|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 2 | Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis显示文摘The recent outbreak of COVID-19 has been rapidly spreading on a global scale.To date,there is no specific vaccine against the causative virus,SARS-CoV-2,nor is there an effective medicine for treating COVID-19,thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19.By extracting and analyzing all available published clinical data,we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19.Specifically,preexisting chronic conditions such as hypertension,cardiovascular disease,chronic kidney disease,and diabetes are strongly associated with an increased risk of developing severe COVID-19;surprisingly,however,we found no correlation between chronic liver disease and increased disease severity.In addition,we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality.Given the high risk of comorbidity and the high mortality rate associated with tissue damage,organ function should be monitored closely in patients diagnosed with COVID-19,and this approach should be included when establishing new guidelines for managing these high-risk patients.Moreover,additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe,potentially fatal complications,and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease.Taken together,these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19. | Xinhui Wang Xuexian Fang Zhaoxian Cai Xiaotian Wu Xiaotong Gao Junxia Min Fudi Wang | 2020 | Research2020，，1： | 13 |
| 3 | Using autologistic spatial models to simulate the distribution of land-use patterns in Zhangjiajie, Hunan Province显示文摘Nowadays,spatial simulation on land use patterns is one of the key contents of LUCC.Modeling is an important tool for simulating land use patterns due to its ability to inte-grate measurements of changes in land cover and the associated drivers.The conventional regression model can only analyze the correlation between land use types and driving factors, but cannot depict the spatial autocorrelation characteristics.Land uses in Yongding County, which is located in the typical karst mountain areas in northwestern Hunan province,were investigated by means of modeling the spatial autocorrelation of land use types with the purpose of deriving better spatial land use patterns on the basis of terrain characteristics and infrastructural conditions.Through incorporating components describing the spatial autocor-relation into a conventional logistic model,we constructed a regression model(Autologistic model),and used this model to simulate and analyze the spatial land use patterns in Yong- ding County.According to the comparison with the conventional logistic model without con- sidering the spatial autocorrelation,this model showed better goodness and higher accuracy of fitting.The distribution of arable land,wood land,built-up land and unused land yielded areas under the ROC curves(AUC)was improved to 0.893,0.940,0.907 and 0.863 respec- tively with the autologistic model.It is argued that the improved model based on autologistic method was reasonable to a certain extent.Meanwhile,these analysis results could provide valuable information for modeling future land use change scenarios with actual conditions of local and regional land use,and the probability maps of land use types obtained from this study could also support government decision-making on land use management for Yongding County and other similar areas. | WU Guiping ZENG Yongnian XIAO Pengfeng FENG Xuezhi HU Xiaotian | 2010 | Journal of Geographical Sciences2010，20，2： | 6 |
| 4 | Progress and Challenges for Live-cell Imaging of Genomic Loci Using CRISPR-based Platforms显示文摘Chromatin conformation,localization,and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased states,the requirement for cell fix-ation precludes the comprehensive dynamic analysis necessary to fully understand chromatin activ-ities. This has spurred the development and application of a variety of imaging methodologies for visualizing single chromosomal loci in the native cellular context. In this review,we describe currently-available approaches for imaging single genomic loci in cells,with special focus on clus-tered regularly interspaced short palindromic repeats (CRISPR)-based imaging approaches. In addition,we discuss some of the challenges that limit the application of CRISPR-based genomic imaging approaches,and potential solutions to address these challenges. We anticipate that,with continued refinement of CRISPR-based imaging techniques,significant understanding can be gained to help decipher chromatin activities and their relevance to cellular physiology and pathogenesis. | Xiaotian Wu Shiqi Mao Yachen Ying Christopher J.Krueger Antony K. Chen | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 5 |
