|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy显示文摘Low-dose aspirin(LDA) is clinically used for the prevention of cardiovascular and cerebrovascular events with the advent of an aging society.On the other hand,a very low dose of aspirin(10 mg daily) decreases the gastric mucosal prostaglandin levels and causes significant gastric mucosal damage.The incidence of LDAinduced gastrointestinal mucosal injury and bleeding has increased.It has been noticed that the incidence of LDA-induced gastrointestinal hemorrhage has increased more than that of non-aspirin non-steroidal anti-inflammatory drug(NSAID)-induced lesions.The pathogenesis related to inhibition of cyclooxygenase(COX)-1 includes reduced mucosal flow,reduced mucus and bicarbonate secretion,and impaired platelet aggregation.The pathogenesis related to inhibition of COX-2 involves reduced angiogenesis and increased leukocyte adherence.The pathogenic mechanisms related to direct epithelial damage are acid back diffusion and impaired platelet aggregation.The factors associated with an increased risk of upper gastrointestinal(GI) complications in subjects taking LDA are aspirin dose,history of ulcer or upper GI bleeding,age > 70 years,concomitant use of non-aspirin NSAIDs including COX-2-selective NSAIDs,and Helicobacter pylori(H.pylori) infection.Moreover,no significant differences have been found between ulcer and non-ulcer groups in the frequency and severity of symptoms such as nausea,acid regurgitation,heartburn,and bloating.It has been shown that the ratios of ulcers located in the body,fundus and cardia are significantly higher in bleeding patients than the ratio of gastroduodenal ulcers in patients taking LDA.Proton pump inhibitors reduce the risk of developing gastric and duodenal ulcers.In contrast to NSAIDinduced gastrointestinal ulcers,a well-tolerated histamine H2-receptor antagonist is reportedly effective in prevention of LDA-induced gastrointestinal ulcers.The eradication of H.pylori is equivalent to treatment with omeprazole in preventing recurrent bleeding.Continuous aspirin therapy for patients with gastrointestinal bleeding may increase the risk of recurrent bleeding but potentially reduces the mortality rates,as stopping aspirin therapy is associated with higher mortality rates.It is very important to prevent LDA-induced gastroduodenal ulcer complications including bleeding,and every effort should be exercised to prevent the bleeding complications. | Junichi Iwamoto Yoshifumi Saito Akira Honda Yasushi Matsuzaki | 2013 | World Journal of Gastroenterology2013，19，11： | 29 |
| 2 | 顺铂、异环磷酰胺和长春酰胺联合用药治疗非小细胞肺癌的Ⅱ期研究显示文摘用顺铂(CDDP,100mg/m^2)、异环磷酰胺(IFX,2g/m^2×3,合并Mcsna)和长春酰胺(VDS,3mg/m^2)联合化疗方案(CIV)治疗47例不能手术的非小细胞肺癌。3周或5周重复一次。40例可评价的病人,19例(47.5%) 获部分缓解(PR)(其中鳞癌78.6%、腺癌30.1%),没有完全缓解(CR)病例。本方案的血液学毒性不严重,但是,肾毒性相当高,2例病人发生肾功能衰竭,随后死于全血细胞减少症和脓毒血症。作者认为,对于非小细胞肺癌,特别是鳞癌,CI方案比CDDP+VDS更有效,但是,所治疗的病人应经严格选择。 | Ryoichi Honda Akihisa Fujita YuhjiInoue Mitsuo Asakawa Akira Suzuki 刘云英 | 1992 | 癌症1992，11，3： | 14 |
| 3 | Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding显示文摘AIM: To investigate the clinical differences between small intestinal injuries in low-dose aspirin(LDA) users and in non-steroidal anti-inflammatory drug(NSAID) users who were examined by capsule endoscopy(CE) for obscure gastrointestinal bleeding(OGIB). METHODS: A total of 181 patients who underwent CE for OGIB were included in this study. Based on clinical records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, the types and duration of LDA and NSAID use, and endoscopic characteristics of CE were reviewed.RESULTS: Out of a total of 45 cases of erosive lesions, 27 cases were taking LDA or NSAIDs(7 were on NSAIDs, 9 were on LDA alone, 9 were on LDA and thienopyridine, and 2 were on LDA and warfarin).The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64.3%, 80.0%, and 75.0%, respectively. Erosive lesions were observed predominantly in chronic LDA users, while ulcerative lesions were detected mainly in NSAID users. However, concomitant use of thienopyridine such as clopidogrel with LDA increased the proportion of ulcers. The erosive lesions were located in the whole of the small intestine(jejunum and ileum), whereas ulcerative lesions were mainly observed in the ileum(P < 0.05). CONCLUSION: Our CE findings indicate that chronic LDA users and NSAID users show different types and locations of small-bowel mucosal injuries. The concomitant use of anti-platelet drugs with LDA tends to exacerbate the injuries from LDA-type to NSAID-type injuries. | Junichi Iwamoto Yuji Mizokami Yoshifumi Saito Koichi Shimokobe Akira Honda Tadashi Ikegami Yasushi Matsuzaki | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 4 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 5 | Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis显示文摘A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver tumors.He was diagnosed with hepatocellular carcinoma(HCC) arising from decompensated hepatitis B virus(HBV)-related cirrhosis.Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC.His Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 year.His indocyanine green at 15 min after injection test score was 48%before lamivudine treat-ment,improving to 22%after 2 years and to 5%after 4 years.Radiofrequency ablation controlled the HCC foci and maintained his liver function.In April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal vein.Since his indocyanine green test results had improved to less than 10%,we performed a right hepatectomy,which was successful.To our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis.The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC. | Koichi Honda Masataka Seike Shin-ichiro Maehara Koichiro Tahara Hideaki Anai Akira Moriuchi Toyokichi Muro | 2012 | World Journal of Gastroenterology2012，18，20： | 7 |
| 6 | Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy显示文摘 | Akiko Miki Naoshi Kondo Suiho Yanagisawa Hiroaki Bessho Shigeru Honda Akira Negi | 2013 | Ophthalmology2013，，： | 2 |
| 7 | Hand-Sewn Versus Mechanical Esophagogastric Anastomosis After Esophagectomy: A Systematic Review and Meta-Analysis显示文摘 | Michitaka Honda Akira Kuriyama Hisashi Noma Souya Nunobe Toshi A Furukawa | 2013 | Annals of Surgery2013，，2： | 2 |
| 8 | Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma显示文摘 | Yohji Honda Tomoki Kimura Hiroshi Aikata Tomoki Kobayashi Takayuki Fukuhara Keiichi Masaki Takashi Nakahara Noriaki Naeshiro Atsushi Ono Daisuke Miyaki Yuko Nagaoki Tomokazu Kawaoka Shintaro Takaki Akira Hiramatsu Masaki Ishikawa Hideaki Kakizawa Masahiro | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 9 | Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia显示文摘 | Akira Ito Yuko Kuga Hiroyuki Honda Hiroyuki Kikkawa Atsushi Horiuchi Yuji Watanabe Takeshi Kobayashi | 2004 | Cancer Letters2004，，2： | 1 |
| 10 | Host factor Ebp1: Selective inhibitor of influenza virus transcriptase 显示文摘 | Ayae Honda Takuto Okamoto Akira Ishihama | 2007 | Genes to Cells2007，12，2： | 1 |
| 11 | Magnetite Nanoparticle-loaded Anti-HER2 Immunoliposomes for Combination of Antibody Therapy with Hyperthennia 显示文摘 | Akira Ito Yuko Kuga Hiroyuki Honda | 2004 | Cancer Lett2004，212，2： | 1 |
| 12 | Electrochemical Photolysis of Water at an Semiconductor Electrode显示文摘 | Akira Fujishima Kenichi Honda | 1972 | Nature1972，238，： | 1 |
| 13 | Minimum molecular architectures for transcription and replication of the influenza virus 显示文摘 | Ayae Honda Kiyohisa Mizumoto Akira Ishihama | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 14 | Selective contribution of IFN- alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection 显示文摘 | Honda K Sakaguchi S Nakajima C Watanabe A Yanai H Matsumoto M Ohteki T Kaisho T Takaoka A Akira S Seya T Taniguchi T | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
| 15 | Electrochemical Photo- lysis of Water at a Semiconductor Electrode显示文摘 | Akira Fujishima Kenichi Honda | 1972 | Nature1972，238，： | 1 |
| 16 | Guidelines for donor selection and an overview of the donor operation in living related liver transplantation显示文摘 | Taisuke Morimoto Masato Ichimiya Akira Tanaka Iwao Ikai Yuzo Yanamoto Yoshiaki Nakamura Yasugu Takada Yukihiro Inomata Kazuo Honda Takashi Inamoto Koichi Tanaka Yoshio Yamaoka | 1996 | Transplant International1996，，3： | 1 |
| 17 | Antitnmor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma显示文摘 | Akira Ito Fumiko Matsuoka Hiroyuki Honda | 2004 | Cancer Immunol Immunother2004，53，： | 1 |
| 18 | 显示文摘 | Akira Fujishima Kenichi Honda | 1972 | Nature1972，238，： | 1 |
| 19 | Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2显示文摘 | Osamu Nakahara Hiroshi Takamori Masaaki Iwatsuki Yoshifumi Baba Yasuo Sakamoto Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Keiichiro Kanemitsu Yumi Honda Ken-ichi Iyama Hideo Baba | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 20 | 'Aqua-space',a new headspace method for isolation of natural floral aromas using humidified air as a carrier gas显示文摘 | MASASHI ISHIKAWA TSUTIMU HONDA AKIRA FUJITA | 2004 | Biosci Biotechnol Biochem2004，68，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员