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| 1 | Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO显示文摘胃的溃疡(GU ) 是在全世界影响许多人的普通病理。过多的白酒消费是 GU 的主要原因之一;然而,仍然有为 GU 的预防或治疗的有效的药的缺乏。在这研究,我们在老鼠把保护的效果和 kaempferol (KAE ) 的可能的机制与尖锐导致乙醇的损害作比较到胃的 mucosa。Fasted 老鼠口头上地被给车辆(0.9% 盐) , omeprazole (20 mg/kg ) ,或为在在由有绝对乙醇(10 ml/kg ) 的挑战的 GU 模型的建立以前的不同试验性的集合的 1 h 的 KAE (40, 80,或 160 mg/kg ) 。动物是 euthanized 在乙醇吸入以后的 1 h,和他们的血浆和胃纸巾服从于进一步的检查。宏观、显微镜的损害,和免疫学的和生物化学的参数被观察。发炎的效果用下列指示物被调查:肿瘤坏死因素 --(TNF-) , interleukin-1 (IL-1 ) , IL-6, myeloperoxidase (军邮局) ,和氮的氧化物(没有) 。结果证明 KAE 显著地减少了溃疡索引,增加了预防索引,完全保护了 mucosa 免受损害,和保存胃的 mucosal glycoprotein 的伤害。KAE 减少了军邮局活动和支持 inflammatory cytokine (TNF- ,和 IL-1 ) 铺平,并且没改进层次。KAE 的 gastroprotective 活动可能被归因于胃的有粘液的 glycoproteins 层次的保藏,这样由禁止嗜中性的累积和军邮局活动,调整支持 inflammatory cytokines 的层次,并且不改进生产。 | Qinchen Li Xinxin Hu Yanhan Xuan Jianghua Ying Yujia Fei Jielu Rong Yong Zhang Jian Zhang Chunyan Liu Zheng Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 18 |
| 2 | Single crystalline CH_3NH_3PbI_3 self-grown on FTO/TiO_2 substrate for high efficiency perovskite solar cells显示文摘Since its first report in 2009,CH_3NH_3PbI_3-based perovskite solar cells(PSCs)have emerged as one of the most exciting developments in the next generation photovoltaic(PV)technologies[1],with its PV conversion efficiency(PCE)rising spectacularly from3.81% to 22.1% in just 7 years.Such rapid advance is | Jinjin Zhao Guoli Kong Shulin Chen Qian Li Boyuan Huang Zhenghao Liu Xingyuan San Yujia Wang Chen Wang Yunce Zhen Haidan Wen Peng Gao Jiangyu Li | 2017 | Science Bulletin2017，62，17： | 12 |
| 3 | Characterization and fine mapping of an early senescence mutant (es-t) in Oryza sativa L.显示文摘An es-t (early senescence-temporary) mutant, produced by ethylene methylsulfonate treatment of strain Nipponbare, was identified in rice. The leaves of es-t appeared yellow at the seedling stage, and had decreased chlorophyll content. Rust spots were found during growth in es-t, especially at the leaf margin and tip. The plants showed a typical early-senescence phenotype at the milky stage. The leaf surface of es-t appeared smoother than wild-type leaves under a scanning electron microscope, because the leaves lack siliceous protuberances around the stoma. Chloroplasts grow abnormally and are filled with many starch grains in es-t. Paraffin section analysis showed that the development of the sclerenchyma cells and vascular bundles were also abnormal in es-t. Genetic analysis indicated that es-t was controlled by a recessive gene, which was finely mapped to a 42-kb interval on chromosome 5. These results will facilitate the positional cloning and functional studies of the gene. | YANG YaoLong RAO YuChun LIU HuiJuan FANG YunXia DONG GuoJun HUANG LiChao LENG YuJia GUO LonBiao ZHANG GuangHeng HU Jiang GAO ZhenYu QIAN Qian ZENG DaLi | 2011 | Chinese Science Bulletin2011，56，23： | 8 |
| 4 | Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome显示文摘Regulatory T(Treg) cells, a subtype of immunosuppressive CD4^+T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3(FOXP3), a member of the forkhead-wingedhelix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particular, the mutation of FOXP3 can result in immune dysregulation,polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome, which is a rare genetic disease mostly diagnosed in early childhood and can soon be fatal. IPEX syndrome is related to several manifestations,including dermatitis, enteropathy, type 1 diabetes, thyroiditis, and so on. Here, we summarize some recent findings on FOXP3 regulation and Treg cell function. We also review the current knowledge about the underlying mechanism of FOXP3 mutant-induced IPEX syndrome and some latest clinical prospects.At last, this review offers a novel insight into the role played by the FOXP3 complex in potential therapeutic applications in IPEX syndrome. | Qianru Huang Xu Liu Yujia Zhang Jingyao Huang Dan Li Bin Li | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 5 | Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress显示文摘Homoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks. Intercellular communication is