| 5 | PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer显示文摘Objective:As a member of the peptidyl arginine deiminase(PAD)family,PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer tissues.However,the role of PADI3 in colon cancer is unclear.In this study,we investigated the function and molecular mechanism of PADI3 in colon cancer tumorigenesis.Methods:Western blot and real-time PCR were used to detect the expression levels of several genes.CCK-8,flow cytometry(FCM)and colony formation assays were used to examine cell proliferation,the cell cycle and colony formation ability.RNAsequencing analysis was used to study the molecular mechanism of PADI3 in tumorigenesis.A truncation mutation experiment was performed to determine the key functional domain of PADI3.Results:PADI3 overexpression inhibited cell proliferation and colony formation and led to G1 phase arrest in both HCT116(originating from primary colon cancer)and LoVo(originating from metastatic tumor nodules of colon cancer)cells.PADI3-expressing HCT116 cells had a lower tumor formation rate and produced smaller tumors than control cells.PADI3 significantly decreased Sirtuin2(Sirt2)and Snail expression and AKT phosphorylation and increased p21 expression,and Sirt2 overexpression partly reversed the effects induced by PADI3 overexpression.Immunocytochemistry showed that PADI3 is mainly localized in the cytoplasm.Truncation mutation experiments showed that the C-domain is the key domain involved in the antitumor activity of PADI3.Conclusions:PADI3 suppresses Snail expression and AKT phosphorylation and promotes p21 expression by downregulating Sirt2 expression in the cytoplasm,and the C-domain is the key domain for its antitumor activity. | Xiaotian Chang Zhengbin Chai Jiaorui Zou Hongxing Wang Yao Wang Yabing Zheng Hui Wu Chunyan Liu | 2019 | Cancer Biology & Medicine2019，16，4： | 4 |
| 6 | Current advances of transition metal dichalcogenides in electromagnetic wave absorption:A brief review显示文摘Transition metal dichalcogenides(TMDs)show great advantages in electromagnetic wave(EMW)absorption due to their unique structure and electrical properties.Tremendous research works on TMD-based EMW absorbers have been conducted in the last three years,and the comprehensive and systematical summary is still a rarity.Therefore,it is of great significance to elaborate on the interaction among the morphologies,structures,phases,components,and EMW absorption performances of TMD-based absorbers.This review is devoted to analyzing TMD-based absorbers from the following perspectives:the EMW absorption regulation strategies of TMDs and the latest progress of TMD-based hybrids as EMW absorbers.The absorption mechanisms and component-performance dependency of these achievements are also summarized.Finally,a straightforward insight into industrial revolution upgrading in this promising field is proposed. | Shijie Zhang Jiying Li Xiaotian Jin Guanglei Wu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，3： | 3 |
| 7 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 8 | Optimal Design of Novel Electromagnetic-Ring Active Balancing Actuator with Radial Excitation显示文摘Imbalance vibration is a typical failure mode of rotational machines and has significant negative effects on the efficiency,accuracy,and service life of equipment.To automatically reduce the imbalance vibration during the operational process,different types of active balancing actuators have been designed and widely applied in actual production.However,the existing electromagnetic-ring active balancing actuator is designed based on an axial excitation structure which can cause structural instability and has low electromagnetic driving efficiency.In this paper,a novel radial excitation structure and the working principle of an electromagnetic-ring active balancing actuator with a combined driving strategy are presented in detail.Then,based on a finite element model,the performance parameters of the actuator are analyzed,and reasonable design parameters are obtained.Self-locking torque measurements and comparative static and dynamic experiments are performed to validate the self-locking torque and driving efficiency of the actuator.The results indicate that this novel active balancing actuator has sufficient self-locking torque,achieves normal step rotation at 2000 r/min,and reduces the driving voltage by 12.5%.The proposed novel balancing actuator using radial excitation and a combination of permanent magnets and soft-iron blocks has improved electromagnetic efficiency and a more stable and compact structure. | Xin Pan Xiaotian He Haiqi Wu Chuanlong Ju Zhinong Jiang Jinji Gao | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 9 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
