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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 3 | The Determinants of Positive Long-term Performance in Strategic Mergers:Corporate Focus and Cash显示文摘 | Angela Morgan Lance Nail | 2000 | Journal of Banking & Finance2000，48，52： | 1 |
| 4 | Developing a pain assessment tool for use by nurses in an adult intensive care unit显示文摘 | Audrey Blenkharn Siobhan Faughnan Angela Morgan | 2002 | Intensive & Critical Care Nursing2002，，6： | 1 |
| 5 | The determinants of positive long-term performance in strategic mergers:Corporate focus and cash显示文摘 | Megginson William L Angela Morgan Lance Nail | 2004 | Journal of Banking & Finance2004，，28： | 1 |
| 6 | CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis显示文摘 | Tao Fu Emmanouil P. Pappou Angela A. Guzzetta Jana Jeschke Ruby Kwak Pujan Dave Craig M. Hooker Richard Morgan Stephen B. Baylin Christine A. Iacobuzio-Donahue Christopher L. Wolfgang Nita Ahuja | 2012 | Clinical Cancer Research2012，，17： | 1 |
| 7 | Linking pay of performance - compensation proposals in the S&P500 显示文摘 | Angela G morgan tte B poulsen | 2001 | Journal of Financial Economics2001，3，26： | 1 |
| 8 | The assessment of body composition in patients with cirrhosis显示文摘 | Marsha Y. Morgan Angela M. Madden | 1996 | European Journal of Nuclear Medicine1996，，2： | 1 |
| 9 | The determinants of positive longterm performance in strategic mergers: Corporate focus and cash显示文摘 | William L Megginson Angela Morgan Lance Nail | 2004 | Journal of Banking & Finance2004，28，： | 1 |
| 10 | Early sucking and swallowing problems as predictors of neurodevelopmental outcome in children with neonatal brain injury: a systematic review显示文摘 | JUSTINE SLATTERY ANGELA MORGAN JACINTA DOUGLAS | 2012 | Developmental Medicine & Child Neurology2012，，： | 1 |
| 11 | Linking Pay to Performance - compensation Proposals in the S&P 500 显示文摘 | Morgan Angela G Annette B Poulsen | 2001 | Journal of Financial Econom-ies2001，，62： | 1 |
| 12 | 母亲颗粒物空气污染暴露与足月出生体重:效应与异质性的多国评估显示文摘[背景]越来越多的证据显示,母亲空气污染暴露与对胎儿生长的不良影响之间存在关联;但是,现有的文献并不一致。[目的]研究9个国家14个中心的数据,量化母亲颗粒物空气污染暴露与足月出生体重和低出生体重(LBW)之间的关联,并探讨此关联中地点特征和暴露评估方法对中心之间异质性的影响。[方法]空气污染与妊娠结局国际合作(ICAPPO)的各中心采用共同的分析方案,对PM10和PM2.5(颗粒物≤10和2.5μm)与足月LBW和连续出生体重进行效应评估。采用meta分析将各个中心(~300万例出生)的效应评估结合起来,并采用meta回归分析在报告的效应评估中,中心特征和暴露评估方法对中心之间异质性的影响。[结果]随机效应meta分析显示,调整母亲的社会经济地位后,在整个妊娠期间,足月LBW与PM10[比值比(OR)=1.03;95%CI:1.01~1.05]和PM2.5[OR=1.10;95%CI:1.03~1.18]每增加10μg/m3呈正相关。在充分调整随机效应的meta分析中,作为一个连续性的结果,PM10暴露每增加10μg/m3与足月出生体重呈负相关(-8.9g;95%CI:-13.2^-4.6 g)。meta回归分析显示,具有较高平均PM2.5水平和PM2.5∶PM10比率的中心,以及采用时间暴露评估(与时空相比)的中心,所报告的关联更强。[结论]在研究人群中,母亲颗粒物污染暴露与足月LBW相关联。有3个地点特征和暴露评估方法学方面的不同导致各个中心报告的关联的差异。 | Payam Dadvand Jennifer Parker Michelle L. Bell Matteo Bonzini Michael Brauer Lyndsey A. Darrow Ulrike Gehring Svetlana V. Glinianaia Nelson Gouveia Eun-hee Ha Jong Han Leem Edith H. van den Hooven Bin Jalaludin Bill M. Jesdale Johanna Lepeule Rachel Morello-Frosch Geoffrey G. Morgan Angela Cecilia Pesatori Frank H. Pierik Tanja Pless-Mulloli David Q. Rich Sheela Sathyanarayana Juhee Seo Rémy Slama Matthew Strickland Lillian Tamburic Daniel Wartenberg Mark J. Nieuwenhuijsen Tracey J. Woodruff | 2013 | 环境与职业医学2013，30，6： | 0 |
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