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| 1 | Identification of microRNA-like RNAs in Ophiocordyceps sinensis显示文摘Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth. While miRNAs are increasingly recognized for their roles in post-transcriptional regulation of gene expression in animals and plants, miRNAs in fungi were less studied until the discovery of microRNA-like RNA(milRNA). High-throughput sequencing and bioinformatics approaches were used to identify conserved and novel milRNAs in O. sinensis. 40 conserved milRNAs were identified, while 23 pre-miRNA candidates encoding 31 novel milRNAs were predicted. Furthermore, the potential target genes of milRNAs in human were predicted and gene ontology analysis was applied to these genes. Enrichment analysis of GO-represented biological process showed that target genes of both conserved and novel milRNAs are involved in development, metabolic and immune processes, indicating the potential roles of milRNAs of O. sinensis in pharmacological effects as health food and traditional Chinese medicine. This study is the first report on genome-wide analysis of milRNAs in O. sinensis and it provides a useful resource to further study the potential roles of milRNAs as active components of O. sinensis in health food or traditional Chinese medicine. | Wen Zhang Xiaona Li Lina Ma Uzair Urrehman Xilinqiqige Bao Yujing Zhang Chen-Yu Zhang Dongxia Hou Zhen Zhou | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 2 | A review of silicon-based wafer bonding processes,an approach to realize the monolithic integration of Si-CMOS and III-V-on-Si wafers显示文摘The heterogeneous integration of III-V devices with Si-CMOS on a common Si platform has shown great promise in the new generations of electrical and optical systems for novel applications,such as HEMT or LED with integrated control circuitry.For heterogeneous integration,direct wafer bonding(DWB)techniques can overcome the materials and thermal mismatch issues by directly bonding dissimilar materials systems and device structures together.In addition,DWB can perform at wafer-level,which eases the requirements for integration alignment and increases the scalability for volume production.In this paper,a brief review of the different bonding technologies is discussed.After that,three main DWB techniques of single-,double-and multi-bonding are presented with the demonstrations of various heterogeneous integration applications.Meanwhile,the integration challenges,such as micro-defects,surface roughness and bonding yield are discussed in detail. | Shuyu Bao Yue Wang Khaw Lina Li Zhang Bing Wang Wardhana Aji Sasangka Kenneth Eng Kian Lee Soo Jin Chua Jurgen Michel Eugene Fitzgerald Chuan Seng Tan Kwang Hong Lee | 2021 | Journal of Semiconductors2021，42，2： | 5 |
| 3 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsvk9n6npxwo9v6k0x.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 4 | Desertification: China provides a solution to a global challenge显示文摘Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and social development. As a stubborn world problem, focused on by the United Nations 2030 sustainable development goal 15.3, China aims to combat desertification by implementing the 'eight-column fourbeam' strategy, and also suggest the 'four-medicine'approach for global desertification governance. This includes the development of the United Nations Convention to Combat Desertification protocol, unified global compliance and compliance metrics; building a global observation network, and monitoring land changes based on remote sense; preparing the global natural desert(heritage) list, leaving the original deserts for future generations; initiating the global action of combating desertification, and striving to achieve a land degradationneutral world by 2030. | Yingshuang BAO Leilei CHENG Yanfeng BAO Liu YANG Lina JIANG Chao LONG Zhe KONG Peng PENG Jun XIAO Qi LU | 2017 | Frontiers of Agricultural Science and Engineering2017，4，4： | 3 |
