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| 1 | Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRI显示文摘AIM: Irritable bowel syndrome (IBS) is characterized by abdominal pain and changes in stool habits. Visceral hypersensitivity is a key factor in the pathophysiology of IBS. The aim of this study was to examine the effect of rectal balloon-distention stimulus by blood oxygenation leveldependent functional magnetic resonance imaging (BOLDfMRI) in visceral pain center and to compare the distribution,extent, and intensity of activated areas between IBS patients and normal controls.
METHODS: Twenty-six patients with IBS and eleven normal controls were tested for rectal sensation, and the subjective pain intensity at 90 ml and 120 ml rectal balloon-distention was reported by using Visual Analogue Scale. Then, BOLDfMRI was performed at 30 ml, 60 ml, 90 ml, and 120 ml rectal balloon-distention in all subjects.
RESULTS: Rectal distention stimulation increased the activity of anterior cingulate cortex (35/37), insular cortex (37/37),prefrontal cortex (37/37), and thalamus (35/37) in most cases.At 120 ml of rectal balloon-distention, the activation area and percentage change in MR signal intensity of the regions of interest (ROI) at IC, PFC, and THAL were significantly greater in patients with IBS than that in controls. Score of pain sensation at 90 ml and 120 ml rectal balloon-distention was significantly higher in patients with IBS than that in controls.
CONCLUSION: Using fMRI, some patients with IBS can be detected having visceral hypersensitivity in response to painful rectal balloon-distention. fMRI is an objective brain imaging technique to measure the change in regional cerebral activation more precisely. In this study, IC and PFC of the IBS patients were the major loci of the CNS processing of visceral perception. | Yao-ZongYuan Ran-JunTao BinXu JingSun Ke-MinChen FeiMiao Zhong-WeiZhang Jia-YuXu | 2003 | World Journal of Gastroenterology2003，9，6： | 31 |
| 2 | Expression and significance of heparanase and nm23-Hl in hepatocellular carcinoma显示文摘AIM: To explore the relation between heparanase (HPA)and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC.METHODS: Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used to measure the expressions of HPA mRNA and nm23-H1protein in primary tumor tissue and paracancerous tissue of 33 cases of HCC. Paracancerous tissues of 9 cases of benign liver tumor were used as normal controls. The results were analyzed in combination with the results of clinicopathological examination and follow-up.RESULTS: The positive expression of HPA gene was significantly higher in primary tumor tissues of HCC (48.5%,L6/33) as compared to the paracancerous tissues of HCC and normal controls (3.03%, 1/33) (P<0.01). HPA expression was not related with the size of tumor, envelope formation, AFP level, HBsAg state and cirrhosis of liver.The positive rates of HPA mRNA in the group with high tendency to metastasis or recurrence and in the group with metastasis or recurrence during the follow-up were significantly higher than those in the group with low tendency to metastasis or recurrence (62.5% vs 37.5%,P<0.05) and in the group without metastasis or recurrence (78.6% vs 21.4%, P<0.01). The poorly differentiated tumor and tumor of TNM stages Ⅲ-Ⅳ had a higher positive rate of HPA gene expression than the well differentiated tumor and tumor of TNM stages Ⅰ-Ⅱ (66.7% vs 33.3%, P<0.05). The positive expression rate of nm23-H1 protein in HCC tissue was significantly lower than that in corresponding non-cancerous or normal liver tissue (45.5, 72.7, 88.9%, P<0.05). nm23-H1 expression was not related with the size of tumor, envelope formation,AFP level, HBsAg state, cirrhosis of liver, Edmondson grade,and TNM stage (P>0.05). The positive rates of nm23-H1 in the group with high tendency to metastasis and recurrence and in patients with metastasis or recurrence during the follow-up were obviously higher than those in the group with low tendency to metastasis and recurrence (P = 0.018) and in the patients without metastasis and recurrence (P = 0.024); but no significant difference was found between HPA positive and negative groups(P = 0.082). According to the results of follow-up, the rate of accuracy in predicting metastasis of positive HPA,negative nm23-H1 an1378-12-381d combination of positive HPA with negative nm23-H1 was 78.6% (11/114), 68.8% (11/16)and 88.9% (8/9), respectively.CONCLUSION: Expression of HPA and/or nm23-H1 is related with metastasis and recurrence of HCC. Detection of the expression rate of HPA and nm23-H1 may help increase the accuracy in predicting post-operative metastasis and recurrence of HCC. | Ying-BinLiu Shun-LiangGao Xiao-PengChen Shu-YouPeng He-QingFang Yu-LianWu Cheng-HongPeng ZheTang BinXu Jian-WeiWang Gui-LongDeng Hai-JunLi Xue-DongFeng Hao-RanQian | 2005 | World Journal of Gastroenterology2005，11，9： | 14 |
