|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Comparative study of galectin-3 and B-type natriuretic peptide as biomarkers for the diagnosis of heart failure显示文摘BackgroundHeart 失败(HF ) 是有复杂 pathophysiological 原因的普通疾病。HF 的诊断通常依靠病历和症状的全面分析,并且源于 echocardiography 和生物化学的测试。Galectin-3,在 HF 的相对新的 biomarker,被 US 食物药品管理局为 HF 在风险的层化作为一个标记在 2010 同意。我们与保存喷射部分(pEF ) 在病人为 HF 诊断作为 biomarker 估计了 galectin-3 并且把它的性能与 B 类型 natriuretic 的作比较肽(BNP ).MethodsThirty -- 有 HF (HFpEF 组) 的五个 pEF 病人和没有 HF (控制组) 的 43 个 pEF 病人被注册。在 HFpEF 和控制题目的 galectin-3 和 BNP 的血浆层次是坚定的。象为 HF 诊断的标记的 galectin-3 和 BNP 的敏感,特性,预兆的价值,和精确性被计算, galectin-3 和 BNP 的 compared.ResultsLevels 是 23.09 ±6.97 ng/mL 和 270.46 ±在 HFpEF 组的 330.41 pg/mL,和 16.74 ±2.75 ng/mL 和 59.94 ±在控制组的 29.93 pg/mL 分别地。在在二个组之间的 galectin-3 和 BNP 的层次的差别是重要的(P <0.01 ) 。作为为在学习题目的 HF 诊断的 biomarker,分别地, galectin-3 在 17.8 ng/mL 的截止价值显示出 94.3% 和 65.1% 的敏感和特性。分别地, BNP 在 100 pg/mL 的截止价值显示出 77.1% 和 90.7% 的敏感和特性。Galectin-3 是一显著地更敏感(P <0.05 ) 但是不太特定(P <0.01 ) biomarker 与 BNP 相比。在在 galectin-3 和 BNP 标记之间的积极预兆的价值,否定预兆的价值,和精确性的差别不是重要的(P >0.05 ) 。在操作典型曲线(95% 信心间隔) 的接收装置下面的区域是 0.891 (0.808-0.974 ) 并且(0.809-0.984 ) 分别地, 0.896 没有二之间的重要差别为 galectin-3 和 BNP 珍视(P >0.05 ) galectin-3 的 .ConclusionsThe 水平显著地与 HF 在病人被提高。Galectin-3 和 BNP 是为在有 pEF 的病人的 HF 的诊断的有用 biomarkers。 | Qiu-Sheng YIN Bing SHI Lan Dong Lei BI | 2014 | Journal of Geriatric Cardiology2014，11，1： | 29 |
| 3 | Treatment of phenol wastewater by microwave-induced CIO_2-CuO_x/Al_2O_3 catalytic oxidation process显示文摘CuOx/Al2O3 的催化剂被剧降沉积方法作为一个支持者用γ - Al2O3 准备。CuO 和 Cu2O 在 Al2O3 的表面上被装载,由 X 光检查衍射(XRD ) 和 X 光检查光电子光谱学(XPS ) 描绘了。面对 CuOx/Al2O3,导致微波的氯二氧化物(ClO2 ) 催化氧化过程为包含 100 mg/L 酚的合成废水的处理被进行。影响酚移动的因素被调查,结果证明那个导致微波的 ClO2-CuOx/Al2O3 过程能有效地降级在有低氧化剂剂量的一短反应时间的沾染物,广泛的 pH 范围。在一个给定的条件下面(ClO2 集中 80 mg/L,微波力量 50 W,接触时间 5 min,催化剂剂量 50 g/L, pH 9 ) ,酚移动百分比接近了 92.24% ,相应于 79.13% CODCr 移动。由导致微波的 ClO2-CuOx/Al2O3 催化氧化过程的酚的移动是复杂非同类的固体 / 水的反应,它由动力学适合伪 first-order。与传统的 ClO2 氧化, ClO2 催化氧化和导致微波的 ClO2 氧化相比,导致微波的 ClO2 催化氧化系统能显著地提高降级效率。它为酚废水的移动提供一种有效技术。 | BI Xiao-yi WANG Peng JIANG Hong XU Huan-yan SHI Shu-jie HUANG Jun-li | 2007 | Journal of Environmental Sciences2007，19，12： | 28 |
| 4 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 5 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 6 | Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injury via suppression of dynamin-related protein 1显示文摘Electroacupuncture preconditioning at acupoint Baihui(GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1(Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20(depth 2 mm, intensity 1 m A, frequency 2/15 Hz, for 30 minutes, once a day). Neurological function was assessed using the Longa neurological deficit score. Pathological changes in the ischemic penumbra on the injury side were assessed by hematoxylin-eosin staining. Cellular apoptosis in the ischemic penumbra on the injury side was assessed by terminal deoxyribonucleotidyl transferase-mediated d UTP-digoxigenin nick end labeling staining. Mitochondrial ultrastructure in the ischemic penumbra on the injury side was assessed by transmission electron microscopy. Drp1 and cytochrome c expression in the ischemic penumbra on the injury side were assessed by western blot assay. Results showed that electroacupuncture preconditioning decreased expression of total and mitochondrial Drp1, decreased expression of total and cytosolic cytochrome c, maintained mitochondrial morphology and reduced the proportion of apoptotic cells in the ischemic penumbra on the injury side, with associated improvements in neurological function. These data suggest that electroacupuncture preconditioning-induced neuronal protection involves inhibition of the expression and translocation of Drp1. | Gao-feng Zhang Pei Yang Zeng Yin Huai-long Chen Fu-guo Ma Bin Wang Li-xin Sun Yan-lin Bi Fei Shi Ming-shan Wang | 2018 | Neural Regeneration Research2018，13，1： | 16 |
