|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Physical Location of the Rice Pi-5(t), Glh and RTSV Genes by ISH of BAC Clones显示文摘Mapplng of low of slngle-copy sequences on plant chromosomes has proven dirricult because ofvery low frequency or slgnal detectlon. Rlce BAC Ilbrary ls belng used wldely ln rlce genome research due tolts distlnctlve advantages over other llbrary systems. In tkls study, two blotln-Iabeled rice BAC clones closelylinked to a rlce blast reslstance, green Ieaf hopper reslstance and tungro spherlcal virus resistance gene,Pi-5(t),Glh, RTSV, were in situ hybrldlred to rlce ckromosomes. They were located on the long arm andshort arm of ckromosome 4 with FL value of 40% and 100% respectively-The rrequency of signal detectionreacked 46. 8% and 59- 2%- The slgnal location were conslstent wltk the selectlve marker on rice saturatedm0Iecular map. The results demonstrated the advautages to Iocate BAC cIones to ckromosomes by in sho hybrldization and will racilitate tke rlce low of slngle-copy gene Iocation by using the BAC library. | Yan Huimin, Song Yunchun, Li Lijia, Bi Xuezhi, Fu Binying(College of Life Sciences, Wuhan University, Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 24 |
| 3 | Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells显示文摘AIM:To investigate whether umbilical cord human mesenchymal stem cell(UC-MSC)was able to differentiate into neural stem cell and neuron in vitro.·METHODS:The umbilical cords were obtained from pregnant women with their written consent and the approval of the Clinic Ethnics Committee.UC-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum(FBS),then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation medium.We investigated whether UC-MSC was able to differentiate into neural stem cell and neuron in vitro by using flow cytometry,reverse transcriptase-polymerase chain reaction(RT-PCR)and immunofluorescence(IF)analyzes.·RESULTS:A substantial number of UC-MSC was harvested using the tissue explants adherent method at about 2wk.Flow cytometric study revealed that these cells expressed common markers of MSCs,such as CD105(SH2),CD73(SH3)and CD90.After induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase(NSE)and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,respectively.Cells showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger refraction.RT-PCR and IF analysis showed that microtubule-associated protein 2(MAP2)and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION:Human umbilical cord derived MSCscan be cultured and proliferated in vitro and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases. | Song Chen Wei Zhang Ji-Ming Wang Hong-Tao Duan Jia-Hui Kong Yue-Xin Wang Meng Dong Xue Bi Jian Song | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 22 |
| 4 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 5 | Platelet to lymphocyte ratio as a novel prognostic tool for gallbladder carcinoma显示文摘AIM:To preliminarily investigate the prognostic significance of the platelet to lymphocyte ratio(PLR) in patients with gallbladder carcinoma(GBC).METHODS:Clinical data of 316 surgical GBC patients were analyzed retrospectively,and preoperative serum platelet and lymphocyte counts were used to calculate the PLR.The optimal cut-off value of the PLR for detecting death was determined by the receiver operating characteristic(ROC) curve.The primary outcome was overall survival,which was estimated by the Kaplan-Meier method.The log-rank test was used to compare the differences in survival.Then,we conducted multivariate Cox analysis to assess the independent effect of the PLR on the survival of GBC patients.RESULTS:For the PLR,the area under the ROC curve was 0.620(95%CI:0.542-0.698,P = 0.040) in detecting death.The cut-off value for the PLR was determined to be 117.7,with 73.6% sensitivity and 53.2% specificity.The PLR was found to be significantlypositively correlated with CA125 serum level,tumornode-metastasis(TNM) stage,and tumor differentiation.Univariate analysis identified carcinoembryonic antigen(CEA),CA125 and CA199 levels,PLR,TNM stage,and the degree of differentiation as significant prognostic factors for GBC when they were expressed as binary data.Multivariate analysis showed that CA125 > 35 U/mL,CA199 > 39 U/mL,PLR ≥ 117.7,and TNM stage Ⅳ were independently associated with poor survival in GBC.When expressed as a continuous variable,the PLR was still an independent predictor for survival,with a hazard ratio of 1.018(95%CI:1.001-1.037 per 10-unit increase,P = 0.043).CONCLUSION:The PLR could be used as a simple,inexpensive,and valuable tool for predicting the prognosis of GBC patients. | Qing