| 3 | Effect of ischemic preconditioning on P-selectin expression in hepatocytes of rats with cirrhotic ischemia-reperfusion injury显示文摘AIM: To investigate the effects and mechanisms of ischemic preconditioning (IPC) on the ischemia/reperfusion (I/R) injury of liver cirrhosis in rats and the effect of IPC on P-selectin expression in hepatocytes.METHODS: Forty male SD rats with liver cirrhosis were randomly divided into sham operation group (SO group),ischemia/reperfusion group (I/R group), ischemic preconditioning group (IPC group), L-Arginine preconditioning group (APC group), L-NAME preconditioning group (NPC group), eight rats in each group. Hepatocellular viability was assessed by hepatic adenine nucleotide level and energy charge (EC) determined by HPLC, ALT, AST and LDH in serum measured by auto- biochemical analyzer and bile output.The expression of P-selectin in the liver tissue was analyzed by immunohistochemical technique. Leukocyte count in ischemic hepatic lobe was calculated.RESULTS: At 120 min after reperfusion, the level of ATP and EC in IPC and APC groups was higher than that in I/R group significantly. The increases in AST, ALT and LDH were prevented in IPC and APC groups. The livers produced more bile in IPC group than in I/R group during 120 min after reperfusion (0.101±0.027 versus 0.066±0.027 ml/g liver,P=0.002). There was a significant difference between APC and I/R groups, (P=0.001). The leukocyte count in liver tissues significantly increased in I/R group as compared with SO group (P<0.05). The increase in the leukocyte count was prevented in IPC group. Administration of L-arginine resulted in the same effects as in IPC group. However,inhibition of NO synthesis (NPC group) held back the beneficial effects of preconditioning. Significant promotion of P-selectin expression in hepatocytes in the I/R group was observed compared with the SO group (P<0.01). IPC or L-arginine attenuated P-selectin expression remarkably (P<0.01). However, inhibition of NO synthesis enhanced Pselectin expression (P<0.01). The degree of P-selectin expression was positively correlated with the leukocyte counts infiltrating in liver (r=0.602, P=0.000).CONCLUSION: IPC can attenuate the damage induced by I/R in cirrhotic liver and increase the ischemic tolerance of the rats with liver cirrhosis. IPC can abolish I/R induced leukocyte adhesion and infiltration by preventing postischemic P-selectin expression in the rats with liver cirrhosis via a NO-initiated pathway. | Xiang-DongCheng Xian-ChuanJiang Yin-BingLiu Cheng-HongPeng BinXu Shu-YouPeng | 2003 | World Journal of Gastroenterology2003，9，10： | 7 |
| 4 | Safe major abdominal operations:Hepatectomy,gastrectomy and pancreatoduodenectomy in elder patients显示文摘AIM: To evaluate the impact of advanced age on outcome METHODS: Two hundreds and eleven patients undergone hepatectomy, gastrectomy and pancreatoduodenectomy from January 1998 to September 2002 were analyzed retrospectively. Clinicopathologic features and operative outcome of 83 patients aged 65 years or more were compared with that in 128 younger patients aged less than 65 years.RESULTS: The nutritional state, such as pre-operation level of serum albumin and hemoglobin in the older patients was poorer than that in the younger patients. The older patients had higher comorbidities than the younger patients (48.2% vs 15.6%). No significant difference was observed in pedoperative mortality, and complication rate between the older and younger patients (2.4% vs 1.6% and 22.9% vs 20.3%, respectively). Multivariate analysis demonstrated that pancreatoduodenectomy, hepatectomy with resection of more than 2 segments and comorbidities were independent predictors of postoperative complication, whereas age was not (P=0.3172).CONCLUSION: It is safe for patients aged 65 years or moreto undergo hepatic, pancreatic and gastric resection if greatcare is taken during perioperative period. | Yu-LianWu Jun-XiuYu BinXu | 2004 | World Journal of Gastroenterology2004，10，13： | 6 |
| 5 | AFM Study on Interface of HTHP As-grown Diamond Single Crystal and Metallic Film显示文摘The study for the interface of as-grown diamond and metallic film surrounding diamond is an attractive way for understanding diamond growth mechanism at high temperature and high pressure (HTHP), because it is that through the interface carbon atom groups from the molten film are transported to growing diamond surface. It is of great interest to perform atomic force microscopy (AFM) experiment, which provides a unique technique different from that of normal optical and electron microscopy studies, to observe the interface morphology. In the present paper,we report first that the morphologies obtained by AFM on the film are similar to those of corresponding diamond surface, and they are the remaining traces after the carbon groups moving from