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| 1 | Mechanism of Kinect-based virtual reality training for motor functional recovery of upper limbs after subacute stroke显示文摘The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller,and provides rehabilitation training for stroke patients with lower limb dysfunctions.However,the underlying mechanism remains unclear.In this study,18 healthy subjects and five patients after subacute stroke were included.The five patients were scanned using functional MRI prior to training,3 weeks after training and at a12-week follow-up,and then compared with healthy subjects.The Fugl-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up.Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects.Contralateral primary sensorimotor cortex,the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects.Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients,and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sensorimotor cortex. | Xiao Bao Yurong Mao Qiang Lin Yunhai Qiu Shaozhen Chen Le Li Ryan S.Cates Shufeng Zhou Dongfeng Huang | 2013 | Neural Regeneration Research2013，8，31： | 15 |
| 2 | Early Permian Tarim Large Igneous Province in northwest China显示文摘Tarim Large Igneous Province(TLIP)is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP,and is a hot research topic in geosciences.On the basis of the analysis of research history about TLIP,this paper summarizes the research result during last twenty years and suggests the key research area in the future.The residual distribution range of TLIP is up to 250000 km2,and the largest residual thickness is 780 m.The eruption of basalt happened during 290–288 Ma and belongs to LIPs magmatic event with fast eruption of magma.The lithological units of the TLIP include basalt,diabase,layered intrusive rock,breccia pipe mica-olivine pyroxenite,olivine pyroxenite,gabbro,ultramafic dyke,quartz syenite,quartz syenite porphyry and bimodal dyke.The basalt and diabase of TLIP exhibit OIB-like trace element patterns and enrichment of LILE and HFSE,and mainly belong to high TiO2series.There is an obvious difference in isotope among the basalt from Keping and the basalt and dibase from the northern Tarim Basin.The basalt from Keping with negative Nd and high REE value derives from enriched mantle,and the diabase and basalt from the northern Tarim Basin with positive Nd and low REE value are related to depleted mantle.The crust uplifting in the Early Permian and the development of picrite and large scale dyke and formation of large scale V-Ti-Magnetite deposit in Wajilitag area support the view that the TLIP is related to mantle plume.The TLIP has a temporal-spatial relationship with Permian basic to ultra-basic igneous rock,which is distributed widely in Central Asia,and they represent a tectono-magmatic event with very important geodynamic setting.This paper also suggests that the deep geological process,the relation with mantle plume,mineralization,the relation with environmental change and biological evolution,and the geodynamics of the TLIP will be the key research topics in the future. | YANG ShuFeng CHEN HanLin LI ZiLong LI YinQi YU Xing LI DongXu MENG LiFeng | 2013 | Science China Earth Sciences2013，56，12： | 12 |
| 3 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 4 | Development of solid-state electrolytes for sodium-ion battery–A short review显示文摘All-solid-state sodium-ion battery is regarded as the next generation battery to replace the current commercial lithium-ion battery, with the advantages of abundant sodium resources, low price and high-level safety. As one critical component in sodium-ion battery, solid-state electrolyte should possess superior operational safety and design simplicity, yet reasonable high room-temperature ionic conductivity. This paper gives a comprehensive review on the recent progress in solid-state electrolyte materials for sodium-ion battery, including inorganic ceramic/glass-ceramic, organic polymer and ceramic-polymer composite electrolytes, and also provides a comparison of the ionic conductivity in various solid-state electrolyte materials. The development of solid-state electrolytes suggests a bright future direction: all solid-state sodium-ion battery could be fully used to power all electric road vehicles, portable electronic devices and large-scale grid support. | Yumei Wang Shufeng Song Chaohe Xu Ning Hu Janina Molenda Li Lu | 2019 | Nano Materials Science2019，1，2： | 7 |
