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| 1 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 2 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 3 | Graphene: a promising 2D material for electrochemical energy storage显示文摘Graphene, with unique two-dimensional form and numerous appealing properties, promises to remarkably increase the energy density and power density of electrochemical energy storage devices(EESDs),ranging from the popular lithium ion batteries and supercapacitors to next-generation high-energy batteries. Here, we review the recent advances of the state-of-the-art graphene-based materials for EESDs,including lithium ion batteries, supercapacitors, micro-supercapacitors, high-energy lithium-air and lithium-sulfur batteries, and discuss the importance of the pore, doping, assembly, hybridization and functionalization of different nano-architectures in improving electrochemical performance. The major roles of graphene are highlighted as(1) a superior active material,(2) ultrathin 2D flexible support,and(3) an inactive yet electrically conductive additive. Furthermore, we address the enormous potential of graphene for constructing new-concept emerging graphene-enabled EESDs with multiple functionalities of lightweight, ultra-flexibility, thinness, and novel cell configurations. Finally, future perspectives and challenges of graphene-based EESDs are briefly discussed. | Yanfeng Dong Zhong-Shuai Wu Wencai Ren Hui-Ming Cheng Xinhe Bao | 2017 | Science Bulletin2017，62，10： | 22 |
| 4 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 5 | Precise Large Deviations for Sums of Negatively Associated Random Variables with Common Dominatedly Varying Tails显示文摘在这篇论文,我们在精确大偏差上获得结果因为非鈥搑a ndom 和随机与普通 dominatedly 变化的尾巴分发功能否定地联系的 nonnegative 随机变量加。我们发现在某些条件下面,有不同集中的数字的三精确大鈥揹e viation 可能性等价于对方。而且,我们与某些否定地依赖的出现为否定地联系的 nonnegative 随机变量的和调查精确大偏差。获得的结果扩大并且改善 Ng,唐, Yan 和杨的相应结果(J。Appl。Prob, 41, 93 鈥 ? 07, 2004 ) 。否定地联系的关键词 - dominatedly 变化的尾巴 - 精确大偏差先生(2000 ) 题目分类 60F10 - 60F05 - 60G50 研究由中国(号码 10271087 ) | Yue Bao WANG Kai Yong WANG Dong Ya CHENG | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 19 |
| 6 | Computed tomographic demonstrations of HIV seropositive pulmonary tuberculosis and their relationship with CD4+ T-lymphocyte count显示文摘调停房间的免疫和过敏症的背景因素一起在肺的肺结核(PTB ) 和它的预后的致病起他们的作用。这研究的目的是调查在它的致病和CD4+T淋巴细胞 count.Methods 之间的 HIV seropositive PTB 和关系的计算 tomographic 示范有 HIV seropositive PTB 的 44 个病人的一个总数的记录 CT 图象,毫无疑问由 etiological 或病理学的考试诊断了,他们的临床的数据和他们的CD4+T淋巴细胞计数是回顾地在那里的 reviewed.Results 是粟疹的肺结核的 15 个案例,为34.1%全部的大小写的财务榴状的肺结核的 15 个案例, 34.1% ;地面眼镜暗的 6 个案例, 13.6% ;喜欢绳索的纤维阴影的 5 个案例, 11.4% ;片状、絮凝的阴影的 16 个案例, 36.4% ;成穴的 5 个案例, 11.4% ;肿瘤阴影的 5 个案例, 11.4% ;肋膜的变厚的 2 个案例,肋膜的流出的 4.5% 和 11 案例, 25.0% ;石灰化的 1 个案例, 2.3% ;lymphadenectasis 的 16 个案例, 36.4% 。foci 在肺的核,优异脑叶的前面的片断,劣等的脑叶的基础片断,中间的脑叶和语言的脑叶附近被定位。CD4+T 淋巴细胞计数仔细与 HIV seropositive PTB.Conclusions CT 的成像示范有关正在扫描能表明 PTB 的各种各样的符号。CD4+T 淋巴细胞水平决定 HIV seropositive PTB 和它的预后的成像示范的变化。 | ZHANG Yu-zhong LI Hong-jun CHENG Jing-liang WU Hao BAO Dong-ying | 2011 | Chinese Medical Journal2011，，5： | 18 |