| 7 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 8 | Memory materials and devices:From concept to application显示文摘Memory cells have always been an important element of information technology.With emerging technologies like big data and cloud computing,the scale and complexity of data storage has reached an unprecedented peak with a much higher requirement for memory technology.As is well known,better data storage is mostly achieved by miniaturization.However,as the size of the memory device is reduced,a series of problems,such as drain gate-induced leakage,greatly hinder the performance of memory units.To meet the increasing demands of information technology,novel and high-performance memory is urgently needed.Fortunately,emerging memory technologies are expected to improve memory performance and drive the information revolution.This review will focus on the progress of several emerging memory technologies,including two-dimensional material-based memories,resistance random access memory(RRAM),magnetic random access memory(MRAM),and phasechange random access memory(PCRAM).Advantages,mechanisms,and applications of these diverse memory technologies will be discussed in this review. | Zhenhan Zhang Zongwei Wang Tuo Shi Chong Bi Feng Rao Yimao Cai Qi Liu Huaqiang Wu Peng Zhou | 2020 | InfoMat2020，2，2： | 15 |
| 9 | Acupuncture preconditioning protects hippocampal neurons from transient ischemia/reperfusion injury显示文摘The present study established a model of brain ischemia in aged rats using four-vessel occlusion.We observed hippocampal CA1 neuronal apoptosis and apoptosis-mediated protease caspase-3 expression following preconditioning of electroacupuncture at Baihui(GV 20).Our results showed that the number of hippocampal CA1 normal neurons was decreased,and degenerated neurons were increased 12 hours to 3 days following cerebral ischemia/reperfusion.The number of hippocampal CA1 apoptotic neurons and caspase-3-positive neurons in rats with cerebral ischemia/reperfusion injury was significantly decreased following acupuncture preconditioning.Acupuncture preconditioning protects aged rats against ischemia/reperfusion injury by regulating caspase-3 protein expression. | Mingshan Wang Haipeng Zhou Fei Shi Shilong Ma Yanlin Bi Yuqiu Liu Hong Liu Haiou Li | 2011 | Neural Regeneration Research2011，6，15： | 12 |
| 10 | PRDM14 Promotes the Migration of Human Non-small Cell Lung Cancer Through Extracellular Matrix Degradation in vitro显示文摘 | Hong-Xia Bi Han-Bing Shi Ting Zhang Ge Cui | 2015 | Chinese Medical Journal2015，，3： | 10 |
| 11 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 12 | Tonifying Qi and activating blood circulation in terms of Traditional Chinese Medicine: their effects in patients with myocardial infarction显示文摘OBJECTIVE: To investigate the effects of tonifying Qi and activating blood circulation(SQABC), a method in Traditional Chinese Medicine(TCM), on end-point events in patients with myocardial infarction(MI) in this retrospective cohort study.METHODS: Clinical data were obtained from the medical records of patients with acute MI(AMI),both during hospitalization and follow-up, and included general demographic information(age, gender, and contact information), TCM regimens used,and end-point events.RESULTS: A total of 1596 patients with AMI were enrolled to this study, but data of only 1210 casesare accessible till follow-up. We classified the patients based on the exposure levels of SQABC.When comparing the results between all exposure and non-exposure groups, significant differences were identified, both during hospitalization and follow-ups. During hospitalization, cardiac death(4.40% vs 21.55%, P < 0.05) and cardiac shock(3.04% vs 11.62%, P < 0.05) were significantly lower in the exposure group than the non-exposure group. Similarly, during the follow-up, cardiac death(12.04% vs 20.49%, P < 0.05), acute heart failure(7.27% vs 11.81%, P < 0.05), composite endpoint of reinfarction and stroke(9.11% vs 15.28%,P < 0.05), and rehospitalization due to angina(25.49% vs 34.38%, P < 0.05) were significantly lower in the exposure group than the non-exposure group.CONCLUSION: Our findings suggest that SQABC can significantly benefits the subjects in the management of high-risk AMI in them. | Gao Wulin Dai Guohua Zhang Tong Bi Dongxue Liu Chunhua Shi Xiaojing Zhao Fang Zhao Chen | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 7 |
| 13 | Highly diversified Zika viruses imported to China, 2016显示文摘 | Yanjun Zhang Wenxian Chen Gary Wong Yuhai Bi Juying Yan Yi Sun Enfu Chen Hao Yan Xiuyu Lou Haiyan Mao Shichang Xia George F.Gao Weifeng Shi Zhiping Chen | 2016 | Protein & Cell2016，7，6： | 7 |
