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| 1 | Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent显示文摘Background:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC),while the necessity of No.14 v lymph node(14v) dissection for distal GC is still controversial.Methods:A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital were enrolled in this study,of whom,243 patients also had the 14 v dissected.Other 677 patients without 14 v dissection were used for comparison.Results:Forty-five(18.5%) patients had 14 v metastasis.There was no significant difference in 3-year overall survival(OS) rate between patients with and without 14 v dissection.Following stratified analysis,in TNM stages I,II,IIIa and IV,14 v dissection did not affect 3-year OS;in contrast,patients with 14 v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc.In multivariate analysis,14 v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio(HR),1.568;95% confidence interval(CI):1.186-2.072;P=0.002].GC patients with 14 v dissection had a significant lower locoregional,especially lymph node,recurrence rate than those without 14 v dissection(11.7 % vs.21.1%,P=0.035).Conclusions:Adding 14 v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM Ⅲb/Ⅲc. | Yuexiang Liang Liangliang Wu Xiaona Wang Xuewei Ding Hongmin Liu Bin Li Baogui Wang Yuan Pan Rupeng Zhang Ning Liu Han Liang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 2 | Relations between sedimentary sequence and paleoclimatic changes during last 200 ka in the southern South China Sea显示文摘Core NS-93-5 was taken from the mild slope terrace of the southern South China Sea (SCS), which has preserved the steadiness depositional record of the normal marine environment since late Quaternary. Sedimentary sequence and oxygen isotopic stratigraphy of high resolution in the near 200 ka of the southern SCS has been established. By the comparative analysis with GISP2’s ice core, the depositional record of D/O’s events 1-21 and Heinrich’s events H1-H6 in the southern SCS that reflected the quick climate change in short time scale since the last interglacial stage is revealed, which indicates that in the last 200 ka in the southern SCS and the Arctic area there was tele-connection of paleoclimate and the unstability of the Western Pacific Warm Pool. This note shows that the sedimentary layers order of this sea area classified by color identification and by oxygen isotope stratum has the very good corresponding relation. The color feature of sediment changes along with the climate and the former | Muhong Chen Xia Tu Fan Zheng Wen Yan Xianzan Tang Jun Lu Baogui Wang Miao’an Lu | 2000 | Chinese Science Bulletin2000，45，14： | 12 |
| 3 | Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis显示文摘Objective: Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level(PDL) on overall survival(OS) of gastric cancer(GC) patients undergoing curative surgery by applying propensity score analysis.Methods: A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute &Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL: the elevated group(EG) and the normal group(NG). To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results: In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm(67.5% vs. 55.8%, P=0.006), elder mean age(64.0±10.8 years vs. 60.5±11.6 years, P<0.001) and advanced tumor(T), node(N), and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL(27.0% vs. 42.6%, P<0.001), however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio: 1.13, 95% confidence interval(95% CI): 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG(P=0.809, log-rank).Conclusions: The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself. | Yuexiang Liang Donglei He Liangliang Wu Xuewei Ding Xiaona Wang Baogui Wang Rupeng Zhang Han Liang | 2018 | Chinese Journal of Cancer Research2018，30，2： | 6 |
