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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Effect of renal re- placement therapy on retinol-binding protein 4 isoforms 显示文摘 | Frey SK Andrea H Britta N | 2009 | Clin Chim Acta2009，401，12： | 1 |
| 4 | Astrocytes accumulate AI3 42 and give rise to astrocyte amyloid plaques in Alzheimer disease 显示文摘 | Robert G N Michael R D Andrea H L | 2003 | Brain Research2003，97，1： | 1 |
| 5 | 早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择:依据 ASCO 对 CCO临床实践指南的改编显示文摘目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,ASCO小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HER2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HER2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HER2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。 | Neelima Denduluri Mark R Somerfield Andrea Eisen Jamie N Holloway Arti Hurria Tari A King Gary H Lyman Ann H Partridge Melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 | 2016 | 中国全科医学2016，19，18： | 1 |
| 6 | Gain of lq21 and distinct adversecytogenetic abnormalities correlate with increased microcirculation in multiplemyeloma显示文摘 | Jens H Christian MZ Andreas N et a1 | 2008 | Int J Cancer2008，122，12： | 1 |
| 7 | Influence of Interface and Al Structure on Layer Exchange during Aluminum-induced Crystallization of Amorphous Silicon显示文摘 | Oliver N Andreas H J | 2000 | Journal of Applied Physics2000，88，2： | 1 |
| 8 | Identification of copper-induced genes in Pseudomoas fluorescens and use of a reporter strain to monitor bioavailable copper in soil显示文摘 | ANDREAS T P CARSTEN H OLE N | 2001 | FEMS Microbiology Ecology2001，38，： | 1 |
| 9 | Incidence and predictability of amiodarone--induced thyrotoxicosis and hypothyroidism显示文摘 | Andrea H Clemens N Sedat O | 2008 | Wien Kiln Wochenschr2008，120，： | 1 |
| 10 | Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants显示文摘 | David M C Herminia L T Andrea H N | 2005 | Ferns Microbiology Reviews2005，29，： | 1 |
| 11 | Markers of Inflammation, Endothelial Activation, and Arterial Stiffness in Hypertensive Heart Disease and the Effects of Treatment: Results From the SILVHIA Study显示文摘 | Andreas Jekell Karin Malmqvist N. H?kan Wallén David M?rtsell Thomas Kahan | 2013 | Journal of Cardiovascular Pharmacology2013，，6： | 1 |
| 12 | Angular distribution of light scattered by single biological cells and oriented particle agglomerates显示文摘 | JORG N CARSTEN G ANDREAS H | 2003 | App Opt2003，42，31： | 1 |
| 13 | sulfur gases and aerosols in and above the Equatorial African rain forest显示文摘 | H G Andreae M O Andreae T W Artaxo P Helas G Jacob D J Mihalopoulos N and Nguyen B C | 1992 | Geophys Res1992，97，： | 1 |
| 14 | Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma显示文摘 | JENS H CHRISTIAN M Z ANDREAS N | 2008 | Cancer2008，122，： | 1 |
| 15 | Effect of reant replacement therapy on retinol-binding protein 4 iostforme显示文摘 | Frey SK Andrea H Britta N | 2009 | Chim Acta2009，401，12： | 1 |
| 16 | Effect of renal replacement therapy on retinol-hinding protein 4 isoforms 显示文摘 | Frey SK Andrea H Britta N | 2009 | Clinica Chimica Acta2009，401，12： | 1 |
| 17 | Starch phosphorylation: A new front line in starch research 显示文摘 | ANDREAS B SCCREN B E TOM H N | 2002 | Trends in Plant Science2002，7，10： | 1 |
| 18 | Cell biomass and exopolymer composition in sewer biofilms显示文摘 | ANDREAS J PER H N | 1998 | Water Science Technology1998，37，1： | 1 |
| 19 | Zircon M257-a homogeneous natural reference material for the ion microprobe U-Pb analysis of zircon显示文摘 | Nasdala L Norberg N Schaltegger U Lutz N Wolfgang H Nicholas N James M M Fernando C Wolfgang D Sandra L K Allen K K Andreas K Peter W R Dirk F Jan K Wan Y S Jens G Tobias H Alfred K John W V | 2008 | Geostandards and Geoanalytical Research2008，32，： | 1 |
| 20 | Gain of lq21 and distinct adverse eytogenetic abnormalities correlate with increased microcirculation in multiple myeloma 显示文摘 | Jens H Christian M Z Andreas N | 2008 | Cancer2008，122，12： | 1 |
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