| 14 | Interaction between retanning agents and wet white tanned by a novel bimetal complex tanning agent显示文摘A promising and practical chrome-free tanning system has been developed based on a novel Al–Zr bimetal complex tanning agent.However,to achieve satisfactory resultant leather,the retanning process that is compatible with this emerging tannage needs to be investigated systematically.This paper aims to explore the interaction between the bimetal complex tanned wet white and retanning agents.The isoelectric point(pI)of wet white was 7.2,which was nearly the same as wet blue.The electropositivity of wet white was even higher than that of wet blue during post-tanning processes,resulting in higher uptake rate of retanning agents.The distribution of various retanning agents in wet white was analyzed by pI measurement of layered leather and fluorescent tracing technique.The retanning agents were unevenly distributed throughout the cross-section,which might be an important restriction factor in obtaining satisfactory organoleptic properties of the crust leather.This fact is mainly due to the strong electrostatic interaction between anionic retanning agents and wet white.Applying a high dosage of multiple retanning agents in a proper sequence of addition benefited the full penetration of retanning agents in leather matrix and thus improved the organoleptic properties of crust leather.This work provides guidance for optimizing retanning process of the wet white leather. | Wanli Huang Ying Song Yue Yu Ya-nan Wang Bi Shi | 2020 | Journal of Leather Science and Engineering2020，2，1： | 7 |
| 15 | Numerical simulations of compressible mixing layers with a discontinuous Galerkin method显示文摘Discontinuous Galerkin(DG) method is known to have several advantages for flow simulations,in particular,in fiexible accuracy management and adaptability to mesh refinement. In the present work,the DG method is developed for numerical simulations of both temporally and spatially developing mixing layers. For the temporally developing mixing layer,both the instantaneous fiow field and time evolution of momentum thickness agree very well with the previous results. Shocklets are observed at higher convective Mach numbers and the vortex paring manner is changed for high compressibility. For the spatially developing mixing layer,large-scale coherent structures and self-similar behavior for mean profiles are investigated. The instantaneous fiow field for a three-dimensional compressible mixing layer is also reported,which shows the development of largescale coherent structures in the streamwise direction. All numerical results suggest that the DG method is effective in performing accurate numerical simulations for compressible shear fiows. | Xiao-Tian Shi Jun Chen Wei-Tao Bi Chi-Wang Shu Zhen-Su She | 2011 | Acta Mechanica Sinica2011，27，3： | 6 |
| 16 | A Systematic Assessment of Blood Lead Level in Children and Associated Risk Factors in China显示文摘In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 IJ.g/L, and the prevalence of elevated BLL (EBLL, defined as BLL 〉_100 Ixg/L) was l&.4&% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China. | WANG Lu LI Zhen HUANG Shao Xin DU Chuang WANG Hong HE Li Ping BI Yong Yi SHI Yong WANG Chun Hong | 2015 | Biomedical and Environmental Sciences2015，28，8： | 6 |
| 17 | Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis显示文摘BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP. | Bo Tu Yue-Ning Zhang Jing-Feng Bi Zhe Xu Peng Zhao Lei Shi Xin Zhang Guang Yang En-Qiang Qin | 2020 | World Journal of Gastroenterology2020，26，29： | 5 |
| 18 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 19 | Current developments in drug delivery with thermosensitive liposomes显示文摘Thermosensitive liposomes(TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-snglyce-ro-3-phosphocholine(DPPC) as the primary liposomal lipid, many studies have been done using this type of liposome from basic and practical aspects. While TSLs composed of DPPC enhance the cargo release near the phase transition temperature, it has been shown that many factors affect their temperature sensitivity. Thus numerous attempts have been undertaken to develop new TSLs for improving their thermal response performance. The main objective of this review is to introduce the development and recent update of innovative TSLs formulations, including combination of radiofrequency ablation(RFA), highintensity focused ultrasound(HIFU), magnetic resonance imaging(MRI) and alternating magnetic field(AMF). In addition, various factors affecting the design of TSLs, such as lipid composition, surfactant, size and serum components are also discussed. | Hongshu Bi Jianxiu Xue Hong Jiang Shan Gao Dongjuan Yang Yan Fang Kai Shi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 5 |
| 20 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员