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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma显示文摘Background:Effective therapeutic options are limited for patients with advanced esophageal squamous cell carcinoma(ESCC).The incorporation of an immune checkpoint inhibitor and a molecular anti-angiogenic agent into the commonly adopted chemotherapy may produce synergistic effects.Therefore,we aimed to investigate the efficacy and safety of camrelizumab plus apatinib combined with chemotherapy as the first-line treatment of advanced ESCC.Methods:In this single-arm prospective phase II trial,patients with unresectable locally advanced or recurrent/metastatic ESCC received camrelizumab 200 mg,liposomal paclitaxel 150 mg/m2,and nedaplatin 50 mg/m2 on day 1,and apatinib 250 mg on days 1-14.The treatments were repeated every 14 days for up to 9 cycles,followed by maintenance therapy with camrelizumab and apatinib.The primary endpoint was objective response rate(ORR)according to the Response Evaluation Criteria in Solid Tumors(version 1.1).Secondary endpoints included disease control rate(DCR),progression-free survival(PFS),overall survival(OS),and safety.Results:We enrolled 30 patients between August 7,2018 and February 23,2019.The median follow-up was 24.98 months(95%confidence interval[CI]:23.05-26.16 months).The centrally assessed ORR was 80.0%(95%CI:61.4%-92.3%),with a median duration of response of 9.77 months(range:1.54 to 24.82+months).The DCR reached 96.7%(95%CI:82.8%-99.9%).The median PFS was 6.85 months(95%CI:4.46-14.20 months),and the median OS was 19.43 months(95%CI:9.93 months–not reached).The most common grade 3-4 treatmentrelated adverse events(AEs)were leukopenia(83.3%),neutropenia(60.0%),and increased aspartate aminotransferase level(26.7%).Treatment-related serious AEs included febrile neutropenia,leukopenia,and anorexia in one patient(3.3%),and single cases of increased blood bilirubin level(3.3%)and toxic epidermal necrolysis(3.3%).No treatment-related deaths occurred.Conclusions:Camrelizumab plus apatinib combined with liposomal paclitaxel and nedaplatin as first-line treatment demonstrated feasible anti-tumor activity and manageable safety in patients with advanced ESCC.Randomized trials to evaluate this new combination strategy are warranted.Trial registration:This trial was registered on July 27,2018,at ClinicalTrials.gov(identifier:NCT03603756). | Bo Zhang Ling Qi Xi Wang Jianping Xu Yun Liu Lan Mu Xingyuan Wang Lidan Bai Jing Huang | 2020 | Cancer Communications2020，40，12： | 38 |
| 4 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 5 | Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume显示文摘AIM: Our research attempted to evaluate the overall functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and ChildPugh′s classification, and to discuss its value of clinical application.METHODS: Ninety two patients with portal hypertension due to hepatic cirrhosis were investigated. All had a historyof haematemesis and hematochezia, esophageal and gastric fundus varices, splenomegaly and hypersplenia.A 2-year follow-up was routinely performed and no one was lost. Twenty two healthy volunteers were used as control group. Blood and urine samples were collected 4times before and after intravenous D-sorbitol infusion.The hepatic clearance (CLH) of D-sorbitol was then calculated according to enzymatic spectrophotometric method while the total blood flow (QToTAL) and intrahepatic shunt (RINs) were detected by multicolor Doppler ultrasound, and the liver volume was measured by spiral CT. Data were estimated by t-test, variance calculation and chi-squared test. The relationships between all these parameters and different groups were investigated according to Child-Pugh classification and postoperative complications respectively.RESULTS: Steady blood concentration was achieved 120 mins after D-sorbitol intravenous infusion, which was (0.358±0.064) mmoⅠ@L-1 in cirrhotic group and (0.189±0.05)mmol@L-1 in control group (P<0.01). CLH=(812.7±112.4) ml@min-1,QTOTAL=(1280.6±131.4) ml@min-1, and RINS=(36.54±10.65)%in cirrhotic group and CLH=(1248.3±210.5) ml.min-1, QTOTAL=(1362.4-±126.9) ml@min-1, and RINS=(8.37±3.32) % in control group (P<0.01). The liver volume of cirrhotic group was 1057±249 cm3, 851±148 cm3 and 663±77 cm3 in Child A, B and C group respectively with significant difference (P<0.001).The average volume of cirrhotic liver in Child B, C group was significantly reduced in comparison with that in control group (P<0.001). The patient, whose