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| 1 | Epidemiology and risk factors of colorectal cancer in China显示文摘In China, colorectal cancer(CRC) ranked fourth and fifth in the highest incidence and mortality rates of all malignancies in 2018, respectively. Although these rates are below the world average, China placed first worldwide in the number of new CRC cases and CRC-related deaths because of its comparatively large population. This disease represents a threat to the health of population and incurs a heavy economic burden on the society and individuals. CRC has various risk factors, including age, sex, lifestyle, genetic factors, obesity, diabetes, gut microbiota status, and precancerous lesions. Furthermore, incidence and mortality rates of CRC are closely related to socioeconomic development levels, varying according to regional and population characteristics. Prevention is the main strategy to reduce incidence and mortality rates of CRC. This can be achieved through strategies stimulating lifestyle changes, healthy diet habits, and early screening for high-risk individuals. To reduce the burden of CRC, public health officials should promote prevention and management of modifiable risk factors through national policies. The rising incidence and mortality rates of CRC in China may be timely curbed by clarifying specific epidemiological characteristics, optimizing early screening strategies, and strictly implementing diagnosis and treatment guidelines. Thus, this study aimed to collect and report the current research status on epidemiology and risk factors of CRC in China. | Yong Yang Zihan Han Xin Li An Huang Jingyi Shi Jin Gu | 2020 | Chinese Journal of Cancer Research2020，32，6： | 42 |
| 2 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 3 | Targeting stem cell signaling pathways for drug discovery:advances in the Notch and Wnt pathways显示文摘Signaling pathways transduce extracellular stimuli into cells through molecular cascades to regulate cellular functions.In stem cells,a small number of pathways,notably those of TGF-?/BMP,Hedgehog,Notch,and Wnt,are responsible for the regulation of pluripotency and differentiation.During embryonic development,these pathways govern cell fate specifications as well as the formation of tissues and organs.In adulthood,their normal functions are important for tissue homeostasis and regeneration,whereas aberrations result in diseases,such as cancer and degenerative disorders.In complex biological systems,stem cell signaling pathways work in concert as a network and exhibit crosstalk,such as the negative crosstalk between Wnt and Notch.Over the past decade,genetic and genomic studies have identified a number of potential drug targets that are involved in stem cell signaling pathways.Indeed,discovery of new targets and drugs for these pathways has become one of the most active areas in both the research community and pharmaceutical industry.Remarkable progress has been made and several promising drug candidates have entered into clinical trials.This review focuses on recent advances in the discovery of novel drugs which target the Notch and Wnt pathways. | AN Songzhu Michael DING Qiang ZHANG Jie XIE JingYi LI LingSong | 2014 | Science China(Life Sciences)2014，57，6： | 5 |
| 4 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 5 | Photochemistry of hypocrellin derivatives under anaerobic conditions显示文摘To improve the red absorption and solubility of hypocrellin, we have synthesized a series of hypocrellin B derivatives. The pnotochemistry of these new compounds in anaerobic media has been investigated by using electronic paramagnetic resonance (EPR) and spectrophotometric methods. The semiquinone anion radicals can be produced by self-electron transfer on irradiation, with the formation efficiency and EPR hyperfine structures of the semiquinone anion radicals dependent on the structures of the derivatives. When an electron donor is present, the electron transfer from electron donor to hypocrellin B derivatives enhanced the production of the corresponding semiquinone anion radical; in addition, the semiquinone anion radical and hydroquinone can be detected spectrophotometrically. Structural modifications exert little effect on the absorption position of semiquinone anion radical and hydroquinone, but influence their formation efficiency significantly. | Yuying He An Jingyi Lijin Jiang | 2000 | Chinese Science Bulletin2000，45，7： | 2 |
| 6 | Indocyanine green assembled free oxygen-nanobubbles towards enhanced near-infrared induced photodynamic therapy显示文摘Photodynamic therapy(PDT)has shown a promising capability for cancer treatment with minimal side effects.Indocyanine green(ICG),the only clinically approved near-infrared(NIR)fluorophore,has been used as a photosensitizer for PDT in clinical application.However,the main obstacle of directly utilizing ICG in the clinic lies in its low singlet oxygen(1O_(2))quantum yield(QY)and instability in aqueous solution.To improve the PDT efficacy of ICG,free ICG molecules were assembled with free oxygen nanobubbles(NBs-O_(2))to fabricate ICG-NBs-O_(2) by hydrophilic-hydrophobe interactions on the gas-liquid interface.Interestingly,1O2 QY of ICG-NBs-O_(2) solution was significantly increased to 1.6%,which was estimated to be 8 times as high as that of free ICG solution.Meanwhile,ICG-NBs-O_(2) exhibited better aqueous solution stability compared with free ICG.Furthermore,through establishing tumor models in nude mice,the therapeutic efficacy of ICG-NBs-O_(2) was also assessed in the PDT treatment of oral cancer.The tumor volume in ICG-NBs-O_(2) treated group on day 14 decreased to 0.56 of the initial tumor size on day 1,while the tumor volume in free ICG treated group increased to 2.4 times.The results demonstrated that ICG-NBs-O_(2) showed excellent tumor ablation in vivo.Therefore,this facile method provided an effective strategy for enhanced PDT treatment of ICG and showed great potential in clinical application. | Li Yang Bin Huang Shiqi Hu Yuan An Jingyi Sheng Yan Li Yuxin Wang Ning Gu | 2022 | Nano Research2022，15，5： | 2 |
| 7 | Synthesis and surface properties of several nonionic–anionic surfactants with straight chain alkyl-benzyl hydrophobic group显示文摘 | Xianguang Wang Feng Yan Zhenquan Li Lu Zhang Sui Zhao Jingyi An Jiayong Yu | 2007 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2007，，1： | 1 |