largely mediated by gap junctions(GJs), a type of specialized membrane contact composed of variable number of channels that enable direct communication between cells by allowing small molecules to pass directly into the cytoplasm of neighbouring cells. Although considerable evidence indicates that gap junctions contribute to the functions of many organs, such as the bone, intestine, kidney, heart, brain and nerve, less is known about their role in oral development and disease. In this review, the current progress in understanding the background of connexins and the functions of gap junctions in oral development and diseases is discussed. The homoeostasis of tooth and periodontal tissues, normal tooth and maxillofacial development, saliva secretion and the integrity of the oral mucosa depend on the proper function of gap junctions.Knowledge of this pattern of cell–cell communication is required for a better understanding of oral diseases. With the everincreasing understanding of connexins in oral diseases, therapeutic strategies could be developed to target these membrane channels in various oral diseases and maxillofacial dysplasia. | Wenjing Liu Yujia Cui Jieya Wei Jianxun Sun Liwei Zheng Jing Xie | 2020 | International Journal of Oral Science2020，12，2： | 7 |
| 6 | Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning显示文摘Parasitic infections constitute a major global public health issue.Existing screening methods that are based on manual microscopic examination often struggle to provide sufficient volumetric throughput and sensitivity to facilitate early diagnosis.Here,we demonstrate a motility-based label-free computational imaging platform to rapidly detect motile parasites in optically dense bodily fluids by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism.Based on this principle,a cost-effective and mobile instrument,which rapidly screens~3.2 mL of fluid sample in three dimensions,was built to automatically detect and count motile microorganisms using their holographic time-lapse speckle patterns.We demonstrate the capabilities of our platform by detecting trypanosomes,which are motile protozoan parasites,with various species that cause deadly diseases affecting millions of people worldwide.Using a holographic speckle analysis algorithm combined with deep learningbased classification,we demonstrate sensitive and label-free detection of trypanosomes within spiked whole blood and artificial cerebrospinal fluid(CSF)samples,achieving a limit of detection of ten trypanosomes per mL of whole blood(~five-fold better than the current state-of-the-art parasitological method)and three trypanosomes per mL of CSF.We further demonstrate that this platform can be applied to detect other motile parasites by imaging Trichomonas vaginalis,the causative agent of trichomoniasis,which affects 275 million people worldwide.With its costeffective,portable design and rapid screening time,this unique platform has the potential to be applied for sensitive and timely diagnosis of neglected tropical diseases caused by motile parasites and other parasitic infections in resource-limited regions. | Yibo Zhang Hatice Ceylan Koydemir Michelle M.Shimogawa Sener Yalcin Alexander Guziak Tairan Liu Ilker Oguz Yujia Huang Bijie Bai Yilin Luo Yi Luo Zhensong Wei Hongda Wang Vittorio Bianco Bohan Zhang Rohan Nadkarni Kent Hill Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 7 | Spatiotemporal evolution of prehistoric Neolithic-Bronze Age settlements and influencing factors in the Guanting Basin, northeast Tibetan Plateau显示文摘For almost two decades, the relationship between prehistoric natural disasters that struck the Guanting Basin in northeast Tibetan Plateau and the destruction of Lajia, an archeological site, has attracted scholarly attention and been widely discussed. Whereas most studies have focused on the impacts of disasters on a single site within the Guanting Basin, few have examined patterns of spatiotemporal evolution of human settlements from the Neolithic to the Bronze Age. Consequently, there is a lack of clarity on the processes and mechanisms underlying the evolution of prehistoric human-land