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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | High-resolution MRI of intracranial large artery diseases:how to use it in clinical practice?显示文摘High-resolution MRI(HRMRI)has emerged as a useful tool for clinical research in recent years.Compared with traditional cranial and vessel imaging,HRMRI provides more additional valuable pathophysiology information that is helpful for the differential diagnosis of intracranial atherosclerosis,dissection and vasculitis.However,there are some points that a neurologist should keep in mind.First,although enhanced vessel wall imaging is widely applied for research purposes,it is not appropriate for routine clinical use.Any injury or inflammation within vessel wall can result in enhancement,which is unspecific for a diagnosis.Second,although plaque components identified on HRMRI arouse researchers’interest,they may have limited positive predictive value for future stroke.Ruptured plaques may have higher prevalence in asymptomatic patients than expected.More prospective observational studies are required.Third,the vessel wall morphology features remain the useful and reliable clue for a diagnosis.It is true that eccentric vessel wall lesions most likely represent atherosclerosis if vessel dissection is easily excluded.For concentric wall lesions,however,the underlying pathophysiology is complicated,either atherosclerotic or non-atherosclerotic.Fourth,HRMRI can show luminal thrombus directly and provide valuable details.All in all,when HRMRI is used by a neurologist,it should not be viewed as the only key for a diagnosis.The diagnosis should be made based on patient history,lab works,other imaging technique and even genetic examinations. | Weihai Xu | 2019 | Stroke & Vascular Neurology2019，4，2： | 10 |
| 4 | Organotin compounds in surface sediments from selected fishing ports along the Chinese coast显示文摘The concentrations and species of organotin compounds(OTCs) in 52 surface sediment samples from nine fishing ports along the Chinese coast were studied.Butyltins(BTs) and phenyltins(PhTs) were derivatized using sodium tetraethylborate(NaBEt 4) and determined by head-space solid-phase microextraction(HS-SPME) gas chromatography coupled with a flame photometric detector(GC-FPD).The concentrations of OTCs ranged from <3.6 to 194 ng(Sn) g-1 dry weight(dw) for monobutyltin(MBT),<2.3 to 41.5 ng(Sn) g-1 dw for dibutyltin(DBT),<0.7 to 86.0 ng(Sn) g-1 dw for tributyltin(TBT) and <5.1 to 66.1 ng(Sn) g-1 dw for monophenyltin(MPhT),respectively.The concentrations of diphenyltin(DPhT) and triphenyltin(TPhT) were below the limit of detection(LOD).BTs were the main species in the sediments except for the samples collected from Shazikou fishing port in Qingdao.The concentrations of MBT were higher than DBT and TBT.The concentrations of OTCs in the sediments varied widely among different sampling locations.The concentrations of BTs were much higher in the samples collected from fishing ports close to the South China Sea than those in coast of the East China Sea and the Yellow Sea.MPhT was prevalent in most sampling stations except for those in coast of the East China Sea.The environmental and ecotoxicological risks of TBT in most sediment samples were low. | ZHANG KeGang SHI JianBo HE Bin XU WeiHai LI XiangDong JIANG GuiBin | 2013 | Chinese Science Bulletin2013，58，2： | 7 |
| 5 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 6 | Organic Matters and Lipid Biomarkers in Surface Sediments from the Northern South China Sea:Origins and Transport显示文摘In this study,content and distribution of organic matters(OM)and lipid biomarkers in surface sediments from northern South China Sea(SCS)were identified to reveal the sources and transport of fine-grained sediments.Organic matters and lipid biomarkers exhibited distinct spatial variation in northern SCS.Terrestrial discharge from the Pearl River and some mountainous rivers in southwestern Taiwan may contribute to the relatively high organic matters in the corresponding sea areas.The detection of unsaturated fatty acid homologues suggested the algal and/or bacterial OM contribution to surface sediments.The composites and distribution of lipid biomarkers indicate their mixed sources from terrestrial plants,marine algae and bacterial.Together with the proof of clay mineral composites in the sediments,the results suggested that the currents,including the Guangdong Coastal Current and Kuroshio Current,control the transport and distribution of terrestrial sediment and the sedimentary environment in the northern SCS. | Weihai Xu Wen Yan Zhong Chen Han Chen Weixia Huang Tian Lin | 2014 | Journal of Earth Science2014，25，1： | 4 |