liver volume decreased by 40 % with the CLH below 600 ml@min-1, would have a higher incidence of postoperative complications. There was no strict correspondent relationship between CLH, liver volume and Child-Pugh′s classification.CONCLUSION: The hepatic clearance of D-sorbitol, CT measured liver volume can be reliably used for the evaluation of hepatic functional blood flow and liver metabolic volume. Combined with the Child-Pugh′s classification, it could be very useful for further understanding the liver functional reserve, therefore help determine reasonable therapeutic plan, choose surgical procedures and operating time. | Yi-Ming Li Fan Lv Xin Xu Hong Ji Wen-Tao Gao Tuan-Jie Lei Gui-Bing Ren Zhi-Lan Bai Qiang Li General Surgery Department,the 2~(nd)Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,ShaanXi Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 16 |
| 6 | Rapid and high throughput detection of HBV YMDD mutants with fluorescence polarization显示文摘AIM: To develop a simple and rapid detection of HBV gene variants and prediction of lamivudine-resistance in patients.METHODS: Initially, plasmids harboring the wild-type or mutant HBV DNA fragments were used in a model system.The technique was then applied to clinical samples for an analysis of YMDD mutations. The sera were extracted from chronic hepatitis patients who had received lamivudine treatment for more than one year. P region gene of HBV was amplified by polymerase chain reaction. The excess primers and dNTPs in PCR products were removed by cleaning-up reagents. Template-directed dye-terminator incorporation reaction was performed and R110 or TAMRA labeled acyclo-terminator was added on the 3' end of TDIprimer specifically. Fluorescence polarization value was measured with Victor 2 multilabel counter and the genotypes of HBV were analyzed.RESULTS: The YMDD genotypes in recombined positive plasmid and 56 serum samples of HBV infected patients were analyzed by using our TDI-FP method and the specificity and sensitivity were confirmed by DNA sequencing. Five of 56 serum samples showed YVDD phenotype (9%), including 1 YMDD and YVDD mixed infection. Four of 56 showed YIDD phenotype (7.1%).CONCLUSION: This is a simple, rapid, low cost and high throughput assay to detect HBV polymerase gene variants and suitable for large-scale screening and prediction of the lamivudine-resistance in clinical samples. | Yui-Jie Bai Jin-Rong Zhao Guan-Ting Lv Wen-Hong Zhang Yan Wang Xiao-Jun Yan, Institute of Genetic Diagnosis, Fourth Military Medical University, Xi’an 710032, Shannxi Province, China | 2003 | World Journal of Gastroenterology2003，9，10： | 16 |
| 7 | Seasonal and inter-annual variations in carbon fluxes and evapotranspiration over cotton field under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘Xinjiang is the largest semi-arid and arid region in China, and drip irrigation under plastic mulch is widely used in this water-limited area. Quantifying carbon and water fluxes as well as investigating their environmental drivers over cotton fields is critical for understanding regional carbon and water budgets in Xinjiang, the largest cotton production basin of China. In this study, an eddy covariance(EC) technique was used to measure the carbon and water fluxes of cotton field under drip irrigation with plastic mulch in the growing seasons of 2009, 2010, 2012 and 2013 at Wulanwusu Agrometeorological Experiment Station, a representative oasis cropland in northern Xinjiang. The diurnal patterns of gross primary production(GPP), net ecosystem exchange(NEE) and evapotranspiration(ET) showed obviously sinusoidal variations from June to September, while the diurnal ecosystem respiration(Res) was stable between daytime and nighttime. The daytime hourly GPP and ET displayed asymptotic relationships with net solar radiation(Rnet), while showed concave patterns with raising vapor pressure deficit(VPD) and air temperature(Ta). The increases in hourly GPP and ET towards the maximum occurred over half ranges of VPD and Ta. The seasonal variations of GPP, NEE and ET were close to the cotton phenology, which almost reached the peak value in July. The cumulative GPP averaged 816.2±55.0 g C/m2 in the growing season(from April to October), and more than half of GPP was partitioned into NEE(mean value of –478.6±41.4 g C/m2). The mean seasonal ET was 501.3±13.9 mm, and the mean water use efficiency(WUE) was 1.0±0.1(mg C/g H2O)/d. The agro-ecosystem behaved as a carbon sink from squaring to harvest period, while it acted as a carbon source before the squaring time as well as after the harvest time. | Jie BAI Jin WANG Xi CHEN Ge Ping LUO Hao SHI Long Hui LI Jun Li LI | 2015 | Journal of Arid Land2015，7，2： | 12 |
