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26篇 您的检索式:作者名="Bingqian Li"
    题名 作者 年代 出处 被引量
1A Chance-Constrained Wind Range Quantification Approach to Robust SCUC by Determining Dynamic Uncertainty Intervals显示文摘With increasing penetration of wind energy,the variability and uncertainty of wind resources have become important factors for power systems operation.In particular,an effective method is required for identifying the stochastic range of wind power output,in order to better guide the operational security of power systems.This paper proposes a metric to determine accurate wind power output ranges so that the probability of actual wind power outputs being out of the range would be less than a small pre-defined value.A mixed-integer linear programming(MILP)based chance-constrained optimization model is proposed for efficiently determining optimal wind power output ranges,which are quantified via maximum and the minimum wind generation levels with respect to a certain time interval.The derived wind power range is then used to construct dynamic uncertainty intervals for the robust securityconstrained unit commitment(SCUC)model.A comparison with the deterministic SCUC model and the traditional robust SCUC model with presumed static uncertainty interval demonstrates that the proposed approach can offer more accurate wind power variabilities(i.e.,different variability degrees with respect to different wind power output levels at different time periods).The proposed approach is also shown to offer more effective and robust SCUC solutions,guaranteeing operational security and economics of power systems.Numerical case studies on a 6-bus system and the modified IEEE 118-bus system with realworld wind power data illustrate the effectiveness of the proposed approach.Aditi Upadhyay Bingqian Hu Jie Li Lei Wu 2016CSEE Journal of Power and Energy Systems2016,2,1:6
2Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu 2017Acta Biochimica et Biophysica Sinica2017,49,5:5
3Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia.Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li 2021Acta Biochimica et Biophysica Sinica2021,53,7:3
4Nematode-Encoded RALF Peptide Mimics Facilitate Parasitism of Plants through the FERONIA Receptor Kinase显示文摘The molecular mechanism by which plants defend against plant root-knot nematodes(RKNs)is largely unknown.The plant receptor kinase FERONIA and its peptide ligands,rapid alkalinization factors(RALFs),regulate plant immune responses and cell expansion,which are two important factors for successful RKN parasitism.In this study,we found that mutation of FERONIA in Arabidopsis thaliana resulted in plants showing low susceptibility to the RKN Meloidogyne incognita.To identify the underlying mechanisms associated with this phenomenon,we identified 18 novel RALF-likes from multiple species of RKNs and showed that two RALF-likes(i.e.,MiRALF1 and MiRALF3)from M.incognita were expressed in the esophageal gland with high expression during the parasitic stages of nematode development.These nematode RALF-likes also possess the typical activities of plant RALFs and can directly bind to the extracellular domain of FERONIA to modulate specific steps of nematode parasitism-related immune responses and cell expansion.Genetically,both MiRALF1/3 and FERONIA are required for RKN parasitism in Arabidopsis and rice.Collectively,our study suggests that nematode-encoded RALFs facilitate parasitism via plant-encoded FERONIA and provides a novel paradigm for studying host-pathogen interactions.Xin Zhang Huan Peng Sirui Zhu Junjie Xing Xin Li Zhaozhong Zhu Jingyuan Zheng Long Wang Bingqian Wang Jia Chen Zhenhua Ming Ke Yao Jinzhuo Jian Sheng Luan Devin Coleman-Derr Hongdong Liao Yousong Peng Deliang Peng Feng Yu 2020Molecular Plant2020,13,10:3
5Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways显示文摘Monascus vinegar(MV) is a typical fermented food with various health-promoting effects. This study aimed to evaluate the role of MV in alleviating high-fat-diet-induced inflammation in rats with hyperlipidemia and elucidate the possible regulatory mechanisms. In the study, serum lipid profiles, liver pathology and liver inflammatory cytokines were analyzed in hyperlipidemia rats with MV(0.5 mL/kg mb, 2 mL/kg mb). Results showed that the administration of MV alleviated dyslipidemia by decreasing the serum and liver levels of triglyceride and total cholesterol. Increase in hepatic lipase and carnitine palmitoyl transferase 1(CPT-1)levels and decrease in hepatocyte steatosis, nephritis, and intestinal tissue injury in the HD group showed that high-dose MV can significantly suppress hepatic lipid accumulation and steatosis. In