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| 1 | Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1显示文摘AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse model.METHODS:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of cerulein.Once AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h period.Blood samples were taken 6 h later to determine serum amylase,lipase,and cytokine levels.The pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain reaction.To specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase method.Then the cells were pre-treated with SSM,then stimulated with cerulein.The cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were measured.Furthermore,the regulating mechanisms of SSM action were evaluated.RESULTS:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and necrosis.SSM treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during AP.In accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 release.SSM also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κB.CONCLUSION:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB. | Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok Choi Won-Seok Jung Su-Young Jung Jung-Hee Cho Mee-Ok Choi Ho-Joon Song Sung-Joo Park | 2013 | World Journal of Gastroenterology2013，19，10： | 6 |
| 2 | Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry)显示文摘ObjectivesTo 评估年龄相关的一个年专业在在尖锐心肌的梗塞(AMI ) 的经皮的冠的干预(一种总线标准) 以后的不利 cardiocerebrovascular 事件(MACCE ) 。我们从在 2011 年 11 月之间的健康(KAMIR-NIH ) 的朝鲜尖锐心肌的梗塞登记公民 Institue 在 13,104 个 AMI 病人全部的 AMI.MethodsA 以后分析了在年龄和一个年 MACCE 之间的协会, 2015 年 12 月根据年龄被分类进四个组(组我, < 60 年, n = 4199;组 II, 60-70 年, n = 2577;组织 III;70-80 年, n = 2774;组 IV, 80 年, n = 1018 ) 。病人们为 MACCE 合成的一个年被分析(心脏的死亡,心肌的梗塞,目标容器 revascularization,脑血管的事件) 在 AMI.ResultsThe 一个年以后,在 AMI 的 MACCE 是 3.5%( 组我) , 6.3%( 组 II ) , 9.6%( 组 III ) 并且 17.6%( 组 IV ) 。在为使参数惊讶的调整以后,分析结果证明有 AMI 的病人有一个年 MACCE 的增长风险[组 II,调整危险比率(aHR )= 1.224, 95% CI:0.965-1.525, P = 0.096;组 III, aHR = 1.316, 95% CI:1.037-1.671, P = 0.024;组 IV, aHR = 1.975, 95% CI:1.500-62.601, P < 0.001 ) 与相比组我。特别,心脏的死亡在玩的主要结束点合成在这效果的一个主要角色(组 II, aHR = 1.335, 95% CI:0.941-1.895, P = 0.106;组 III, aHR = 1.575, 95% CI:1.122-2.210, P = 0.009;组 IV, aHR = 2.803, 95% CI:1.937-4.054, P < 0.001 ).ConclusionsDespite 在 AMI 为一种总线标准推进了技术和药,年龄仍然在临床的结果施加强大的影响。小心的途径,甚至在发达心病学的现代时代被需要为在 AMI 干预年老人口。 | Dae-Won Kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung Chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung | 2018 | Journal of Geriatric Cardiology2018，15，9： | 4 |
| 3 | Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis显示文摘AIM:To determine if the fraction of Nardostachys jatamansi(NJ) has the potential to ameliorate the severity of acute pancreatitis(AP).METHODS:Mice were administered the biologically active fraction of NJ,i.e.,the 4th fraction(NJ4),intraperitoneally,and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h.Six hours after the last cerulein injection,the pancreas,lung,and blood were harvested for morphological examination,measurement of cytokine expression,and examination of neutrophil infiltration.RESULTS:NJ4 administration attenuated the severity of AP and lung injury associated with AP.It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1(HO-1).Furthermore,NJ4 and its biologically active fraction,NJ4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar cells.CONCLUSION:These results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression. | Gi-Sang Bae Min-Sun Kim Kyoung-Chel Park Bon Soon Koo Il-Joo Jo Sun Bok Choi Dong-Sung Lee Youn-Chul Kim Tae-Hyeon Kim Sang-Wan Seo Yong Kook Shin Ho-Joon Song Sung-Joo Park | 2012 | World Journal of Gastroenterology2012，18，25： | 4 |
| 4 | Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study显示文摘Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer patients.However,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested prospectively.We investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic cancer.Methods:A multicenter phase II prospective open-label,single-arm study was conducted at 14 hospitals.Patients with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were eligible.Attenuated FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 weeks.The primary endpoint was progression-free survival from the initiation of FOLFIRINOX.Secondary endpoints were the objective response rate,disease control