| 5 | Increasing open circuit voltage by adjusting work function of hole-transporting materials in perovskite solar cells显示文摘一系列传导性的聚合物,即, poly (3-methylthiophene )(PMT ) , poly (thiophene )( 磅) , poly (3-bromothiophene )(PBT ) 并且 poly (3-chlorothiophene )(%) ,经由电气化学的聚合过程被准备。随后,他们是的申请在 CH 3 NH 3 PbI 3 perovskite 太阳能电池被探索。讲道理地增加 HTM 的工作功能在改进开的电路电压证明有益,这被发现(V 有 ITO/conductive-polymer/CH 3)> NH 3 PbI 3/C60/BCP/Ag 结构。另外, higher-V 有 higher-work-function HTM 的 oc 设备展出了更高的再结合电阻。1.04 V 的最高开的电路电压与 % 从设备被获得,与工作功能 of-5.4 eV,作为搬运洞的层。它的功率变换效率达到了约16.5%的价值,与高度充满 0.764 的因素, 1.01 V 的可估计的开的电压和 21.4 mAmedian 的短路电流密度为 Zn 的大约 5 ility 的轨道的集体估计, Cu , Se , Mn ,我, Fe ,瞬间和 Br 。mea 覈 ? 覈?? | Weibo Yan Yu Li Senyun Ye Yunlong Li Haixia Rao Zhiwei Liu Shufeng Wang Zuqiang Bian Chunhui Huang | 2016 | Nano Research2016，9，6： | 7 |
| 6 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 7 | Deformation geometry and timing of the Wupoer thrust belt in the NE Pamir and its tectonic implications显示文摘 | Xiaogan CHENG Hanlin CHEN Xiubin LIN Shufeng YANG Shenqiang CHEN Fenfen ZHANG Kang LI Zelin LIU | 2016 | Frontiers of Earth Science2016，10，4： | 6 |
| 8 | Stable high-performance hybrid perovskite solar cells with ultrathin polythiophene as hole-transporting layer显示文摘经由电气化学的聚合准备的 Ultrathin polythiophene 电影成功地被用作搬运洞的材料,代替常规 HTM-PEDOT : PSS,在平面 p-i-n CH 3 NH 3 PbI 3基于 perovskite 的太阳能电池,负担得起一系列 ITO/polythiophene/CH 3 NH 3 PbI 3/C60/BCP/Ag 设备。ultrathin polythiophene 电影拥有好发射度,高传导性,光滑的表面,高 wettability,与 PbI 2 DMF 答案的相容性,和匹配 CH 3 NH 3 PbI 3 perovskite 材料。大约 15.4% 的 A 答应功率变换效率,展示高度充满 0.774 的因素, 0.99 V 的开的电压,和电线走火 20.3 mAve 的当前的密度可逆纠纷。在我们的分析使用的一个不可缺少的工具是 Gnerating 潜力的一张有条件的表格。分析?? | Weibo Yan Yunlong Li Yu Li Senyun Ye Zhiwei Liu Shufeng Wang Zuqiang Bian Chunhui Huang | 2015 | Nano Research2015，8，8： | 6 |
| 9 | Microstructure and mechanical properties of ZrO_2(Y_2O_3)-Al_2O_3 nanocomposites prepared by spark plasma sintering显示文摘Zirconia (yttria)-alumina ceramic nanocomposites were fabricated from different powders by spark plasma sintering (SPS). One powder was a commercially available nanocomposite powder TZP-3Y20A, consisting of 3 mol% yttria-stabilized zirconia (3-YSZ) reinforced with 20 wt% alumina, and the other, used as a comparison, was a conventional mechanically mixed powder 3YSZ-20A, a blend made of 3 mol% yttria-stabilized zirconia powder ZrO2 (3Y) and 20 wt% -alumina powder. The effect of the sintering tem- perature on the densification, the sintering behavior, the mechanical properties and the microstructure of the composites was investigated. The results showed that the density increased with increasing sintering temperature, and thus, the mechanical properties were strengthened because of the increased densification. The nanocomposite powder TZP-3Y20A was easily sintered, and good mechanical properties were achieved as compared with the powder from the conventional mechanically mixed method, the maximum flexural strength and fracture toughness of which were 967 MPa and 5.27 MPa m1/2, respectively. | Shufeng Li Hiroshi Izui Michiharu Okano Weihua Zhang Taku Watanabe | 2012 | Particuology2012，10，3： | 5 |
| 10 | Using Physical Model Experiments for Hazards Assessment of Rainfall-Induced Debris Landslides显示文摘Using physical simulation models, rainfall-induced landslides have been simulated under various rainfall intensities. During these simulations, we have monitored the physical and mechanical behaviors of the landslide over the slip surface at different heights of the model slopes, as well as taking the whole slope to identify its deformation and failure processes. The results show that the rainfall duration corresponding to the initiation of the debris landslide and is exponentially related to rainfall intensity. Corresponding to the three intervals of the rainfall intensity, there are three types of slope failure modes:(1) the small-slump failure at the leading edge of the slope;(2) the block-slump failure but sometimes there are large blocks sliding down;and(3) the bulk failure but sometimes there is the block-slump failure. Based on the total rainfall-lasting time and the associated proportion of failed mass volume, the early warning of debris landslide can be classified into five grades, i.e., red, orange to red, orange, yellow to orange and yellow, which correspond to the five slope failure modes, respectively. | Qianqian Li Dong Huang Shufeng Pei Jianping Qiao Meng Wang | 2021 | Journal of Earth Science2021，32，5： | 4 |
