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| 1 | Morning Surge in Blood Pressure as a Predictor of Silent and Clinical Cerebrovascular Disease in Elderly Hypertensives: A Prospective Study显示文摘 | Kazuomi Kario Thomas G. Pickering Yuji Umeda Satoshi Hoshide Yoko Hoshide Masato Morinari Mitsunobu Murata Toshio Kuroda Joseph E. Schwartz Kazuyuki Shimada | 2003 | Circulation: Journal of the American Heart Association2003，，10： | 3 |
| 2 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 3 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 4 | Hepatocyte growth factor and transforming growth factor β1 contribute to regeneration of small-for-size liver graft immediately after transplantation显示文摘 | Mizuki Ninomiya Noboru Harada Satoko Shiotani Shoji Hiroshige Ryosuke Minagawa Yuji Soejima Taketoshi Suehiro Takashi Nishizaki Mitsuo Shimada Keizo Sugimachi | 2003 | Transplant International2003，，11： | 2 |
| 5 | Extended Indication for Living Donor Liver Transplantation in Patients With Hepatocellular Carcinoma显示文摘 | Yuji Soejima Akinobu Taketomi Tomoharu Yoshizumi Hideaki Uchiyama Shinich Aishima Takahiro Terashi Mitsuo Shimada Yoshihiko Maehara | 2007 | Transplantation2007，，7： | 2 |
| 6 | Biofuel production process by novel biocatalysts 显示文摘 | Yasuhisa Asano Hideki Fukuda Yuji Shimada | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，35： | 1 |
| 7 | Enzymatic synthesis of steryl esters of polyunsaturated fatty acids显示文摘 | Yuji Shimada Yoshinori Hirota Takashi Baba | 1999 | JAOCS1999，76，： | 1 |
| 8 | Conversion of degummed soybean oil to biodiesel with immobilized Candida Antarctica lipase显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 9 | Enzymatic enrichment of astaxanthin from Haematococcus pluvialis cell extracts显示文摘 | Toshihiro Nagao Tadashi Fukami Yoshiharu Horita Sadao Komemushi Akio Sugihara Yuji Shimada | 2003 | Journal of the American Oil Chemists’ Society2003，，10： | 1 |
| 10 | Review:Enzymatic alocoholysis for bio-diesel fuel production and application of the reaction to oil processing显示文摘 | Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，： | 1 |
| 11 | Conversion of vegetable oil to biodiesel using immobilized candida antarctica lipase显示文摘 | Yuji Shimada Yomi Watanbe Tachi Samukawa | 1999 | 76(7) :789 - 7921999，76，7： | 1 |
| 12 | Donor Risk in Adult-to-Adult Living Donor Liver Transplantation: Impact of Left Lobe Graft显示文摘 | Akinobu Taketomi Hiroto Kayashima Yuji Soejima Tomoharu Yoshizumi Hideaki Uchiyama Toru Ikegami Yoichi Yamashita Noboru Harada Mitsuo Shimada Yoshihiko Maehara | 2009 | Transplantation2009，，3： | 1 |
| 13 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 14 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara Yoshio Tominaga | 2002 | B, Enzymatic2002，，3： | 1 |
| 15 | Enzymatic alcoholysis for biodiesel fuel production and application of the reaction to oil processing显示文摘 | Yuji Shimada Yomi Watanabe Akio Sugihara | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，6： | 1 |
| 16 | Enzymatic conversion of waste edible oil to biodiesel fuel in a fixed-bed bioreactor显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara Yoshio Tominaga | 2001 | Journal of the American Oil Chemists’ Society2001，，7： | 1 |
| 17 | Biofuel Production Process by Novel Biocatalysts显示文摘 | Yasuhisa Asano Hideki Fukuda Yuji Shimada | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
| 18 | Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke显示文摘 | Nobukazu Miyamoto Yasutaka Tanaka Yuji Ueno Miyako Kawamura Yoshiaki Shimada Ryota Tanaka Nobutaka Hattori Takao Urabe | 2011 | Journal of Stroke and Cerebrovascular Diseases2011，，： | 1 |
| 19 | Current concept of small-for-size grafts in living donor liver transplantation显示文摘 | Toru Ikegami Mitsuo Shimada Satoru Imura Yusuke Arakawa Akira Nii Yuji Morine Hirofumi Kanemura | 2008 | Surgery Today2008，，11： | 1 |
| 20 | Conversion of degummed soybean oil to biodiesel with immobilized candida antarctica lipase显示文摘 | Yomi Watanabe Yuji Shimada Akio Sugihara | 2002 | Journal of Molecular Catalysis B:Enzymatic2002，17，35： | 1 |
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