| 5 | Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma显示文摘Bacterial antitumor therapy has great application potential given its unique characteristics,including genetic manipulation, tumor targeting specificity and immune system modulation. However,the nonnegligible side effects and limited efficacy of clinical treatment limit their biomedical applications. Engineered bacteria for therapeutic applications ideally need to avoid their accumulation in normal organs and possess potent antitumor activity. Here, we show that macrophage-mediated tumor-targeted delivery of Salmonella typhimurium VNP20009 can effectively reduce the toxicity caused by administrating VNP20009 alone in a melanoma mouse model. This benefits from tumor-induced chemotaxis for macrophages combined with their slow release of loaded strains. Inspired by changes in the tumor microenvironment, including a decrease in intratumoral dysfunctional CD8+T cells and an increase in PDL1 on the tumor cell surface, macrophages were loaded with the engineered strain VNP-PD1nb, which can express and secrete anti-PD1 nanoantibodies after they are released from macrophages. This novel triple-combined immunotherapy significantly inhibited melanoma tumors by reactivating the tumor microenvironment by increasing immune cell infiltration, inhibiting tumor cell proliferation, remodeling TAMs to an M1-like phenotype and prominently activating CD8+T cells. These data suggest that novel combination immunotherapy is expected to be a breakthrough relative to single immunotherapy. | Leyang Wu Lin Li Shufeng Li Lina Liu Wenjie Xin Chenyang Li Xingpeng Yin Xuebo Xu Feifei Bao Zichun Hua | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 6 | Distribution characteristics and indicator significance of Dechloranes in multi-matrices at Ny-lesund in the Arctic显示文摘In recent years, Dechloranes have been widely detected in the environment around the world.However, understanding and knowledge of Dechloranes in remote regions, such as the Arctic,remain lacking. Therefore, the concentrations of 5 Dechloranes in surface seawater, sediment,soil, moss, and dung collected from Ny-lesund in the Arctic were measured with the concentrations 93 pg/L, 342, 325, 1.4, and 258 pg/g, respectively, which were much lower than those in Asian and European regions. The mean ratios of anti-Dechlorane Plus(DP) to total DP(fanti) in seawater, sediment, soil, moss, dung, and atmospheric samples were 0.36, 0.21, 0.18,0.27, 0.66, and 0.43, respectively. Results suggested that the main source of DP in seawater,sediment, soil, and moss was long-range atmospheric transport. However, the ratio identified in dung was different, for which the migration behavior of the organism is probably the main source of DP. | Guangshui Na Wei Wei Shiyao Zhou Hui Gao Xindong Ma Lina Qiu Linke Ge Chenguang Bao Ziwei Yao | 2015 | Journal of Environmental Sciences2015，27，2： | 3 |
| 7 | Cretaceous Phytoplankton Assemblages from Songke Core-1,North and South(SK-1,N and S) of Songliao Basin,Northeast China显示文摘来自最新完成的核心洞的白垩纪浮游植物(SK-1, N&S ) 在中央 Songliao,盆被学习。目标间隔从到 Mingshui 形成的上面的白垩纪的上面的 Quantou 形成。dinoflagellates 的 12 个类,六 acritarcha 和三 chlorophyta 深从 2300-m 在 588 件样品被识别核心。十个浮游植物集合被分类:Tetranguladinium-Subtilisphaera-Botryococcus, Botryococcus-Pediastrum, Pediastrum, Dinogymniopsis-Chlamydophrella-Vesperopsis 区分, Dinogymniopsis minor-Balmula, Pediastrum-Botryococcus, Schizosporis-Campenia, Kiokansium-Dinogymniopsis-Botryococcus, Dinogymniopsis-Granodiscus-Filisphaeridium 和 Granodiscus。根据上面提及的调查结果,上面的 Qantou 形成的年龄是 Cenomanian, Qingshankou 形成属于上面的 Cenomanian-Turonian, Yaojia 形成到 Coniancian-Santonian 年龄, Nenjiang 形成具有 Campanian 年龄,和 Sifangtai-Mingshui 形成被指 Maastrichtian 舞台。浮游植物的生态学是仔细与水有关咸度。浮游植物的每种类型在类型其进化反映松劳·莱克的咸度变化的某个生活的水团以内。从 SK-1 的集合显示有淡水的周期的水咸度变化轻视略有盐味的水略有盐味的水忽视在湖的略有盐味的水淡水。 | ZHANG Yiyi BAO Lina | 2009 | Acta Geologica Sinica(English Edition)2009，83，5： | 3 |
| 8 | Detection of ocean internal waves based on Faster R-CNN in SAR images显示文摘Ocean internal waves appear as irregular bright and dark stripes on synthetic aperture radar(SAR)remote sensing images.Ocean internal waves detection in SAR images consequently constituted a difficult and popular research topic.In this paper,ocean internal waves are detected in SAR images by employing the faster regions with convolutional neural network features(Faster R-CNN)framework;for this purpose,888 internal wave samples are utilized to train the convolutional network and identify internal waves.The experimental results demonstrate a 94.78%recognition rate for internal waves,and the average detection speed is 0.22 s/image.In addition,the detection results of internal wave samples under different conditions are analyzed.This paper lays a foundation for detecting ocean internal waves using convolutional neural networks. | BAO Sude MENG Junmin SUN Lina LIU Yongxin | 2020 | Journal of Oceanology and Limnology2020，38，1： | 2 |