the film to growing diamond. The fine particles and a terrace structure with homogeneous average step height are respectively found on the diamond (100) and (111) surface. Diamond growth conditions show that its growth rates and the temperature gradients in the boundary layer of the molten film at HTHP result in the differences of surface morphologies on diamond planes,being rough on (100) plane and even on the (111) plane. The diamond growth on the (100) surface at HPHT could be considered as a process of unification of these diamond fine particles or of carbon atom groups recombination on the growing diamond crystal surface. Successive growth layer steps directly suggest the layer growth mechanism of the diamond (111) plane. The sources of the layer steps might be two-dimensional nuclei and dislocations. | BinXU MusenLI LongweiYIN JianjunCUI JianhongGONG | 2003 | Journal of Materials Science & Technology2003，19，2： | 5 |
| 6 | Heparanase mRNA expression and point mutation in hepatocellular carcinoma显示文摘AIM: To explore the expression of heparanase mRNA and point mutation in hepatocellular carcinoma (HCC). METHODS: Reverse transcription polymerase chain reaction was used to measure the expression of heparanase mRNA in the primary tumor tissues and surrounding liver tissues of 33 HCC patients. T-A cloning and sequencing were used to detect whether there was any mutation in the amplified PCR products. RESULTS: The expression of heparanase mRNA waspositive in 16 primary tumor tissues of HCC, and the positive rate was 48.5%, which was significantly higher than that in the surrounding liver parenchyma (P<0.01). The positive rate for heparanase gene in high-tendency to metastatic recurrence group (71.4%, 10/14) was obviously higher than that in low-tendency to metastatic recurrence group (31.6%, 6/19) (P= 0.023). The positive rate for heparanase gene in paltients with metastatic recurrence during postoperative follow-up (78.6%, 11/14) was also significantly higher than that in those without metastatic recurrence (21.4%, 3/14) (P = 0.003). Sequence analysis of the HPA PCR products was made in 7 patients, and 2-point mutations were found in 4 patients, one of which was sense mutation, neither base insertion nor deletion was detected. The mutation rate was 57.1% (4/7). CONCLUSION- The expression rate of heparanase mRNA increases in HCC, and HPA mRNA may be one of the reliable markers for the metastatic activity gained by the liver tumor cells and could be used clinically in predicting metastatic recurrence of HCC. Point mutation may be one of the causes for enhanced heparanase mRNA expression. | Xiao-PengChen Yin-BibLiu JingRui Shu-YouPeng Cheng-HongPeng Zi-YanZhou Liang-HuiShi Hong-WeiShen BinXu | 2004 | World Journal of Gastroenterology2004，10，19： | 5 |
| 7 | A functional polymorphism in Pre‐miR‐146a gene is associated with prostate cancer risk and mature miR‐146a expression in vivo显示文摘 | BinXu Ning‐HanFeng Peng‐ChaoLi JunTao DeyaoWu Zheng‐DongZhang NaTong Jin‐FengWang Ning‐HongSong WeiZhang Li‐XinHua Hong‐FeiWu | 2010 | Prostate2010，，5： | 1 |
| 8 | Multinational enterprises, technology diffusion, and host country productivity growth 显示文摘 | BinXu | 2000 | Joumal of Development Economics2000，，62： | 1 |
| 9 | Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer显示文摘 | BoFeng Wei‐BinXu Min‐HuaZheng Jun‐JunMa QuCai YiZhang JunJi Ai‐GuoLu YingQu Jian‐WenLi Ming‐LiangWang Wei‐GuoHu Bing‐YaLiu Zheng‐GangZhu | 2006 | Journal of Gastroenterology and Hepatology2006，，10： | 1 |
| 10 | Biphasic Catalytic Hydroformylation of 1-Dodecene in Micellar System with Cationic Gemini Surfactants显示文摘The promotion effect of cationic gemini surfactants for the hydroformylation of 1-dodecene in the organic/aqueous biphasic catalytic system is reported. The hydroformylation reaction in the presence of gemini surfactant occurred with higher turnover frequency and higher selectivity for linear aldehyde than using conventional monomeric surfactant CTAB. | MinLI BinXU HuaCHEN HongJieZHENG XueYuanHUANG YaoZhongLI XianJunLI | 2004 | Chinese Chemical Letters2004，15，9： | 1 |
| 11 | Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing显示文摘 | Ju LinXie Hui NingBian Shao HaiQi Hua DeChen Hou DongLi Ying BinXu Tian ZengLi Xu ShengLiu Hui Z.Liang Bang RongXin YongHuan | 2008 | Wound Repair and Regeneration2008，，： | 1 |