relationships in the Guanting Basin. We therefore examined spatiotemporal variations in settlements in the Guanting Basin during the period, based on the locations, altitudes, and areas of archaeological sites. We found that four sites were located on the third terrace of the Yellow River during the late Yangshao period(5500–5000 cal yr BP) and distributed within a small area. During the period between the Majiayao and Qijia cultures(5300–3600 cal yr BP), the number of sites evidently increased and the scale and distribution of settlements expanded, with settlements generally shifting toward the lower elevation areas of the Guanting Basin.During the Xindian period(3400–2700 cal yr BP), the number and scale of sites showed a downward trend and the distribution of settlements contracted. The Xindian settlement underwent altitude-based spatial differentiation, with some groups moving to areas at higher altitudes and others remained in lower altitude areas. Moreover, we found that the number, scale, and distribution range of Neolithic and Bronze Age sites in the Guanting Basin were closely related to the evolution and distribution patterns of prehistoric cultures in the regions of Gansu and Qinghai, which were further affected by climate change and agricultural development. Furthermore, there is no evidence that the altitudinal distribution pattern of Neolithic and Bronze Age settlements in the Guanting Basin was influenced by paleofloods rather it was primarily influenced by changes in subsistence strategies. | CUI YiFu LIU YuJia MA MinMin | 2018 | Science China Earth Sciences2018，61，2： | 5 |
| 8 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 9 | Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea显示文摘Polysaccharides from Fuzhuan brick tea(FBTPS),one of most important bioactive components in tea,showed various health-promoting functions.Our previous work demonstrated that the crude FBTPS(CFBTPS)could modulate the gut microbiota.However,which purified fraction in CFBTPS contributing to the modulation of gut microbiota remains unclear.Thus,the fermentation characteristics and probiotic activity of a purified fraction(FBTPS-2-1)of CFBTPS were evaluated in this work.The results showed that gut microbiota could utilize FBTPS-2-1 to produce short-chain fatty acids including acetic,propionic,n-butyric and n-valeric acids.FBTPS-2-1 could modulate the structure and metabolic pathways of gut microbiota.FBTPS-2-1 could increase the health-promoting gut microbiota such as Prevotellaceae and Bifidobacteriaceae,and decreased the harmful bacteria such as Enterobacteriaceae and Fusobacteriaceae.The results of metagenomics showed that Prevotella copri and Megamonas funiformis were the dominant bacteria after fermentation of FBTPS-2-1.Furthermore,FBTPS-2-1 could regulate the biosynthesis and metabolism pathways of gut microbiota.Thus,the enrichment of food with FBTPS-2-1 is expected as a potential strategy for promoting human health due to modulation of gut microbiota. | Guijie Chen Ziqi Zeng Minhao Xie Yujia Peng Wangting Zhou Weiqi Xu Yi Sun Xiaoxiong Zeng Zhonghua Liu | 2022 | Food Science and Human Wellness2022，11，3： | 4 |
| 10 | Therapeutic applications of genetic code expansion显示文摘In nature,a limited,conservative set of amino acids are utilized to synthesize proteins.Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids(ncAAs)through orthogonal aminoacyltRNA synthetase(aaRS)/tRNA pairs.The past decade has witnessed the rapid growth in diversity and scope for therapeutic applications of this technology.Here,we provided an update on the recent progress using genetic code expansion in the following areas:antibody-drug conjugates(ADCs),bispecific antibodies(BsAb),immunotherapies,long-lasting protein therapeutics,biosynthesized peptides,engineered viruses and cells,as well as other therapeutic related applications,where the technique was used to elucidate the mechanisms of biotherapeutics and drug targets. | Yujia Huang Tao Liu | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 4 |
