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| 1 | Hydrolysis of polyaluminum chloride prior to coagulation:Effects on coagulation behavior and implications for improving coagulation performance显示文摘The effects of polyaluminum chloride(PACl) hydrolysis prior to coagulation on both the coagulation zone and coagulation performance of a kaolin suspension were investigated by a novel jar test named the 'reversed coagulation test'.The tests showed that PACl hydrolysis prior to coagulation decreased the performance of charge neutralization coagulation in the case of short-time slow mixing(10 min;G = 15 sec-1) and increased the optimal dosage for charge neutralization and sweep coagulation.Moreover,the hydrolysis time had insignificant effects on the size and zeta potential of PACl precipitates and the residual turbidity of the raw water.However,PACl hydrolysis prior to coagulation and the size of PACl precipitates had a negligible effect on the performance of sweep coagulation.The results imply that,in practice,preparing a PACl solution with deionized water,rather than tap water or the outlet water from a wastewater treatment unit,can significantly save PACl consumption and improve the performance of charge neutralization coagulation,while preparing the PACl solution with tap or outlet water would not affect the performance of sweep coagulation.In addition,the optimal rapid mixing intensity appears to be determined by a balance between the degree of coagulant hydrolysis before contacting the primary particles and the average size of flocs in the rapid mixing period.These results provide new insights into the role of PACl hydrolysis and will be useful for improving coagulation efficiency. | Zhongguo Zhang Jun Wang Dan Liu Jiuyi Li Xiaolin Wang Boyu Song Bing Yue Kehui Zhao Yun Song | 2017 | Journal of Environmental Sciences2017，29，7： | 4 |
| 2 | Anti-arthritic effects of microneedling with bee venom gel显示文摘Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and mice to construct the model.Bee venom gelemicroneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.Results:Compared with the model group,the bee venom gelemicroneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate,and on LPS induced mouse model of acute inflammation effect and the micro.Conclusions:Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction.Choose the 750 mm microneedle with 10N force on skin about 3 minutes,bee venom can play the optimal role,and the anti-inflammatory effect is obvious.Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 3 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 4 | NO removal performance of CO in carbonation stage of calcium looping for CO_(2) capture显示文摘Calcium looping realizes CO_(2)capture via the cyclic calcination/carbonation of CaO.The combustion of fuel supplies energy for the calciner.It is unavoidable that some unburned char in the calciner flows into the carbonator,generating CO due to the hypoxic atmosphere in the carbonator.CO can reduce NO in the flue gases from coal-fired power plants.In this work,NO removal performance of CO in the carbonation stage of calcium looping for CO_(2)capture was investigated in a bubbling fluidized bed reactor.The effects of carbonation temperature,CO concentration,CO_(2)capture,type of CaO,number of CO_(2)capture cycles and presence of char on NO removal by CO in carbonation stage of calcium looping were discussed.CaO possesses an efficient catalytic effect on NO removal by CO.High temperature and high CO concentration lead to high NO removal efficiency of CO in the presence of CaO.Taking account of better NO removal and CO_(2)capture,the optimal carbonation temperature is 650℃.The carbonation of CaO reduces the catalytic activity of CaO for NO removal by CO due to the formation of CaCO_(3).Besides,the catalytic performance of CaO on NO removal by CO gradually decreases with the number of CO_(2)capture cycles.This is because the sintering of CaO leads to the fusion of CaO grains and blockage of pores in CaO,hindering the diffusion of NO and CO.The high CaO content and porous structure of calcium-based sorbents are beneficial for NO removal by CO.The presence of char promotes NO removal by CO in the carbonator.CO_(2)/NO