| 8 | Distribution of lipids in modern soils from various regions with continuous climate (moisture-heat) change in China and their climate significance显示文摘Total 26 modern soil samples were collected from various regions under different climate conditions from tropical to arid temperate in China and systematically analyzed for their organic matters by GC/MS in order to evaluate climatic impacts on soil organic components. Abundant lipids molecules were recognized, including n-alkanes, n-alkenones, and long-chain branched alkanes. We find the pre- dominance of main peaks of long-chain n-alkanes (nC29, nC31, nC33) and short-chain ones (nC16, nC17, nC18) records information of soil generation in warm-humid and cold-dry regions. The proportion of n-alkanes (nC16+nC17+nC18) to (nC29+nC31+nC33) varies in good agreement with moisture-heat conditions and thus probably can serve as a new index for climate change. The ratios of C21-/nC22+, nC17/nC31 and (nC15+nC17+nC19) / ( nC27+nC29 +nC31) of n-alkanes, indicating respectively input ratios of lower bacterial alga, aquatic organisms, and higher plants and terraneous organisms, co-vary well in different climate regions from forest to grassland and desert, suggesting that they have also reflected the difference of climates between monsoon region and inland one. The C21-/C22+ ratio of n-alkan-2-one records largely the discrepancy of temperature from north to south of China bordered by the Qinling Mountains, but less humidity. The C21-/C22+ ratio of n-alkan-3-ones changes well with climatic factors, such as tem- perature and humidity. The biogenic source of series A-D long-chain branched alkanes may be derived from some kinds of special epiphyte that most likely live in weak oxic-anoxic and moisture-heat envi- ronments, suggesting their distribution record as well some information on climatic change. All these researches demonstrate that the distributions of lipids molecules in modern soils in China record well signals of climates from quite different climatic regions, and can serve as important climatic proxies to reveal climatic change over China. | WANG YongLi FANG XiaoMin BAI Yan XI XiaoXia ZHANG XiZheng WANG YouXiao | 2007 | Science China Earth Sciences2007，50，4： | 11 |
| 9 | 7~Be: A Geochemical Tracer for Seasonal Erosion of Surface Soil in Watershed of Lake Hongfeng, Guizhou, China显示文摘7Be penetrative depth in undisturbed surface soil is within 4mm.^7Be activity shows exponential decrease with soil depth,which is expressed as a diffusion process.7Be penetrative depth in undisturbed surface soil is apparently deeper in the fall (0.22-0.37g cm^-1) than in the spring (0.11-0.28g cm^-2) at the same site;Whereas,^7Be apparent activity at the top of surface soil is higher in the spring (0.3-2.2Bq g^-1)than in the fall (0.2-0.5Bqg^-1) at the same site,The 7Be inventory(189-544Bq m^-2)changes with both locations and seasons.Although the ^7Be flux to the earth's surface increases with amount of precipitation,its maximum inventory in the soil profiles decreases to 30%-40% after the rainy period.Calculated by the diffusion equation,the erosion and accumulation rates of soil particles are agreeable with the observation in situ,Which shows that the rates in fall are 1.5 times those in spring.The eroded soil particles almost all have been removed on the tablelands rathel than transported into the drainage system.This indicates that the soil erosion process in the karst region is only partial transportation within a short distance. | BAI ZHANGUO WAN GUOJIANG WANG CHANGSHENG WAN XI HUANGRONGGUI P.H. SANTSCHIZ and M. BASKARANZ(1￣State Key Lab. Of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences,Guiyang 550002 (China))(2￣Department Of Marine Scien | 1996 | Pedosphere1996，6，1： | 10 |