| 11 | Differential expression of FOXO1 during development and myoblast differentiation of Qinchuan cattle and its association analysis with growth traits显示文摘Our previous work reported a relationship between FOXO1 mutations and growth of Qinchuan(QC) cattle. Here, we performed differential expression analysis of FOXO1 and its association analysis with growth traits in QC cattle. First, we measured the expression of the FOXO1 gene in nine tissues during three developmental stages. The results showed that FOXO1 was abundantly expressed in tissues of calves but was strongly repressed in adulthood, although there was significant transcription in skeletal muscle. FOXO1 expression showed gradual up-regulation during differentiation of primary bovine skeletal muscle cells.We also identified six SNPs of the bovine FOXO1 gene by sequencing DNA pools of samples from 488 individuals, and association analysis indicated that five SNPs were significantly associated with some growth traits in the QC population. We further analyzed four haplotype combinations of the six SNPs and found significant correlation with body length(P<0.01). In conclusion, FOXO1 participates in bovine myocyte differentiation and expression, and may be a strong candidate as a gene that affects growth traits that could be exploited in a QC cattle breeding program. More generally, our data provide a new theoretical basis for QC beef breeding and beef quality improvement. | Yujia Sun Kunpeng Liu Yongzhen Huang Xianyong Lan Hong Chen | 2018 | Science China(Life Sciences)2018，61，7： | 4 |
| 12 | Transforming growth factor-β1-induced N-cadherin drives cell–cell communication through connexin43 in osteoblast lineage显示文摘Gap junction(GJ)has been indicated to have an intimate correlation with adhesion junction.However,the direct interaction between them partially remains elusive.In the current study,we aimed to elucidate the role of N-cadherin,one of the core components in adhesion junction,in mediating connexin 43,one of the functional constituents in gap junction,via transforming growth factor-β1(TGF-β1)induction in osteoblasts.We first elucidated the expressions of N-cadherin induced by TGF-β1 and also confirmed the upregulation of Cx43,and the enhancement of functional gap junctional intercellular communication(GJIC)triggered by TGF-β1 in both primary osteoblasts and MC3T3 cell line.Colocalization analysis and Co-IP experimentation showed that N-cadherin interacts with Cx43 at the site of cell–cell contact.Knockdown of N-cadherin by siRNA interference decreased the Cx43 expression and abolished the promoting effect of TGF-β1 on Cx43.Functional GJICs in living primary osteoblasts and MC3T3 cell line were also reduced.TGF-β1-induced increase in N-cadherin and Cx43 was via Smad3 activation,whereas knockdown of Smad3 signaling by using siRNA decreased the expressions of both N-cadherin and Cx43.Overall,these data indicate the direct interactions between N-cadherin and Cx43,and reveal the intervention of adhesion junction in functional gap junction in living osteoblasts. | Yueyi Yang Wenjing Liu JieYa Wei Yujia Cui Demao Zhang Jing Xie | 2021 | International Journal of Oral Science2021，13，2： | 4 |
| 13 | Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii显示文摘Sterol C24-methyltransferase(SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-methyl sterols. Here, we report the cloning and characterization of a cDNA encoding a sterol C24-methyltransferase from Tripterygium wilfordii(Tw SMT1). Tw SMT1(Gen Bank access number KU885950) is a 1530 bp cDNA with a 1041 bp open reading frame predicted to encode a 346-amino acid, 38.62 k Da protein. The polypeptide encoded by the SMT1 cDNA was expressed and purified as a recombinant protein from Escherichia coli(E. coli) and showed SMT activity. The expression of Tw SMT1 was highly up-regulated in T. wilfordii cell suspension cultures treated with methyl jasmonate(Me JA). Tissue expression pattern analysis showed higher expression in the phellem layer compared to the other four organs(leaf, stem, xylem and phloem), which is about ten times that of the lowest expression in leaf. The results are meaningful for the study of sterolbiosynthesis of T. wilfordii and will further lay the foundations for the research in regulating both the content of other main compounds and growth and development of T. wilfordii. | Hongyu Guan Yujun Zhao Ping Su Yuru Tong Yujia Liu Tianyuan Hu Yifeng Zhang Xianan Zhang Jia Li Xiaoyi Wu Luqi Huang Wei Gao | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 4 |