removal efficiencies can reach above 90%.The efficient simultaneous NO and CO_(2)removal by CO and CaO in the carbonation step of the calcium looping seems promising. | Wan Zhang Yingjie Li Yuqi Qian Boyu Li Jianli Zhao Zeyan Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 5 | A protective AAV vaccine for SARS-CoV-2显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the COVID-19 pandemic,with more than 528 million infections and 6.2 million deaths.To fight against this rapidly spreading pandemic,prophylactic vaccines have been developed using different techniques,such as inactivated virus,messenger RNAs,recombinant proteins,and viral-vectored vaccines.However,rapidly spreading variants of SARS-CoV-2,such as alpha,beta,delta,and omicron variants,have been emerging. | Simeng Zhao Junzi Ke Boyu Yang Fangzhi Tan Jie Yang Chao-Po Lin Haopeng Wang Guisheng Zhong | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 6 | fractures after vertebroplasty surgery risk factors 显示文摘 | Yang Boyu Zhao Qingan Sun Yanyu | 2008 | China Journal of Orthopaedics2008，16，4： | 1 |
| 7 | Annealing treatment of focused gallium ion beam processing of SERS gold substrate显示文摘Raman spectroscopy is a type of inelastic scattering spectroscopy that is widely used in determining and analyzing molecular structure.It also has a number of practical applications in evaluating food safety,medicine,and forensics.The Raman spectral signal is weak,but the development of the surface-enhanced Raman scattering(SERS)technique has overcome this problem and led to further developments in Raman spectroscopy.This paper describes a fundamental study of the use of focused ion beam(FIB)direct writing for preparing gold substrates for SERS.Molecular dynamics and Monte Carlo simulation methods are used to investigate the damage induced by gallium ion implantation of a gold substrate.Based on characterization by x-ray photoelectron spectroscopy(XPS)and scanning electron microscopy,the mechanism by which ion implantation and annealing influence the damage induced by a gallium FIB is analyzed.After annealing at 350 XC,a mixture of metallic gallium,its oxide Ga2O3 conforming to the stoichiometric ratio,and its sub-stable oxide(Ga2Ox)in sub-stoichiometric ratio precipitated on the surface are detected by XPS.Annealing treatment can effectively reduce the effect of gallium ion implantation on a SERS substrate fabricated by FIB direct writing. | Zhixiang Tao Wei Zhao Shang Wang Boyu Zhao Rushuai Hua Ji Qin Zongwei Xu | 2021 | Nanotechnology and Precision Engineering2021，4，4： | 1 |
| 8 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 9 | Mo-based perpendicularly magnetized thin films with low damping for fast and low-power consumption magnetic memory显示文摘Perpendicular magnetic anisotropy-based magnetic tunnel junctions(p-MTJs) with low Gilbert damping constant(α) are of particular interest for fast and low-power consumption magnetic random-access memory(MRAM). However, obtaining a faster switching speed and lower power consumption is still a big challenge. Herein, we report a Mo-based perpendicular double free layer structure with a low Gilbert damping constant of 0.02 relative to W-based films, as measured by time-resolved magnetooptical Kerr effect equipment. To show the influence of different film structures on the Gilbert damping constant, we measured the Mo-based single free layer. Thereafter, we deposited the full stacks with the Mo-based double free layer and obtained a high tunneling magnetoresistance of 136.3% and high thermal stability. The results of high-resolution transmission electron microscopy(HR-TEM) and energy-dispersive X-ray spectroscopy(EDS) showed that the Mo-based films had better crystallinity,sharper interfaces, and weaker diffusion than the W-based films and thus produced a weaker external contribution of the Gilbert damping constant. As a result of the weak spin-orbit coupling in the Mo-based structure, the intrinsic contribution of the Gilbert damping constant was also weak, thereby leading to the small Gilbert damping constant of the Mo-based stacks. In addition, the macro-spin simulation results demonstrated that the magnetization switching by the spin transfer torque of the Mo-based