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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 3 | 建成环境对步行和自行车出行的影响——以波哥大为例显示文摘哥伦比亚波哥大以可持续的城市交通系统闻名,包括其密集的自行车道网络以及Ciclovía系统——为骑车者和行人预留的道路空间,可在星期日和节假日休闲出行使用。探讨此类设施以及建成环境的其他属性——城市密度、混合用地、可达性以及与公共交通车站的距离——如何影响步行和自行车出行行为以及Ciclovía的使用。结果表明,道路设施设计要素例如道路密度、连通性、与Ciclovía车道的距离,与体力活动相关;而建成环境的其他属性如密度和用地混合程度,对体力活动影响甚微。这可能是由于波哥大建成区的大部分街区均在非机动交通出行占绝对优势的时期演变发展——紧凑、用地混合、交通可达性水平相似。由此可见,影响非机动交通出行的因素是设施设计而非一般的街区用地属性。 | Robert Cervero Olga L.Sarmiento Enrique Jacoby Luis Fernando Gomez Andrea Neiman 耿雪 | 2016 | 城市交通2016，14，5： | 13 |
| 4 | Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing显示文摘In recent years,femtosecond(fs)-lasers have evolved into a versatile tool for high precision micromachining of transparent materials because nonlinear absorption in the focus can result in refractive index modifications or material disruptions.However,when high pulse energies or low numerical apertures are required,nonlinear side effects such as self-focusing,filamentation or white light generation can decrease the modification quality.In this paper,we apply simultaneous spatial and temporal focusing(SSTF)to overcome these limitations.The main advantage of SSTF is that the ultrashort pulse is only formed at the focal plane,thereby confining the intensity distribution strongly to the focal volume and suppressing detrimental nonlinear side effects.Thus,we investigate the optical breakdown within a water cell by pump-probe shadowgraphy,comparing conventional focusing and SSTF under equivalent focusing conditions.The plasma formation is well confined for low pulse energies,2 mJ,but higher pulse energies lead to the filamentation and break-up of the disruptions for conventional focusing,thereby decreasing the modification quality.In contrast,plasma induced by SSTF stays well confined to the focal plane,even for high pulse energies up to 8 mJ,preventing extended filaments,side branches or break-up of the disruptions.Furthermore,while conventional focusing leads to broadband supercontinuum generation,only marginal spectral broadening is observed using SSTF.These experimental findings are in excellent agreement with numerical simulations of the nonlinear pulse propagation and interaction processes.Therefore,SSTF appears to be a powerful tool to control the processing of transparent materials,e.g.,for precise ophthalmic fs-surgery. | Robert Kammel Roland Ackermann Jens Thomas Jorg Gotte Stefan Skupin Andreas Tunnermann Stefan Nolte | 2014 | Light(Science & Applications)2014，3，1： | 11 |
| 5 | First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases显示文摘AIM To evaluate rebleeding, primary failure(PF) and mortality of patients in whom over-the-scope clips(OTSCs) were used as first-line and second-line endoscopic treatment(FLET, SLET) of upper and lower gastrointestinal bleeding(UGIB, LGIB).METHODS A retrospective analysis of a prospectively collected database identified all patients with UGIB and LGIB in a tertiary endoscopic referral center of the University of Freiburg, Germany, from 04-2012 to 05-2016(n= 93) who underwent FLET and SLET with OTSCs. The complete Rockall risk scores were calculated from patients with UGIB. The scores were categorized as < or ≥ 7 and were compared with the original Rockall data. Differences between FLET and SLET were calculated. Univariate and multivariate analysis were performed to evaluate the factors that influenced rebleeding after OTSC placement.RESULTS Primary hemostasis and clinical success of bleeding lesions(without rebleeding) was achieved in 88/100(88%) and 78/100(78%), respectively. PF was significantly lower when OTSCs were applied as FLET compared to SLET(4.9% vs 23%, P = 0.008). In multivariate analysis, patients who had OTSC placement as SLET had a significantly higher rebleeding risk compared to those who had FLET(OR 5.3; P = 0.008). Patients with Rockall risk scores ≥ 7 had a significantly higher in-hospital mortality compared to those with scores < 7(35% vs 10%, P = 0.034). No significant differences were observed in patients with scores < or ≥ 7 in rebleeding and rebleeding-associated mortality.CONCLUSION Our data show for the first time that FLET with OTSC might be the best predictor to successfully prevent rebleeding of gastrointestinal bleeding compared to SLET. The type of treatment determines the success of primary hemostasis or primary failure. | Hans-Jürgen Richter-Schrag Torben Glatz Christine Walker Andreas Fischer Robert Thimme | 2016 | World Journal of Gastroenterology2016，22，41： | 11 |