| 7 | Effect of Traditional Chinese Medicine plus narrow-band medium-wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series显示文摘OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. | Li Tiantian Zhou Dongmei Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 8 | Bioaccumulation and changes of trace metals over the last two decades in marine organisms from Guangdong coastal regions, South China显示文摘Trace metal(Cr, Ni, Cu, Zn, Cd and Pb) exposures, distribution and bioaccumulation were investigated in marine organisms from Guangdong coastal regions, South China. The results showed that all of the selected metals were observed in marine organisms with a predomination of Cu and Zn. The metal exposure levels exhibited obvious variations between species with the decreasing order of crab > shellfish > shrimp > fish. The higher metals enrichment seen in shellfish and crab species primarily attributed to their living habits and the higher sediment background values of trace metals. Endpoint bioaccumulation factor(BAFfd) was used to characterize the bioaccumulation potentials of marine organisms to trace metals, of which Cu and Zn were the most accumulated elements. The exposure of trace metals in the cultured organisms was far lower than those in wild marine organisms, which is probably due to the effect of growth dilution. Comparisons with previous studies demonstrated that the concentration profiles of most trace metals declined over the last one to two decades, except Cu, that increased indistinctively. | Lulu Zhang Wen Yan Zhiyong Xie Guanqiang Cai Wenying Mi Weihai Xu | 2020 | Journal of Environmental Sciences2020，32，12： | 2 |
| 9 | Residues of enrofloxacin,furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)显示文摘 | Xu WeiHai Zhu XiaoBin Wang XinTing | 2006 | Aquaculture2006，254，14： | 1 |
| 10 | Determination of selected antibiotics in the Victoria Harbour and the Pearl River,South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry显示文摘 | Xu Weihai Zhang Gan Zou Shichun | 2007 | Environmental Pollution2007，145，3： | 1 |
| 11 | Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China显示文摘 | XU Weihai ZHANG Gan LI Xiangdong | 2007 | Water Re- search2007，41，19： | 1 |
| 12 | H∞ Output Feedback Control with Spectrum Constraints for Uncertain Stochastic Systems显示文摘 | Jun-e Feng Shengyuan Xu Weihai Zhang | 2007 | Circuits Systems & Signal Processing2007，，2： | 1 |
| 13 | Determination of selected antibiotics in the Victoria Harbour and the Pearl River,South China using high-performance liquid chromatog- raphy-electrospray ionization tandem mass spectrometry显示文摘 | XU Weihai ZHANG Gan ZOU Shichun | 2007 | Environmental Pollution2007，145，3： | 1 |
| 14 | A preliminary investigation on the occurrence and distribution of antibiotics in the Yellow River and its tributaries,China显示文摘 | XU Weihai ZHANG Gan ZOU Shichun | 2009 | Water Envi- ronment Research2009，81，3： | 1 |
| 15 | Occurrence and distribution of antibiotics in coastal water of the Bohai Bay,China: impacts of river discharge and aquaculture activi- ties显示文摘 | ZOU Shichun XU Weihai ZHANG Ruijie | 2011 | Environmental Pollution2011，159，10： | 1 |
| 16 | Wear-resistant Ag-MAX phase 3D interpenetrating-phase composites:Processing,structure,and properties显示文摘Electrical contact materials are generally Ag-or Cu-based composites and play a critical role in ensuring the reliability and efficiency of electrical equipments and electronic instruments.The MAX(M is an early transition metal,A is an element from III or IV main groups,and X is carbon or/and nitrogen)phase ceramics display a unique combination of properties and may serve as an ideal reinforcement phase for electrical contact materials.The biological materials evolved in nature generally exhibit three-dimensional(3D)interpenetrating-phase architectures,which may offer useful inspiration for the architectural design of electrical contact materials.Here,a series of bi-continuous Ag-Ti_(3)SiC_(2) MAX phase composites with high ceramic contents exceeding 50 vol.%and having micron-and ultrafine-scaled 3D interpenetrating-phase architectures,wherein both constituents were continuous and mutually interspersed,were exploited by pressureless infiltration of Ag melt into partially sintered Ti_(3)SiC_(2) scaffolds.The mechanical and electrical properties as well as the friction and wear performance of the composites were investigated and revealed to be closely dependent on the ceramic contents and characteristic structural dimensions.The composites exhibited a good combination of properties with high hardness over 2.3 GPa,high flexural strength exceeding 530 MPa,decent fracture toughness over 10 MPa·m^(1/2),and good wear resistance with low wear rate at an order of 10^(-5)mm^(3)/(N·m),which were much superior compared to the counterparts made by powder metallurgy methods.In particular,the hardness,electrical conductivity,strength,and fracture toughness of the composites demonstrated a simultaneous improvement as the structure was refined from micron-to ultrafine-scales at equivalent ceramic contents.The good combination of properties along with the facile processing route makes the Ag-Ti_(3)SiC_(2)3D interpenetrating-phase composites appealing for electrical contact applications. | Yu Guo Xi Xie Zengqian Liu Longchao Zhuo Jian Zhang Shaogang Wang Qiqiang Duan Qing Jia Dake Xu Weihai Xue Deli Duan Filippo Berto Zhefeng Zhang Rui Yang | 2024 | Nano Research2024，17，2： | 1 |
| 17 | Determination ofselected antibiotics in the Victoria Harbour and the Pearl River,South China using high-performance liquid chromatography -electrospray ionization tandem mass spectrometry 显示文摘 | XU Weihai ZHANG Gan ZOU Shichan | 2007 | EnvironPollut2007，145，3： | 1 |
| 18 | Occurrence andelimination of antibiotics at four sewage treatment plants in thePearl River Delta ( PRD) , South China显示文摘 | XU Weihai ZHANG Gan LI Xiangdong | 2007 | Water Res2007，41，19： | 1 |
| 19 | Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia( Oreochromis niloticus) 显示文摘 | Xu Weihai Zhu Xiaobin Wang Xinting | 2006 | Aquaculture2006，254，14： | 1 |
| 20 | Residues of en-rofloxacin,furazolidone and their metabolites in nile tilapia (ore-ochromis niloticus)显示文摘 | XU Weihai ZHU Xiaobin Wang Xinting | | 0，，04： | 1 |
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