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| 1 | Bone Density and Mechanical Properties in Femoral Bone of Swim Loaded Aged Mice显示文摘Effects of swirnming on bone density and mechanical properties of femur were investigated in aged male and female mice. R/1 strain of senescence accelerated mouse (SAM) at eleven months old was used. Two groups of males and two groups of females each consisting of 7 mice were used. One male and one female groups were loaded with a swim regiment of 40 min a day, 5 days a week for 6 consecutive weeks. The remaining groups were used as the controls. All mice were fed with the standard diet and water ad libitum during the experiments.The results of this study indicated that (i) the hady weight was significantly (P<0.05) lower in the swimming groups than in the control groups in boh sexes. (ii) The bone density was significantly higher (P <0.05) in the swimming groups than in the control groups in boh sexes. However, there was no sighficant difference in cortical thickness index. (iii) In the mechanical properties of bone, there were no significant differences in the level of the maximum breaking force, the ultimate stress and the deformation between the swimndng and the contro groups in beth sexes. However, the elasticity of the bone of the female hoce in the swimming group was significantly higher (P<0.05) than that of the control group.These results suggest that regimented swimming for the aged mice might suppress age-associated bone loss, and the effect of exercise in the females is greater that in the males. | AKIO HOSHI HIROMI WATANABE MOMOKO CHIBA AND YUTAKA INABA (Department of Health and Physical Education, Nippon Dental University, 1-8-2 Fu-jimi, Chiyoda-ku, Tokyo, Japan )(Department of Health and Physical Education, Nippon Dental University, Fugimi, T | 1998 | Biomedical and Environmental Sciences1998，11，3： | 4 |
| 2 | Fetal heart rate pattern reflecting the severity of placental abruption显示文摘 | Rie Usui Shigeki Matsubara Akihide Ohkuchi Tomoyuki Kuwata Takashi Watanabe Akio Izumi Mitsuaki Suzuki | 2008 | Archives of Gynecology and Obstetrics2008，，3： | 3 |
| 3 | Microvascular Invasion in Patients with Hepatocellular Carcinoma and Its Predictable Clinicopathological Factors显示文摘 | Shuji Sumie MD Ryoko Kuromatsu MD Koji Okuda MD Eiji Ando MD Akio Takata MD Nobuyoshi Fukushima MD Yasutomo Watanabe MD Masamichi Kojiro MD Michio Sata MD | 2008 | Annals of Surgical Oncology2008，，5： | 2 |
| 4 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 5 | Conversion of degummed soybean oil to biodiesel with immobilized Candida Antarctica lipase显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 6 | Review:Enzymatic alocoholysis for bio-diesel fuel production and application of the reaction to oil processing显示文摘 | Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，： | 1 |
| 7 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 8 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara Yoshio Tominaga | 2002 | B, Enzymatic2002，，3： | 1 |
| 9 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，6： | 1 |
| 10 | Enzymatic conversion of waste edible oil to biodiesel fuel in a fixed-bed bioreactor显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara Yoshio Tominaga | 2001 | Journal of the American Oil Chemists’ Society2001，，7： | 1 |
| 11 | 显示文摘 | Yoji Imai Akio Watanabe | 2002 | Intermetallics2002，10，4： | 1 |
| 12 | Conversion of degummed soybean oil to biodiesel with immobilized candida antarctica lipase显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 13 | 显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara | 2000 | Jour-nal of the American Oil Chemists Society2000，77，4： | 1 |
| 14 | Structure-activity relationship in piericidins inhibitors on the electron transport system in mitochondria显示文摘 | Shigeo Yoshida Yuichiro Nagao Akio watanabe | 1980 | Agric Biol Chem1980，44，12： | 1 |
| 15 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，，17： | 1 |
| 16 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，，7： | 1 |
| 17 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，： | 1 |
| 18 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，35： | 1 |
| 19 | Review:Enzymatic alocoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，： | 1 |
| 20 | Identification of mutations that occurred on the genome of Japanese encephalitis virus during the attenuation process显示文摘 | Shinobu Aihara Rao Chunming Yu Yong-Xin Tomio Lee Koji Watanabe Tomoyoshi Komiya Hideo Sumiyoshi Hiroshi Hashimoto Akio Nomoto | 1991 | Virus Genes1991，，2： | 1 |
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