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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | Treatment of laryngopharyngeal reflux disease: A systematic review显示文摘BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success rate.AIM To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.METHODS Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of LPRD.Clinical prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed LPRD.The criteria for considering studies for the review were based on the population,intervention,comparison,and outcome framework.RESULTS The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk.The most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor antagonists.CONCLUSION Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux. | Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez | 2019 | World Journal of Clinical Cases2019，7，19： | 9 |
| 3 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 4 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 4 |
| 5 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 6 | PCH1 and PCHL Directly Interact with PIF1,Promote Its Degradation,and Inhibit Its Transcriptional Function during Photomorphogenesis显示文摘PHOTOPERIODIC CONTROL OF HYPOCOTYL 1(PCH1)and PCH1-LIKE(PCHL)were shown to directly bind to phytochrome B(phyB)and suppress phyB thermal reversion,resulting in plants with dramatically enhanced light sensitivity.Here,we show that PCH1 and PCHL also positively regulate various light responses,including seed germination,hypocotyl gravitropism,and chlorophyll biosynthesis,by physically interacting with PHYTOCHROME INTERACTING FACTOR 1(PIF1)and CONSTITUTIVE PHOTOMORPHO-GENIC 1(COP1).PCH1 and PCHL interact with PIF1 both in the dark and light,and regulate PIF1 abundance.Moreover,PCH1 and PCHL facilitate the physical interaction between phyB and PIF1 in vivo to promote the light-induced degradation of PIF1.PCH1 and PCHL also inhibit the DNA-binding ability of PIF1 to negatively regulate the expressions of PIF1 target genes.In addition,PCH1 and PCHL interact with COP1 and undergo degradation through the 26S proteasome pathway in the dark.Consistently,pch1 suppresses cop1 phenotype in darkness.Collectively,our study reveals a novel mechanism by which PCH1 and PCHL regulate diverse light responses not only by stabilizing phyB Pfrform but also by directly interacting with PIF1 and COP1,providing a molecular understanding of the control of hypocotyl growth by these proteins. | Mei-Chun Cheng Beatrix Enderle Praveen Kumar Kathare Rafya Islam Andreas Hiltbrunner Enamul Huq | 2020 | Molecular Plant2020，13，3： | 3 |
| 7 | Cardiac magnetic resonance in clinical cardiology显示文摘Over the last decades, cardiac magnetic resonance(CMR) has transformed from a research tool to a widely used diagnostic method in clinical cardiology. This method can now make useful, unique contributions to the work-up of patients with ischemic and non-ischemic heart disease. Advantages of CMR, compared to other imaging methods, include very high resolution imaging with a spatial resolution up to 0.5 mm × 0.5 mm in plane, a large array of different imaging sequences to provide in vivo tissue characterization, and radiationfree imaging. The present manuscript highlights the relevance of CMR in the current clinical practice and new perspectives in cardiology. | Andreas Kumar Rodrigo Bagur | 2015 | World Journal of Cardiology2015，7，1： | 3 |
| 8 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 9 | Fecal stream diversion and mucosal cytokine levels in collagenous colitis:A case report显示文摘In this case report, we examined the levels of cytokines expressed before and during fecal stream diversion and after intestinal continuity was restored in a patient with collagenous colitis. We report the case of a46-year-old woman with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with the following drugs:loperamide, cholestyramine, budesonide, methotrexate and adalimumab. Due to the intractable nature of the disease and because the patient was having up to 15 watery bowel movements per day, she underwent a temporary ileostomy. Colonic biopsies were analyzed for mucosal cytokine protein levels before and during fecal stream diversion and after intestinal continuity was restored. Mucosal protein levels of interleukin(IL)-1β,IL-2, IL-6, IL-12, IL-17 A, IL-23, TNF, IFN-γ, IL-4, IL-5,IL-10 and IL-13 were all higher during active disease and decreased to non-detectable or considerably lower levels during fecal stream diversion. One month after the restoration of bowel continuity, when the patient experienced a relapse of symptoms, IL-2, IL-23 and IL-21 levels were again increased. Our results indicate that fecal stream diversion in this patient suppressed the levels of all cytokines analyzed in colonic biopsies. With the recurrence of clinical symptoms and histological changes after bowel reconstruction,the levels of primarily proinflammatory cytokines increased. Our findings support the hypothesis that a luminal factor triggers the inflammation observed in collagenous colitis. | Niki Daferera Ashok Kumar Kumawat Elisabeth Hultgren-Honquist Simone Ignatova Magnus Strom Andreas Münch | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 10 | Clinical and Microbiologic Characteristics of Invasive Streptococcus pyo- genes Infections in North and South India 显示文摘 | Axana Haggar Andreas Nerlich Rajesh Kumar | 2012 | J Clin Microbiol2012，50，5： | 1 |
| 11 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 1 |
| 12 | Synthesis of In 2 O 3 –ZnO core–shell nanowires and their application in gas sensing显示文摘 | Nandan Singh Andrea Ponzoni Raju Kumar Gupta Pooi See Lee Elisabetta Comini | 2011 | Sensors & Actuators: B Chemical2011，，1： | 1 |
| 13 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 1 |
| 14 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 1 |
| 15 | Diagnostic Performance of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis显示文摘 | Hassan Abdel-Aty Philipp Boyé Anja Zagrosek Ralf Wassmuth Andreas Kumar Daniel Messroghli Petra Bock Rainer Dietz Matthias G. Friedrich Jeanette Schulz-Menger | 2005 | Journal of the American College of Cardiology2005，，11： | 1 |
| 16 | The okra ( Abelmoschus esculentus ) transcriptome as a source for gene sequence information and molecular markers for diversity analysis显示文摘 | Roland Schafleitner Sanjeet Kumar Chen-yu Lin Satish Gajanana Hegde Andreas Ebert | 2013 | Gene2013，，1： | 1 |
| 17 | Andreou,Heteroscedastic discriminant analysis and reduced rand HMMs for improved speech recognition 显示文摘 | Andreas G | 1998 | Speech communication1998，26，： | 1 |
| 18 | Heteroscedastic dis- criminant analysis and reduced rank HMMs for improved speech recognition 显示文摘 | Nagendra Kumar Andreas G Andreou | 1998 | Speech Communication1998，26，： | 1 |
| 19 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 1 |
| 20 | Detection and Quantification of Myocardial Reperfusion Hemorrhage Using T2*-Weighted CMR显示文摘 | Andreas Kumar Jordin D. Green Jane M. Sykes Pinhas Ephrat Jeffrey J.L. Carson Andrea J. Mitchell Gerald Wisenberg Matthias G. Friedrich | 2011 | JACC: Cardiovascular Imaging2011，，12： | 1 |
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