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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 3 | CD 147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression显示文摘Major gaps in understanding the molecular mechanisms of colorectal cancer(CRC)progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders.Trefoil factor 3(TFF3)has been reported to be involved in CRC progression and intestinal mucosal repair;however,how TFF3 drives tumors to become more aggressive or metastatic and how TFF3 promotes intestinal mucosal repair are still poorly understood.Here,we found that the upregulated TFF3 in CRC predicted a worse overall survival rate.TFF3 deficiency impaired mucosal restitution and adenocarcinogenesis.CD147,a membrane protein,was identified as a binding partner for TFF3.Via binding to CD147,TFF3 enhanced CD147-CD44s interaction,resulting in signal transducer and activator of transcription 3(STAT3)activation and prostaglandin G/H synthase 2(PTGS2)expression,which were indispensable for TFF3-induced migration,proliferation,and invasion.PTGS2-derived PGE2 bound to prostaglandin E2 receptor EP4 subtype(PTGER4)and contributed to TFF3-stimulated CRC progression.Solution NMR studies of the TFF3-CD147 interaction revealed the key residues critical for TFF3 binding and the induction of PTGS2 expression.The ability of TFF3 to enhance mucosal restitution was weakened by a PTGS2 inhibitor.Blockade of TFF3-CD147 signaling using competitive inhibitory antibodies or a PTGS2 inhibitor reduced CRC lung metastasis in mice.Our findings bring strong evidence that CD147 is a novel receptor for TFF3 and PTGS2 signaling is critical for TFF3-induced mucosal restitution and CRC progression,which widens and deepens the understanding of the molecular function of trefoil factors. | Hong-Yong Cui Shi-Jie Wang Fei Song Xu Cheng Gang Nan Yu Zhao Mei-Rui Qian Xi Chen Jia-Yue Li Fen-Ling Liu Yu-Meng Zhu Ruo-Fei Tian Bin Wang Bin Wu Yang Zhang Xiu-Xuan Sun Ting Guo Xiang-Min Yang Hai Zhang Ling Li Jing Xu Hui-Jie Bian Jian-Li Jiang Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 3 |
| 4 | Transcriptome analysis reveals the differential regulatory effects of red and blue light on nitrate metabolism in pakchoi(Brassica campestris L.)显示文摘Pakchoi(Brassica campestris L. ssp. chinensis) is an important leafy vegetable. Various light spectra, especially red and blue light, play vital roles in the regulation of nitrate metabolism. Information on the effects of red and blue light on nitrate metabolism at the transcriptome level in pakchoi is still limited, so this study used RNA sequencing technology to explore this molecular mechanism. Through pairwise comparisons with white LED light, 3 939 and 5 534 differentially expressed genes(DEGs) were identified under red and blue light, respectively. By Kyoto Encyclopedia of Genes and Genomes(KEGG) and Gene Ontology(GO) analyses, these unigenes were found to be involved in nitrate assimilation, plant-pathogen interaction, biosynthesis of secondary metabolites, and phenylpropanoid biosynthesis. The differential effects of light spectra on the nitrate concentration and metabolism-related enzyme activities were also confirmed at the physiological level. Several signal transduction modules, including Crys/Phys-COP1-HY5/HY5-like, were found to be involved in red and blue light-induced nitrate metabolism, and the transcript levels for this complex were consistent with the observed degree of nitrate assimilation. The expression patterns of 15 randomly selected DEGs were further validated using qPCR. Taken together, the results of this study could help improve our understanding of light spectrumregulated nitrate metabolism in pakchoi at the transcriptome level. | FAN Xiao-xue BIAN Zhong-hua SONG Bo XU Hai | 2022 | Journal of Integrative Agriculture2022，21，4： | 1 |