| 4 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 5 | Regional gravity field modeling based on rectangular harmonic analysis显示文摘Regional gravity field modeling with high-precision and high-resolution is one of the most important scientific objectives in geodesy,and can provide fundamental information for geophysics,geodynamics,seismology,and mineral exploration.Rectangular harmonic analysis(RHA)is proposed for regional gravity field modeling in this paper.By solving the Laplace’s equation of gravitational potential in local Cartesian coordinate system,the rectangular harmonic expansions of disturbing potential,gravity anomaly,gravity disturbance,geoid undulation and deflection of the vertical are derived,and so are the formula for signal degree variance and error degree variance of the rectangular harmonic coefficients(RHC).We also present the mathematical model and detailed algorithm for the solution of RHC using RHA from gravity observations.In order to reduce the edge effects caused by periodic continuation in RHA,we propose the strategy of extending the size of computation domain.The RHA-based modeling method is validated by conducting numerical experiments based on simulated ground and airborne gravity data that are generated from geopotential model EGM2008 and contaminated by Gauss white noise with standard deviation of 2 mGal.The accuracy of the 2.5′×2.5′geoid undulations computed from ground and airborne gravity data is 1 and 1.4cm,respectively.The standard error of the gravity disturbances that downward continued from the flight height of 4 km to the geoid is only 3.1 mGal.Numerical results confirm that RHA is able to provide a reliable and accurate regional gravity field model,which may be a new option for the representation of the fine structure of regional gravity field. | JIANG Tao LI JianCheng DANG YaMin ZHANG ChuanYin WANG ZhengTao KE BaoGui | 2014 | Science China Earth Sciences2014，57，7： | 4 |
| 6 | Heinrich layer in Antarctic marine sediments and its significance to global changes显示文摘Results of grain size analysis and rock magnetic measurements of core NP95-1 from Prydz Bay, Antarctica revealed two series of ice-rafted detritus layers, which correspond to cold climatic events, Younger Dryas and Heinrich event 1, occurring at about 11.7-10.3 and 14.3-13.6 kaB.P. respectively. Studies also show that the sequence of paleoclimatic changes in Antarctica can be correlated with that in other parts of the world, and that the millennial climate of the earth could change synchronously and globally. In addition, magnetic fabric analysis also shows a close relationship between paleoclimatic change and ocean circulation re-assemblage. | Hongrning Hou Youlang Luo Honghan Zheng Baogui Wang Xianzan Tang | 1998 | Chinese Science Bulletin1998，43，21： | 3 |
| 7 | Influence of Perioperative Blood Transfusion on Prognosis in Patients with Colon Cancer显示文摘客观:探索起作用的仙子的影响有结肠癌的病人的手术后的幸存上的输血。方法:Univariate 和 multivariateretrospective 分析总共在 10 年的一个时期期间通过手术被对待的 723 个结肠癌病人的在幸存上被执行。结果:Kaplan-Meier 估计显示出起作用的那超过 800 mL 仙子输血幸存预言者。输血显著地影响了病人的预后 40 岁并且更年轻,那些 undergoinghelicoloectomy 左边,那些与乳头状腺癌,那些与大肿瘤(直径≥ 8cm ) ,那些与阶段Ⅰ肿瘤,那些与没有肝转移的淋巴的节点转移和那些。在里面多变量分析仅仅肿瘤地点,操作的 radicality,淋巴的侵略,肝转移,肿瘤侵略的深度和 TNM 舞台保留了他们的 significance.Conclusion:Perioperative 输血是为有到某程度的结肠癌的病人的预示的因素。输血的指示必须严格地被限制,特殊比 40 岁年轻的住院病人与右边损害,乳头状腺癌,大肿瘤(直径≥ 8 厘米) ,阶段Ⅰ肿瘤和淋巴的节点转移或没有肝转移。Butperioperative 输血不能为有阶段Ⅳ疾病并且与远转移的病人是有害的。 | LIANG Han WANG Xiaona WANG Baogui PAN Yuan LIU Ning WANG Dianchang HAO Xishan | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 8 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 9 | Floristic composition and biogeography of tropical montane rain forest in southern Yunnan of China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2006 | Gardens′ Bulletin Singapore2006，58，： | 1 |
| 10 | Biogeography and floristic affinity of the Limestone flora in southern Yunnan, China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2003 | Annals of the Missouri Botanical Garden2003，90，3： | 1 |
| 11 | High Efficiency Hypocrellin Production by a Novel Mutant Isolated from Shiraia bambusicola显示文摘The fungus Shiraia bambusicola GZ19 M1 is biotechnologically important due to its ability to biosynthesis the pigment hypocrellins.Results showed that ethyl methane sulfonate( EMS) was effective mutagenic agent for strain and potentially produced large numbers of random mutations broadly and uniformly over the whole genome to generate unique strains. Wild-type cultures of S. bambusicola GZ19 were subjected to EMS( 80 mM) induction targeted at approximately 20% spores' survival. When surviving spores were selected in sufficient numbers and cultured on PDA medium for 7 d at 26℃,five novel mutagenized S. bambusicola strains were obtained. A mutant GZ19 M1 that exhibited an activity of more than two times over the wild strain was obtained. Also,batch experiments were carried out to achieve the suitable conditions for hypocrellin. Glucose and rice extract were the most favorable carbon and nitrogen sources for hypocrellin production by submerged culture of S. bambusicola GZ19 M1,and initial glucose and rice extract concentrations were at 35 and 250 g/L,respectively. The optimal surfactant were found to be 0. 