| 10 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 11 | Reducing the mode-mismatch noises in atom–light interactions via optimization of the temporal waveform显示文摘Atom–light interface is at the core of quantum metrology and quantum information science.Associated noises during interaction processes are always inevitable and adverse.In this paper,we perform the stimulated Raman scattering(SRS)in a hot Rb 87 vapor cell and demonstrate the reduction of related noises originated from mode mismatch via optimizing the temporal waveform of the input seed.By using the seed with the optimized mode,the intensity fluctuation of the signal field generated in atom–light interaction is decreased by 4.3 dB.Furthermore,the fluctuation of the intensity difference between the signal and atomic spin wave is reduced by 3.1 dB.Such a temporal mode-cleaning method can be applied to improve the precision of atom interferometry using SRS and should be helpful for quantum information processing based on an atom–light correlated system. | Xiaotian Feng Zhifei Yu Bing Chen Shuying Chen Yuan Wu Donghui Fan Chun-Hua Yuan L.Q.Chen Z.Y.Ou Weiping Zhang | 2020 | Photonics Research2020，8，11： | 1 |
| 12 | Maternal genetic history of southern East Asians over the past 12,000 years显示文摘Southern East Asia,including Guangxi and Fujian provinces in China,is home to diverse ethnic groups,languages,and cultures.Previous studies suggest a high complexity regarding population dynamics and the history of southern East Asians.However,large-scale genetic studies on ancient populations in this region are hindered by limited sample preservation.Here,using highly efficient DNA capture techniques,we obtain 48 complete mitochondrial genomes of individuals from Guangxi and Fujian in China and reconstruct their maternal genetic history over the past 12,000 years.We find a strong connection between southern East Asians dating to~12,000-6000 years ago and present-day Southeast Asians.In addition,stronger genetic affinities to northern East Asians are observed in historical southern East Asians than Neolithic southern East Asians,suggesting increased interactions between northern and southern East Asians over time.Overall,we reveal dynamic connections between ancient southern East Asians and populations located in surrounding regions,as well as a shift in maternal genetic structure within the populations over time. | Yalin Liu Tianyi Wang Xichao Wu Xuechun Fan Wei Wang Guangmao Xie Zhen Li Qingping Yang Peng Cao Ruowei Yang Feng Liu Qingyan Dai Xiaotian Feng Wanjing Ping Bo Miao Yun Wu Yichen Liu Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 13 | Printable and stable all-polymer solar cells based on non-conjugated polymer acceptors with excellent mechanical robustness显示文摘All-polymer solar cells(all-PSCs)trigger enormous commercial applications,and great progress has been made in recent years.However,from small-area devices to large-area modules,the poor adaption of the materials for printing methods and the large efficiency loss are still great challenges.Herein,three novel non-conjugated polymer acceptors(PTH-Y,PTClm-Yand PTClo-Y)are developed for all-PSCs.It can be found that non-conjugated polymer acceptors can effectively minimize the technique and efficiency gaps between small-area spin-coating and large-area blade-printing method,which can facilitate the preparation of large-area flexible device.By directly inheriting the spin-coating condition,the blade-coating processed device based on PTCloY achieves an impressive power conversion efficiency(PCE)of 12.42%,comparable to the spin-coating processed one(12.74%).Such a non-conjugated polymer system also can well tolerate large-scale preparation and flexible substrate.Notable PCE of 11.94%for large-area rigid device and 11.56%for large-area flexible device are obtained,which is the highest value for large-area flexible all-PSCs fabricated by blade-coating.In addition,the non-conjugated PTClo-Y-based devices show excellent thermal stability and mechanical robustness.These results demonstrate that the non-conjugated polymer acceptors are potential candidates for the fabrication of highly-efficient,large-area and robust flexible all-PSCs by printing methods. | Dong Chen Siqi Liu Xiaotian Hu Feiyan Wu Jiabin Liu Kangkang Zhou Long Ye Lie Chen Yiwang Chen | 2022 | Science China Chemistry2022，65，1： | 1 |