addition, compared with the model(MOD) group, the HD group showed significantly down-regulated the level of serum or hepatic alanine aminotransferase(ALT), aspartate aminotransferase(AST), CPT-1, interleukin(IL)-2, IL-6, IL-12,and tumor necrosis factor α(TNF-α). Moreover, the HD group showed repressed hepatic nuclear factor κB(NF-κB) pathway and inactivated phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR) pathway mitigated liver inflammation. Similar results were obtained from cell experiments. Collectively, these findings revealed that MV might attenuate high-fat-diet-induced inflammation by inhibiting the NF-κB and PI3K/Akt/mTOR pathways.Huanmei Meng Jia Song Bingqian Fan Yingqi Li Jiaojiao Zhang Jinping Yu Yu Zheng Min Wang 2022Food Science and Human Wellness2022,11,4:2
6Nanogold–polyaniline–nanogold microspheres-functionalized molecular tags for sensitive electrochemical immunoassay of thyroid-stimulating hormone显示文摘Yuling Cui Huafeng Chen Li Hou Bing Zhang Bingqian Liu Guonan Chen Dianping Tang 2012Analytica Chimica Acta2012,,:1
7Combined organic-inorganic fertilization builds higher stability of soil and root microbial networks than exclusive mineral or organic fertilization显示文摘Plant health and performance are highly dependent on the root microbiome.The impact of agricultural management on the soil microbiome has been studied extensively.However,a comprehensive understanding of how soil types and fertilization regimes affect both soil and root microbiome is still lacking,such as how fertilization regimes affect the root microbiome's stability,and whether it follows the same patterns as the soil microbiome.In this study,we carried out a longterm experiment to see how different soil types,plant varieties,and fertilizer regimens affected the soil and root bacterial communities.Our results revealed higher stability of microbial networks under combined organic-inorganic fertilization than those relied solely on inorganic or organic fertilization.The root microbiome variation was predominantly caused by total nitrogen,while the soil microbiome variation was primarily caused by pH and soil organic matter.Bacteroidetes and Firmicutes were major drivers when the soil was amended with organic fertilizer,but Actinobacteria was found to be enriched in the soil when the soil was treated with inorganic fertilizer.Our findings demonstrate how the soil and root microbiome respond to diverse fertilizing regimes,and hence contribute to a better understanding of smart fertilizer as a strategy for sustainable agriculture.Luhua Yang Renhua Sun Jungai Li Limei Zhai Huiling Cui Bingqian Fan Hongyuan Wang Hongbin Liu 2023Soil Ecology Letters2023,5,2:1
8Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi 2016Acta Biochimica et Biophysica Sinica2016,48,12:1
9Resequencing of sweetpotato germplasm resources reveals key loci associated with multiple agronomic traits显示文摘Sweetpotato is an important crop that exhibits hexaploidy and high heterozygosity,which limits gene mining for important agronomic traits.Here,314 sweetpotato germplasm resources were deeply resequenced,and 4599509 SNPs and 846654 InDels were generated,among which 196124 SNPs were nonsynonymous and 9690 InDels were frameshifted.Based on the Indels,genome-wide marker primers were designed,and 3219 of 40366 primer pairs were selected to construct the core InDel marker set.The molecular ID of 104 sweetpotato samples verified the availability of these primers.The sweetpotato population structures were then assessed through multiple approaches using SNPs,and diverse approaches demonstrated that population stratification was not obvious for most Chinese germplasm resources.As many as 20 important agronomic traits were evaluated,and a genome-wide association study was conducted on these traits.A total of 19 high-confidence loci were detected in both models.These loci included several candidate genes,such as IbMYB1,IbZEP1,and IbYABBY1,which might be involved in anthocyanin metabolism,carotenoid metabolism,and leaf morphogenesis,respectively.Among them,IbZEP1 and IbYABBY1 were first reported in sweetpotato.The variants in the promoter and the expression levels of IbZEP1 were significantly correlated with f lesh color(orange or not orange)in sweetpotato.The expression levels of IbYABBY1 were also correlated with leaf shape.These results will assist in genetic and breeding studies in sweetpotato.Shizhuo Xiao Xibin Dai Lingxiao Zhao Zhilin Zhou Lukuan Zhao Pan Xu Bingqian Gao An Zhang Donglan Zhao Rui Yuan Yao Wang Jie Wang Qinglian Li Qinghe Cao 2023Horticulture Research2023,10,1:1
10Structural morphologies of Cu–Sn–Bi immiscible alloys with varied compositions显示文摘Bingqian Ma Jianqiang Li Zhijian Peng Guocai Zhang 2012Journal of Alloys and Compounds2012,,:1