rate,overall survival,safety,and tolerability.We estimated overall survival and progression-free survival using the Kaplan-Meier methods.Results:We enrolled 39 patients from 14 institutions.The objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,respectively.Median progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),respectively.Grade 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock occurred.Conclusion:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabine-refractory pancre-atic cancer. | Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung Soon Jang Do Hyoung Lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway显示文摘 | Miran Jo Mi Hee Park Pushpa Saranya Kollipara Byeong Jun An Ho Sueb Song Sang Bae Han Jang Heub Kim Min Jong Song Jin Tae Hong | 2011 | Toxicology and Applied Pharmacology2011，，1： | 2 |
| 6 | Serum amyloid A induces WISH cell apoptosis显示文摘目的:浆液淀粉的 A ( SAA )是重要哺乳动物的尖锐 reactant.Here ,我们 aimto 在人的羊膜的 WISHcells.Methods 在 apoptosis 和它行动的机制上调查 SAA 的效果:甲酰肽受体( FPRL1 )的表示,作为 SAAreceptor 被报导,在增殖上与标记收音机的 FPRL1 ligand.The effectof SAA 用 RT-PCR 和 ligand 绑定试金被测试房间人口被 thymidine 加入 assay.The proteinphosphorylation 评估层次和 caspase-3 | Seong-ho JO Jeanho YUN Jong-min KIM Chuhee LEE Suk-hwan BAEK5 Yoe-sik BAE | 2007 | Acta Pharmacologica Sinica2007，28，1： | 2 |
| 7 | Functional properties of raw and cooked pork patties with added irradiated, freeze-dried green tea leaf extract powder during storage at 4℃显示文摘 | Cheorun Jo Jun Ho Son Cheon Bae Son Myung Woo Byun | 2003 | Meat Science2003，64，1： | 1 |
| 8 | The impact of information release on stock price volatility and trading volume:the rights offering case显示文摘 | Bae Sung Hoje Jo | 1999 | Review of Quantitative Finance and Accounting1999，，2： | 1 |
| 9 | Hypoxic induction of human vis- latin gene is directly mediated by hypoxia-inducible factor 显示文摘 | Bae SK Kim SR Kim JO | 2006 | FEBS Lett2006，580，17： | 1 |
| 10 | Aerobic training during hemodialysis improves body composition, muscle function, physical performance, and quality of life in chronic kidney disease patients 显示文摘 | Bae YH Lee SM Jo]I | 2015 | J Phys Ther Sci2015，27，5： | 1 |
| 11 | Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor显示文摘 | Hyun Jung Lee Kyungmin Lee Dong Gwang Lee Kwang-Hee Bae Jang-Seong Kim Zhe Long Liang Song Mei Huang Yoon Suk Oh Ha Yon Kim Deog Yeon Jo Jeong-Ki Min Jin-Man Kim Hyo Jin Lee | 2012 | Clinical Cancer Research2012，，12： | 1 |
| 12 | Functional properties of raw and cooked pork patties with added irradiated, freeze-dried green tea leaf extract powder during storage at 4 °C显示文摘 | Cheorun Jo Jun Ho Son Cheon Bae Son Myung Woo Byun | 2002 | Meat Science2002，，1： | 1 |
| 13 | Thymosin beta4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-lalpha-dependent manner 显示文摘 | Jo J O Kim S R Bae M K | 2010 | Biochim Biophys Acta2010，1803，11： | 1 |
| 14 | A Comparison of Preferences of Targeted Therapy for Metastatic Renal Cell Carcinoma between the Patient Group and Health Care Profes-sional Group in South Korea显示文摘 | Park MH Jo C Bae EY | 2012 | Value in Health2012，15，6： | 1 |
| 15 | Effect of uniaxial drawing on surface chain structure and surface tension of poly(trimethylene terephthalate) film 显示文摘 | Jeong Y G Bae W J Jo W H | 2005 | Polymer2005，46，19： | 1 |
| 16 | p H-induced micelle formation of poly(histidine-co-phenylalanine)-blockpoly(ethylene glycol)in aqueous media显示文摘 | KIM G M BAE Y H JO W H | 2005 | M acromolecular Bioscience2005，5，11： | 1 |
| 17 | Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol显示文摘 | Ki Hong Lee Myung Ho Jeong Ha Mi Kim Youngkeun Ahn Jong Hyun Kim Shung Chull Chae Young Jo Kim Seung Ho Hur In Whan Seong Taek Jong Hong Dong Hoon Choi Myeong Chan Cho Chong Jin Kim Ki Bae Seung Wook Sung Chung Yang Soo Jang Seung Woon Rha Jang Ho Bae Jeo | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 18 | Fisetin attenu- ates cerulein-induced acute pancreatitis through down regula- tion of JNK and NF-KB signaling pathways显示文摘 | Jo I1-Joo Bae Gi-Sang Choi SunBok | 2014 | European Jour- nal of Pharmacology2014，，737： | 1 |
| 19 | Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade显示文摘 | Huang J Bae JO Tsai JP | 2009 | Int J Oncol2009，34，1： | 1 |
| 20 | Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium显示文摘 | JO Y S HUONG D T BAE K | 2002 | Plant Med2002，68，1： | 1 |
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