MTJs was faster than that of the W-based MTJs. These findings help to understand the mechanism behind the good performance of Mo-based p-MTJ films and show the great promise of these structures in low-power consumption MRAM or other spintronic devices. | Houyi Cheng Boyu Zhang Yong Xu Shiyang Lu Yuxuan Yao Rui Xiao Kaihua Cao Yongshan Liu Zilu Wang Renyou Xu Danrong Xiong Yan Wang Helin Ma Sylvain Eimer Chao Zhao Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 10 | Rhodanine flanked indacenodithiophene as non-fullerene acceptor for efficient polymer solar cells显示文摘A fused-ring electron acceptor IDT-2BR1 based on indacenodithiophene core with hexyl side-chains flanked by benzothiadiazole rhodanine was designed and synthesized.In comparison with its counterpart with hexylphenyl side-chains(IDT-2BR),IDT-2BR1exhibits higher highest occupied molecular orbital(HOMO)energy but similar lowest unoccupied molecular orbital(LUMO)energy(IDT-2BR1:HOMO=-5.37eV,LUMO=-3.67eV;IDT-2BR:HOMO=-5.52eV,LUMO=-3.69eV),red-shifted absorption and narrower bandgap.IDT-2BR1 has higher electron mobility(2.2×10^(-3)cm^2 V^(-1)s^(-1))than IDT-2BR(3.4×10^(-4)cm^2 V^(-1)s^(-1))due to the reduced steric hindrance and ordered molecular packing.Fullerene-free organic solar cells based on PTB7-Th:IDT-2BRl yield power conversion efficiencies up to 8.7%,higher than that of PTB7-Th:IDT-2BR(7.7%),with a high open circuit voltage of0.95 V and good device stability. | Boyu Jia Yao Wu Fuwen Zhao Cenqi Yan Siya Zhu Pei Cheng Jiangquan Mai Tsz-Ki Lau Xinhui Lu Chun-Jen Su Chunru Wang Xiaowei Zhan | 2017 | Science China Chemistry2017，60，2： | 0 |
| 11 | Spatio-temporal Variation of Water Heat Flux Using MODIS Land Surface Temperature Product over Hulun Lake,China During 2001–2018显示文摘Heat flux is important for studying interactions between atmosphere and lake.The heat exchange between air-water interfaces is one of the important ways to govern the temperature of the water surface.Heat exchange between the air-water interfaces and the surrounding environment is completed by solar radiation,conduction,and evaporation,and all these processes mainly occur at the air-water interface.Hulun Lake was the biggest lake which is also an important link and an indispensable part of the water cycle in Northeast China.This study mapped surface energy budget to better understand spatial and temporal variations in Hulun Lake in China from 2001 to 2018.Descriptive statistics were computed to build a historical time series of mean monthly heat flux at daytime and nighttime from June to September during 2001–2018.Remote sensing estimation methods we used was suitable for Hulun Lake(R2=0.81).At month scale,shortwave radiation and latent heat flux were decrease from June to September.However,the maximum sensible heat flux appeared in September.Net longwave radiation was the largest in August.The effective heat budget showed that Hulun Lake gained heat in the frost-free season with highest value in June(686.31 W/m2),and then steadily decreased to September(439.76 W/m2).At annual scale,net longwave radiation,sensible heat flux and latent heat flux all show significant growth trend from 2001 to 2018(P<0.01).Wind speed had the well correlation on sensible heat flux and latent heat flux.Water surface temperature showed the highest coefficient in sensitivity analysis. | ZHAO Boyu DU Jia SONG Kaishan Pierre-Andre JACINTHE XIANG Xiaoyun ZHOU Haohao YANG Zhichao ZHANG Liyan GUO Pingping | 2020 | Chinese Geographical Science2020，30，6： | 0 |
| 12 | Pharmacokinetics of gene recombined angiogenesis inhibitor Kringle 5 in vivo using 131I specific markers and SPECT/CT显示文摘The previous pharmacokinetic methods can be only limited to drug analysis in vitro, which provide less information on the distribution and metabolismof drugs, and limit the interpretation and assessment of pharmacokinetics, the determination of metabolic principles, and evaluation of treatment effect. The objective of the study was to investigate the pharmacokinetic characteristics of gene recombination angiogenesis inhibitor Kringle 5 in vivo. The SPECT/CT and specific^(131)I-Kringle 5 marked by Iodogen method were both applied to explore the pharmacokinetic characteristics