Pang Ling-Qiang Zhang Rui-Tao Wang Jian-Bin Bi Jing-Yao Zhang Kai Qu Su-Shun Liu Si-Dong Song Xin-Sen Xu Zhi-Xin Wang Chang Liu | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 6 | Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave显示文摘Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model(v3.14 and v4.18) are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method(PS) effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH(indicating the two authors) is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov(TC) package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages(ACC350 and BJA) obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing waveinduced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered,particularly in air–wave–current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a background Pacific Ocean hindcast for high wave climate research and China Sea swell type analysis. | BI Fan SONG Jinbao WU Kejian XU Yao | 2015 | Acta Oceanologica Sinica2015，34，9： | 10 |
| 7 | SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer显示文摘SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that SIRT7 expression declines during human mesenchymal stem cell(hMSC)aging and that SIRT7 deficiency accelerates senescence.Mechanistically,SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins,thus maintaining the repressive state of heterochromatin at nuclear periphery.Accordingly,deficiency of SIRT7 results in loss of heterochromatin,derepression of the LINE1 retrotransposon(LINE1),and activation of innate immune signaling via the cGAS-STING pathway.These agingassociated cellular defects were reversed by overexpression of heterochromatin proteins or treatment with a LINE1 targeted reverse-transcriptase inhibitor.Together,these findings highlight how SIRT7 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging. | Shijia Bi Zunpeng Liu Zeming Wu Zehua Wang Xiaoqian Liu Si Wang Jie Ren Yan Yao Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2020 | Protein & Cell2020，11，7： | 10 |
| 8 | Distribution and Provenance of Detrital Minerals in Southern Coast of Shandong Peninsula显示文摘Detrital minerals of 137 offshore and 22 river sediment samples collected from Qingdao coastal areas have been analyzed. Four mineral assemblage provinces can be classified by Q-mode cluster analysis. Factor analysis identifies two major factors that account for the total variability in most common minerals: 1) based on the relationship of quartz, hornblende, actinolite, micas, and authigenic pyrite, 41.55% of the variability is related to sediment sources; 2) based on the relationship of epidote, garnet, sphere, and ilmenite, 23.21% can be related to strong hydrodynamic conditions that control transport and sedimentation. By comparing mineral compositions of river waters in the study area, the following four mineral provenances can be identified. The Qingdao-Laoshan nearshore area has a quartz-feldspar-epidote-hornblende-limenite-limonite-sphene assemblage, which is largely attributed to relict sediment and coastal erosion. The Jimo-Haiyang nearshore area has a quartz-feldspar-hornblende-epidote-limonite-mica-actinolite assemblage, derived largely from the Wulong River and Rushan River, and is also affected by the Huanghe River, while the Qianliyan Island area in the deeper offshore area separated by a mud belt has a similar assemblage. The Haiyang-Rushan nearshore area has a quartz-feldspar-hornblende-epidote-micas-limonite assemblage, indicating multiple sources from the Rushan River, the Wulong River, the Huanghe River, and coastal erosion. The central area, located in an eddy center, has a mica-authigenic pyrite-hornblende-quartz-feldspar assemblage, indicating multiple sources dominated by Huanghe River distal sediments. | LIU Jinqing YIN Ping ZHANG Yong SONG Hongying BI Shipu CAO Zhimin LIU Shanshan | 2017 | Journal of Ocean University of China2017，16，5： | 9 |
| 9 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 10 | On the Physical Processes in Contact Binary Systems显示文摘Three importantphysical processes occurringin contact binarysystems are studied. The first one is the effect of spin, orbital rotation and tide on the structure of the components, which includes also the effect of meridian circulation on the mixing of the chemical elements in the components. The second one is the mass and energy exchange between the components. To describe the energy exchange, a new approach is introduced based on the understanding that the exchange is due to the release of the potential, kinetic and thermal energy of the exchanged mass. The third is the loss of mass and angular