11Research on the characteristics of the sweep cir- cuit of streak camera 显示文摘LI Bingqian WANG Yongchang ZHANG Xiaoqiu 1998Journal of Xi'' an Jiaotong University1998,32,4:1
12Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI显示文摘Salvia miltiorrhiza Bge(SMB)has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases.Growing clinical usage has led to a huge demand for artificial planting of SMB.Thus,continuous cropping of SMB is an important challenge that needs to be addressed.Continuous cropping can alter the metabolic profile of plants,resulting in poor growth and low yield.In this study,we tried to image the spatial location and variation of endogenous metabolites in continuously cropped SMB using matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDIMSI).Spatially resolved expressions of tanshinones,salvianolic acids,polyamines,phenolic acids,amino acids,and oligosaccharides in normal and continuously cropped SMB roots were compared.The expressions of dihydrotanshinone Ⅰ,tanshinone Ⅱ A,dehydromiltirone,miltirone,dehydrotanshinone ⅡA,spermine,salvianolic acid B/E,tetrasaccharide,and pentasaccharide in continuously cropped SMB roots were much lower than those in normal roots.There was little difference in the expressions of caffeic acid and salvianolic acid A in normal and continuously cropped SMB roots.Ferulic acid was more widely distributed in xylem of normal SMB but strongly expressed in xylem,phloem,and cambium of continuously cropped SMB.The spatially resolved metabolite information enhances our understanding of the metabolic signature of continuously cropped SMB and also provides insights into the metabolic effects of continuous cropping in other plants.Chenglong Sun Li Cui Bingqian Zhou Xiao Wang Lanping Guo Wei Liu 2022Journal of Pharmaceutical Analysis2022,12,5:1
13The status quo review and suggested policies for shale gas development in China显示文摘Li Yanbin Li Yun Wang Bingqian Chen Zhuo&apos er Nie Dan 2016Renewable and Sustainable Energy Reviews2016,59,:1
14Novel structural annotation and functional expression analysis of GTP_EFTU conserved genes in pepper based on the PacBio sequencing data显示文摘Genes containing GTP_EFTU domain mainly express elongation factors(EF),Small GTPases,and GTP-binding proteins,which are closely related to protein synthesis,extension and ATP synthesis.In this study,we identified 39 genes containing GTP_EFTU domains from peppers.The evolutionary trees constructed from capsicum,Arabidopsis,rice,and tomato are mainly divided into 7 subfamilies.Using PacBio(Pacific Biosciences)sequencing and assembly data,we extracted these 39 gene sequences,fromwhich 25 genes had alternative splicing.Particularly,the Capana08g000545 had 16 alternative splicing processes.Accordingly,we performed promoter sequence analysis,subcellular location prediction,the expression analysis of different tissues and periods,and also the GO(Gene ontology)analysis of co-expressed genes.Lastly we did the qRTPCR analysis in 5 stages of pepper fruit development.These analyses revealed important structural and functional information for the identified 39 genes that contain GTP_EFTU domains,providing important references for further follow-up experiments to verify the genes function on plants or their unique roles in peppers.Bingqian Tang Lingling Xie Xuefeng Li Huiping Yang Yi Liu Xiang Cheng Chenliang Liang Juan Chen Shudong Zhou Duanhua Wang Jingyuan Zheng Xiongze Dai Xuexiao Zou Feng Liu 2021Horticultural Plant Journal2021,7,5:1
15Atomic switches of metallic point contacts by plasmonic heating显示文摘Electronic switches with nanoscale dimensions satisfy an urgent demand for further device miniaturization.A recent heavily investigated approach for nanoswitches is the use of molecular junctions that employ photochromic molecules that toggle between two distinct isoforms.In contrast to the reports on this approach,we demonstrate that the conductance switch behavior can be realized with only a bare metallic contact without any molecules under light illumination.We demonstrate that the conductance of bare metallic quantum contacts can be reversibly switched over eight orders of magnitude,which substantially exceeds the performance of molecular switches.After the switch process,the gap size between two electrodes can be precisely adjusted with subangstrom accuracy by controlling the light intensity or polarization.Supported by simulations,we reveal a more general and straightforward mechanism for nanoswitching behavior,i.e.,atomic switches can be realized by the expansion of nanoelectrodes due to plasmonic heating.Weiqiang Zhang Hongshuang Liu Jinsheng Lu Lifa Ni Haitao Liu Qiang Li Min Qiu Bingqian Xu Takhee Lee Zhikai Zhao Xianghui Wang Maoning Wang Tao Wang Andreas Offenhausser Dirk Mayer Wang-Taek Hwang Dong Xiang 2019Light(Science & Applications)2019,8,1:1
16NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry显示文摘Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread.Therefore,the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial.Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus(PRV)and vesicular stomatitis virus(VSV)infection,we found that U18666A,a specific inhibitor of Niemann-Pick C1(NPC1),is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma mem-brane,thereby inhibiting the dynamics of clathrin-coated pits(CCPs),which are indispensable for clathrin-mediated endocytosis.Significantly,exogenous cholesterol can complement the dynamics of CCPs,leading to efficient viral entry and infectivity.Administration of U18666A improves the survival and pathology of PRV-and influenza A virus-infected mice.Thus,our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity,indicating a potential new therapeutic strategy against SARS-CoV-2,as well as other emerging viruses.Guoli Li Bingqian Su Pengfei Fu Yilin Bai Guangxu Ding Dahua Li Jiang Wang Guoyu Yang Beibei Chu 2022Science China(Life Sciences)2022,65,2:1
17Effects of confined space and near vision stimulation on refractive status and vitreous chamber depth in adolescent rhesus monkeys显示文摘This study aimed to investigate the effects of sustained near vision stimulation,on the refractive development and elongation of the vitreous chamber in adolescent rhesus monkeys.A total of 12 adolescent rhesus monkeys(1.5-2.0 years old) were randomly assigned to 3 groups.In groups A(n=4) and B(n=4),monkeys were reared in close-vision cages for 8 and 4 h d-1,respectively;tiny granules were added on the cage floor to avoid visual deprivation and to encourage near gaze.In group C(n=4),monkeys were reared in open-vision cages,with non-granule food as a control.Vitreous chamber depth,refractive status,and corneal refractive power were assessed over 18 months.Paired t-test was used to compare the differences and a P-value<0.05 was considered to be statistically significant.In group A,vitreous chamber depth and optical axis elongated significantly,and refractive error shifted towards myopia during the observation period.In group B,vitreous chambers and optical axis elongated but the refractive power did not show significant changes.In group C,there was no significant elongation in vitreous chambers and optical axis,and the refractive power changed slightly towards hypermetropia.There were no significant changes in corneal refractive power in each group.Sustained near vision can promote vitreous chamber growth and induce myopic shifts in refractive power in adolescent monkeys.Our results demonstrate the potential for a primate model of near-work-related myopia.LENG YunXia,LAN WeiZhong,YU KeMing,LIU BingQian,YANG ZhiKuan,LI Zheng,ZHONG XingWu,ZHANG ShaoChong & GE Jian* State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China 2010Science China(Life Sciences)2010,53,12:1
18Irrigation and nitrogen fertiliser optimisation in protected vegetable fields of northern China:Achieving environmental and agronomic sustainability显示文摘Globally,sub-optimal use of nitrogen (N) fertiliser and elevated N irrigation groundwater have led to high leached nitrate (NO_(3)^(–)) losses from protected vegetable field systems.Optimising fertiliser and irrigation management in different soil types is crucial to reduce future N loads from such systems.The present 4-year study examined leached N loads from lysimeter monitoring arrays set up across 18 protected vegetable system sites encompassing the dominant soil types of northern China.The treatments applied at each field site were:1) a high N and high irrigation input treatment (HNHI);2) a low N but high irrigation input treatment (LNHI) and 3) a low N with low irrigation input treatment (LNLI).Results showed that the mean annual leached total nitrogen loads from the HNHI,LNHI and LNLI treatments were 325,294 and 257 kg N ha^(–1) in the fluvo-aquic soil,114,100 and 78 kg N ha^(–1) in the cinnamon soil and 79,68 and 57 kg N ha^(–1) in the black soil,respectively.The N dissolved in irrigation water in the fluvo-aquic soil areas was 8.26-fold higher than in the cinnamon areas.A structural equation model showed that N fertiliser inputs and leaching water amounts explained 14.7 and 81.8%of the variation of leached N loads,respectively.Correspondingly,reducing irrigation water by 21.5%decreased leached N loads by 20.9%,while reducing manure N and chemical N inputs by 22 and 25%decreased leached N loads by only 9.5%. This study highlights that protected vegetable fields dominated by fluvo-aquic soil need management to curtail leached N losses in northern China.Bingqian Fan Yitao Zhang Owen Fenton Karen Daly Jungai Li Hongyuan Wang Limei Zhai Xiaosheng Luo Qiuliang Lei Shuxia Wu Hongbin Liu 2024Journal of Integrative Agriculture2024,23,3:0