| 8 | Photochemistry of hypocrellin derivatives under aerobic conditions显示文摘Hypocrellins are a novel type of photosensitizers. A series of new hypocrellin B (HB) derivatives have been synthesized to overcome their limitations, i.e. to improve their red absorption and amphiphilicity. The generation of reactive oxygen species (including superoxide anion radical, hydroxyl radical and singlet oxygen) is investigated in the presence of oxygen. The chemical structures of HB derivatives affect not only the generation efficiencies of superoxide and hydroxyl radicals, but also quantum yields of singlet oxygen. | Yuying He Jingyi An Lijin Jiang | 2000 | Chinese Science Bulletin2000，45，12： | 1 |
| 9 | Applications of high -temperature aqueous media for synthetic organic reactions 显示文摘 | AN JINGYI BAGNELL L CABLEWSKI T | 1997 | J Org Chem1997，62，： | 1 |
| 10 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 11 | Morphological and Sulfur-Isotopic Characteristics of Pyrites in the Deep Sediments from Xisha Trough,South China Sea显示文摘Pyrite is one of the common authigenic minerals in marine sediments.Previous studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it is formed.To better understand the for-mation mechanism of authigenic pyrite,we analyzed the isotopic composition,morphology,and distribution of pyrite in the sediment at 500m below the seafloor from Xisha Trough,South China Sea.Mineral morphologies were observed by scanning electron micros-copy and Raman spectrography.X-Ray computed tomography was applied to measure the particle size of pyrite.The size of pyrite crystals in the matrix sediment mainly ranged between 25 and 65µm(av.ca.40µm),although crystals were larger(av.ca.50μm)in the veins.The pyrites had a fine-grained truncated octahedral shape with occasionally well-developed growth steps,which implies the low growth rate and weak anaerobic oxidation of methane-sulfate reduction when pyrite was formed.Theδ^(34)S values of pyrites ranged from+20.8‰Vienna-defined Canyon Diablo Troilite(V-CDT)to+33.2‰V-CDT and from+44.8‰V-CDT to+48.9‰,which suggest two growth stages.In the first stage,with the continuous low methane flux,the pyrite possibly formed in an environment with good access to seawater.In the second stage,the pyrites mainly developed in sediment fractures and appeared in veins,probably due to the limited availability of sulfate.The less exposure of pyrite to the environment in the second stage was probably caused by sediment accumulation or perturbation.In this study,an episodic pyritization process was identified,and the paleoenvironment was reconstructed for the sediment investigated. | CHANG Jingyi LIU Yujia LU Hailong LU Jing’an SU Xin YE Jianliang XIE Wenwei | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 12 | Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration显示文摘Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts.Here,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects.Loose and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their biosafety.The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus.After internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium ions.Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications. | Jingyi Lu Miao Sun Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang | 2023 | Bio-Design and Manufacturing2023，6，5： | 0 |
| 13 | Epidemiology and early screening strategies for colorectal cancer in China显示文摘China ranks the first worldwide in the number of new colorectal cancer(CRC) cases and CRC-related deaths. The increasing incidence of early-onset CRC in recent years highlights the challenges related to CRC screening and prevention. High-quality colonoscopy is the universally used gold standard for CRC screening. Risk assessment combined with a two-step screening strategy based on colonoscopy and non-invasive examinations was proven to be highly effective. However, systematic use of well-established risk factors associated with CRC, beyond age, could better identify those who might harbor advanced colorectal neoplasia, improve the diagnostic yield of current screening modalities, and optimize the selection of individuals who might benefit most from preventive strategies.“Personalization” and “Standardization” are the future development directions of CRC screening, from the initiation of screening in those at high risk for CRC to follow-up after treatment, which are the key to ensure the screening efficiency. | Yong Yang Zhaoya Gao An Huang Jingyi Shi Zhuang Sun Haopeng Hong Jin Gu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 14 | Single event transients induced by pulse laser in Ge pMOSFETs and its supply voltage dependence显示文摘Dear editor,Germanium(Ge) has been considered as a promising candidate of channel material for sub-7 nm owing to its high carrier mobility and good compatibility with conventional Si CMOS process [1]. Although Ge-based technology is still under development and not in massive production, it is quite meaningful to explore its single event effect(SEE) before potential space applications. | Jingyi LIU Xia AN Gensong LI Zhexuan REN Ming LI Xing ZHANG Ru HUANG | 2022 | Science China(Information Sciences)2022，65，8： | 0 |
| 15 | SUBSTRUCTURE ALTERATION OF STAINLESS STEEL DURING CONSTANT STRAIN FATIGUE显示文摘The alteration of substructure of an austenitic stainless steel has been investigated during con-stant strain fatigue.No plateau stage on the cyclic stress-strain curve was observed for thestainless steel in contrast with a monocrystalline pure copper specimen.This may relate to itslow stacking fault energy.During strain fatigue under various amplitudes the substructure ofdislocation in austenite alterates correspondingly.It revealed to associate with the appearancechange of the cyclic stress-strain curve. | WANG Jingyi Xi’an Institute of Technology,Xi’an,ChinaTAN Yuxu MA Zenghai Xi’an Jiaotong University,Xi’an,China Institute of Mealic Materials and Strength,Xi’an Jiaotong University,Xi’an 710049,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，5： | 0 |
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