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| 1 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 2 | FH 17 cells in human recurrent pregnancy loss and ~re-eclampsia显示文摘 | Binqing Fu | 2014 | Cellular & Molecular Immunology2014，11，6： | 36 |
| 3 | Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface显示文摘During early pregnancy,an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development.Remodeling of the immune system involves natural killer cells(NKs),macrophages,T cells and dendritic cells(DCs) altering the microenvironment in the deciduas.In particular,a unique population of NK cells with a CD56^(bright)CD16^- phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy.However,there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the maternal immune system should be suppressed.This tendency is misleading.We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth.We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells. | Binqing Fu Haiming Wei | 2016 | Science China(Life Sciences)2016，59，12： | 15 |
| 4 | α-Asarone suppresses the proliferation and migration of ASMCs through targeting the IncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats显示文摘气喘是长期的煽动性的肺的疾病,呼吸 syncytial 病毒(RSV ) 感染是在婴儿和小孩子的更低的呼吸的道病的一个普通原因。-Asarone 介绍许多药理学效果并且被表明了在对待气喘有用。然而,在感染 RSV 的气喘的 -asarone 的功能的机制没被调查。长非编码的 RNA (lncRNAs ) 被报导了在许多生物过程起关键作用。尽管许多 lncRNAs 被描绘了,很少在气喘被报导,特别在导致 RSV 的气喘。当前,一条新奇 post-transcriptional 规定在哪个 lncRNAs 作为竞争内长的 RNA (ceRNAs ) 工作竞争地擦掉 miRNAs 被建议了,从而调整目标基因。在现在的学习,我们建立了一个感染 RSV 的 Sprague-Dawley 老鼠模型并且证明 lncRNA-PVT1 在对待导致 RSV 的气喘,和 lncRNA-PVT1 涉及 -asarone 的机制由作为竞争地擦掉 miR-203a 的 ceRNA 工作调整 E2F3 的表示。 | Xiao Yu Zhe Zhe Binqing Tang Shaobin Li Ling Tang Yingen Wu Xiaorong Chen Hong Fang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 14 |
| 5 | Effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation显示文摘OBJECTIVE: To observe the effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation. METHODS: One hundred and fifty one patients with moderate to severe persistent asthma were randomly divided into a treatment group (n=74) and a control group (n=69). Both groups were given basic treatment according to the Global Initiative for Asthma scheme. The treatment group was also treated with herbal paste in the winter. The frequency of asthma exacerbation, cold and cold-re-lated asthma exacerbation, scores of the asthma control test (ACT), and kidney-deficiency syndrome during the one-year follow-up in each group were recorded. RESULTS: Compared with the control group, the onset frequencies of catching cold, asthma exacerbation, cold-related asthma exacerbation, and kidney-deficiency syndrome score were significantly reduced. There was no significant difference in scores of ACT between the two groups. CONCLUSION: 'Yang-warming and kidney essence-replenishing' herbal paste could reduce cold-related asthma exacerbation. | Binqing Tang Kehua Shi Xiaoqi Li Hongchang Wang Hong Fang Bidan Xiong Yingen Wu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 3 |
| 6 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 7 | Arabidopsis ECAP Is a New Adaptor Protein that Connects JAZ Repressors with the TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation显示文摘Suppression mechanisms mediated by transcriptional repressors commonly exist in diverse phytohormone signaling pathways.In Arabidopsis thaliana,JASMONATE-ZIM DOMAIN(JAZ)proteins are transcriptional repressors that function as negative regulators of diverse JA responses.Novel Interactor of JAZ(NINJA)is an adaptor protein connecting JAZs with the co-repressor,TOPLESS(TPL),to mediate gene repression in JA-dependent root growth inhibition and defense pathways.However,whether NINJA or other adaptor proteins are employed in other JA-responsive biological processes remains to be elucidated.In the present study,we demonstrate that a previously uncharacterized protein,ECAP(EAR motif-Containing Adaptor Protein),directly interacts with JAZ6 and JAZ8 and enhances their transcriptional repression activities.We provide evidence that ECAP is a novel adaptor protein for JAZ6/8 recruitment of the transcriptional co-repressor,TOPLESS-RELATED 2(TPR2),into a transcriptional repressor complex that represses the WD-repeat/bHLH/MYB complex,an important transcriptional activator in the JA-dependent anthocyanin biosynthesis pathway.Our findings,together with previous reports,reveal that specific adaptor proteins play a critical role in distinct JA responses by pairing different JAZs(which possess overlapping but also specific functions)with the general co-repressors,TPL and TPRs. | Changjiang Li Lei Shi Yanan Wang Wei Li Binqing Chen Lei Zhu Ying Fu | 2020 | Molecular Plant2020，13，2： | 2 |