| 11 | Petrogenetic model of the Permian Tarim Large Igneous Province显示文摘Over the last two decades great strides have been made in characterizing the spatial distribution, time sequence,geochemical characteristics, mantle sources, and magma evolution processes for various igneous rocks in the Early Permian Tarim Large Igneous Province(TLIP). This work has laid a solid foundation for revealing the evolutionary processes and genetic models of large igneous provinces(LIPs). This study systematically demonstrates the two-stage melting model for the TLIP based on our previous research work and predecessor achievements, and highlights the two types of magmatic rocks within the TLIP.The two-stage melting model suggests that the formation of the TLIP is mantle plume related. The early hot mantle plume caused the low-degree partial melting of the lithosphere mantle, while in the later stage, the plume partially melted due to adiabatic uplift and decompression. Therefore, this model carries signatures of both the 'Parana' and 'Deccan' models in terms of mantle plume activity. During the early stage, the mantle plume provided the heat required for partial melting of sub-continental lithosphere mantle(SCLM), similar to the 'Parana Model', while later the plume acted as the main avenue for melting, as in the 'Deccan Model'. Basalts that erupted in the first stage have higher 87Sr/86 Sr, lower 143Nd/144 Nd ratios, and are enriched in large ion lithophile elements and high field strength elements, indicating a possible origin from the enriched continental lithosphere mantle,similar to the Parana type geochemical features. The basic-ultrabasic intrusive rocks in the second stage exhibit lower 87Sr/86 Sr,higher 143Nd/144 Nd ratios relative to the basalts, consistent with the involvement of a more depleted asthenospheric material,such as a mantle plume, similar to the Deccan type geochemical features. The first stage basalts can be further subdivided into two categories, i.e., Group 1 and Group 2 basalts. Group 2 basalts have lower 87Sr/86 Sr and higher 143Nd/144 Nd ratios than Group 1 basalts, and lie between compositions of the Group 1 basalts and second stage magmatism. Group 2 basalts may be the intermediate component of the TLIP, and the whole TLIP is the result of plume and lithosphere interaction. Developing this petrogenetic model for the TLIP aids in comprehensively understanding its magmatism and deep geological and geodynamic processes. Furthermore, this work enriches the theories describing the origin of large igneous province and mantle plume activity. | YU Xing YANG ShuFeng CHEN HanLin LI ZiLong LI YinQi | 2017 | Science China Earth Sciences2017，60，10： | 4 |
| 12 | Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma显示文摘Bacterial antitumor therapy has great application potential given its unique characteristics,including genetic manipulation, tumor targeting specificity and immune system modulation. However,the nonnegligible side effects and limited efficacy of clinical treatment limit their biomedical applications. Engineered bacteria for therapeutic applications ideally need to avoid their accumulation in normal organs and possess potent antitumor activity. Here, we show that macrophage-mediated tumor-targeted delivery of Salmonella typhimurium VNP20009 can effectively reduce the toxicity caused by administrating VNP20009 alone in a melanoma mouse model. This benefits from tumor-induced chemotaxis for macrophages combined with their slow release of loaded strains. Inspired by changes in the tumor microenvironment, including a decrease in intratumoral dysfunctional CD8+T cells and an increase in PDL1 on the tumor cell surface, macrophages were loaded with the engineered strain VNP-PD1nb, which can express and secrete anti-PD1 nanoantibodies after they are released from macrophages. This novel triple-combined immunotherapy significantly inhibited melanoma tumors by reactivating the tumor microenvironment by increasing immune cell infiltration, inhibiting tumor cell proliferation, remodeling TAMs to an M1-like phenotype and prominently activating CD8+T cells. These data suggest that novel combination immunotherapy is expected to be a breakthrough relative to single immunotherapy. | Leyang Wu Lin Li Shufeng Li Lina Liu Wenjie Xin Chenyang Li Xingpeng Yin Xuebo Xu Feifei Bao Zichun Hua | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 13 | Pliocene flora and paleoenvironment of Zanda Basin, Tibet, China显示文摘This paper describes a plant megafossil assemblage from the Pliocene strata of Xiangzi, Zanda Basin in the western Qinghai-Tibet Plateau. Twenty-one species belonging to 12 genera and 10 families were identified. Studies show that the