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| 1 | Histological evaluation for chemotherapeutic responses of metastatic lymph nodes in gastric cancer显示文摘AIM: To investigate the effect of preoperative chemotherapy(pre-CTx) for metastatic lymph nodes(MLNs) of gastric cancer(GC). METHODS: A retrospective cohort of patients with advanced GC, who underwent pre-CTx followed by gastrectomy, was reviewed. The histological tumor regression grade(TRG), which considered the percentage of residual cancer in the visible tumor bed, was applied to primary tumors and individual MLNs: G1a(complete response), G1b(< 10%), G2(10%-50%) and G3(> 50%). The clinical response to pre-CTx was retrospectively evaluated using only MLNs information, and we compared the histological and clinical evaluations of MLNs.RESULTS: Twenty-eight patients were enrolled. A total of 438 MLNs were retrieved, and 22(5%), 48(11%), 63(14%) and 305(70%) LNs were assigned as G1 a, G1 b, G2 and G3, respectively. Stratification of the residual MLNs based on the TRGs was as follows: 28 G1 b MLNs(9%), 48 G2 MLNs(15%), and 253 G3 MLNs(76%) in the D1 region; 20(23%), 15(17%), and 52(60%) in the D2 region, respectively. However, no significant correlation was found between TRGs in MLNs and clinical response in the subgroup for which evaluation of clinical response was available.CONCLUSION: Pre-CTx does not provide any outstanding histological benefit for MLNs, and an appropriate D2 lymphadenectomy should routinely be performed to offer the chance of curative resection. | Osamu Kinoshita Daisuke Ichikawa Yusuke Ichijo Shuhei Komatsu Kazuma Okamoto Mitsuo Kishimoto Akio Yanagisawa Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，48： | 2 |
| 2 | Characteristic of Local Boiling Heat Transfer of Ammonia and Ammonia/Water Binary Mixture on the Plate Type Evaporator显示文摘Power generation using small temperature difference such as ocean thermal energy conversion(OTEC)and discharged thermal energy conversion(DTEC)is expected to be the countermeasures against global warming problem.As ammonia and ammonia/water are used in evaporators for OTEC and DTEC as working fluids,the research of their local boiling heat transfer is important for improvement of the power generation efficiency.Measurements of local boiling heat transfer coefficients were performed for ammonia/water mixture(z=0.9-1)on a vertical flat plate heat exchanger in a range of mass flux(7.5-15 kg/m2s),heat flux(15-23 kW/m 2),and pressure(0.7-0.9 MPa).The result shows that in the case of ammonia/water mixture,the local heat transfer coefficients increase with an increase of mass flux and composition of ammonia,and decrease with an increase of heat flux. | Akio OKAMOTO Hirofumi ARIMA Yasuyuki IKEGAMI | 2011 | Journal of Thermal Science2011，20，4： | 2 |
| 3 | Non-ossifying fibromas: Case series, including in uncommon upper extremity sites显示文摘AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower extremities.METHODS We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow ossification.CONCLUSION NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress. | Akio Sakamoto Ryuzo Arai Takeshi Okamoto Shuichi Matsuda | 2017 | World Journal of Orthopedics2017，8，7： | 2 |
| 4 | Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A显示文摘 | Shigehiko Sainokami Koichi Abe Ichiro Kumagai Akio Miyasaka Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Hitoshi Mizuo Yoshiki Sugai Yoshihiro Akahane Yoichi Koizumi Yoshiaki Yajima Hiroaki Okamoto | 2004 | Journal of Gastroenterology2004，，7： | 1 |
| 5 | Gastric carcinoma originating from the heterotopic submucosal gastric gland treated by laparoscopy and endoscopy cooperative surgery显示文摘Gastric carcinoma is derived from epithelial cells in the gastric mucosa. We reported an extremely rare case of submucosal gastric carcinoma originating from the heterotopic submucosal gastric gland(HSG) that was safely diagnosed by laparoscopy and endoscopy cooperative surgery(LECS). A 66-year-old man underwent gastrointestinal endoscopy, which detected a submucosal tumor(SMT) of 1.5 cm in diameter on the lesser-anterior wall of the upper gastric body. The tumor could not be diagnosed histologically, even by endoscopic ultrasound-guided fine-needle aspiration biopsy. Local resection by LECS was performed to confirm a diagnosis. Pathologically, the tumor was an intra-submucosal well differentiated adenocarcinoma invading 5000 μm intothe submucosal layer. The resected tumor had negative lateral and vertical margins. Based on the Japanese treatment guidelines, additional laparoscopic proximal gastrectomy was curatively performed. LECS is a less invasive and safer approach for the diagnosis of SMT, even in submucosal gastric carcinoma originating from the HSG. | Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Hiroki Kobayashi Mahito Miyamae Shoji Hirajima Tsutomu Kawaguchi Takeshi Kubota Toshiyuki Kosuga Kazuma Okamoto Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kiyoshi Ogiso Nobuaki Yagi Akio Yanagisawa Takashi Ando Eigo Otsuji | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 1 |
| 6 | A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL显示文摘 | Arinobu Tojo Kensuke Usuki Akio Urabe Yasuhiro Maeda Yukio Kobayashi Itsuro Jinnai Kazuma Ohyashiki Miki Nishimura Tatsuya Kawaguchi Hideo Tanaka Koichi Miyamura Yasushi Miyazaki Timothy Hughes Susan Branford Shinichiro Okamoto Jun Ishikawa Masaya Okada N | 2009 | International Journal of Hematology2009，，5： | 1 |
| 7 | Recent progress on arrayed waveguide gratings for DWDM applications 显示文摘 | Akimasa Kaneko Akio Sugita Katsunari Okamoto | 2000 | IEICETrans Electron2000，83，6： | 1 |
| 8 | A case of chronic hepatitis C developing insulin-dependent diabetes mellitus associated with various autoantibodies during interferon therapy显示文摘 | Hirofumi Uto Hitoshi Matsuoka Mitsuhiro Murata Tsuyoshi Okamoto Yoshifumi Miyata Takeshi Hori Akio Ido Shuichi Hirono Katsuhiro Hayashi Hirohito Tsubouchi | 2000 | Diabetes Research and Clinical Practice2000，，2： | 1 |
| 9 | Recent progress on arrayed waveguide gratings for DWDM applications显示文摘 | Akimasa Kaneko Akio Sugita Katsunatri Okamoto | 2000 | IEICE Transactions on Electronics2000，83，6： | 1 |
| 10 | Effects of adsorbent properties on zone spreading in expanded bed chromatography显示文摘 | SHUICHI YAMAMOTO AKIO OKAMOTO PETER WATLER | 2001 | Bioseparation2001，10，： | 1 |
| 11 | Confocal microphotoluminescence of InGaN-based light-emitting diodes显示文摘 | Koichi Okamoto Akio Kaneta Yoichi Kawakami | 2005 | Journal of Applied Physics2005，98，06： | 1 |
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