| 10 | Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart显示文摘This work characterizes the mitochondrial proteomic profile in the failing heart and elucidates the molecular basis of mitochondria in heart failure. Heart failure was induced in rats by myocardial infarction, and mitochondria were isolated from hearts by differential centrifugation. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry, a system biology approach was employed to investigate differences in mitochondrial proteins between normal and failing hearts. Mass spectrometry identified 27 proteins differentially expressed that involved in energy metabolism. Among those, the up-regulated proteins included tricarboxylic acid cycle enzymes and pyruvate dehydrogenase complex subunits while the down-regulated proteins were involved in fatty acid oxidation and the OXPHOS complex. These results suggest a substantial metabolic switch from free fatty acid oxidation to glycolysis in heart failure and provide molecular evidence for alterations in the structural and functional parameters of mitochondria that may contribute to cardiac dysfunction during ischemic injury. | WANG Jun1,2, BAI Ling1,2, LI Jing3, SUN ChaoFeng1,2, ZHAO Jin1, CUI ChangCong1,2, HAN Ke1,2, LIU Yu1,2, ZHUO XiaoZhen1,2, WANG TingZhong1,2, LIU Ping1,2, FAN FenLing1,2, GUAN YouFei3 & MA AiQun1,2 1 Department of Cardiology, First affiliated hospital of medical college of Xi’an Jiaotong University, Xi’an 710061, China 2 Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi’an 710061, China 3 Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education, Peking University Health Science Center, Beijing 100083, China | 2009 | Science China(Life Sciences)2009，52，11： | 10 |
| 11 | Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia显示文摘Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stochastic dynamic causal modeling(s DCM) to quantify connections among the left dorsolateral prefrontal cortex(inner speech monitoring), auditory cortex(auditory processing), hippocampus(memory retrieval), thalamus(information filtering), and Broca's area(language production) in 17 first-episode drug-na?¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic(ROC) analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence. | Baojuan Li Long-Biao Cui Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu | 2017 | Neuroscience Bulletin2017，33，3： | 8 |
| 12 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 13 | Comparison of detrital mineral compositions between stream sediments of the Yangtze River (Changjiang) and the Yellow River (Huanghe) and their provenance implication显示文摘A comparative comparative study on the detrital mineral composition of stream sediments of the Yangtze River (Changjiang) and Yellow River (Huanghe) shows that, light minerals of the Yangtze River basin were mainly quartz, feldspar, and detritus, the compositional characteristics of light minerals differed among tributaries, the main stream had a generally higher maturity index than tributaries;heavy mineral content tended to decrease progressively from the upper stream to lower stream of the Yangtze River, the primary assemblage was magnetite-hornblende-augite-garnet-epidote, and diagnostic minerals of different river basins were capable of indicating the nature and distribution of the source rock. Detrital mineral assemblages in sediments of tributaries and the main stream of the Yellow River were basically similar, Primary heavy mineral assemblage was opaque mineral-garnet-epidote-carbonate mineral and alteration mineral. Variations in the contents of garnet, opaque mineral, and hornblende mainly reflected the degree of sedimentary differentiation in suspended sediment and the hydrodynamic intensity of a drainage system. The heavy mineral differentiation index F revealed sedimentary differentiation of diagnostic detrital mineral composition due to changes in regional hydrodynamic intensity and can serve as an indicator for studying the dynamic sedimentary environment of a single-provenance river and the degree of sedimentary differentiation of its detrital minerals. Changes in detrital mineral content of the Yellow River was not completely controlled by provenance but reflected gravity sorting of the detrital mineral due to variations in the ephemeral river hydrodynamic intensity and sedimentary environment, however the index changing of Yangtze River were mainly influenced by the complex sediment sources. Therefore caution must be exercised in using the detrital mineral composition of marginal sea to determine the contribution of the Yangtze River and Yellow River. | Zhong-bo Wang Ri-hui Li Shou-ye Yang Feng-long Bai Xi Mei Jian Zhang Kai Lu | 2019 | China Geology2019，2，2： | 8 |
