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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 3 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 4 | Late Glacial temperature and precipitation changes in tile lowland Neotropics by tandem measurement of lSO in biogenic carbonate and gypsum hydration water显示文摘 | DAVID A H ALEXANDRA V T CAMILLA J W | 2012 | Geochimica et Cosmochimica Acta2012，77，： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | Transgenic Myocardial Overexpression of Fibroblast Growth Factor-1 Increases Coronary Artery Density and Branching 显示文摘 | Borja F Alexandra B Swen W | 2000 | Circulation Research2000，87，： | 1 |
| 7 | Food scares and trust:a european study显示文摘 | MARIO M ALEXANDRA L BRUCE T W | 2008 | Journal of Agricultural Eco-nomics2008，59，1： | 1 |
| 8 | Pyrrolizidine alkaloids from Gynura divaricata 显示文摘 | Erhard R Alexandra E Helmut W | 1996 | Planta Med1996，62，4： | 1 |
| 9 | Effect of high-pressure treatment on the tryptic hydrolysis of bovine β-lactogloblin AB显示文摘 | Francoise M Alexandra W Jorg H | 1998 | International Dairy Journal1998，8，： | 1 |
| 10 | Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention显示文摘 | Eugenia Nikolsky Roxana Mehran Diane Turcot Eve D Aymong Gary S Mintz Zoran Lasic Alexandra J Lansky Emmanouil Tsounias Jeffrey W Moses Gregg W Stone Martin B Leon George D Dangas | 2004 | The American Journal of Cardiology2004，，3： | 1 |
| 11 | Development and evaluation in vlvo of a long-term dilivery system for vapreotide, a somatostain analogue显示文摘 | ALEXANDRA R W KAMEL B YVES D Z | 1998 | Controlled rel1998，52，： | 1 |
| 12 | In vivo imaging of Ca2+,pH,and reactive oxygen species using fluorescent probes in plants显示文摘 | Swanson S J Choi W G Alexandra C | | 0，，： | 1 |
| 13 | The past, present and future of HIV-vaccine development: a critical view 显示文摘 | Alexandra B Ludwig D Ralf W | 2002 | DTT2002，7，1： | 1 |
| 14 | The cow as a geomorphic agent - A critical review显示文摘 | Trimble Stanley W Mendel Alexandra C | 1995 | Geomorphology1995，13，： | 1 |
| 15 | Vertical breast extensionduring treadmill running显示文摘 | Joanna S Jennifer W Alexandra M | 2011 | Portuguese Journal of Sport Sciences2011，11，2： | 1 |
| 16 | Auxin trig- gers transient local short article signaling for cell specification in Arabidopsis embryogenesis显示文摘 | DOLF W ALEXANDRA S JASMIN S E | 2006 | Developmental Cell2006，10，2： | 1 |
| 17 | Subdura hygrogoma as a complication of Endoscopic Neurosurgery显示文摘 | Dirk F Alexandra W Ulrike E | 2002 | Neurol Med Chit2002，42，： | 1 |
| 18 | Novel porous silicon formation without external contaet显示文摘 | ALEXANDRA S JORG S BENECKE W | 2004 | Micromachining and Microfabrication Process Technology VI2004，，6： | 1 |
| 19 | Meta-Analysis of Risedronate for the Treatment of Postmenopausal Osteoporosis显示文摘 | Ann C Peter T Jonathan A Bruce W Nicole Z Alexandra P Vivian R Beverley S George W Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 20 | Novel porous silicon formation without external contact显示文摘 | ALEXANDRA S JORG S BENECKE W | 2000 | Micromachining and Microfabrication Process Technology Ⅵ2000，4174，6： | 1 |
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