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| 1 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 2 | Diverse roles of macrophages in intraocular neovasculardiseases:a review显示文摘Macrophages are involved in angiogenesis,and might also contribute to the pathogenesis of intraocular neovascular diseases.Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization,and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages.Moreover,a large number of cytokines released by macrophages not only participate in macrophage polarization,but also associate with retinal and choroidal neovascular diseases.Therefore,macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye.This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization. | Ye-Di Zhou Shigeo Yoshida Ying-Qian Peng Yoshiyuki Kobayashi Lu-Si Zhang Luo-Sheng Tang | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 5 |
| 3 | Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma显示文摘Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases. | Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa Yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda Shigeo Horiike Takeshi Okanoue Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，17： | 5 |
| 4 | Applications of CRISPR/Cas9 in retinal degenerative diseases显示文摘Gene therapy is a potentially effective treatment for retinal degenerative diseases.Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9) system has been developed as a new genome-editing tool in ophthalmic studies.Recent advances in researches showed that CRISPR/Cas9 has been applied in generating animal models as well as gene therapy in vivo of retinitis pigmentosa(RP) and leber congenital amaurosis(LCA).It has also been shown as a potential attempt for clinic by combining with other technologies such as adeno-associated virus(AAV) and induced pluripotent stem cells(i PSCs).In this review,we highlight the main points of further prospect of using CRISPR/Cas9 in targeting retinal degeneration.We also emphasize the potential applications of this technique in treating retinal degenerative diseases. | Ying-Qian Peng Luo-Sheng Tang Shigeo Yoshida Ye-Di Zhou | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 2 |
| 5 | Increased vitreal levels of interleukin-10 in diabetic retinopathy:a Meta-analysis显示文摘AIM:To conduct a Meta-analysis for the change of interleukin-10(I1-10)concentration in vitreous samples of patients with diabetic retinopathy(DR).METHODS:Systemic search for literature was conducted from the databases of PubMed,Web of Science and Cochrane Library by August 2019.Statistical analyses including standard mean difference(SMD)and its 95%confidence interval(CI)were performed by using RevMan 5.3 software.RESULTS:Totally 194 studies were screened and finally 11 studies were included in the Meta-ana lysis.The concentration of IL-10 in the DR group was higher than in the control group(P=0.003.SMD:0.77.95%CI:0.25-1.28).Significant heterogeneity was found among all studies(P<0.00001,I^2=92%).The subgroup analysis showed that the concentration of IL-10 increased in vitreous samples from patients with DR compared to the non-DR controls(P=0.004.SMD:1.44.95%CI:0.46-2.42).Moreover,the concentration of IL-10 in samples of proliferative diabetic retinopathy(PDR)patients was significantly higher than that of non-proliferative diabetic retinopathy(NPDR)patients(P=0.01.SMD:0.61.95%CI:0.13-1.08).CONCLUSION:The vitreal concentration of IL-10 is significantly increased in patients with DR.Further studies are needed to reveal the mechanisms of IL-10 in DR. | Wei Tan Jing-Ling Zou Shigeo Yoshida Bing Jiang Ye-Di Zhou | 2020 | International Journal of Ophthalmology(English edition)2020，13，9： | 2 |
| 6 | Physiological Roles of Brassinosteroids in Early Growth of Arabidopsis: Brassinosteroids Have a Synergistic Relationship with Gibberellin as well as Auxin in Light-Grown Hypocotyl Elongation显示文摘 | Kiwamu Tanaka Yasushi Nakamura Tadao Asami Shigeo Yoshida Tomoaki Matsuo Shigehisa Okamoto | 2003 | Journal of Plant Growth Regulation2003，，3： | 1 |