| 14 | Crosstalk between TGF-β signaling and epigenome显示文摘在胚胎的开发,织物动态平衡,成年免疫,和创伤的主要角色修理的 ligands 戏的转变生长因素贝它(TGF-) 家庭。表明小径的 TGF- 的 Dysregulation 导致严重疾病。它的关键部件在过去的二十年被揭示了。由激活受体的 cytokines 幕的这个家庭激活的 SMAD (R-SMAD ) 抄写因素,它接着调制目标基因的特定的集合的表示。一个多细胞的有机体的细胞有一样的基因信息,然而,他们由于他们的基因的微分表示显示出结构、功能的差别。研究表明了那条 epigenetic 规定,发信号的 TGF- 的不可分的部分,使房间能察觉到并且对以一种房间上下文依赖者方式发信号的 TGF- 作出回应。作为 TGF- 发信号的中央抄写因素, R-SMAD 能招募塑造 transcriptome 的各种各样的 epigenetic 管理者。在这评论,我们在在哺乳动物的开发和疾病期间发信号的 TGF- 在 epigenetic 上集中规章的机制并且在这条 epigenetic 规定讨论在 R-SMAD 和各种各样的 epigenetic 管理者之间的相互作用的中央角色。在 TGF- 发信号和 epigenome 之间的串音能在疾病的胚胎的开发和前进期间为 transcriptional 规定用作万用的调整机制,特别地癌症。 | Jianbo Bai Qiaoran Xi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 7 |
| 15 | Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection显示文摘The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A. | Hong Bai Xiaoling Gao Lei Zhao Ying Peng Jie Yang Sai Qiao Huili Zhao Shuhe Wang YiJun Fan Antony George Joyee Zhi Yao Xi Yang | 2017 | Cellular & Molecular Immunology2017，14，10： | 7 |
| 16 | MoS2 yolk-shell microspheres with a hierarchical porous structure for efficient hydrogen evolution显示文摘蛋黄壳体系结构由于他们的唯一的结构和令人兴奋的应用程序吸引了广泛的注意。瞬间 2 被切开水为氢进化认为是最有希望的催化材料之一。在这个工作,一条简单自我模板 solvothermal 途径被反应的哞 2 microspheres 与 L 半胱氨酸与层次多孔的结构为新奇瞬间 2 蛋黄壳 microspheres 的合成开发。dissolutionrecrystallization 形成机制为瞬间 2 蛋黄壳 microspheres 被建议。由于结构的优势,新材料建筑学展览改进了 photoelectrochemical 性质,包括有效的氢进化反应催化活动,高光电流密度,小过电位,和一个低费用转移电阻。 | Qiqi Zhang Hua Bai Qing Zhang Qiang Ma Yahui Li Chongqing wan Guangcheng Xi | 2016 | Nano Research2016，9，10： | 6 |
| 17 | Characteristics of gas-solid micro fluidized beds for thermochemical reaction analysis显示文摘Fuel conversion and clean energy reaction systems involve a variety of catalytic and non-catalytic gas-solid thermochemical reactions.A good understanding of the correct reaction mechanism and kinetics,as well as the profiles of reaction products,is of great significance to the development,design,and operation of such reaction systems.The micro fluidized bed reaction analysis provides an efficient and reliable method to acquire this essential information with low capital and operating costs,low energy consumption and enhanced safety.This paper provides an overview of the system and its characteristics for the micro fluidized bed reaction analyzer that has been well proven to be a reliable new approach as well as an instrument for characterizing various gas-solid thermochemical reactions. | Zhennan Han Junrong Yue Xi Zeng Jian Yu Fang Wang Shaozeng Sun Hong Yao Guangqian Luo Xuejing Liu Yining Sun Fu Ding Liangliang Fu Lei Shi Kangjun Wang Jiebin Yang Shaonan Wang Xueqing Chen Dingrong Bai Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 6 |
| 18 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 19 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
| 20 | Development and application of rapid rehabilitation system for reconstruction of maxillofacial soft-tissue defects related to war and traumatic injuries显示文摘Background: Maxillofacial war injuries usually cause severe facial organ defects and deformities, handicapping the patient's daily activities, even result in a tendency to commit suicide. The application of maxillofacial prosthesis is an alternative to surgery in functional–aesthetic facial reconstruction. Computer aided design and computer aided manufacturing has opened up a new approach to the fabrication of maxillofacial prosthesis. An intelligentized rapid simulative design and manufacture system for prosthesis was developed to facilitate the prosthesis fabrication procedure.Methods: Maxillofacial prosthesis rapid simulation design and rapid fabrication system consists of three components: digital impression, intelligentized prosthesis designing, and rapid manufacturing. The patients' maxillofacial digital impressions were taken with Structured-light 3D scanner; and then the 3D model of prostheses and their negative molds could be designed in specific software; finally, with the resin molds fabricated by rapid prototyping machine, the prostheses could be produced directly and quickly.Results: Fifteen patients of maxillofacial defect caused by traumatic injuries received prosthesis rehabilitation provided by the established system. The contour of the prostheses coordinated properly with the appearance of the patients, and the uniform-thickness border sealed well to adjacent tissues. All the patients were satisfied with their prostheses.Conclusions: The rapid simulative rehabilitation system of maxillofacial defects has been approaching completion. It could provide advanced technological reservation for the Army in the issue of maxillofacial defect rehabilitation. | Shi-Zhu Bai Zhi-Hong Feng Rui Gao Yan Dong Yun-Peng Bi Guo-Feng Wu Xi Chen | 2014 | Journal of Medical Colleges of PLA(China)2014，29，1： | 5 |
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