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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015,21,1: | 6 |
| 2 | Altered central pain processing after pancreatic surgery for chronic pancreatitis显示文摘 | S. A. Bouwense U. Ahmed Ali R. P. ten Broek Y. Issa C. H. van Eijck O. H. Wilder‐Smith H. van Goor | 2013 | Br J Surg2013,,13: | 3 |
| 3 | Abdominal compartment syndrome in acute pancreatitis:a systematic review显示文摘 | van Brunschot S Schut AJ Bouwense SA | 2014 | Pancreas2014,43,5: | 1 |
| 4 | Compari-son of mesiodistal root angulation with posttreatment pano-ramic radiographs and cone-beam computed tomography显示文摘 | Bouwens DG Cevidanes L Ludlow JB | | 0,,01: | 1 |
| 5 | Endoscopic appearance of proximal colorectal neoplasms and potential implications for colonoscopy in cancer prevention显示文摘 | Eveline J.A. Rondagh Mari?lle W.E. Bouwens Robert G. Riedl Bjorn Winkens Rogier de Ridder Tonya Kaltenbach Roy M. Soetikno Ad A.M. Masclee Silvia Sanduleanu | 2012 | Gastrointestinal Endoscopy2012,,6: | 1 |
| 6 | Abdominal compartment syndrome in acute pancreatitis: a systematic review显示文摘 | van Brunschot S Schut AJ Bouwense SA | 2014 | Pancreas2014,43,5: | 1 |
| 7 | Pregabalin Reduces Pain in Patients With Chronic Pancreatitis in a Randomized, Controlled Trial显示文摘 | S?ren Schou Olesen Stefan A.W. Bouwense Oliver H.G. Wilder–Smith Harry van Goor Asbj?rn Mohr Drewes | 2011 | Gastroenterology2011,,2: | 1 |
| 8 | Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial 显示文摘 | OLESEN S S BOUWENSE S A WILDER-SMITH O H | 2011 | Gastroenterology2011,141,2: | 1 |
| 9 | Has Central Sensitization Become Independent of Nociceptive Input in Chronic Pancreatitis Patients Who Fail Thoracoscopic Splanchnicectomy?显示文摘 | Stefan A.W. Bouwense Hessel C.J.L. Buscher Harry van Goor Oliver H.G. Wilder-Smith | 2011 | Regional Anesthesia and Pain Medicine2011,,6: | 1 |
| 10 | In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells显示文摘 | L. Baeyens S. Breuck J. Lardon J. K. Mfopou I. Rooman L. Bouwens | 2005 | Diabetologia2005,,1: | 1 |
| 11 | Safety of cholecystectomy in the first 48 hours after admission for gallstone pancreatitis not yet proven显示文摘 | Bouwense SA Bakker OJ van Santvoort HC | 2011 | Ann Surg2011,253,5: | 1 |
| 12 | Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas显示文摘 | Jessy Lardon Niki Huyens Ilse Rooman Luc Bouwens | 2004 | Virchows Archiv2004,,1: | 1 |
| 13 | Mitogenic Effect of Gastrin and Expression of Gastrin Receptors in Duct-like Cells of Rat Pancreas显示文摘 | Ilse Rooman Jessy Lardon Daisy Flamez Frans Schuit Luc Bouwens | 2001 | Gastroenterology2001,,4: | 1 |
| 14 | Abdominal compartment syndrome in acute pancreatitis: a systematic review 显示文摘 | Van Brunschot S Schut AJ Bouwense SA | 2014 | Pancreas2014,43,5: | 1 |
| 15 | S- ketamine modulates hyperalgesia in patients with chronic pancreafitis pain显示文摘 | BOUWENSE S A BUSCHER H C VAN GOOR H | 2011 | Regional Anesth Pain Med2011,36,3: | 1 |
| 16 | Pancreatitis of biliary origin,optimal timing of cholecystectomy (PONCHO trial):study protocol for a randomized controlled trial 显示文摘 | Bouwense SA Besselink MG Brunschot S | 2012 | Trials2012,13,1: | 1 |
| 17 | Cellular plasticity of the pancreas显示文摘 | Luc Baeyens Luc Bouwens | 2009 | Biological Chemistry2009,,10: | 1 |
| 18 | Preoperative opioid use and the outcome of thoracoscopic splanchnicectomy in chronic pancreatitis: a systematic review显示文摘 | Yama Issa Usama Ahmed Ali Stefan A. W. Bouwense Hjalmar C. Santvoort Harry Goor | 2014 | Surgical Endoscopy2014,,2: | 1 |
| 19 | Safety of cholecystectomy in the first 48 hours after admission for gallstone pancreatitis not yet proven显示文摘 | Bouwense SA Bakker OJ van SHC et aI | 2011 | Ann Surg2011,253,5: | 1 |
| 20 | Pancreatitis of biliary origin, Optimal timing of chole- eystectomy( poncho trial) :study protocol for a randomized controlled trial显示文摘 | Bouwense SA Besselink MG Va brunschot S | 2012 | Trial2012,26,13: | 1 |