| 5 | PP/PP‐g‐MAH/layered expanded graphite oxide nanocomposites prepared via masterbatch process显示文摘 | Jun Bian Xiao Wei Wei Hai Lan Lin I Ta Chang Erol Sancaktar | 2013 | J Appl Polym Sci2013，，4： | 1 |
| 6 | Impact of nocturnal planetary boundary layer on air pollutants: measurements from a 250 meter tower over Tianjin, China显示文摘 | Han Suqin Bian Hai Tie Xuexi | 2006 | J Hazard Mater2006，162，： | 1 |
| 7 | PP/PP‐g‐MAH/layered expanded graphite oxide nanocomposites prepared via masterbatch process显示文摘 | Jun Bian Xiao Wei Wei Hai Lan Lin I Ta Chang Erol Sancaktar | 2013 | J Appl Polym Sci2013，，4： | 1 |
| 8 | Torsional static and vibration analysis of functionally graded nanotube with bi-Helmholtz kernel based stress-driven nonlocal integral model显示文摘A torsional static and free vibration analysis of the functionally graded nanotube(FGNT)composed of two materials varying continuously according to the power-law along the radial direction is performed using the bi-Helmholtz kernel based stress-driven nonlocal integral model.The differential governing equation and boundary conditions are deduced on the basis of Hamilton’s principle,and the constitutive relationship is expressed as an integral equation with the bi-Helmholtz kernel.Several nominal variables are introduced to simplify the differential governing equation,integral constitutive equation,and boundary conditions.Rather than transforming the constitutive equation from integral to differential forms,the Laplace transformation is used directly to solve the integro-differential equations.The explicit expression for nominal torsional rotation and torque contains four unknown constants,which can be determined with the help of two boundary conditions and two extra constraints from the integral constitutive relation.A few benchmarked examples are solved to illustrate the nonlocal influence on the static torsion of a clamped-clamped(CC)FGNT under torsional constraints and a clamped-free(CF)FGNT under concentrated and uniformly distributed torques as well as the torsional free vibration of an FGNT under different boundary conditions. | Peiliang BIAN Hai QING | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，3： | 1 |
| 9 | Distribution of Avian Influenza A Viruses in Poultry-Related Environment and Its Association with Human Infection in Henan, 2016 to 2017显示文摘Objective To survey avian influenza A viruses(AIVs) in the environment and explore the reasons for the surge in human H7 N9 cases.Methods A total of 1,045 samples were collected from routine surveillance on poultry-related environments and 307 samples from human H7 N9 cases-exposed environments in Henan from 2016 to2017. The nucleic acids of influenza A(Flu A), H5, H7, and H9 subtypes were detected by real-time polymerase chain reaction.Results A total of 27 H7 N9 cases were confirmed in Henan from 2016 to 2017, 24 had a history of live poultry exposure, and 15 had H7 N9 virus detected in the related live poultry markets(LPMs). About 96%(264/275) Flu A positive-environmental samples were from LPMs. H9 was the main AIV subtype(10.05%) from routine surveillance sites with only 1 H7-positive sample, whereas 21.17% samples were H7-positive in H7 N9 cases-exposed environments. Samples from H7 N9 cases-exposed LPMs(47.56%)had much higher AIVs positive rates than those from routine surveillance sites(12.34%). The H7+H9 combination of mixed infection was 78.18%(43/55) of H7-positive samples and 41.34%(43/104) of H9-positive samples.Conclusion The contamination status of AIVs in poultry-related environments is closely associated with the incidence of human infection caused by AIVs. Therefore, systematic surveillance of AIVs in LPMs in China is essential for the detection of novel reassortant viruses and their potential for interspecies transmission. | MA Hong Xia WANG Ruo Lin NIE Yi Fei SU Jia LI Dong Xiao LI Yi DU Yan Hua WEI Hai Yan LI Xing Le WANG Zhe XU Bian Li HUANG Xue Yong | 2019 | Biomedical and Environmental Sciences2019，32，11： | 1 |