008 V/V Tween 80,it was added into cultivation medium at 24 h. Hypocrellin concentration reached 498. 89 mg/L under optimal nutritional conditions,an increment of about 8. 70 times of hypocrellins production was observed compared with that of in non-optimized medium by the wild strain. | Wen DU Baogui WANG | 2019 | Asian Agricultural Research2019，11，2： | 1 |
| 12 | Cretaceous-early tertiary paleolatitude migration in the Sanshui basin of South China and the evolution of the South China Sea显示文摘 | Yuan Youren Wang Baogui Tang Xianzan | 1994 | Tectonophysics1994，，235： | 1 |
| 13 | Effects of precipitant on microstructure and luminescent properties of Lu2O3 : Eu^3+ nanopowders and ceramics 显示文摘 | Wang Zhifang Zhang Weiping You Baogui | 2008 | Spectrochimica Acta Part A2008，70，4： | 1 |
| 14 | RF power design optimization in MRI system显示文摘Magnetic resonance image quality and patient safety have been the focus of engineering and research ever since the invention of equipment in the early 1970s.In high field(or ultrahigh field)MRI systems,the emerging techniques induced by B1 field challenges have promoted various potential solutions.This paper describes the relationship between RF power and B1þfield performance,and the overall requirements considered in RF subsystem design.The design of the RF in the MR system is systematically summarized,including the entire transmission chain,sequence algorithm and RF pulse design,and the probabilities for improvement and optimization in the system design are indicated.At the same time,the radio frequency related issues of the human whole-body 7 T MR and animal MR systems are discussed,especially the promising future showed by the technologies such as radio frequency parallel transmission technology in the ultrahigh field. | Baogui Zhang Kun Wang Tianzi Jiang | 2021 | Magnetic Resonance Letters2021，1，1： | 1 |
| 15 | Paleomagnetism and paleoclimate change in the South China Sea since the late Pleistocene显示文摘Signal processing techniques of cross-correlation, power spectral analysis and cross-power spectral analysis are used to determine the relationships between paleomagnetic properties and the oxygen isotope record of the South China Sea during the late Pleistocene. On the basis of correlation tests between the δ18O time series of cores V3 and A15 with the paleomagnetic properties of core SCS01, five events of susceptibility and intensity of natural remanent magnetization are identified as glacial events corresponding to δ18O positive events. The magnetic properties of the sediments which are independent of the geomagnetic field are sensitive climatic indicators which have frequencies corresponding to the Milankovitch orbital parameters. | Xidong Chen, Douglas F. Williams, Yuan Youren, Wang Baogui, Tang Xianzan, Fan Shiqing and Liu Zongyang 1. University of South Carolina, USA2. South China Sea Institute of Oceanology, Academia Sinica, Guangzhou 510301, China | 1992 | Acta Oceanologica Sinica1992，11，4： | 1 |
| 16 | Longitudinal two-dimensional strain rate imaging: a potential approach to predict the response to cardiac resynchronization therapy显示文摘 | Haoying Shi Xianhong Shu Fang Wang Jie Cui Haozhu Chen Baogui Sun Shaowen Liu | 2009 | The International Journal of Cardiovascular Imaging2009，，： | 1 |
| 17 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 18 | Dissolved organic matter in biologically treated sewage effluent (BTSE): Characteristics and comparison显示文摘 | Jin Guo Yongzhen Peng Jianhua Guo Juan Ma Wei Wang Baogui Wang | 2011 | Desalination2011，，1： | 1 |
| 19 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 20 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
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