| 7 | Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting显示文摘Glioblastomas(GBMs)are highly lethal primary brain tumors.Despite current therapeutic advances in other solid cancers,the treatment of these malignant gliomas remains essentially palliative.GBMs are extremely resistant to conventional radiation and chemotherapies.We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells(GSCs)promotes therapeutic resistance.We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth,which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs.Furthermore,stem cell-like cancer cells(cancer stem cells)have been shown to promote metastasis.Although GBMs rarely metastasize beyond the central nervous system,these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection,and GSCs display an aggressive invasive phenotype.These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment.Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells,but also display critical distinctions that provide important clues into useful therapeutic targets.In this review,we summarize the current understanding and advances in glioma stem cell research,and discuss potential targeting strategies for future development of anti-GSC therapies. | Zhi Huang Lin Cheng Olga A.Guryanova Qiulian Wu Shideng Bao | 2010 | Protein & Cell2010，1，7： | 18 |
| 8 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 9 | Monthly discharge forecasting using wavelet neural networks with extreme learning machine显示文摘Accurate and reliable hydrological forecasting is essential for water resource management. Feedforward neural networks can provide satisfactory forecast results in most cases, but traditional gradient-based training algorithms are usually time-consuming and may easily converge to local minimum. Hence, how to obtain more appropriate parameters for feedforward neural networks with more precise prediction within shorter time has been a challenging task. Extreme learning machine(ELM), a new training algorithm for single-hidden layer feedforward neural networks(SLFNs), has been proposed to avoid these disadvantages. In this study, a conjunction model of wavelet neural networks with ELM(WNN-ELM) is proposed for 1-month ahead discharge forecasting. The à trous wavelet transform is used to decompose the original discharge time series into several sub-series. The sub-series are then used as inputs for SLFNs coupled with ELM algorithm(SLFNs-ELM); the output is the next step observed discharge. For comparison, the SLFNs-ELM and support vector machine(SVM) are also employed. Monthly discharge time series data from two reservoirs in southwestern China are derived for validating the models. In addition, four quantitative standard statistical performance evaluation measures are utilized to evaluate the model performance. The results indicate that the SLFNs-ELM performs slightly better than the SVM for peak discharge estimation, and the proposed model WNN-ELM provides more accurate forecast precision than SLFNs-ELM and SVM. | LI Bao Jian CHENG Chun Tian | 2014 | Science China(Technological Sciences)2014，57，12： | 17 |
| 10 | OsVPS9A Functions Cooperatively with OsRAB5A to Regulate Post-Golgi Dense Vesicle-Mediated Storage Protein Trafficking to the Protein Storage Vacuole in Rice Endosperm Cells显示文摘在米饭内乳房间, glutelins 作为 proglutelins 在不平的 endoplasmic 蜂窝胃上被综合并且被排序到称为蛋白质身体 II (PBII ) 的 theprotein 存储液泡(PSV ) ,在他们被变换成成熟形式的地方。稠密的泡(DV ) 调停了在大米种子的 proglutelins 的 trafficking 被建议了,但是这个过程的 post-Golgi 控制是 largelyunknown。DV 是否能与 PSV 直接熔化,是争论的另一件事。在这研究,我们建议规章的 mechanismunderlying 调停 DV, post-Golgi proglutelin trafficking 到 PBII (PSV ) 。gpa2, OsVPS9A 的 loss-of-function 异种,编码 OsRAB5A 的 GEF,积累了 uncleaved proglutelins。Proglutelins 对到沿着在 DV 形式的房间墙的 apoplast 的 paramural bodiesand 指向 mis,它在 PBII 尺寸导致了伴随物减小。Previouslyreported gpa1,在 OsRab5a 变异,有类似的显型,当时两倍异种加重了的 gpa1gpa2 条件。另外, OsVPS9A 在 vitro 并且在 vivo 与 OsRAB5A 交往了。我们断定 OsVPS9A 和 OsRAB5A 可以一起工作并且在调停 DV 的 post-Golgi proglutelintrafficking 起一个规章的作用到 PBII (PSV ) 。DV 可能直接熔化到 PBII (PSV ) 交付货物的证据也是 presented.Key 词: | Feng Liu Yulong Ren Yihua Wang Cheng Peng Kunneng Zhou Jia Lv Xiuping Guo Xin Zhang Jianmin wan Yiqun Bao | 2013 | Molecular Plant2013，6，6： | 16 |
