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| 1 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 2 | Winter wheat carbon exchange in Thuringia, Germany显示文摘 | Anthoni P M Freibauer A Kolle O | 2004 | Agricultural and Forest Meteorology2004，121，12： | 1 |
| 3 | Assessment of bio- markers of protein anabolism in skeletal muscle during the life span of the rat : sarcopenia despite elevated protein synthesis 显示文摘 | Kimball S R O' Malley J P Anthony J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 4 | As sessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated pro rein synthesis显示文摘 | KIMBALL S R O'MALLEY J P ANTHONY J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 5 | Evaluation of downstream effects of specialty chemicals in the Bayer process显示文摘 | David O O Lawrence J C Peter A D Anthony E G Nancy L P | 1991 | Light Metals1991，，： | 1 |
| 6 | Winter wheat carbon exchange in Thuringia, Germany显示文摘 | Anthoni P M Freibauer A Kolle O | 2004 | Agricultural and Forest Meteorology2004，121，： | 1 |
| 7 | Terahertz pulsed imaging of freshly excised human colonic tissues显示文摘 | Caroline B Reid Anthony Fitzgerald George Reese Robert Goldin Paris Tekkis P S O’Kelly Emma Pickwell-MacPherson Adam P Gibson Vincent P Wallace | 2011 | Physics in Medicine and Biology2011，，： | 1 |
| 8 | Australians living with and managing hepatitis C 显示文摘 | Anthony P O'Brien Wendy M Cross Peter Higgs | 2010 | Issues in Mental Health Nursing2010，31，： | 1 |
| 9 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
| 10 | Thirsty roots and hungry leaves: unravelling the roles of carbon and water dynamics in tree mortality 显示文摘 | Anthony P O Patrick J M M Elizabeth A | 2013 | New Phytologist2013，200，2： | 1 |
| 11 | Satellite structure in the X ray photoelectron spectra of some binary and mixed oxides of lanthanum and cerium显示文摘 | BURROUGHS P HAMNE'IT A ANTHONY F O | 1976 | Journal of the Chemical Society Dalton Transactions1976，17，： | 1 |
| 12 | Obesity and Non-Alcoholic Fatty Liver Disease in Chronic Hepatitis C显示文摘 | Zobair M Younossi Arthur J McCullough Janus P Ong David S Barnes Anthony Post Anthony Tavill Diane Bringman Lisa M Martin Jennifer Assmann Terry Gramlich Kevin D Mullen Robert O’Shea William D Carey Roy Ferguson | 2004 | Journal of Clinical Gastroenterology2004，，8： | 1 |
| 13 | Mean power frequency and amplitude of the mechanomyographic and electromyographic signals during incremental cycle ergometry显示文摘 | Sharon R Perry Terry J Housh Joseph P Weir Glen O Johnson Anthony J Bull Kyle T Ebersole | 2001 | Journal of Electromyography and Kinesiology2001，，4： | 1 |
| 14 | The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial显示文摘 | Andrew L Lux Stuart W Edwards Eleanor Hancock Anthony L Johnson Colin R Kennedy Richard W Newton Finbar JK O’Callaghan Christopher M Verity John P Osborne | 2004 | The Lancet2004，，9447： | 1 |
| 15 | Winter wheat carbon exchange in Thuringia, Germany显示文摘 | Anthoni P M Freibauer A Kolle O | 2004 | Agricultural and Forest Meteorology2004，121，12： | 1 |
| 16 | Controlling the collapse/swelling transition in charged ydrogels显示文摘 | Jamie O Mona P Anthony L | 2004 | Biomaterials2004，25，： | 1 |
| 17 | 显示文摘 | THORFINNUR G ANTHONY P D JOHN E O | 2002 | Org Lett2002，4，15： | 1 |
| 18 | Selectivity and mass transfer limitati-ons in pressure -retarded osmosis at high concenWations and increased operaling presstne显示文摘 | Anthony P Straub Chinedum O Osuji Tzahi Y | 2015 | Environmental Seiene & Technology2015，49，12： | 1 |
| 19 | Winter wheat carbon exchange in Thuringia, Germany显示文摘 | Anthoni P M Freibauer A Kolle O | 2004 | Agricultur- al and Forest Meteorology2004，121，12： | 1 |
| 20 | Cost control into the 1990s显示文摘 | Lyall D Kwasi O Anthony P | 1990 | Management Accounting1990，，4： | 1 |
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