| 10 | Studies on the Neodymium-induced Pinacol Coupling of Aromatic Aldehydes and Ketones in Aqueous Media显示文摘Pinacol coupling reactions of aromatic aldehydes and ketones were carried out using Nd-36% HOAc-CH2Cl2 system with stirring at r. t. for 4 h (in 14-70% yield). The reactions in the same system gave pinacols in 10-93% yield under ultrasound irradiation at r. t. for 2 h. | Yan Jiang BIAN Hai Long WANG Bo WU Ji Tai LI | 2006 | Chinese Chemical Letters2006，17，5： | 1 |
| 11 | Study of vertical distributive characters of O3 in autumn with 255m meteorological tower in tianjin, china显示文摘 | HAN Suqin Liu Aixia Bian Hai | 2007 | Abstracts of papers of American Chemical Society2007，，： | 1 |
| 12 | Effect of aerosols onvisibility and radiation in spring 2009 in Tianjin, China 显示文摘 | HAN Suqin BIAN Hai ZHANG Yufeng | 2012 | Aerosol and Air Quality Research2012，12，： | 1 |
| 13 | Analysis of the relationship between 03, NO and NO2 in Tianjin, China 显示文摘 | HAN Suqin BIAN Hai FENG Yinchang | 2011 | Aerosol and Air Quality Research2011，11，2： | 1 |
| 14 | Evidence of impact of aerosols on surface ozone concentration in Tianjin, China 显示文摘 | BIAN Hai HAN Suqin TIE Xuexi | 2007 | Atmos Environ2007，41，22： | 1 |
| 15 | Impact of nocturnal planetary boundary layer on urban air pollutants: measurements from a 250 m tower over Tianjin, China显示文摘 | HAN Suqin BIAN Hai TIE Xuexi | 2009 | J Hazard Mater2009，162，1： | 1 |
| 16 | Synthesis of 2-Heterocyclomethyl-5-diphenylmethylene-cyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth显示文摘Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTT assay in human breast cancer T47D cells. | Yun Hai ZHANG Lin Xiang ZHAO Zhen Jun BIAN Rui WANG Fu Yuan SUN | 2006 | Chinese Chemical Letters2006，17，9： | 0 |
| 17 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping ZhuZhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 18 | NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss显示文摘Objective The effects of interactions between genetic and environmental factors on the noise-induced hearing loss(NIHL)are still unclear.This study aimed to assess interactions among gene polymorphisms,noise metrics,and lifestyles on the risk of NIHL.Methods A case-control study was conducted using 307 patients with NIHL and 307 matched healthy individuals from five manufacturing industries.General demographic data,lifestyle details,and noise exposure levels were recorded.The Kompetitive allele-specific polymerase chain reaction(KASP)was used to analyze the genotypes of 18 SNPs.Results GMDR model demonstrated a relevant interaction between NRN1 rs3805789 and CAT rs7943316(P=0.0107).Subjects with T allele of rs3805789 or T allele of rs7943316 had higher risks of NIHL than those with the SNP pair of rs3805789-CC and rs7943316-AA(P<0.05).There was an interaction among rs3805789,rs7943316,and kurtosis(P=0.0010).Subjects exposed to complex noise and carrying both rs3805789-CT and rs7943316-TT or rs3805789-CT/TT and rs7943316-AA had higher risks of NIHL than those exposed to steady noise and carrying both rs3805789-CC and rs7943316-AA(P<0.05).The best six-locus model involving NRN1 rs3805789,CAT rs7943316,smoking,video volume,physical exercise,and working pressure for the risk of NIHL was found to be the interaction(P=0.0010).An interaction was also found among smoking,video volume,physical exercise,working pressure,and kurtosis(P=0.0107).Conclusion Concurrence of NRN1 and CAT constitutes a genetic risk factor for NIHL.Complex noise exposure significantly increases the risk of NIHL in subjects with a high genetic risk score.Interactions between genes and lifestyles as well as noise metrics and lifestyles affect the risk of NIHL. | LIU Shuang Yan SONG Wei Qin XIN Jia Rui LI Zheng LEI Song CHEN Ying Qi ZHAO Tian Yu WANG Hai Yan XU Liang Wen ZHANG Mei Bian HONG Yu YANG Lei | 2021 | Biomedical and Environmental Sciences2021，34，9： | 0 |
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