| 9 | Influence of SiO 2 coating on morphology, phase and upconversion luminescence properties of NaYF 4 :Yb 3+ ,Er 3+ submicrocubes during annealing显示文摘 | Lina Liu Chunjuan Tang Yongsheng Zhang Chunhe Zang Dongmei Zhang Hongyu Xiao Ruifei Qin Zhigang Bao | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 10 | Biodegradation of crude oil using an efficient microbial consortium in a simulated marine environment 显示文摘 | Bao Mutat Wang Lina Sun Peiyan | 2012 | Marine Pollution Bulletin2012，64，： | 1 |
| 11 | A novel mifepristoneloaded implant for long-term treatment of endometriosis:in vitro and in vivo studies显示文摘 | MEI Lin BAO Junbo TANG Lina | 2010 | Eur J Pharm Sci2010，39，5： | 1 |
| 12 | Chemoenzymatic synthesis amphiphilic H-shaped copolymer and its self-assembly behavior显示文摘ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring-opening polymerization (eROP) of ε-CL in the presence of biocatalyst Novozyme 435. The chains ended with hydroxyl of block copolymers were modified by the esterification of 2,2-dichloro acetyl chloride (DCAC) to obtain the tetrafunctional macroinitiator,which was used in the ATRP of 4-vinylpyridine (4-VP). CuCl/HMTETA was used as the catalyst system in the ATRP of 4-VP to acquire the H-shaped block copolymers (PVP)2-b-PCL-b-PEG-b-PCL-b-(PVP)2. The H-shaped block copolymers were characterized by FTIR,NMR,and GPC. Copolymers with high molecular weights (Mn = 46121 g/mol) and low polydispersities (Mw/Mn = 1.30) were prepared. Moreover,the morphology of the copolymer was examined with dynamic light scattering (DLS) and atomic force microscopy (AFM). Spherical micelles with a diameter of 70 nm in aqueous solution were obtained. | ShuWei Wang Bao Zhang Peng Ai Ming Zhu Wei Wang ZhongPeng Sa LiNa Ma YaPeng Li | 2009 | Science China Chemistry2009，52，12： | 1 |
| 13 | Qualitative identification of crude oils from different oil fields using terahertz time-domain spectroscopy显示文摘 | Honglei Zhan Shixiang Wu Rima Bao Lina Ge Kun Zhao | 2015 | Fuel2015，，： | 1 |
| 14 | A Nonlinear Small-Gain Theorem for Large-Scale Infinite-Dimensional Systems显示文摘这份报纸为由无限维的分系统组成的动态网络开发大规模小获得的结果。分系统是 input-to-output 马厩(IOS ) 和无界,这被假定看得见(UO ) ,并且如果建议小获得的条件满足,大规模无限维的系统能被证明是 IOS 和 UO。 | BAO Adiya LIU Tengfei JIANG Zhong-Ping ZHANG Lina | 2018 | Journal of Systems Science & Complexity2018，31，1： | 1 |
| 15 | Constructing Eco-industrial Park: The Road for Tianjin Economic-technological Development Area显示文摘 | Rong Tan Lina Bao | 2006 | Journal of US-China Public Administration2006，3，2： | 0 |
| 16 | Characters and Microscopic Identification of Aralia cordata显示文摘[Objectives]Characters and microscopic characteristics of Aralia cordata were studied,to improve identification method for Aralia cordata.[Methods]Using pharmacognostic identification method,original plant morphology of Aralia cordata was observed,and microscopic observation of its root cross section and powder was conducted.[Results]It is perennial herb,with rhizome recess,arranged in clusters of nodules.There are double or triple pinnate compound leaves.It is glabrous or sparsely pubescent,with umbel.Flowers are white,while fruits are spherical and purple black.In microstructure,the cork layer on the cross section of root consists of 6-10 rows of cells,and there is secondary cortex.The parenchyma cells are rich in starch granules,and the cambium is not obvious.The vessels are uniserial,and the wood fiber is less,and the primary xylem is bipartite.There are many starch granules in powder,mostly single granules,round or quasi round,oval,umbilicus herringbone or short slit,with many marginal pits and reticulate ducts.Calcium oxalate cluster crystals are mostly gathered.Cork cells are yellowish brown and arranged neatly.The fibrous wall is thin,and the pore groove is obvious,and stone cells are occasionally seen.[Conclusions]Using character and microscopic identification method,it could accurately identify medicinal material of Aralia cordata,and provide reference basis for development and utilization of its resources. | Pengfei XIA Kaibin LI Xiaoyan WANG Lina LONG Shimei ZHAO Juan BAO | 2022 | Medicinal Plant2022，13，4： | 0 |