| 6 | Studies on Differential Nuclear Translocation Mechanism and Assembly of the Three Subunits of the Arabidopsis thaliana Transcription Factor NF-Y显示文摘真核细胞的抄写因素 NF-Y 由三个子单元(A, B,和 C ) 组成,它在分别地由 10, 13,和 13 基因组成的 multigene 家庭被编码为 Arabidopsis thaliana。原则上,子单元的所有潜在的联合为 heterotrimeric 建筑群的集会是可能的。我们瞄准了估计每个子单元的概率参予 NF-Y 的集会。在家庭们显示的 NF-Y 子单元的所有成员之中的物理相互作用的评估为在全部建筑群前的 NF-YB/NF-YC heterodimerization 的一个强壮的要求能被完成。借助于修改酵母,到 heterotrimeric 建筑群的所有三个子单元的二混血儿的系统汇编被表明。用 GFP 熔化构造, NF -- 你和在原子核的 NF-YC 本地化被表明,当 NF-YB 完全作为 NF-YC-associated heterodimer NF-YC 被进口进原子核时。二个 Arabidopsis 子单元的这骑在背肩上的运输不同于不是自养的有机体的 NF-Y heterotrimer 的进口。基于 histone-fold-motifs 的一个肽结构模型,在 intramolecular 之中结合的二硫化物保存了 NF-YB 的半胱氨酸残余,它在人和曲霉属菌 nidulans 为 NF-YB 和 NF-YC 的调整氧化还原作用的集会负责,能为 Arabidopsis NF-YB 被排除。 | Dieter Hackenberg Yanfang Wu Andrea Voigt Robert Adams Peter Schramm Bernhard GrimmI | 2012 | Molecular Plant2012，5，4： | 9 |
| 7 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 8 | Transcriptional Control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis Development显示文摘类胡萝卜素是为光合作用, photoprotection 和象骆驼毛的织物和 strigolactones 那样的导出类胡萝卜素的荷尔蒙的生产要求的颜料。类胡萝卜素 biosynthetic 小径在 lycopene 以后区分生产 epsilon 类胡萝卜素和贝它类胡萝卜素,这个分支为决定类胡萝卜素作文是批评的。这里,我们显示出分支点怎么能被修改染色质的 histone methyltransferase 调整,集合领域组 8 (SDG8 ) 指向类胡萝卜素 isomerase (CRTISO ) 。SDG8 被要求在幼苗开发期间维持 CRTISO 的容许的表示,在叶子,射击顶,和一些花的机关。CRTISO 和 SDG8 倡导者显示出记者基因活动的重叠织物特定的模式。有趣地, CRTISO 与花椰菜马赛克病毒 35S 倡导者(CaMV35s ) 和 LCY 倡导者相比以在不同的线之间的更大的可变性显示出不正常的记者基因表示,潜在地,由于 chromosomal,位置完成。CRTISO 倡导者的规定部分地依赖于 SDG8 的存在或缺席。SDG8 (类胡萝卜素和叶绿体规定(ccr1 )) 和 CRTISO (ccr2 ) 的大美人导致改变的类胡萝卜素作文和这能用 CaMV35s 或 CRTISO 倡导者在 ccr2 被恢复。相反,在 ccr1 背景用 CaMV35S 或 CRTISO 倡导者由 CRTISO overexpression 改变 GUS 表示和类胡萝卜素互补的度证明 CRTISO 倡导者和开的读物装裱为 CRTISO 的调停 SDG8 的表示是必要的。 | Christopher I. Cazzonelli Andrea C. Roberts Melanie E. Carmody Barry J. Pogson | 2010 | Molecular Plant2010，3，1： | 8 |
| 9 | 国际生物样本库和网络系统:成功因素和主要预算方案显示文摘概述了分布在欧洲、北美、澳大利亚以及亚洲的16个最大的生物样本库与生物样本信息网络在人类生物样本收集、分发,以及资金的科学运转等方面所采用的方法。这些生物样本库的运转和经济模式取决于他们所在国家和研究所的医学和研究宗旨。生物样本库模式的成功运作取决于各种因素,包括明确的目标,可靠的经营计划,以及具有严格质量控制和操作规范的生物样本收集。 | Jim Vaught Andrea Kelly Robert Hewitt 孙孟红 倪淑娟 杜祥 | 2011 | 医学与哲学(A)2011，32，7： | 8 |
| 10 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018，39，6： | 8 |
| 11 | A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma显示文摘 | Gregory L. Beatty Drew A. Torigian E. Gabriela Chiorean Babak Saboury Alex Brothers Abass Alavi Andrea B. Troxel Weijing Sun Ursina R. Teitelbaum Robert H. Vonderheide Peter J. O’Dwyer | 2013 | Clinical Cancer Research2013，，22： | 6 |
| 12 | Understanding the effects of radiative preheat and self-emission from shock heating on equation of state measurement at 100s of Mbar using spherically converging shock waves in a NIF hohlraum显示文摘Over the last six years many experiments have been done at the National Ignition Facility to measure the Hugoniot of materials,such asCHplastic at extreme pressures,up to 800 Mbar.The“Gbar”design employs a strong spherically converging shock launched through a solid ball of material using a hohlraum radiation drive.The shock front conditions are characterized using x-ray radiography.In this paper we examine the role of radiation in heating the unshocked material in front of the shock to understand the impact it has on equation of state measurements and how it drives the measured data off the theoretical Hugoniot curve.In particular,the two main sources of