| 11 | Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population显示文摘最近的证据证明尿酸对一些神经病学的疾病是保护的,但是能在许多新陈代谢、心血管的混乱有害。在这研究,我们在中国男性和绝经后的女性检验了在尿酸铺平的浆液和骨头新陈代谢之间的协会。943 男性和 4256 绝经后的女性的一个总数在上海被招募。浆液的层次尿酸和骨头周转标记(BTM ) 与另外的生物化学的特点一起被检测。另外,胖分发通过 MRI 和图象分析软件被计算,并且骨头矿物质密度(BMD ) 用双精力的 X 光检查 absorptiometry 是坚定的。为绝经后的女性,骨质疏松症的流行与 normouricemic 组(P=4.65E-06 ) 相比在 hyperuricemia 组是显著地更低的。在女性,浆液尿酸水平显著地与骨质疏松症被联系,与机会比率(或) 并且 0.844 的 95% 信心间隔(95% CI )[0.763;0.933 ](P=0.0009 ) 在好久调整以后,身体团索引, HbA1c,瘦集体、内脏、下的胖区域,白朊, 25-hydroxyvitamin D3 [25 (哦) D3 ] ,并且甲状旁腺的荷尔蒙(PTH ) 。在女性,浆液尿酸水平断然与大腿骨的颈的 BMD 被相关( | Dan-dan YAN Jie WANG Xu-hong HOU Yu-qian BAO Zhen-lin ZHANG Cheng HU Wei-ping JIA | 2018 | Acta Pharmacologica Sinica2018，39，4： | 16 |
| 12 | Autophagic pathways as new targets for cancer drug development显示文摘Autophagy 是涉及长寿蛋白质的降级并且损坏了细胞器的一个 evolutionarily 保存的 lysosomal 自我消化过程。在最近的年里,增加证据显示 autophagy 与很多个病理学的过程被联系,包括癌症。在这评论,我们集中于在包含的 autophagosome 形成和小径被含有的 evolutionarily 保存的 autophagy 相关的基因(ATG ) 的最近的研究。我们讨论几个关键 autophagic 调停人(例如, Beclin-1, UVRAG, Bcl-2,类 III 并且我 PI3K, mTOR,和 p53 ) 在在癌症表明网络的 autophagic 起枢轴的作用。我们在癌症讨论 autophagy 的 Janus 角色并且加亮他们的关系到肿瘤抑制和肿瘤前进。我们也举作为 anticancer 策略指向 ATG 和几蛋白质 kinases 的一些例子,并且作为 antitumor 代理人讨论一些模块化 autophagy 代理人。在 autophagy 和癌症之间的关系的更好的理解将最终允许我们在癌症治疗学为药发现作为新目标利用 autophagic 小径。 | Bo LIU Yan CHENG Qian LIU Jin-ku BAO Jin-Ming YANG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 15 |
| 13 | Association of bone turnover markers with glucose metabolism in Chinese population显示文摘 | Jie WANG Dan-dan YAN Xu-hong HOU Yu-qian BAO Cheng HU Zhen-lin ZHANG Wei-ping JIA | 2017 | Acta Pharmacologica Sinica2017，38，12： | 15 |
| 14 | Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients^1显示文摘瞄准:这研究的目的是与类型 2 糖尿病在病人与 repaglinide 的治疗学的效果调查 KCNJ11 E23K 和 ABCC8 exon16 3T/C 的协会。方法:有最新诊断的类型的 100 个中国病人的一个总数 2 糖尿病与 repaglinide 被治疗 24 个星期。精氨酸刺激测试被执行评估贝它房间功能。基因变化与 PCR 限制碎片长度多型性被检测。应答者被定义由一比在 fasting 血浆葡萄糖的 25% 减少大或一比在血红素 A1c (HbA1c ) 价值的 20% 减少大(或) 在 24 星期 repaglinide 治疗以后。结果:基线 HbA1c 和 HbA1c 的减少在有 KCNJ11 E23K 变体的 E/K 和 K/K 遗传型的病人是显著地更高的什么时候与 E/E 同质接合体相比(P=0.0103 并且 0.0221,分别地) 。在 2 h 的减少饭后的血浆葡萄糖(2hPG ) 比 E/E 同质接合体(P=0.0367 ) 在 E/K 异质接合体是显著地更大的。处于到在 E 和 K 等位基因之间的 repaglinide 治疗的反应率有重要差别(68%vs 82% , P=0.0324 ) 。在 fasting 胰岛素和对胰岛素抵抗的动态平衡模型评价的变化在有 ABCC8 exon16 的病人是显著地更大的 3 C/C 对 T/C 和 T/T 遗传型(P=0.0372 并且 0.0274,分别地) 。结论:KCNJ11 E23K 变体与 repaglinide 的治疗学的效果被联系。另外, ABCC8 exon16 3T/C 变体的 C/C 同质接合体比 T/C 和 T/T 遗传型在胰岛素敏感对 repaglinide 更好作出回应。 | Ya-yi HE Rong ZHANG Xin-yu SHAO Cheng HU Cong-rong WANG Jun-xi LU Yu-qian BAO Wei-ping JIA Kun-san XIANG | 2008 | Acta Pharmacologica Sinica2008，29，8： | 14 |
| 15 | Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population显示文摘 | Xue SUN Feng JIANG Rong ZHANG Shan-shan TANG Miao CHEN Dan-feng PENG Jing YAN Tao WANG Shi-yun WANG Yu-qian BAO Cheng HU Wei-ping JIA | 2014 | Acta Pharmacologica Sinica2014，35，11： | 12 |
