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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Astrocytes accumulate AI3 42 and give rise to astrocyte amyloid plaques in Alzheimer disease 显示文摘 | Robert G N Michael R D Andrea H L | 2003 | Brain Research2003，97，1： | 1 |
| 4 | Femural shaft fracture in a newborn infant treated with axial external fixator: A case report 显示文摘 | D'Andrea L Catena N | 2008 | J Pediatr Orthop2008，28，1： | 1 |
| 5 | Factors that modify therapy adherence in patients with inflammatory bowel disease显示文摘 | Fernando Bermejo Antonio López-San Román Alicia Algaba Iván Guerra Paz Valer Silvia García-Garzón Belén Piqueras Carlos Villa Andrea Bermejo José L. Rodríguez-Agulló | 2010 | Journal of Crohn’s and Colitis2010，，4： | 1 |
| 6 | 早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择:依据 ASCO 对 CCO临床实践指南的改编显示文摘目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,ASCO小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HER2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HER2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HER2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。 | Neelima Denduluri Mark R Somerfield Andrea Eisen Jamie N Holloway Arti Hurria Tari A King Gary H Lyman Ann H Partridge Melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 | 2016 | 中国全科医学2016，19，18： | 1 |
| 7 | Amphidial structure of ivermectin-resistant and susceptible laboratory and field strains of Haemonchus contortus显示文摘 | Andrea S F Catherine N Jian L | 2003 | Vet Parasitol2003，110，： | 1 |
| 8 | Hazards and Landscape Changes(Degradations) on Hungarian Karst Mountains Due to Natural and Human Effects显示文摘In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the Bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water labeling.We recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial sensitivity.In the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst areas.These differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(e.g.the intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes. | Móga JNOS Kiss KLAUDIA Szabó MRIA Kériné Borsodi ANDREA Kéri ANDRS Mari LSZLó Knáb MóNIKA Iván VERONIKA | 2013 | Journal of Mountain Science2013，10，1： | 1 |
| 9 | Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants显示文摘 | David M C Herminia L T Andrea H N | 2005 | Ferns Microbiology Reviews2005，29，： | 1 |
| 10 | The relative contribution of symbiotic N2 fixation and other nitrogen sources to grassland ecosystems along an altitudinal gradient in the Alps显示文摘 | Katja A. Jacot Andreas Lüscher Josef N?sberger Ueli A. Hartwig | 2000 | Plant and Soil (-)2000，，1： | 1 |
| 11 | Differential evolution for sequencing and scheduling optimization 显示文摘 | Andreas N C Omirou S L | 2006 | Journal of Heurisctic2006，12，6： | 1 |
| 12 | Performance analysis of theSIFT operator for automatic feature extraction and matching in phntogrammetric applications显示文摘 | Andrea L Davide M Francesco N | 2009 | Sensors2009，9，5： | 1 |
| 13 | The Technology - Activities of Daily Living Questionnaire: A Version with a Technology-Related Subscale显示文摘 | Mu?oz-neira Carlos López Oscar L Riveros Rodrigo Nú?ez-huasaf Javier Flores Patricia Slachevsky Andrea | 2012 | Dementia and Geriatric Cognitive Disorders2012，，6： | 1 |
| 14 | Zircon M257-a homogeneous natural reference material for the ion microprobe U-Pb analysis of zircon显示文摘 | Nasdala L Norberg N Schaltegger U Lutz N Wolfgang H Nicholas N James M M Fernando C Wolfgang D Sandra L K Allen K K Andreas K Peter W R Dirk F Jan K Wan Y S Jens G Tobias H Alfred K John W V | 2008 | Geostandards and Geoanalytical Research2008，32，： | 1 |
| 15 | Spectral and complexity features of the EEG changed by visual input in a case of subcortical stroke compared to healthy controls显示文摘 | Márk Molnár Roland Csuhaj Szabolcs Horváth Ildikó Vastagh Zsófia Anna Gaál Balázs Czigler Andrea Bálint Dóra Csikós Zoltán Nagy | 2006 | Clinical Neurophysiology2006，，4： | 1 |
| 16 | Firm Diversification and CEO Compensation:Managerial Ability or Executive Entrenchment? 显示文摘 | Rose N L Andrea S | 1997 | RAND Journal of Economics1997，28，3： | 1 |
| 17 | Fault tree analysis for integrated and probabilistic risk analysis of drinking water systems显示文摘 | Andreas L Lars R Tommy N Olof B | 2009 | Water Research2009，43，6： | 1 |
| 18 | An integrated framework for enhancing the semantic transformation, edi- ting and querying of relational databases显示文摘 | KONSTANTINOS N V ANDREAS L S GEORGIOS T K | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 19 | Comparison of two qualitative assays,the UBC rapid test and the BTA star test, in the diagnosis of urothelial cell carcinoma of the bladder显示文摘 | CHRISTINE M I A N MICHELE L ANDREA H | 2000 | Urology2000，56，2： | 1 |
| 20 | Comparative eutrophication development in two Brazilian water supply reservoirs with respect to nutrient concentrations and bacteria gro-h显示文摘 | EDUARDO von S ANDREA C da S F GOMES L N | 2008 | Desalination2008，226，123： | 1 |
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