momentum through the outer Lagrangian point. The rate of mass loss and the angular momentum carried away by the lost mass are discussed. To show the effects of these processes, we follow the evolution of a binary system consisting of a 12M and a 5M star with mass exchange between the components and mass loss via the outer Lagrangian point, both with and without considering the effects of rotation and tide. The result shows that the effect of rotation and tide advances the start of the semi-detached and the contact phases, and delays the end of the hydrogen-burning phase of the primary. Furthermore, it can change not only the occurrence of mass and angular momentum loss via the outer Lagrangian point, but also the contact or semi-contact status of the system. Thus, this effect can result in the special phenomenon of short-term variations occurring over a slow increase of the orbital period. The occurrence of mass and angular momentum loss via the outer Lagrangian point can affect the orbital period of the system significantly, but this process can be influenced, even suppressed out by the effect of rotation and tide. The mass and energy exchange occurs in the common envelope. The net result of the mass exchange process is a mass transfer from the primary to the secondary during the whole contact phase. | Run-Qian Huang Han-Feng Song Shao-Lan Bi | 2007 | Chinese Journal of Astronomy and Astrophysics2007，7，2： | 8 |
| 11 | Green tea polyphenol epigallocatechin-3-gallate inhibits the expression of nitric oxide synthase and generation of nitric oxide induced by ultraviolet B in HaCaT cells显示文摘Background Nitic oxide (NO) has been implicated in the pathogenesis of various inflammatory diseases, including sunburn and pigmentation induced by ultraviolet irradiation. Epigallocatechin-3-gallate (EGCG) is the major effective component in green tea and can protect skin from ultraviolet-induced damage. The purpose of this study was to investigate the protective mechanisms of EGCG on inducible nitric oxide synthase (iNOS) expression and NO generation by ultraviolet B (UVB) irradiation in HaCaT cells. Methods HaCaT cells were irradiated with UVB 30 mJ/cm2 and pretreated with EGCG at varying concentrations. The iNOS mRNA was detected by reverse transcriptase polymerase chain reaction (RT-PCR) and NO production was quantified by spectrophotometric method. The expression of NF-κB P65 was measured by immunofluorescence cytochemistry staining. Results The expression of iNOS mRNA and generation of NO in HaCaT cells were increased by UVB irradiation. EGCG down regulated the UVB-induced iNOS mRNA synthesis and NO generation in a dose dependent manner. The UVB-induced activation and translocation of NF-κB were also down regulated by EGCG treatment in HaCaT cells (P<0.01). Conclusions Green tea derived-EGCG can inhibit and down regulate the UVB-induced activation and translocation of NF-κB, expression of iNOS mRNA and generation of NO respectively, indicating EGCG may play a protective role from UVB-induced skin damage. | SONG Xiu-zu BI Zhi-gang XU Ai-e | 2006 | Chinese Medical Journal2006，，4： | 7 |
| 12 | Climate and extrema of ocean waves in the East China Sea显示文摘Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East China Sea to reconstruct a 15-year wave field from 1988 to 2002 for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East China Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is applied. | Hailun HE Jinbao SONG Yefei BAI Yao XU Juanjuan WANG Fan BI | 2018 | Science China Earth Sciences2018，61，7： | 7 |
| 13 | Interaction between retanning agents and wet white tanned by a novel bimetal complex tanning agent显示文摘A promising and practical chrome-free tanning system has been developed based on a novel Al–Zr bimetal complex tanning agent.However,to achieve satisfactory resultant leather,the retanning process that is compatible with this emerging tannage needs to be investigated systematically.This paper aims to explore the interaction between the bimetal complex tanned wet white and retanning agents.The isoelectric point(pI)of wet white was 7.2,which was nearly the same as wet blue.The electropositivity of wet white was even higher than that of wet blue during post-tanning processes,resulting in higher uptake rate of retanning agents.The distribution of various retanning agents in wet white was analyzed by pI measurement of layered leather and fluorescent tracing technique.The retanning agents were unevenly distributed throughout the cross-section,which might be an important restriction factor in obtaining satisfactory organoleptic properties of the crust leather.This fact is mainly due to the strong electrostatic interaction between anionic retanning agents and wet white.Applying a high dosage of multiple retanning agents in a proper sequence of addition benefited the full penetration of retanning agents in leather matrix and thus improved the organoleptic properties of crust leather.This work provides guidance for optimizing retanning process of the wet white leather. | Wanli Huang Ying Song Yue Yu Ya-nan Wang Bi Shi | 2020 | Journal of Leather Science and Engineering2020，2，1： | 7 |