| 16 | THE EFFECTS OF RADIATION STRESS ON WAVE HEIGHTS AND SEA LEVEL IN THE INTERACTION OF COUPLED WAVE-TIDE-SURGE IN THE COASTAL AREA显示文摘Based on coastal high resolution (2′×2′) coupled wave tide surge interaction numerical model, the effects of radiation stress on wave heights and sea level in the coastal area of Huanghe Delta were studied. By comparisons of simulated and measured wave heights and sea level for two mediately strong weather cases, it is demonstrated that the results simulated by coupled wave tide surge model are closer to the measured and particularly in excellent agreement in the extreme values of the wave heights and set up. This study shows that the radiation stress can increase the wave heights maximally to 67cm and sea level to 40cm. It is also found that there are areas of over 50cm wave height increase and an area of over 20cm sea level increase in the Huanghe Delta coastal area, and this find may be very important in engineering. For this reason, it is suggested that in the practical engineering application, the coupled wave tide surge interaction numerical model should be prefered. | Lin Xiang, Yin Bao shu, Hou Yi jun, Su Jing zhi, Cheng Ming hua Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China | 2003 | Journal of Hydrodynamics2003，15，1： | 12 |
| 17 | Study on the spatial differences and its time lag effect on climatic factors of the vegetation in the Longitudinal Range-Gorge Region显示文摘这篇文章包括温度和降水分析 NDVI 和二个气象学的数据的关联,并且探查回答植被的敏感到温度和降水变化的空间模式。由构造 NDVIr 索引,在在纵的范围峡区域(LRGR ) 的植被盖子和陆地使用之间的关系被揭示。结论如下:(1 ) 时间落后那植被回答到温度和降水变化的效果被证明。不同区域有相应于最大的关联系数的不同延期时间。根据降水和温度联合的反应时间,也就是,三种温度降水形式被定义在一样的时间的降水和温度,在温度以前的降水和在降水以前的温度。(2 ) 敏感的空间分发,哪个对温度的植被回答,被几个高、低的散布关联中心描绘。与温度,二个感觉迟钝的区域和二条敏感的带不同被形成介绍植被的反应给降水。(3 ) NDVIr 被构造,它能完美地在 LRGR 反映在气象学的因素和陆地使用状况之间的相应关系。 | BAO YaJing SONG GuoBao LI ZhengHai GAO JiXi LU HaiYan WANG HaiMei CHENG Yan XU Tian | 2007 | Chinese Science Bulletin2007，52，A02： | 12 |
| 18 | SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses显示文摘The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression,and participates in cytokine secretion in many diseases.However,the effects of the SOCS1/JAK2/STAT3 axis in experimental subarachnoid hemorrhage remain to be studied.A subarachnoid hemorrhage model was established in rats by infusing autologous blood into the optic chiasm pool.Some rats were first treated with JAK2/STAT3 small interfering RNA(Si-JAK2/Si-STAT3)or overexpression plasmids of JAK2/STAT3.In the brains of subarachnoid hemorrhage model rats,the expression levels of both JAK2 and STAT3 were upregulated and the expression of SOCS1 was downregulated,reaching a peak at 48 hours after injury.Simultaneously,the interactions between JAK2 and SOCS1 were reduced.In contrast,the interactions between JAK2 and STAT3 were markedly enhanced.Si-JAK2 and Si-STAT3 treatment alleviated cortical neuronal cell apoptosis and necrosis,destruction of the blood-brain barrier,brain edema,and cognitive functional impairment after subarachnoid hemorrhage.This was accompanied by decreased phosphorylation of JAK2 and STAT3 protein,decreased total levels of JAK2 and STAT3 protein,and increased SOCS1 protein expression.However,overexpression of JAK2 and STAT3 exerted opposite effects,aggravating subarachnoid hemorrhage-induced early brain injury.Si-JAK2 and Si-STAT3 inhibited M1-type microglial conversion and the release of pro-inflammatory factors(inducible nitric oxide synthase,interleukin-1β,and