anti-tumor effect in vitro and in vivo may serve as a candidate for pancreatic cancer therapy. | Yan Wang Xinxin Wang Jing Zhang Li Wang Chunqing Ou Yaqian Shu Qinjie Wu Guolin Ma Changyang Gong | 2019 | Chinese Chemical Letters2019，30，4： | 0 |
| 16 | Association between soft drink consumption types and risk of lung cancer and all-cancer: A prospective study of PLCO data显示文摘Diet/sugar-free soft drinks are considered to be healthier than regular soft drinks.However,few studies have examined the relationship between the types of soft drinks(regular and diet/sugar-free)and lung cancer(LC)/all-cancer(AC)risk.In this study,we comprehensively assessed the influence of the type of soft drink consumption on LC/AC risk based on the Prostate,Lung,Colorectal,and Ovarian(PLCO)Cancer Screening Trial.Multivariable Cox proportional hazards and competing risks Fine-Gray regression models adjusted for relevant confounders were used to estimate hazard ratios(HRs)and subdistribution HRs for different types of soft drink consumption.In the PLCO population,female subgroup,and the ever/current smoker subgroup,consumption of both regular and diet soft drinks was associated with a significantly reduced risk of LC compared with no soft drinks at all.For the non-lung cancer(NLC)risk,consumption of only diet soft drinks had a significant positive association for the total population and female subgroup.Based on our findings,it was suggested that partial replacement of regular soft drinks with diet soft drinks might be beneficial to LC prevention,especially for females and ever/current smokers.Additionally,completely replacing regular soft drinks with diet soft drinks might be detrimental to NLC prevention,especially for females. | Dongfang You Hongyang Xu Xin Chen Jiawei Zhou Yaqian Wu Yingdan Tang Zhongtian Wang Yang Zhao Fang Shao | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
| 17 | PA1426 regulates Pseudomonas aeruginosa quorum sensing and virulence:an in vitro study显示文摘Objective:Pseudomonas aeruginosa(P.aeruginosa)contains a hierarchy of quorum sensing(QS)network,consisting of the las,rhl and pqs systems,which play a key role in coordinating the expression of virulence factors.PA2146 was found to be associated with P.aeruginosa pathogenicity in macrophage and host Immune response.The aim of this study was to investigate the effects of PA2146 on the virulence of P.aeruginosa and explore its mechanism.Methods:PA2146 gene knockout strain and complement strain of P.aeruginosa PAO1 were constructed.The biomass of biofilm was detected by crystal violet staining;the virulence factors were measured,including pyocyanin,rhamnolipid,LasA elastase,LasB elastase and hemolytic activity;RNA-seq and label-free relative quantitative proteomics analyses were carried out to test the influence of PA2146 on transcriptomics and proteomics.This study was approved by the Institutional Review Board of the Third Xiangya Hospital,Central South University,China(approval No.2019-S021).Results:PA2146-deficient strains showed reduced biofilm formation and increased pyocyanin,rhamnolipid,LasA elastase,LasB elastase,and hemolytic activity,as well as increased motility,compared with the wild-type strain.RNA-seq and label-free relative quantitative proteomics analyses revealed that PA2146 repressed the transcription of several genes that are integral to the pqs system and to pyocyanin biosynthesis,and increased the expression of MexEF-OprN efflux pump components at the gene and protein level.Conclusion:PA2146 gene was found to inhibit the pqs system.PA2146 may affect quorum sensing by directly inhibiting the pqs system or by enhancing the expression of MexEF-OprN efflux pump components,thereby promoting efflux of 2-heptyl-4(1H)-quinolone,a Pseudomonas quinolone signal precursor,and thus affecting P.aeruginosa virulence. | Fang Tan Pengfei She Linying Zhou Shijia Li Xianghai Zeng Lanlan Xu Yaqian Liu Zubair Hussain Yong Wu | 2021 | Journal of Bio-X Research2021，4，1： | 0 |
| 18 | Hierarchically Porous and Defective Carbon Fiber Cathode for Efficient Zn‑Air Batteries and Microbial Fuel Cells显示文摘Developing low-cost,efficient oxygen reduction reaction(ORR)catalysts to replace Pt-based materials is urgently required for the application of Zn-air batteries(ZABs)and microbial fuel cells(MFCs).In this work,meso-microporous carbon fibers with tunable defect density were synthesized by carrageenan fibers.A highly defective carbon fiber(HDCFs)was produced which exhibited an outstanding ORR catalytic activity,reaching to the half-wave potential of 0.841 and 0.44 V in alkaline and neutral electrolytes,respectively.These HDCFs can also act as highly efficient air cathodes for ZABs(delivered potential of 0.69 V and power density of 220 mW cm^(–2) at 300 mA cm^(–2))and MFCs(high power density of 69.7 mW cm^(–2)).Simulation by the density functional theory indicated that a high density of defections in a carbon based framework can remarkably modulate the electrical properties.For instance the charge entrapments in the carbon active sites may reduce the energy barrier of ORR. | Daohao Li Xiaojing Long Yaqian Wu Huijie Hou Xueyao Wang Jun Ren Lijie Zhang Dongjiang Yang Yanzhi Xia | 2022 | Advanced Fiber Materials2022，4，4： | 0 |
| 19 | Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy显示文摘Considerable developments have been observed in fragment-based lead/drug discovery(FBLD/FBDD)recently,with four drugs approved and many others under investigation.Nuclear magnetic resonance(NMR)has gained increasing popularity in FBLD due to its intrinsic capability in characterizing protein-ligand interactions in a large dynamic range of affinity,from weak hits to highly potent drugs.Here,we summarize NMR applications in fragment-based hit-to-lead evolution,including the construction of a fragment library,screening methods,spectra processing,and the delineation of the protein-ligand binding modes.These state-of-the-art NMR techniques have been exemplified in the discovery of inhibitors against multiple targets over the past five years,and they are expected to continue to provide new insights in the future. | Lei Wang Jia Gao Rongsheng Ma Yaqian Liu Mingqing Liu Fumei Zhong Jie Hu Shuju Li Jihui Wu Hualiang Jiang Jiahai Zhang Ke Ruan | 2022 | Magnetic Resonance Letters2022，2，2： | 0 |
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