| 17 | Iron oxide nanoparticles:A promising approach for diagnosis and treatment of cardiovascular diseases显示文摘Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases(CVDs),it remains a leading cause of mortality and morbidity worldwide.This underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease burden.Iron oxide nanoparticles(IONPs),with their unique magnetism and bioproperties,have shown great potential in this regard.In this review,we will begin with a brief overview of the synthesis and properties of IONPs.We will then focus on the latest applications of IONPs in CVDs,including diagnosis and treatment.The use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field,and will be addressed in a separate section.The translational potential and challenges of IONPs will also be discussed.In conclusion,ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively,and offer more personalized and efficient options for the diagnosis and treatment of CVDs. | Xue Bao Yu Mao Guangxiang Si Lina Kang Biao Xu Ning Gu | 2023 | Nano Research2023，16，11： | 0 |
| 18 | On the collection and integration of SARS-CoV-2 genome data显示文摘Genome data of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential for virus diagnosis,vaccine development,and variant surveillance.To archive and integrate worldwide SARS-CoV-2 genome data,a series of resources have been constructed,serving as a fundamental infrastructure for SARS-CoV-2 research,pandemic prevention and control,and coronavirus disease 2019(COVID-19)therapy.Here we present an over-view of extant SARS-CoV-2 resources that are devoted to genome data deposition and integration.We review deposition resources in data accessibility,metadata standardization,data curation and annotation;review integrative resources in data source,de-redundancy processing,data curation and quality assessment,and variant annotation.Moreover,we address issues that impede SARS-CoV-2 genome data integration,including low-complexity,inconsistency and absence of isolate name,sequence inconsistency,asynchronous update of genome data,and mismatched metadata.We finally provide insights into data standardization consensus and data submission guidelines,to promote SARS-CoV-2 genome data sharing and integration. | Lina Ma Wei Zhao Tianhao Huang Enhui Jin Gangao Wu Wenming Zhao Yiming Bao | 2023 | Biosafety and Health2023，5，4： | 0 |
| 19 | Remote sensing survey and research on internal solitary waves in the South China Sea-Western Pacific-East Indian Ocean(SCS-WPAC-EIND)显示文摘Internal solitary waves(ISWs)are common mesoscale dynamic processes in the ocean that are spread throughout the world’s oceans.The South China Sea(SCS),Western Pacific(WPAC)and Indian Ocean(EIND)(SCS-WPACEIND)are areas where ISWs frequently occur.In particular,in the northern part of the South China Sea,Sulu Sea,Celebes Sea,Andaman Sea,Lombok Strait and northeastern part of Taiwan Island,ISWs exist almost year-round.Remote sensing is an important technique to carry out investigations and research on ISWs on a large scale.In particular,optical sensors represented by the Moderate Resolution Imaging Spectroradiometer(MODIS)can observe ISWs for a long time and on a large scale,while SAR sensors such as Sentinel-1 A/B can compensate for the deficiencies in optical sensors and comprehensively observe ISWs.Based on many years of remote sensing surveys of ISWs,this paper uses MODIS and Sentinel-1 satellite remote sensing images of more than 70000 scenes from 2010 to 2020 to carry out survey studies of ISWs in the SCS-WPAC-EIND.The survey systematically gives the temporal and spatial distribution characteristics of ISWs in the SCS-WPAC-EIND and focuses on the analysis of the ISW characteristics in main areas in the SCS-WPAC-EIND,thereby providing basic data for further research on ISWs. | Junmin Meng Lina Sun Hao Zhang Beilei Hu Fucheng Hou Sude Bao | 2022 | Acta Oceanologica Sinica2022，41，10： | 0 |
| 20 | Investigating the reason for high FF from ternary organic solar cells显示文摘Organic solar cells(OSCs)have attracted huge attention because of their unique merits[1−3].In last few years,thanks to the design of new materials and device engineering,the power conversion efficiencies(PCEs)of OSCs have surpassed 18%[4−8].The PM6:Y6 cells are efficient binary cells,offering high PCEs over 16%[9−11].The high performance originates from the efficient free charge generation and the ground state dipole field at the donor-acceptor interface that promotes the exciton dissociation[12]. | Danqin Li Yihan Zeng Zeng Chen Shifeng Leng Zuo Xiao Qifan Xue Tianyu Hao Meng Lv Hongbo Wu Lina Lin Jianming Yang Zaifei Ma Jinquan Chen Rong Huang Feng Liu Haiming Zhu Xianjie Liu Liming Ding Mats Fahlman Qinye Bao | 2021 | Journal of Semiconductors2021，42，9： | 0 |
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