| 14 | Identification and characterization of soybean dreg soluble dietary fibre by combination of extrusion pre-treatment and enzymatic modification显示文摘OBJECTIVES:Soybean dreg is a by-product of soy milk processing,which contains high levels of soluble dietary fibre(SDF).In this study,we aimed to provide comprehensive processes of pre-treated extrusion for the improving structure and properties of soybean dreg soluble dietary fibre(SDSDF),which would be a valuable approach to enhance physiological activity.METHODS:Here,we characteristic the functional role of SDSDF employing to extrusion pretreatment.Soybean dregs were pre-treated using the twin screw extrusion method followed by enzymatic modification using neutral protease,α-amylase,glucoamylase,and cellulose to produce SDSDF.The physical properties and antioxidant activity of SDSDF were investigated.RESULTS:The morphology and crystal structure of SDSDF were observed that,through extrusion processing and enzymatic modification,the SDSDF yield increased by 106.28%.Moreover,the surface structure showed block-shaped or reticular formations in the extruded SDSDF,and the size of block-shaped cells was about 10μm.Infrared spectroscopic analysis showed that a characteristic absorption peak of polysaccharide appeared at 1631 cm−1 during extrusion processing.However,after extrusion processing,decreased absorption peaks were observed for the extruded SDSDF.Furthermore,XRD analysis showed that the 2θdiffraction peak changed at 24.16°for the extruded SDSDF.CONCLUSIONS:The overall findings suggest that the water holding capacity(WHC),oil holding capacity(OHC),expansibility,and the water solubility were significantly decreased in extruded SDSDF.In addition,the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl(DPPH),-OH,O_(2)^(-),and the total reducing power were significantly improved,indicating that beneficial changes had taken place in the crystal structure of cellulose or hemicellulose to improve the physiological activity in extruded SDSDF. | Min Qu Yujia Liu Guang Zhang Sophia Jun Xue Hongchen Fan Yan Wang Shiyou Yu | 2017 | Food Quality and Safety2017，1，2： | 3 |
| 15 | Time-slot multiplexing based bandwidth enhancement for fiber distributed acoustic sensing显示文摘Dear editor,The phase-sensitive optical time-domain reflectometry(φ-OTDR)has been demonstrated as the most common technique in fiber distributed acoustic sensing(DAS).However,traditional φ-OTDR based DAS suffered from the inherent trade-off between the maximum frequency response and the distance which can be characterized by distance bandwidth product(DBP),since the time interval of the probe pulses should be larger than the pulse round-trip flight time. | Hao LI Cunzheng FAN Tao LIU Yujia LIU Zhijun YAN Perry SHUM Qizhen SUN | 2022 | Science China(Information Sciences)2022，65，1： | 2 |
| 16 | 雄激素性秃发的中西医治疗进展显示文摘雄激素性秃发(AGA)是临床中常见的遗传相关的脱发性疾病,其发病机制尚不完全清楚,雄激素信号传导通路可能在AGA中扮演重要角色,抗雄激素治疗效果明显,极少部分患者可能因心理作用造成性功能降低,但停药后症状基本消失。以祖国医学'辨证论治'理论为指导的中医诊疗思路对于巩固疗效、降低药物副作用具有一定优势。本文从中、西医不同角度阐述AGA的治疗进展,为临床诊治提供新思路。 | 孙文 高扬 查旭山 CHEN Yujia LIU Hongru DENG Wanying HUANG Shuhong LIU Jing | 2016 | 中国医学文摘(皮肤科学)2016，33，4： | 2 |
| 17 | Design and Analysis of an Active Helical Drive Downhole Tractor显示文摘During oil-gas well drilling and completion,downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works.Downhole tractors have been used to convey tools in complex wellbores, however a very large tractive force is needed to carry more downhole tools to accomplish works with high efficiency. A novel serial active helical drive downhole tractor which has significantly improved performance compared with previous work is proposed. All previously reported helical drive downhole tractors need stators to balance the torque generated by the rotator. By contrast, the proposed serial downhole tractor does not need a stator; several rotator-driven units should