| 14 | Dynamic airspace sectorization via improved genetic algorithm显示文摘This paper deals with dynamic airspace sectorization (DAS) problem by an improved genetic algorithm (iGA). A graph model is first constructed that represents the airspace static structure. Then the DAS problem is formulated as a graph-partitioning problem to balance the sector workload under the premise of ensuring safety. In the iGA, multiple populations and hybrid coding are applied to determine the optimal sector number and airspace sectorization. The sector constraints are well satisfied by the improved genetic operators and protect zones. This method is validated by being applied to the airspace of North China in terms of three indexes, which are sector balancing index, coordination workload index and sector average flight time index. The improvement is obvious, as the sector balancing index is reduced by 16.5 %, the coordination workload index is reduced by 11.2 %, and the sector average flight time index is increased by 11.4 % during the peak-hour traffic. | Yangzhou Chen Hong Bi Defu Zhang Zhuoxi Song | 2013 | Journal of Modern Transportation2013，21，2： | 6 |
| 15 | Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats显示文摘Activity of matrix metalloproteinase-9 increases following cerebral ischemia/reperfusion,and is associated with cerebral microvascular permeability,blood-brain barrier destruction,inflammatory cell infiltration and brain edema.Matrix metalloproteinase-9 also likely participates in thrombolysis.A rat model of middle cerebral artery infarction was established by injecting autologous blood clots into the internal carotid artery.At 3 hours following model induction,urokinase was injected into the caudal vein.Decreased neurological severity score,reduced infarct volume,and increased expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were observed in the cerebral cortex 24 hours after urokinase thrombolysis.These results suggest that urokinase can suppress damage in the acute-early stage of cerebral infarction. | Yuqiang Song Hongli Zou Guofeng Wang Hongxia Yang Zhaohong Xie Jianzhong Bi | 2012 | Neural Regeneration Research2012，7，17： | 6 |
| 16 | ZnO-MWCNTs/Nafion inorganic-organic composite film:Preparation and application in bioelectrochemistry of hemoglobin显示文摘Multi-walled carbon nanotubes(MWCNTs) were coated with ZnO by a hydrothermal method.The resulting nanocomposites were mixed with the Nafion solution to form a composite matrix for the fabrication of hemoglobin(Hb) biosensor.To prevent the leak of Hb molecules of the biosensor,silica sol-gel film was coated on the surface of the Hb/ZnO-MWCNTs/Nafion electrode.The silica sol-gel/Hb/ZnO-MWCNTs/Nafion film exhibited a pair of well-defined,quasi-reversible redox peaks.This biosensor showed excellent electrocatalytic activity to H_2O_2.The sensitivity and apparent Michaelis-Menten constant of this Hb biosensor to H_2O_2 were 1.31 A/(M cm^2) and 82.8μmol/L,respectively,which indicated that Hb had high affinity to H_2O_2. | Wei Ma Wei Song Dan Bi Tian | 2009 | Chinese Chemical Letters2009，20，3： | 6 |
| 17 | Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice显示文摘Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus(MMTV) long terminal repeat(LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway. | Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，2： | 6 |
| 18 | Elective neck dissection or "watchful waiting": optimal management strategy for early stage NO tongue carcinoma using decision analysis techniques显示文摘背景尽管舌头癌症是头和颈的普通疾病,在选任的颈解剖并且“警惕等待”之间的颈治疗的选择与早舞台为病人仍然保持争论没有口头的舌头 carcinoma.Methods 根据头和颈癌症的当前的状态,一个决定分析模型被创造为早舌头 cancer.Expected 价值( EV )比较二治疗策略根据遇见了定义 criteria.Sensitivity | SONG Tao BI Nan GUI Lai PENG Zhe | 2008 | Chinese Medical Journal2008，，17： | 5 |
| 19 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 20 | Therapeutic Effects of Selaginella tamariscina on the Model of Acute Gout with Hyperuricemia in Rats Based on Metabolomics Analysis显示文摘 | Weijia Chen Yi Wu Rongbing Bi Shu Liu Zhongying Liu Zhiqiang Liu Fengrui song Yi Shi | 2017 | Chinese Journal of Chemistry2017，35，7： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员