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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice显示文摘AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in mice.METHODS: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone treatment.RESULTS: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses. | Benot Foligné Jo■lle Dewulf Pascal Vandekerckove Georges Pignède Bruno Pot | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 3 | Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein显示文摘 | Benoit Foligne Rodrigue Dessein Michael Marceau Sabine Poiret Mathias Chamaillard Bruno Pot Michel Simonet Catherine Daniel | 2007 | Gastroenterology2007，，3： | 1 |
| 4 | Dairy Propi- onibacteria as Human Probiotics: A Review of Recent Evi- dence显示文摘 | Cousin F J Mater D D G Folign~ B | 2011 | Dairy Science ~ Technology2011，91，1： | 1 |
| 5 | Anti-inflammatory potential of the probiotic dietary supplement Lactibiane Tolérance: In vitro and in vivo considerations显示文摘 | Sophie Drouault-Holowacz Beno?t Foligné Véronique Dennin Denise Goudercourt Kathleen Terpend André Burckel Bruno Pot | 2006 | Clinical Nutrition2006，，6： | 1 |
| 6 | Consequences of adrenalectomy on small intestine trophic parameters in aged and young rats: evidence of defective adaptation by aging and lack ofcorticoids显示文摘 | Foligne B Senegas-Balas F Cursio R | 2003 | Dig Dis2003，48，6： | 1 |
| 7 | Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects 显示文摘 | Folign B Nutten S Steidler L | 2006 | Dig Dis Sci2006，51，2： | 1 |
| 8 | Antiinflammatory potential of the probiotic dietary supplement Lactibiane Tolérance:in vitro and in vivo considerations显示文摘 | DROUAULT-HOLOWACZ S FOLIGN(E) B DENNIN V | 2006 | Clinical Nutrition2006，25，6： | 1 |
| 9 | A key role of dendritic cells in probiotic functionality显示文摘 | Foligne B Zoumpopoulou G DewulI J | 2007 | PLoS One2007，2，3： | 1 |
| 10 | Changes in Cell Proliferation and Differentiation of Adult Rat Small Intestine Epithelium After Adrenalectomy显示文摘 | Benoit Foligne Sabbah Aissaoui Francoise Senegas-Balas Chantal Cayuela Patrice Bernard Jean-Michel Antoine Daniel Balas | 2001 | Digestive Diseases and Sciences2001，，6： | 1 |
| 11 | Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo显示文摘 | FOLIGNE B DEUTSCH S M BRETON J | | 0，，24： | 1 |
| 12 | A key role of dendritic cells in probiotic functionality显示文摘 | Foligne B Zoumpopoulou G Dewulf J | 2007 | PLoS one2007，2，3： | 1 |
| 13 | Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein 显示文摘 | Foligne B Dessein R Marceau M | 2007 | Gastroenterology2007，133，3： | 1 |
| 14 | A Key role of dendritic cells in probiotic functi0nality显示文摘 | Foligne B Zoumpopoulou G Dewulf J | 2007 | PloS' ONE2007，2，3： | 1 |
| 15 | A key role of dendritic cells in probiotic functionality显示文摘 | FOLIGNE B ZOUMPOPOULOU G DEWULF J | 2007 | PLOS ONE2007，2，3： | 1 |
| 16 | Probiotics from research to market : the possibilities, risks and challenges 显示文摘 | Foligne B Daniel C Pot B | 2013 | Current opinion in microbiology2013，16，3： | 1 |
| 17 | A key role of dendritic cells in probiotic functionality 显示文摘 | Foligne B Zoumpopoulou G Dewulf J | 2007 | PLoS ONE2007，2，3： | 1 |
| 18 | Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats显示文摘BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after surgery.Adherent-invasive Escherichia coli(AIEC)typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease pathogenesis.Saccharomyces cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the gut.AIM To evaluate the efficacy of CNCM I-3856 in preventing POR induced by LF82 in an HLA-B27 transgenic(TgB27)rat model.METHODS Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of life.TgB27 rats were challenged daily with oral administration of LF82(109 colony forming units(CFUs)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFUs/d,n=7)or a combination of LF82 and CNCM I-3856(n=18).nTg rats receiving LF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and LF82(n=9)under the same conditions were used as controls.POR was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)scores.Luminal LF82 quantifications were performed weekly for each animal.Adherent LF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and W18.Data are expressed as the median with the interquartile range.RESULTS nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving LF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving LF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and LF82 had no macroscopic lesions.Compared to untreated TgB27 animals receiving LF82 alone,coadministration of CNCM I-3856 and LF82 significantly reduced the macroscopic[3.5(2-4)vs 1(0-3),P=0.002]and histological lesions by more than 50%[4.5(3.3-5.8)vs 2(1.3-3),P=0.003].The levels of adherent LF82 were correlated with anastomotic macroscopic scores in TgB27 rats(r=0.49,P=0.006),with a higher risk of POR in animals having high levels of luminal LF82(71.4%vs 25%,P=0.02).Administration of CNCM I-3856 significantly reduced the levels of luminal and adherent LF82,increased the production of interleukin(IL)-10 and decreased the production of IL-23 and IL-17 in TgB27 rats.CONCLUSION In a reliable model of POR induced by LF82 in TgB27 rats,CNCM I-3856 prevents macroscopic POR by decreasing LF82 infection and gut inflammation. | Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey Lena M'Ba Lucil Schneider Marie Titecat Benoît Foligné Michaël Genin Christel Neut Philippe Zerbib Pierre Desreumaux | 2023 | World Journal of Gastroenterology2023，29，5： | 1 |
| 19 | Promising Immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo显示文摘 | FOLIGNE B DEUTSCH S M BRETO J | 2010 | Applied and Environmental Microbiology2010，76，24： | 1 |
| 20 | Probiotics from research to market: the possibilities, risks and challenges显示文摘 | Benoit Foligné Catherine Daniel Bruno Pot | 2013 | Current Opinion in Microbiology2013，，： | 1 |
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