| 7 | Synthesis of 2-fluoroabscisic acid: A potential photo-stable abscisic acid显示文摘 | Bum Tae Kim Yong Ki Min Tadao Asami No Kyun Park Oh Young Kwon Kwang Yun Cho Shigeo Yoshida | 1997 | Tetrahedron Letters1997，，10： | 1 |
| 8 | Characterization of the Brassinosteroid Insensitive 1 Genes of Cotton显示文摘 | Yan Sun Mohamed Fokar Tadao Asami Shigeo Yoshida Randy D. Allen | 2004 | Plant Molecular Biology2004，，2： | 1 |
| 9 | The structural revision of piericidin A by combination of CMR spectroscopic and biosynthetic studies显示文摘 | Shigeo Yoshida Shiro Shirashi Nobutaka Takahashi | 1977 | Agric Biol Chem1977，41，3： | 1 |
| 10 | Structure-activity relationship in piericidins inhibitors on the electron transport system in mitochondria显示文摘 | Shigeo Yoshida Yuichiro Nagao Akio watanabe | 1980 | Agric Biol Chem1980，44，12： | 1 |
| 11 | Constructing the National Center Diabetes Database显示文摘 | Ritsuko Yamamoto-Honda Yoshihiko Takahashi Shigeo Yamashita Yasumichi Mori Hidekatsu Yanai Shuichi Mishima Hiroshi Kajio Nobuhiro Handa Kotaro Shimokawa Akiko Yoshida Hiroji Kitazato Takuro Shimbo Shoji Kawazu Mitsuhiko Noda | 2014 | Diabetology International2014，，4： | 1 |
| 12 | Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)‐β signaling from tumor suppression to oncogenesis in early chronic hepatitis B显示文摘 | Miki Murata Koichi Matsuzaki Katsunori Yoshida Go Sekimoto Yoshiya Tahashi Shigeo Mori Yoshiko Uemura Noriko Sakaida Junichi Fujisawa Toshihito Seki Kazuki Kobayashi Koutaro Yokote Kazuhiko Koike Kazuichi Okazaki | 2009 | Hepatology2009，，4： | 1 |
| 13 | Crossing test among floating Ulva thalli forming `green tide’ in Japan显示文摘 | Masanori Hiraoka Masao Ohno Shigeo Kawaguchi Goro Yoshida | 2004 | Hydrobiologia (-)2004，，1： | 1 |
| 14 | Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy显示文摘AIM: To identify disease-related miRNAs in retinas of mice with oxygen-induced retinopathy(OIR), and to explore their potential roles in retinal pathological neovascularization. METHODS: The retinal miRNA expression profile in mice with OIR and room air controls at postnatal day 17(P17) were determined through miRNA microarray analysis. Several miRNAs were significantly up-and down-regulated in retinas of mice with OIR compared to controls by quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR). Two databases including Targetscan7.1 and MirdbV5 were used to predict target genes that associated with those significantly altered mi RNAs in retinas of mice with OIR. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analyses were also conducted to identify possible biological functions of the target genes. RESULTS: In comparison with room air controls, 3 and 8 miRNAs were significantly up-and down-regulated, respectively, in retinas of mice with OIR. The qRT-PCR data confirmed that mmu-miR-350-3 p and mmu-miR-202-3 p were significantly up-regulated, while mmu-miR-711 and mmu-miR-30 c-1-3 p were significantly down-regulated in mice with OIR compared to controls. GO analysis demonstrated that the identified target genes were related to functions such as cellular macromolecule metabolic process. KEGG pathway analysis showed a group of pathways, such as Wnt signaling pathway, transcriptionalmisregulation in cancer, Mucin type O-glycan biosynthesis, and mitogen-activated protein kinase(MAPK) signaling pathway might be involved in pathological process of retinal neovascularization. CONCLUSION: Our findings suggest that the differentially expressed miRNAs in retinas of mice with OIR might provide potential therapeutic targets for treating retinal neovascularization. | Lu-Si Zhang Ye-Di Zhou Ying-Qian Peng Hui-Lan Zeng Shigeo Yoshida Tan-Tai Zhao | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 1 |
| 15 | Wind Turbine Tower Optimization Method Using a Genetic Algorithm显示文摘 | Shigeo Yoshida | 2009 | Wind Engineering2009，，6： | 1 |