| 14 | High-capacity reversible data hiding in en- crypted images by prediction error 显示文摘 | Wu Xiaotian Sun Wei | 2014 | Signal Processing2014，104，11： | 1 |
| 15 | A shape memory scaffold for body temperature self-repairing wearable perovskite solar cells with efficiency exceeding 21%显示文摘Grain boundary cracks in flexible perovskite films can be repaired by filling with self-repairing polymers during the preparation and wearable operation.However,the self-repairing polymers are commonly active through external heating or humidification treatments,which cannot match with the human body's temperature tolerance of wearable devices.Herein,a body temperature-responsive shape memory polyurethane(SMPU)is demonstrated to achieve the real-time mechanical self-repairing of grain boundary cracks(~37°C).Furthermore,the strong intermolecular interaction between SMPU and the uncoordinated Pb2+and I−,can reduce the trap density in perovskite films.The blade-coated device achieves a power conversion efficiency(PCE)of 21.33%,which is among the best reported flexible perovskite solar cells(PSCs;0.10 cm2).Importantly,the device with SMPU can recover more than 80%of the PCE after 6000 cycles(bending radius:8 mm).Finally,the flexible PSCs are used for wearable solar power supply of a smartphone,which show great potential for self-repairing wearable electronics. | Tangyue Xue Zengqi Huang Pei Zhang Meng Su Xiaotian Hu Tingqing Wu Baojin Fan Gangshu Chen Guanghui Yu Wentao Liu Xuying Liu Yiqiang Zhang Yanlin Song | 2022 | InfoMat2022，4，12： | 1 |
| 16 | Adiponectin and metabolic cardiovascular diseases:Therapeutic opportunities and challenges显示文摘Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic disorders.They are the leading causes of death in developing countries.Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes.Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity,improve atherosclerosis,have anti-inflammatory properties,and exert a cardioprotective effect.Low adiponectin con-centrations are correlated with myocardial infarction,coronary atherosclerotic heart disease,hypertrophy,hypertension,and other metabolic cardiovascular dysfunctions.However,the relationship between adiponectin and cardiovascular diseases is complex,and the specific mechanism of action is not fully understood.Our summary and analysis of these issues are ex-pected to contribute to future treatment options. | Xiaotian Lei Sheng Qiu Gangyi Yang Qinan Wu | 2023 | Genes & Diseases2023，10，4： | 1 |
| 17 | Spectroscopic studies on the interaction of hypocrcllin A and hemoglobin显示文摘 | ZHOU Jiahong WU Xiaohong GU Xiaotian ct al | 2009 | Spectrochimica Acta: Part A2009，72，： | 1 |
| 18 | Could urinary ACE2 protein level help identify individuals susceptible to SARS-CoV-2 infection and complication?显示文摘Globally, SARS-CoV-2 has infected 3,113,447 people and killed 216,930 as of April 29, 2020. Identifying populations vulnerable to infection and their disease progression is critical to mitigating the negative impacts on healthcare systems. Recent studies have shown that angiotensin converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 to enter human cells (Zhou et al., 2020), raising the possibility that a higher ACE2 expression level could facilitate SARS-CoV-2infection. | Xiaotian Ni Changqing Sun Yaping Tian Yanjie Huang Tongqing Gong Lan Song Xing Yang Kai Li Nairen Zheng Jianping Wang Hongxing Wu Ruoxian Zhang Yi Wang Guangshun Wang &Jun Qin | 2020 | Science China(Life Sciences)2020，63，11： | 1 |
| 19 | Random Grid-based Visual Secret Sharing for General Access Structures with Cheat-preventing Ability显示文摘 | Wu Xiaotian Sun Wei | 2012 | Journal of Systems and Software2012，85，5： | 1 |
| 20 | 2-Aminopyridine functionalized cellulose based Pd nanoparticles: An efficient and ecofriendly catalyst for the Suzuki cross-coupling reaction显示文摘在 2-aminopyridine functionalized 纤维素上支持的钯催化剂被综合并且充分由诱导地联合的血浆描绘了原子排放光谱学,传播电子显微镜, Fourier 变换红外线的光谱学, thermogravimetric 分析和 X 光检查光电子 spectrometry。这催化剂能在 50% 乙醇与 arylboronic 酸在芳基卤化物的铃木跨 coupling 反应被使用在好收益负担得起 biaryls,并且没有金属 Pd 的损失,容易在反应以后由简单过滤再循环。 | Peibo Hu Yahao Dong Xiaotian Wu Yuping Wei | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员