tumor necrosis factor-α)and increased the release of anti-inflammatory factors(arginase-1,interleukin-10,and interleukin-4).Furthermore,primary neurons stimulated with oxyhemoglobin were used to simulate subarachnoid hemorrhage in vitro,and the JAK2 inhibitor AG490 was used as an intervention.The in vitro results also suggested that neuronal protection is mediated by the inhibition of JAK2 and STAT3 expression.Together,our findings indicate that the SOCS1/JAK2/STAT3 axis contributes to early brain injury after subarachnoid hemorrhage both in vitro and in vivo by inducing inflammatory responses.This study was approved by the Animal Ethics Committee of Anhui Medical University and the First Affiliated Hospital of University of Science and Technology of China(approval No.LLSC-20180202)on March 1,2018. | Yang Wang Xiang-Qian Kong Fei Wu Bin Xu De-Jun Bao Chuan-Dong Cheng Xiang-Ping Wei Yong-Fei Dong Chao-Shi Niu | 2021 | Neural Regeneration Research2021，16，12： | 11 |
| 19 | Hepatitis C virus in human B lymphocytes transformed by Epstein-Barr virus in vitro by in situ reverse transcriptase-polymerase chain reaction显示文摘AIM To study persistence and replication ofheltitis C virus (HCV) in patients' peripheralblood mononuclear cells (PBMC) cultured invitro.METHODS Epstein-Barr virus (EBV) was usedto transform the hepatitis C virus from a HCVpositive patient to permanent lymphoblastoidcell lines (LCL). Positive and negative HCV RNAstrands of the cultured cells and growth mediawere detected by reverse transcriptase-polymerase chain reaction ( RT-PCR ) eachmonth. Core and NS5 proteins of HCV werefurther tested using immunohistochemical SPmethod and in situ RT-PCR.RESULTS HCV RNA positive strands wereconsistently detected the cultured cells for oneyear. The negative-strand RNA in LCL cells andthe positive-strand RNA in supernatants wereobserved intermittently. Immunohistochemicalresults medicated expression of HCV NS3 and Cproteins in LCL cytoplasm mostly. The positivesignal of PCR product was dark blue and mainlylocalized to the LCL cytoplasm. The RT-PCRsignal was eliminated by overnight RNasedigestion but not DNase digestion.CONCLUSION HCV may exist and remainfunctional in a cultured cell line for a longperiod. | Ji Lin Cheng Bao Ling Liu Yi Zhang Wen Bin Tong Zheng Yan Bai Fang Feng Institute of Hepatology,Peoples Hospital,Medical Center of Beijing University,Beijing 10(X)44,China | 2001 | World Journal of Gastroenterology2001，7，3： | 11 |
| 20 | Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients显示文摘现在的学习的目的是调查在 R219K 之间的关系, M883I ,并且ATP有约束力的盒子 transporter 亚科 A 的 R1587K 变体第一号( ABCA1 )基因和反应到在有类型 2 diabetes.Methods 的最新诊断的病人的 rosiglitazone 治疗:没有反多糖症药的历史的 105 个糖尿病的病人的一个总数为 48 与 rosiglitazone ( 4 或 8 mg 日报)被对待星期。三非同义的变体 R219K, M883I,和 R1587K,是在所有 patients.Results 的 genotyped : 93 个病人完成了全部学习。ABCA1 的 R219K 变体为治疗失败与 2.04 的每等位基因机会比率在 rosiglitazone 反应上有效果(P < 0.05 ) 。RR 同质接合体在胰岛素敏感度的指示物有更好的改进,在抗胰岛素性的动态平衡模型评价索引由显著地更大的减少决定了 -2.39 ± 0.46 对 -0.69 ± 0.51,P<0.05) 。没有遗传型显型协会为 M883I 和 R1587K.Conclusion 被检测: ABCA1 的 R219K 变体与 rosiglitazone.The RR 同质接合体的治疗学的效果被联系比次要的 K 等位基因搬运人以胰岛素敏感度改进有更好的回答到 rosiglitazone 治疗。ABCA1 基因的既不 M883I 也不 R1587K 变体与 rosiglitazone 反应被联系。 | Jie WANG Yu-qian BAO Cheng HU Rong ZHANG Cong-rong WANG Jun-xi LU Wei-ping JIA Kun-san XIANG | 2008 | Acta Pharmacologica Sinica2008，29，2： | 10 |
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