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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 3 | Eph-ephrin signalling in adult tissues and cancer 显示文摘 | ANNA M S EDUARD B | 2008 | Curr Opin Cell Biol2008，20，1： | 1 |
| 4 | Induction of macrophage nitric oxide production by gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes显示文摘 | MIZEL S B ANNA N H MARLENA A M | 2003 | The Journal of Immunology2003，170，： | 1 |
| 5 | Solid-phase extraction on sorbents of different retention mechanisms followed by determination by gas chromatography-mass spectrometric and gas chromatography-electron capture detection of pesticide residues in crops 显示文摘 | Anna B Rositsa M Deyana S | 2007 | Journal of Chromatography A2007，1150，12： | 1 |
| 6 | Molecular components of coal and coal structure显示文摘 | Danuta B Anna M | 1981 | Fuel1981，60，： | 1 |
| 7 | MCM41 functionalized with ethylenediaminetriacetic acid for ion-exchange chromatography 显示文摘 | Maria C B Corrado S Anna M T | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 8 | Alternative nuclear functions for NF-KB family members显示文摘 | Llufs E Anna B Maria C M | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 9 | Evaluation of a MBR-RO system to produce high quality reuse water:microbial control,DBP formation and nitrate显示文摘 | Anna M C Robert C A David M B | 2005 | Water research2005，39，16： | 1 |
| 10 | Hematopoietic stem cells convert into liver cells within days without fusion 显示文摘 | JANG Y Y STEPHEN B B ANNA M D | 2004 | Nature Cell Biolo2004，6，6： | 1 |
| 11 | Tumoral distribution of long-circulating dextran-eoated iron oxide nanopartieles in a rodent model 显示文摘 | Anna M Edgaro M Alexei B | 2000 | Radiology2000，214，： | 1 |
| 12 | Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine显示文摘 | Helena Domeij Xiang Hua Jun Su Alexandra B?cklund Zhongqun Yan Anna G. Frosteg?rd Jesper Z. Haeggstr?m Tomas Modéer Johan Frosteg?rd | 2013 | Prostaglandins and Other Lipid Mediators2013，，： | 1 |
| 13 | Effects of mood stabilizers on DNA damage in an animal model of mania 显示文摘 | Andreazza A C Kauer-Sant'Anna M Frey B N | 2008 | J Psychiatry Neurosci2008，33，6： | 1 |
| 14 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 15 | Beneficial effects of breast milk in the neonatal intensive care unit on the developmental outcome of extremely low birth weight infants at 18 months of age显示文摘 | Betty R Brenda B Anna M | 2006 | Pediatrics2006，118，1： | 1 |
| 16 | Understanding apomixis:recent advances and remaining conundrums显示文摘 | ROSS A B Anna M K | 2004 | Plant Cell2004，16，： | 1 |
| 17 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 18 | Experimental study of the virulence of Streptococcus pneumoniae with re duced susceptibility to penicillin 显示文摘 | ANNA B M ANN H ASA M | 2000 | International Journal of Pediatric Otorhinolaryngology2000，55，1： | 1 |
| 19 | Eating quality standards for apples based on consumer preferences显示文摘 | F Roger Harker Eugene M Kupferman Anna B Matin | 2008 | Postharvest Biology and Technology2008，50，： | 1 |
| 20 | The inhibitive action ofmetacryloxypropylmethoxysilane(MAOS)on aluminium corrosion inNaCl solutions显示文摘 | Anna M B Laura C | 1999 | Corrosion Science1999，41，： | 1 |
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