| 8 | Analysis of uterine CD49a^(+) NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion显示文摘Maternal uterine immune cells,especially natural killer(NK)cells,are important for successful pregnancy,and an abnormal number or function of uterine NK cells is closely correlated with an impaired endometrial environment and miscarriage.However,there are currently no noninvasive testing methods using reliable indicators that accurately predict uterine changes leading to miscarriage.Here,we confirmed that before implantation,menstrual blood(MB)from healthy donors had 70%CD49a^(+)tissue-resident NK(trNK)cells,the majority of which were CD49a^(+)Eomes+NK cells.Importantly,MB from patients with recurrent spontaneous abortion(RSA)had many fewer CD49a^(+)trNK cells than MB from controls.Analysis of uNK cell populations in MB may better predict an abnormal endometrial environment associated with miscarriage than peripheral blood(PB)analysis.Therefore,we suggest using MB-and CD49a-related markers as a promising noninvasive way to evaluate endometrial status. | Xianhong Tong Min Gao Xianghui Du Fangting Lu Limin Wu Haiming Wei Binqing Fu | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 9 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 10 | Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface显示文摘 | Binqing Fu Xianchang Li Rui Sun | 2012 | PNAS2012，，12： | 1 |
| 11 | Towards Improvement of Photovoltaic Performance of Aqueous Dye-sensitized Solar Cells by Tungsten-doped Mesoporous Nanobeads TiO_2 Working Electrode显示文摘Tungsten doped(W-doped) TiO_2 mesoporous nanobeads, possessing high surface area and superior scattering effect, were used for photoanode preparation. The W-doping would induce a positive shift of the TiO_2 conduction band, and enhance the driving force for electron injection and collection efficiencies. The electrochemical impedance spectra indicated a retarded charge recombination and increased electron diffusion length after W-doping. By fine-tuning the W-doping concentration to 0.25%, aqueous DSCs produced a significant improved the open circuit voltage of 712 mV and a short circuit current of 7.05 mA·cm^(-2), leading to an overall increased power conversion efficiency of 3.40% at 1 000 W·m^(-2) simulated irradiation, which is roughly 25% enhancement compared to that without W-doping photoanode. | 郭言荣 ZOU Tingting CHENG Qin JIAO Binqing 张晓俐 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 12 | Restoration of HBV-specific CD8+T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-αtherapy显示文摘Patients with chronic hepatitis B(CHB)undergoing interferon(IFN)-α-based therapies often exhibit a poor HBeAg serological response.Thus,there is an unmet need for new therapies aimed at CHB.This study comprised two clinical trials,including 130 CHB patients,who were treatment-naïve;in the first,92 patients were systematically analyzed ex vivo for interleukin-2 receptor(IL-2R)expression and inhibitory molecules expression after receiving Peg-IFN-α-2b therapy.In our second clinical trial,38 non-responder patients,in whom IFN-αtherapy had failed,were treated with or without low-dose IL-2 for 24 weeks.We then examined the hepatitis B virus(HBV)-specific CD8+T-cell response and the clinical outcome,in these patients.Although the majority of the participants undergoing Peg-IFN-α-2b therapy were non-responders,we observed a decrease in CD25 expression on their CD4+T cells,suggesting that IFN-αtherapy may provide a rationale for sequential IL-2 treatment without increasing regulatory T cells(Tregs).Following sequential therapy with IL-2,we demonstrated that the non-responders experienced a decrease in the numbers of Tregs and programmed cell death protein 1(PD-1)expression.In addition,sequential IL-2 administration rescued effective immune function,involving signal