| 16 | Attenuation of periostin in retinal Müller glia by TNF-α and IFN-γ显示文摘AIM: To investigate the regulation and mechanisms of periostin expression in retinal Müller glia, and to explore the relevance to retinal neovascularization. METHODS: The oxygen-induced retinopathy(OIR) mouse model and the human Moorfield/Institute of Ophthalmology-Müller 1(MIO-M1) cell line were used in the study. Immunofluorescence staining was used to determine the distribution and expression of periostin and a Müller glial cell marker glutamine synthetase(GS). Cytokines TNF-α and IFN-γ were added to stimulate the MIO-M1 cells. ShRNA was used to knockdown periostin expression in MIO-M1 cells. Quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR) was conducted to assess the mRNA expression of periostin. RESULTS: Immunofluorescence staining showed that periostin was expressed by MIO-M1 Müller glia. GS-positive Müller glia and periostin increased in OIR retinas, and were partially overlaid. The stimulation of TNF-α and IFN-γ reduced the mRNA expression of periostin significantly and dose-dependently in MIO-M1 cells. Knockdown of periostin reduced mRNA expression of vascular endothelial growth factor A(VEGFA) in MIO-M1 cells, while VEGFA expression was not changed in periostin knock-out OIR retinas. CONCLUSION: Müller glia could be one of the main sources of periostin in the retina, and might contribute to the pathogenesis of retinal neovascularization. Proinflammatory cytokines TNF-α and IFN-γ attenuate the periostin expression in retinal Müller glia, which provides a potential and novel method in treating retinal neovascular diseases. | Ying-Qian Peng Man-Jing Cao Shigeo Yoshida Lu-Si Zhang Hui-Lan Zeng Jing-Ling Zou Yoshiyuki Kobayashi Takahito Nakama Jing-Ming Shi Song-Bai Jia Ye-Di Zhou | 2019 | International Journal of Ophthalmology(English edition)2019，12，2： | 1 |
| 17 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 18 | BES1 Accumulates in the Nucleus in Response to Brassinosteroids to Regulate Gene Expression and Promote Stem Elongation显示文摘 | Yanhai Yin Zhi-Yong Wang Santiago Mora-Garcia Jianming Li Shigeo Yoshida Tadao Asami Joanne Chory | 2002 | Cell2002，，2： | 1 |
| 19 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 20 | Role of interferons in diabetic retinopathy显示文摘Diabetic retinopathy(DR)is one of the major causes of visual impairment and irreversible blindness in developed regions.Aside from abnormal angiogenesis,inflammation is the most specific and might be the initiating factor of DR.As a key participant in inflammation,interferon-gamma(IFN-γ)can be detected in different parts of the eye and is responsible for the breakdown of the blood-retina barrier and activation of inflammatory cells and other cytokines,which accelerate neovascularization and neuroglial degeneration.In addition,IFN-γis involved in other vascular complications of diabetes mellitus and angiogenesis-dependent diseases,such as diabetic nephropathy,cerebral microbleeds,and age-related macular degeneration.Traditional treatments,such as anti-vascular endothelial growth factor agents,vitrectomy,and laser photocoagulation therapy,are more effective for angiogenesis and not tolerable for every patient.Many ongoing clinical trials are exploring effective drugs that target inflammation.For instance,IFN-αacts against viruses and angiogenesis and is commonly used to treat malignant tumors.Moreover,IFN-αhas been shown to contribute to alleviating the progression of DR and other ocular diseases.In this review,we emphasize the roles that IFNs play in the pathogenesis of DR and discuss potential clinical applications of IFNs in DR,such as diagnosis,prognosis,and therapeutic treatment. | Bing-Yan Li Wei Tan Jing-Ling Zou Yan He Shigeo Yoshida Bing Jiang Ye-Di Zhou | 2021 | World Journal of Diabetes2021，12，7： | 1 |
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