| 12 | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities显示文摘Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry. | Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 13 | Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice显示文摘Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application. | Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 14 | Traditional Chinese medicines for non-small cell lung cancer: Therapies and mechanisms显示文摘The most common subtype of lung cancer is non-small cell lung cancer(NSCLC), which has a poor prognosis and seriously threatens the health of human beings. The multidisciplinary comprehensive treatment model has gradually become the mainstream of NSCLC treatment. Traditional Chinese medicine(TCM) can be used effectively either as an adjunctive therapy or alone throughout the NSCLC therapy,which has a significant impact on survival, quality of life, and reduction of toxicity. Therefore, this paper reviewed the theoretical basis, the latest clinical application, and combined treatment mechanisms in order to explore the advantage stage of TCM treatment and the synergistic therapeutic mechanisms. | Fanming Kong Chaoran Wang Linlin Zhao Dongying Liao Xiaoqun Wang Binxu Sun Peiying Yang Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 15 | High-resolution single-cell analysis paves the cellular path for brain regeneration in salamanders显示文摘Salamanders are excellent models for studying vertebrate brain regeneration,with the promise of developing novel therapies for human brain lesions.Yet the molecular and cellular mechanism of salamander brain regeneration remains largely elusive.The insight into the evolution of complex brain structures that lead to advanced functions in the mammalian brain is also inadequate.With high-resolution single-cell RNA sequencing and spatial transcriptomics,three recent studies have reported the differentiation paths of cells in the salamander telencephalon in the journal Science,bringing both old and new cell types into the focus and shedding light on vertebrate brain evolution,devel-opment,and regeneration. | Binxu Yin Xinyun Li Gufa Lin Heng Wang | 2022 | Cell Regeneration2022，11，1： | 0 |
| 16 | Modification Mechanism and Uniaxial Fatigue Performances of A356.2 Alloy Treated by Al-Sr-La Composite Refinement-Modification Agent显示文摘Modification mechanism and uniaxial fatigue properties of A356.2 alloy treated by Al-6Sr-7La and traditional Al-5Ti-1B/Al-10Sr(hereinafter refers to traditional treated alloy) were investigated by constant stress amplitude method. Microstructure, dislocation and Si twinning of the alloys were studied by thermal analysis, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The results showed that Al-6Sr-7La possesses better refining and modification effect than Al-5Ti-1B/Al-10Sr. Meanwhile, fatigue properties of the alloy treated by Al-6Sr-7La are higher than traditional treated alloy, and this is mainly owing to that Al-6Sr-7La treated alloy has more twins in eutectic Si and lower twin spacing. In addition, higher density of nanophases formed on twin faces and La-rich clusters appear at multiple twin intersections. Stacking faults and entrapped nanophases appeared on growing Si twin faces. Impurity induced twinning(IIT) mechanism and twin plane re-entrant edge(TPRE) mechanism are valid for eutectic Si which are important for mechanical optimization of A356.2 alloy. | Liang Chang Qingfeng Zhao Xingchuan Xia Yuming Ding Binxu Guo Jian Ding Ying Tang Zan Zhang Chong Li Xiaomian Sun Junjie Guo Kaihong Song Yongchang Liu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
| 17 | A Bi-modal Model for Chinese Cities: City Size, Car Use and Land Rent显示文摘China is experiencing rapid urbanization and motorization. Urban transport congestion poses a challenge to the cities of China. Policies have been made trying to control the car use and the land use in Chinese cities without sound modelling researches. The existing literature on monocentric city modelling has shown that the parameters are critical for the outcome of the modelling. Following the Alonso-type monocentric model, this paper introduces a bi-modal model to simulate the city size, the distribution of land rent and the modal substitution in Chinese cities. We set the key parameters according to the recent available data of China′s cities, and re-explain the hypothesis of the model. Then we make a sensitivity analysis to reveal the impacts of key parameters on the Chinese cities. According to the results, we find that the wage, the price of car use and the agriculture rent have significant impacts on city size. The land supply for the private transport or the public transport has the strongest impacts on car use and the level of transport congestion. The total population of the city and the wage level have strong impacts on land rent. Some results are counter-intuitive, but explainable. We also discuss implication of these results for policy making. | DAI Teqi WANG Liang ZHOU Binxue | 2016 | Chinese Geographical Science2016，26，5： | 0 |
| 18 | A Styrylpyrone Dimer from the Bark of Goniothalamus leiocarpus显示文摘A dimer of styrylpyrone derivative, leiocarpin E (1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested. | QingMU YiNengHE WeiDongTANG ChaoMingLI LiGuangLOU HanDongSUN BinXU GuoXunYANG ChangQiHU | 2004 | Chinese Chemical Letters2004，15，2： | 0 |
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