19Changes in plant debris and carbon stocks across a subalpine forest successional series显示文摘Background:As a structurally and functionally important component in forest ecosystems,plant debris plays a crucial role in the global carbon cycle.Although it is well known that plant debris stocks vary greatly with tree species composition,forest type,forest origin,and stand age,simultaneous investigation on the changes in woody and non-woody debris biomass and their carbon stock with forest succession has not been reported.Therefore,woody and non-woody debris and carbon stocks were investigated across a subalpine forest successional gradient in Wanglang National Nature Reserve on the eastern Qinghai-Tibet Plateau.Results:Plant debris ranged from 25.19 to 82.89 Mg∙ha−1 and showed a global increasing tendency across the subalpine forest successional series except for decreasing at the S4 successional stage.Accordingly,the ratios of woody to non-woody debris stocks ranged from 26.58 to 208.89,and the highest and lowest ratios of woody to non-woody debris stocks were respectively observed in mid-successional coniferous forest and shrub forest,implying that woody debris dominates the plant debris.In particular,the ratios of coarse to fine woody debris stocks varied greatly with the successional stage,and the highest and lowest ratios were found in later and earlier successional subalpine forests,respectively.Furthermore,the woody debris stock varied greatly with diameter size,and larger diameter woody debris dominated the plant debris.Correspondingly,the carbon stock of plant debris ranged from 10.30 to 38.87 Mg∙ha−1 across the successional series,and the highest and lowest values were observed in the mid-coniferous stage and shrub forest stage,respectively.Most importantly,the carbon stored in coarse woody debris in later successional forests was four times higher than in earlier successional forests.Conclusions:The stock and role of woody debris,particularly coarse woody debris,varied greatly with the forest successional stage and dominated the carbon cycle in the subalpine forest ecosystem.Thus,preserving coarse woody debris is a critical strategy for sustainable forest management.Zhihui Wang Lianjun Zhao Yi Bai Fei Li Jianfeng Hou Xuqing Li Yurui Jiang Yuyue Deng Bingqian Zheng Wanqin Yang 2021Forest Ecosystems2021,8,3:0
20The advantages of penehyclidine hydrochloride over atropine in acute organophosphorus pesticide poisoning:A meta-analysis显示文摘Background:Penehyclidine hydrochloride(PHC)has been used for many years as an anticholinergic drug for the treatment of acute organophosphorus pesticide poisoning(AOPP).The purpose of this meta-analysis was to explore whether PHC has advantages over atropine in the use of anticholinergic drugs in AOPP.Methods:We searched Scopus,Embase,Cochrane,PubMed,ProQuest,Ovid,Web of Science,China Science and Technology Journal Database(VIP),Duxiu,Chinese Biomedical literature(CBM),WanFang,and Chinese National Knowledge Infrastructure(CNKI),from inception to March 2022.After all qualified randomized controlled trials(RCTs)were included,we conducted quality evaluation,data extraction,and statistical analysis.Statistics using risk ratios(RR),weighted mean difference(WMD),and standard mean difference(SMD).Results:Our meta-analysis included 20,797 subjects from 240 studies across 242 different hospitals in China.Compared with the atropine group,the PHC group showed decreased mortality rate(RR=0.20,95%confidence intervals[CI]:0.16–0.25,P<0.001),hospitalization time(WMD=-3.89,95%CI:-4.37 to-3.41,P<0.001),overall incidence rate of complications(RR=0.35,95%CI:0.28–0.43,P<0.001),overall incidence of adverse reactions(RR=0.19,95%CI:0.17–0.22,P<0.001),total symptom disappearance time(SMD=-2.13,95%CI:-2.35 to-1.90,P<0.001),time for cholinesterase activity to return to normal value 50–60%(SMD=-1.87,95%CI:-2.03 to-1.70,P<0.001),coma time(WMD=-5.57,95%CI:-7.20 to-3.95,P<0.001),and mechanical ventilation time(WMD=-2.16,95%CI:-2.79 to-1.53,P<0.001).Conclusion:PHC has several advantages over atropine as an anticholinergic drug in AOPP.Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Xinxin Guo Yi Li Yi Gou Yao Zhang Shengming Li Shaotong Zhang Xiaoxuan Wu Meihong Li Jing Lei Bingqian Li Chengfei Bi Like Ma Qingpeng Luo 2023Journal of Intensive Medicine2023,3,2:0
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