transducer and activator of transcription 1(STAT1)activation.Importantly,IL-2 therapy significantly increased the frequency and function of HBV-specific CD8+T cells,which translated into improved clinical outcomes,including HBeAg seroconversion,among the non-responder CHB patients.Our findings suggest that sequential IL-2 therapy shows efficacy in rescuing immune function in non-responder patients with refractory CHB. | Dongyao Wang Binqing Fu Xiaokun Shen Chuang Guo Yanyan Liu Junfei Zhang Rui Sun Ying Ye Jiabin Li Zhigang Tian Haiming Wei | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 13 | A one ppm NDIR methane gas sensor with single frequency filter denoising algorithm显示文摘 | Zhu Zeping Xu Yuhui Jiang Binqing | 2012 | Sensors2012，12，12： | 1 |
| 14 | Influence of hte Size and the Size Grading of Aggregate on ASR Expansion显示文摘 | Zhang Chengzhi Wang Aiqin Tang Mingshu Wu Binqing Zhang Ning-sheng | 1999 | C ement and Concrete Research1999，29，： | 1 |
| 15 | Source characteristics of long runout rock avalanches triggered by the 2008 Wenchuan earthquake, China显示文摘 | QI SHENGWEN XU QIANQ ZHANG BINQ | 2011 | Journal of Asian Earth Science2011，40，4： | 1 |
| 16 | Hydrogen storage of dense-aligned carbon nanotubes显示文摘 | Anyuan Cao Hongwei Zhu Xianfeng Zhang Xuesong Li Dianbo Ruan Cailu Xu Binqing Wei Ji Liang Dehai Wu | 2001 | Chemical Physics Letters2001，，5： | 1 |
| 17 | Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has become a global public health crisis.Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital.How such retest-positive(RTP)patients become infected again is not known.In this study,30 RTP patients,20 convalescent patients,and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells.We found that absolute numbers of CD4^(+)T cells,CD8^(+)T cells,and natural killer cells were not substantially decreased in RTP patients,but the expression of activation markers on these cells was significantly reduced.The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients.Through transcriptome sequencing,we demonstrated that high expression of inhibitor of differentiation 1(ID1)and low expression of interferon-induced transmembrane protein 10(IFITM10)were associated with insufficient activation of immune cells and the occurrence of RTP.These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP,which may contribute to a better understanding of the mechanisms underlying RTP. | Dongyao Wang Dong Wang Min Huang Xiaohu Zheng Yiqing Shen Binqing Fu Hong Zhao Xianxiang Chen Peng Peng Qi Zhu Yonggang Zhou Jinghe Zhang Zhigang Tian Wuxiang Guan Guiqiang Wang Haiming Wei | 2021 | Journal of Molecular Cell Biology2021，13，10： | 0 |
| 18 | In Situ Growth of Vanadium Oxide on Reduced Graphene Oxide for the Low-Temperature NO-SCR by NH3显示文摘The vanadium oxide/reduced graphene oxide (V2O5/rGO) composite catalyst which determined the selective catalytic reduction activity (SCR) of NO with NH3 was prepared by a simple solvothermal method. The physicochemical properties of the catalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman, X-ray energy spectrometer (XPS) and N2 sorption isotherm measurement (BET). Results of NH3-SCR showed that the NO conversion of V2O5/rGO catalyst could reach 54.3% at 100 °C. And the removal of NO increased to 74.6% when the temperature was up to 220℃. By characterizing the microstructure and morphology of the V2O5/rGO catalysts prepared by in-situ growth and mechanical mixing methods, it was further shown that V2O5 nanoparticles were highly dispersed and in situ growth on the rGO surface. Based on X-ray energy spectrometer, V2O5/rGO catalyst had good low temperature denitrification performance due to the chemical adsorption oxygen and low-valent vanadium oxide contained in V2O5/rGO catalyst, which was beneficial to the redox reaction between V2O5 and graphene. | 李美颜 QI Yanyuan 金伟 JIAO Binqing ZHAO Jie | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，3： | 0 |
| 19 | 肿瘤微环境通过诱导NK细胞代谢重编程抑制杀伤功能显示文摘文章简介自然杀伤(NK)细胞是一种效应淋巴细胞,在机体抵抗肿瘤过程中发挥至关重要的作用。NK细胞无需预先致敏,即能够直接杀伤肿瘤细胞,并且能够通过分泌细胞因子促进适应性免疫的抗肿瘤作用。基于上述原理,NK细胞在肿瘤免疫治疗中的价值已得到广泛认可。 | 丛靖婧 Xianwei Wang Xiaohu Zheng Dong Wang Binqing Fu Rui Sun 田志刚 魏海明 | 2019 | 科学新闻2019，0，2： | 0 |
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