of^(131)I-Kringle 5 in vivo, and to investigate the dynamic distributions of^(131)I-Kringle 5 in target organs. Labeling recombinant angiogenesis inhibitor Kringle 5 using131 I with longer half-life and imaging in vivo using SPECT instead of PET,could overcome the limitations of previous methods. When the doses of^(131)I-Kringle 5 were 10.0, 7.5 and5.0 g/kg, respectively, the two-compartment open models can be determined within all the metabolic process in vivo. There were no significant differences in t1/2α, t1/2β, apparent volume of distribution and CL between those three levels. The ratio of AUC(0 1)among three different groups of 10.0, 7.5 and 5.0 g/kg was 2.56:1.44:1.0, which was close to the ratio(2:1.5:1.0). It could be clear that in the range of 5.0–10.0 g/kg, Kringle 5 was characterized by the first-order pharmacokinetics. Approximately 30 min after^(131)I-Kringle 5 was injected,^(131)I-Kringle 5 could be observed to concentrate in the heart, kidneys, liver and other organs by means of planar imaging and tomography. After 1 h of being injected, more radionuclide retained in the bladder, but not in intestinal. It could be concluded that^(131)I-Kringle 5 is mainly excreted through the kidneys. About 2 h after the injection of^(131)I-Kringle 5, the radionuclide in the heart, kidneys,liver and other organs was gradually reduced, while more radionuclide was concentrated in the bladder.The radionuclide was completely metabolized within 24 h, and the distribution of radioactivity in rats was similar to normal levels. In our study, the specific marker^(131)I-Kringle 5 and SPECT/CT were successfully used to explore pharmacokinetic characteristics of Kringle 5 in rats. The study could provide a new evaluation platform of the specific, in vivo and real-time functional imaging and pharmacokinetics for the clinical application of^(131)I-Kringle 5. | Ge Yan Danrong Yang Yan Yu Jianjun Xue Yifan Jia Xuanzi Sun Boyu Wang Zewei Zhao Maode Wang | 2016 | Journal of Pharmaceutical Analysis2016，6，5： | 0 |
| 13 | Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases显示文摘A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain metastases.Immunotherapy has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from immunotherapy.Dual immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for patients.Here,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the cells.SIL@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model animals.Mechanistic studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T cells.Meanwhile,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is reversed.This study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases. | Zhenhao Zhao Chufeng Li Yiwen Zhang Chao Li Yongchao Chu Xuwen Li Peixin Liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang | 2023 | Bioactive Materials2023，，9： | 0 |
| 14 | Effects of Agricultural Insurance on Poverty Alleviation under Uncertain Price of Agricultural Products显示文摘Poverty alleviation of the rural poor is the most arduous task in building a moderately prosperous society in all respects in China, and agricultural insurance is an important financial tool for this task. Due to different capital levels, individual farmer will adopt production technology with different efficiency. In the case of uncertain price of agricultural products, this paper establishes a series of multiple equilibrium models based on agricultural risk and agricultural insurance. Under the catastrophe risk, the probability of falling into the poverty trap is calculated, and the effects of agricultural insurance on poverty alleviation are discussed respectively. It is found that agricultural insurance can effectively reduce the probability of falling into the poverty trap for the farmers whose initial capital is greater than a certain critical value. While the government subsidizes the premium of agricultural insurance by a certain proportion, the effect on poverty alleviation will be further improved. | Jian ZHANG Boyu YANG Lina ZHAO | 2019 | Asian Agricultural Research2019，11，7： | 0 |