Pliocene vegetation in Zanda Basin was mostly deciduous shrub composed of Cotoneaster, Spiraea, Caragana, Hippophae,Rhododendron, Potentilla fruticosa, etc. Leaf sizes of these taxa were generally small. Paleoclimate reconstruction using Coexistence Analysis and CLAMP showed that this area had higher temperature and precipitation in the Pliocene than today, and distinct seasonal precipitation variability was established. The reconstructed paleoelevation of Zanda Basin in the Pliocene was similar to modern times. In the context of central Asian aridification, the gradual drought in the area beginning in the late Cenozoic caused vegetation to transition from shrub to desert, and the flora composition also changed. | Jian HUANG Tao SU Shufeng LI Feixiang WU Tao DENG Zhekun ZHOU | 2020 | Science China Earth Sciences2020，63，2： | 2 |
| 14 | Microstructure,Phase Transformation,Precipitation Behavior and Mechanical Properties of P/M Cu40Zn-1.0 wt%Ti Brass Alloy via Spark Plasma Sintering and Hot Extrusion显示文摘The effect of titanium addition on the microstructure and mechanical properties of brass Cu40Zn has been studied via the powder metallurgy(P/M) route.The water-atomized Cu40Zn—1.0 wt%Ti alloy powder was consolidated at different temperatures in the range of 400—600 ℃ using spark plasma sintering(SPS) and hot extrusion subsequently.Results show that the super-saturated solid solution titanium element in rapidly cooled brass Cu40Zn powder created high chemical potential for a precipitate reaction,showing significant grain refinement effects on the consolidated Cu40Zn matrix.Consequently,excellent mechanical properties were obtained by precipitation hardening and work hardening after sintering and extrusion,with yield strength of 390 MPa,ultimate tensile strength of 617 MPa,and Vickers micro-hardness of 192 HV,which are 28.7%,23.4%,and 23.9%higher values than those of extruded Cu40Zn brass,respectively. | Shufeng Li Hisashi Imai Katsuyoshi Kondoh | 2013 | Journal of Materials Science & Technology2013，29，11： | 2 |
| 15 | Confined-solution process for high-quality CH3NH3PbBr3 single crystals with controllable morphologies显示文摘 | Yitan Li Lu Han Qiao Liu Wei Wang Yuguang Chen Min Lyu Xuemei Li Hao Sun Hao Wang Shufeng Wang Yan Li | 2018 | Nano Research2018，11，6： | 2 |
| 16 | Estimating the Parental Magma Composition and Temperature of the Xiaohaizi Cumulate-Bearing Ultramafic Rock: Implication for Magma Evolution of the Tarim Large Igneous Province, Northwestern China显示文摘The ultramafic dikes in the Tarim large igneous province(Tarim LIP), exposed in the Xiaohaizi area in the northwestern Tarim Basin of northwestern China, have porphyritic textures, and the olivine and clinopyroxene are as the major phenocryst phases. The groundmass therein consists of clinopyroxene, plagioclase and Fe-Ti oxides, with the cryptocrystalline texture. The olivine phenocrysts in one typical ultramafic dike have Fo(Mg/(Mg+Fe)) numbers ranging from 73 to 85, which are not in equilibrium with the olivine(Mg# of 89) from the host rock crystalized. Combined with microscope observation, both the olivine and clinopyroxene phenocrysts as well as some Fe-Ti oxides in the ultramafic rock are accounted as cumulates. The liquid(parental magma) composition of SiO_2 of 45.00 wt.%–48.82 wt.%, MgO of 9.93 wt.%– 18.56 wt.%, FeO of 5.85 wt.%–14.17 wt.%, CaO of 7.54 wt.%–11.52 wt.%, Al_2O_3 of 8.70 wt.%–11.62 wt.% and TiO_2 of 0.00 wt.%–3.43 wt.% in the Xiaohaizi ultramafic rock was estimated by mass balance, and the results show a reasonable liquid proportion in the cumulate-bearing ultramafic dike(ca. 45%–60% in the whole rock). The estimated parental magma composition corresponds to a melting temperature of 1 300–1 550 oC, which is equal or higher than those of a normal asthenosphere mantle, supporting the involvement of a mantle plume. Combined with other previous studies, an evolution model for the formation processes of the Xiaohaizi ultramafic dike of the Tarim LIP is proposed. | Haowei Sun Yinqi Li Zilong Li Siyuan Zou Charles H.Langmuir Hanlin Chen Shufeng Yang Zhongyuan Ren | 2016 | Journal of Earth Science2016，27，3： | 2 |