radiation heating are the preheating of the unshocked material by the high-energy kilo-electron-volt x-rays in the hohlraum and the heating of the material in front of the shock,as the shocked material becomes hot enough to radiate significantly.Using our model,we estimate that preheating can reach 4 eV in unshocked material,and that radiation heating can begin to drive data off the Hugoniot significantly,as pressures reach above 400 Mb. | Joseph Nilsen Andrea L.Kritcher Madison EMartin Robert E.Tipton Heather D.Whitley Damian C.Swift Tilo Doppner Benjamin L.Bachmann Amy E.Lazicki Natalie B.Kostinski Brian R.Maddox Gilbert W.Collins Siegfried H.Glenzer Roger W.Falcone | 2020 | Matter and Radiation at Extremes2020，5，1： | 5 |
| 13 | 正常眼压性青光眼与高眼压性青光眼视神经图像分析的对比研究显示文摘目的 探讨正常眼压性青光眼 (normal- tension glaucoma,NTG)与高眼压性青光眼 (high-tension glaucoma,HTG)视盘和视神经纤维层 (retinal nerve fiber layer,RNFL )损害的差异。 方法 选择具有青光眼性视神经损害或 RNFL 缺损、相应的视野缺损的青光眼患者 ,NTG至少 2次 2 4 h眼压曲线和多次眼压测量均≤ 2 1mm Hg(1mm Hg=0 .133k Pa) ,HTG的眼压至少 2次测量≥ 2 5 mm Hg。患者进行详细的眼科检查 ,同时用扫描激光偏振仪 (scanning laser polarimetry,SL P)、光学相干断层扫描 (opticalcoherence tomography,OCT)和海德堡视网膜成像仪 (Heidelberg retinal tomography,HRT)定量测定视盘形态和 RNFL厚度。比较两组视盘总体和相同象限测量参数。 结果 30例 NTG和 19例 HTG (共 4 9只眼 )患者的平均年龄分别为 (5 9.6± 8.6 )岁 (39~ 71岁 )和 (5 9.2± 12 .3)岁 (36~ 75岁 )。两组间视野缺损的平均偏差 (mean deviation,MD)差异不显著 (P>0 .0 5 )。HRT测量的视盘 C/ D面积比 ,除鼻侧象限外 ,NTG者视盘总体和上、下、颞侧 3个象限均显著大于 HTG者 (P<0 .0 5 ) ,而盘缘面积小于 HTG者 (P<0 .0 5 ) ;两组间其他视盘参数差异不显著。 3种激光扫描技术所测定的总体和象限 RNFL厚度 。 | 窦宏亮 Pons Mauricio Mistlberger Andrea Ishikawa Hiroshi Liebmann Jeffrey Ritch Robert | 2002 | 中华眼底病杂志2002，18，2： | 4 |
| 14 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 15 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion显示文摘 | Akira Orimo Piyush B. Gupta Dennis C. Sgroi Fernando Arenzana-Seisdedos Thierry Delaunay Rizwan Naeem Vincent J. Carey Andrea L. Richardson Robert A. Weinberg | 2005 | Cell2005，，3： | 3 |
| 16 | Acupuncture for Infertility:Is It An Effective Therapy?显示文摘Acupuncture has been used to treat infertility extensively,including ovulatory dysfunction,in vitro fertilization and embryo transfer(IVF-ET),and male infertility.This review summarizes the recent studies which investigated the role of acupuncture in infertility.In conclusion,most of the existing studies suggest a positive effect of acupuncture in infertility treatment.Firstly,acupuncture may improve ovulation by modulating the central and peripheral nervous systems,the neuroendocrine and endocrine systems,the ovarian blood flow,and metabolism.Secondly,acupuncture can improve the outcome of IVF-ET,and the mechanisms may be related to the increased uterine blood flow,inhibited uterine motility,and the anesis of depression,anxiety and stress. Its effect on modulating immune function also suggests helpfulness in improving the outcome of IVF-ET.Finally, the studies suggest that acupuncture plays a positive role in male infertility,the mechanism of which is not yet clear.Even though a positive effect of acupuncture in infertility has been found,well-designed multi-center, prospective randomized controlled studies are still needed to provide more reliable and valid scientific evidence. Furthermore,it is urgent and necessary to clarify the mechanism of acupuncture for infertility. | 黄冬梅 黄光英 陆付耳 Dieterle Stefan Neuer Andreas Greb Robert | 2011 | Chinese Journal of Integrative Medicine2011，17，5： | 3 |
| 17 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 18 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 3 |
| 19 | Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol显示文摘 | Anke M. J. Kuijpers Boj Mirck Arend G. J. Aalbers Simon W. Nienhuijs Ignace H. J. T. Hingh Martinus J. Wiezer Bert Ramshorst Robert J. Ginkel Klaas Havenga Andreas J. Bremers Johannes H. W. Wilt Elisabeth A. Velde Vic J. Verwaal | 2013 | Annals of Surgical Oncology2013，，13： | 2 |
| 20 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
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