| 15 | Kunming mouse strain is less susceptible to elastase-induced abdominal aortic aneurysms显示文摘Background:Porcine pancreatic elastase(PPE)is successfully used to induce abdominal aortic aneurysm(AAA)in mice.However,differences between mouse strains in susceptibility to PPE induction have been reported.Kunming mouse is one of the most frequently used strains in China but whether it is suitable for induction of AAA by PPE application remains unclear.Methods:PPE infusion(1.5 units/ml)in temporary controlled aorta was performed to induce AAAs in both C57BL/6J and Kunming mice.Phosphatebuffered saline(PBS)application was used as vehicle control.The aorta diameters of all mice were measured at days 0 and 14 after surgery to evaluate the AAA formation.Results:After 14 days of PPE or PBS infusion,all mice were sacrificed and aorta tissues were collected for histological staining analysis.At the 14th day after infusion,PPE successfully induced aortic dilation in Kunming mice and typical AAA in C57BL/6J mice.The aorta diameter increased by 0.23 mm in Kunming mice after PPE infusion,while it was 0.72 mm in the C57BL/6J strain.PPE induced mild elastin degradation,smooth muscle cell(SMC)depletion and mural leucocyte infiltration in Kunming mice,but in PPE-sensitive C57BL/6J mice,it induced total loss of SMCs,elastin disappearance and diffused infiltrated leucocytes in aortic aneurysmal segments.The effects of PPE in inducing angiogenesis and upregulating matrix metalloproteinase 2 and 9 expression in Kunming mice were also weaker than that in C57BL/6J mice.Conclusion:At the reported dose of PPE,Kunming mouse is not as susceptible to AAA formation as C57BL/6J mice.The failure of PPE to induce AAA formation in Kunming mice may be associated to its inability to boost a strong inflammatory response. | Haole Liu Kangli Tian Congcong Xia Panpan Wei Boyu Xu Weilai Fu Yankui Li Yafeng Li Liang Bai Rong Wang Weirong Wang Baohui Xu Enqi Liu Sihai Zhao | 2022 | Animal Models and Experimental Medicine2022，5，1： | 0 |
| 16 | Topology and Semantic Information Fusion Classification Network Based on Hyperspectral Images of Chinese Herbs显示文摘Most methods for classifying hyperspectral data only consider the local spatial relation-ship among samples,ignoring the important non-local topological relationship.However,the non-local topological relationship is better at representing the structure of hyperspectral data.This paper proposes a deep learning model called Topology and semantic information fusion classification network(TSFnet)that incorporates a topology structure and semantic information transmis-sion network to accurately classify traditional Chinese medicine in hyperspectral images.TSFnet uses a convolutional neural network(CNN)to extract features and a graph convolution network(GCN)to capture potential topological relationships among different types of Chinese herbal medicines.The results show that TSFnet outperforms other state-of-the-art deep learning classification algorithms in two different scenarios of herbal medicine datasets.Additionally,the proposed TSFnet model is lightweight and can be easily deployed for mobile herbal medicine classification. | Boyu Zhao Yuxiang Zhang Zhengqi Guo Mengmeng Zhang Wei Li | 2023 | Journal of Beijing Institute of Technology2023，32，5： | 0 |
| 17 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 18 | Ecotourist trail-use affects the taxonomic, functional and phylogenetic diversity of mammals in a protected area: lessons for conservation management显示文摘Ecotourism,by definition,aims to engage peoples’interest in wildlife and the environment.The use of tourist roads and trails to access sites within protected areas(PAs)can detrimentally affect the behavior and distribution of species.The way mammals respond to anthropogenic pressures may differ across taxonomic,functional,and phy-logenetic groups;nevertheless,how ecotourist trail-use affects these different diversity remains under-investigated.Here,we assessed 6 metrics of taxonomic,phylogenetic,and functional diversity for a mammal community in a PA in central China,recording how Trail use(using Trail type as a proxy)and habitat variables affected sightings and signs of mammals across 60 replicate 0.5 km transects.We then examined how Trail use affected the taxonomic,functional,and phylogenetic diversity indices of species(>1 kg).Using generalized liner mixed