| 17 | COOPERATIVE DIRECTIONAL INTER-CELL HANDOVER SCHEME IN HIGH ALTITUDE PLATFORM COMMUNICATIONS SYSTEMS显示文摘A novel Cooperative Directional inter-cell Handover Scheme(CDHS) for High Altitude Platform(HAP) communications systems is proposed,in which the handover target cell and the two cells adjacent to this handover target cell work cooperatively to exploit the traffic fluctuation to improve handover performance.Users in the overlap area of the overloaded handover target cell will be forced to handover directionally before their optimal handover boundary in order to free up resources for the handover calls which would otherwise be dropped due to the shortage of resources and queue time out.Simulation results show that the handover call dropping probability is greatly reduced(at least 60%) compared with the general queue handover scheme,with little performance reduction to the call blocking probability,and the Not in the Best Cell(NBC) average time is only increased moderately.Moreover,an optimal cell radius can be achieved for a specific platform speed by minimizing the unified system performance,which is the linear combination of the handover call dropping probability and the NBC average time. | Li Shufeng Wang Lijie David Grace Ma Dongtang | 2011 | Journal of Electronics(China)2011，28，2： | 2 |
| 18 | New insights into the mechanism of localised corrosion induced by TiN-containing inclusions in high strength low alloy steel显示文摘This work investigated the chemical and electrochemical mechanisms of localised corrosion triggered by CaS·xMgO·y Al_(2)O_(3)·TiN complex inclusions in high strength low alloy steel(HSLAS)under a simulated marine environment.Special focus was given to the role of the TiN portion of the inclusion on the initiation and growth of the corrosion pits.The thermodynamic process of pitting initiation was investigated by Gibbs free energy,Pourbaix diagram and first principle calculation.Localised corrosion is mainly induced by inclusions and triggered by dissolution of adjacent distorted matrix.Chemical dissolution of CaS portion in CaS·xMgO·y Al_(2)O_(3)·TiN complex inclusion creates an acidic aggressive environment that accelerates the further dissolution of inclusion and matrix.Galvanic coupling effect between TiN inclusion and matrix is directly verified.TiN covered with a TiOfilm acts as the cathodic phase in galvanic corrosion,although it has a lower Volta potential than the matrix.This is an unusual correlation with the scanning Kelvin probe force microscopy result,which has been explained for this special system. | Chao Liu Reynier I.Revilla Xuan Li Zaihao Jiang Shufeng Yang Zhongyu Cui Dawei Zhang Herman Terryn Xiaogang Li | 2022 | Journal of Materials Science & Technology2022，，29： | 2 |
| 19 | Carbon-nanotube-modified glassy carbon electrode for simultaneous determination of dopamine, ascorbic acid and uric acid: The effect of functional groups显示文摘 | Huaqing Bi Yanhui Li Shufeng Liu Peizhi Guo Zhongbin Wei Chunxiao Lv Jizhen Zhang X.S. Zhao | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 20 | Study design,general characteristics of participants,and preliminary findings from the metabolome,microbiome,and dietary salt intervention study(MetaSalt)显示文摘Background:High sodium intake is an important risk factor for hypertension and cardiovascular disease.However,the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure(BP)is not well-understood.The metabolome,microbiome,and dietary salt intervention(MetaSalt)study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation.Methods:This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019.Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening,and family members including siblings,offspring,spouses,and parents were subsequently included.All participants participated in a 3-day baseline examination with usual diet consumption,followed by a 10-day low-salt diet(3 g/d of salt or 51.3 mmol/d of sodium)and a 10-day high-salt diet(18 g/d of salt or 307.8 mmol/d of sodium).Differences in mean BP levels were compared according to the intervention phases using a paired Student’s t-test.Results:A total of 528 participants were included in this study,with a mean age of 48.1 years,36.7%of whom were male,76.8%had a middle school(69.7%)or higher(7.1%)diploma,23.4%had a history of smoking,and 24.4%were current drinkers.The mean arterial pressure at baseline was 97.2±10.5 mm Hg for all participants,and significantly decreased during the low-salt intervention(93.8±9.3,P<0.0001)and subsequently increased during the high-salt intervention(96.4±10.0,P<0.0001).Conclusions:Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden,which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases.Trial registration:The study was registered in the Chinese Clinical Trial Registry database(ChiCTR1900025171). | Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 1 |
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