only be connected to one another to achieve a tractive force multifold higher than that was previously reported. As a result,the length of a single unit is shortened, and the motion flexibility of the downhole tractor is increased. The major performance indicators, namely, gear ratio, velocity, and tractive force, are analyzed. Experimental results show that the maximum tractive force of a single-unit prototype with a length of 900 mm is 165.3 kg or 1620 N. The analysis and experimental results show that the proposed design has considerable potential for downhole works. | Yujia LI Qingyou LIU Yonghua CHEN Tao REN | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 2 |
| 18 | Anomaly detection of hot components in gas turbine based on frequent pattern extraction显示文摘Hot components operate in a high-temperature and high-pressure environment. The occurrence of a fault in hot components leads to high economic losses. In general, exhaust gas temperature(EGT) is used to monitor the performance of hot components.However, during the early stages of a failure, the fault information is weak, and is simultaneously affected by various types of interference, such as the complex working conditions, ambient conditions, gradual performance degradation of the compressors and turbines, and noise. Additionally, inadequate effective information of the gas turbine also restricts the establishment of the detection model. To solve the above problems, this paper proposes an anomaly detection method based on frequent pattern extraction. A frequent pattern model(FPM) is applied to indicate the inherent regularity of change in EGT occurring from different types of interference. In this study, based on a genetic algorithm and support vector machine regression, the relationship model between the EGT and interference was tentatively built. The modeling accuracy was then further improved through the selection of the kernel function and training data. Experiments indicate that the optimal kernel function is linear and that the optimal training data should be balanced in addition to covering the appropriate range of operating conditions and ambient temperature. Furthermore, the thresholds based on the Pauta criterion that is automatically obtained during the modeling process, are used to determine whether hot components are operating abnormally. Moreover, the FPM is compared with the similarity theory, which demonstrates that the FPM can better suppress the effect of the component performance degradation and fuel heat value fluctuation. Finally, the effectiveness of the proposed method is validated on seven months of actual data obtained from a Titan130 gas turbine on an offshore oil platform. The results indicate that the proposed method can sensitively detect malfunctions in hot components during the early stages of a fault, and is robust to various types of interference. | LIU JinFu ZHU LinHai MA YuJia LIU Jiao ZHOU WeiXing YU DaRen | 2018 | Science China(Technological Sciences)2018，61，4： | 2 |
| 19 | The neutrophil-to-lymphocyte ratio as a predictor for recurrence of colorectal liver metastases following radiofrequency ablation显示文摘 | Zhihui Chang Jiahe Zheng Yujia Ma Jian Zhao Chuanzhuo Wang Zhaoyu Liu | 2014 | Medical Oncology2014，，3： | 2 |
| 20 | Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex Ⅱ via a water molecule mediated binding feature显示文摘The mitochondrial respiratory complex Ⅱ or succinate:ubiquinone oxidoreductase(SQR)is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration.Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography.Crystal structure of the SQR bound with thiabendazole(TBZ)reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule plays an important role.The obvious inhibitory effect of TBZ based on the biochemical data(IC50~100μmol/L)and the significant structure-based binding affinity calculation(~94μmol/L)draw the suspicion of using TBZ as a good disinfectant compound for nematode infections treatment and fruit storage. | Qiangjun Zhou Yujia Zhai Jizhong Lou Man Liu Xiaoyun Pang Fei Sun | 2011 | Protein & Cell2011，2，7： | 2 |
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