modeling,we identified that more used trail types had a greater adverse effect on all diversity richness indices than did less used trail types.Consequently,tourist pressure was associated with a general tendency to homogenize the site’s mammal community.In contrast,the effects of Trail Types on all diversity evenness indices were non-significant.Further-more,more developed and more heavily used trail types had a greater,significant negative effect on taxonomic,functional,and phylogenetic richness,whereas these richness indices were unaffected by minor trail types,used less intensively.As a general principle,lower biodiversity indices reduce ecosystem resilience,and so it is vital to better understand these responses to balance public access against biodiversity management in PAs. | Boyu LEI Zhenfei ZHENG Jifa CUI Jin ZHAO Chris NEWMAN Youbing ZHOU | 2023 | Integrative Zoology2023，18，4： | 0 |
| 19 | A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy显示文摘Metastasis accounts for 90%of breast cancer deaths,where the lethality could be attributed to the poor drug accumulation at the metastatic loci.The tolerance to chemotherapy induced by breast cancer stem cells(BCSCs)and their particular redox microenvironment further aggravate the therapeutic dilemma.To be specific,therapy-resistant BCSCs can differentiate into heterogeneous tumor cells constantly,and simultaneously dynamic maintenance of redox homeostasis promote tumor cells to retro-differentiate into stem-like state in response to cytotoxic chemotherapy.Herein,we develop a specifically-designed biomimic platform employing neutrophil membrane as shell to inherit a neutrophil-like tumor-targeting capability,and anchored chemotherapeutic and BCSCs-differentiating reagents with nitroimidazole(NI)to yield two hypoxia-responsive prodrugs,which could be encapsulated into a polymeric nitroimidazole core.The platform can actively target the lung metastasis sites of triple negative breast cancer(TNBC),and release the escorted drugs upon being triggered by the hypoxia microenvironment.During the responsiveness,the differentiating agent could promote transferring BCSCs into non-BCSCs,and simultaneously the nitroimidazole moieties conjugated on the polymer and prodrugs could modulate the tumor microenvironment by depleting nicotinamide adenine dinucleotide phosphate hydrogen(NADPH)and amplifying intracellular oxidative stress to prevent tumor cells retro-differentiation into BCSCs.In combination,the BCSCs differentiation and tumor microenvironment modulation synergistically could enhance the chemotherapeutic cytotoxicity,and remarkably suppress tumor growth and lung metastasis.Hopefully,this work can provide a new insight in to comprehensively treat TNBC and lung metastasis using a versatile platform. | Yongchao Chu Yifan Luo Boyu Su Chao Li Qin Guo Yiwen Zhang Peixin Liu Hongyi Chen Zhenhao Zhao Zheng Zhou Yu Wang Chen Jiang Tao Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
| 20 | High-performance and multifunctional organic field-effect transistors显示文摘Organic field-effect transistors(OFETs)refer to field-effect transistors that use organic semiconductors as channel materials.Owing to the advantages of organic materials such as solution processability and intrinsic flexibility,OFETs are expected to be applicable in emergent technologies including wearable electronics and sensors,flexible displays,internet-of-things,neuromorphic computing,etc.Improving the electrical performance and developing multifunctionalities of OFETs are two major and closely relevant aspects for OFETs-related research.The former one aims for investigating the device physics and expanding the horizons of OFETs,while the later one is critical for leading OFETs into practical and emergent applications.The development in each of the two aspects would undoubtfully promote the other and bring more confidence for future development of OFETs.Hence,this review is divided into two parts that respectively summarize the recent progress in high-performance OFETs and multifunctional OFETs. | Yujie Zhao Wei Wang Zihan He Boyu Peng Chong-An Di Hanying Li | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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