|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An air-stable and waterproof lithium metal anode enabled by wax composite packaging显示文摘The reviving use of lithium metal anode(LMA)is one of the most promising ways to upgrade the energy density of lithium ion batteries.In the roadmap towards the real use,besides the formation of the dendrite,various adverse reactions due to the high activity of LMA when exposed to air or the electrolyte limit its practical applications.Learning from the packaging technology in electronic industry,we propose a wax-based coating compositing with the ion conducting poly(ethylene oxide)by a simple dip-coating technology and the prepared LMA is featured with an air-stable and waterproof surface.The LMA thus remains stable for 24 h in ambient air even with the relative humidity of 70% while retaining about85% its electrochemical capacity.More importantly,the LMA is accessible to water and when dipping in water,no obvious adverse reactions or capacity decay is observed.With the composite coating,a steady cycling performance for 500 h in symmetrical cells and a low capacity decay rate of 0.075% per cycle after 300 cycles in lithium-sulfur batteries assembled with the packaged anode have been achieved.This work demonstrates a very simple and effective LMA package technology which is easily scalable and is very promising for speeding up the industrialization of lithium-sulfur batteries and shows potentials for the large-scale production of air-sensitive electrode materials not limited to LMAs. | Yunbo Zhang Wei Lv Zhijia Huang Guangmin Zhou Yaqian Deng Jun Zhang Chen Zhang Boyu Hao Qi Qi Yan-Bing He Feiyu Kang Quan-Hong Yang | 2019 | Science Bulletin2019，64，13： | 7 |
| 2 | Optimal capacity planning of combined renewable energy source-pumped storage and seawater desalination systems显示文摘As water scarcity is becoming a growing threat to human development, finding effective solutions has become an urgent need. To make better use of water resources, seawater desalination and storage systems using renewable energy sources(RES) are designed and implemented around the world. In this paper, an optimal capacity planning method for RES-pumped storage-seawater desalination(RES-PS-D) system is introduced. The configuration of the RES-PS-D system is clarified first, after which a cost-benefit analysis is performed using all cost and benefit components. A function for determining maximum economic benefits of the RES-PS-D system is then established, and the constraints are proposed based on various limitations. The mixed-integer linear programming algorithm is applied to solve the optimal function. A case study is introduced to validate the feasibility and effectiveness of the method. The conclusion shows that the strategy is suitable for solving the configuration optimization problem, and finally both merits and defects of the method are discussed. | Boyu Liu Bowen Zhou Dongsheng Yang Zhile Yang Mingjian Cui | 2019 | Global Energy Interconnection2019，2，4： | 4 |
| 3 | Resorcinol-formaldehyde resin-based porous carbon spheres with high CO_2 capture capacities显示文摘Porous carbon spheres are prepared by direct carbonization of potassium salt of resorcinol-formaldehyde resin spheres, and are investigated as CO_2 adsorbents. It is found that the prepared carbon materials still maintain the typical spherical shapes after the activation, and have highly developed ultra-microporosity with uniform pore size, indicating that almost the activation takes place in the interior of the polymer spheres. The narrow-distributed ultra-micropores are attributed to the 'in-situ homogeneous activation'effect produced by the mono-dispersed potassium ions as a form of -OK groups in the bulk of polymer spheres. The CS-1 sample prepared under a KOH/resins weight ratio of 1 shows a very high CO_2 capture capacity of 4.83 mmol/g and good CO_2/N_2 selectivity of ~17-45. We believe that the presence of a welldeveloped ultra-microporosity is responsible for excellent CO_2 sorption performance at room temperature and ambient pressure. | Xuan Wang Jin Zhou Wei Xing Boyu Liu Jianlin Zhang Hongtao Lin Hongyou Cui Shuping Zhuo | 2017 | Journal of Energy Chemistry2017，26，5： | 3 |
| 4 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 5 | Survey of UAV motion planning显示文摘Motion planning is a vital module for unmanned aerial vehicles(UAVs),especially in scenarios of autonomous navigation and operation.This survey delivers some recent state-of-the-art UAV motion planning algorithms and related applications.The logic flow of this survey is divided as the path finding,which is the front-end of most motion planning systems,and the trajectory optimisation,which usually serves as the back-end.Motivation,methodology,problem formulation and derivation are given in this survey,in detail.Finally,a section about real-world applications is given,where roles and effectiveness of most popular motion planning methods are revealed. | Lun Quan Luxin Han Boyu Zhou Shaojie Shen Fei Gao | 2020 | IET Cyber-Systems and Robotics2020，2，1： | 2 |
| 6 | Enhancing photovoltaic performance via aggregation dynamics control in fused-ring electron acceptor显示文摘A new fused-ring electron acceptor FNIC3 with dynamics controlled aggregation behavior was synthesized.FNIC3 shows strong absorption in 600–900 nm,HOMO/LUMO energy levels of−5.59/−4.04 eV,and electron mobility of 1.2×10^(−3) cm^(2) V^(−1) s^(−1).The aggregation of FNIC3 shows strong dependency on film formation time.Prolongation of film formation time promotes the crystallization of FNIC3,leading to improved crystallinity and enlarged aggregate sizes.Aggregation of FNIC3 significantly influences the photovoltaic device parameters.Appropriate aggregation red-shifts the absorption and improves the mobilities of the blend,which contributes to high photocurrent and fill factor thus high power conversion efficiency(PCE).Overaggregation leads to increased nonradiative energy loss and insufficient charge generation,resulting in decreased open-circuit voltage and short-circuit current density.The blends based on PM6:FNIC3 fabricated under proper film formation time exhibit a PCE of 12.3%,higher than those fabricated under short and long film formation time(10.0–10.5%). | Jiayu Wang Runyu Zhu Shijie Wang Yawen Li Boyu Jia Jiadong Zhou Peiyao Xue Susanne Seibt Yuze Lin Zengqi Xie Wei Ma Xiaowei Zhan | 2021 | Aggregate2021，2，3： | 1 |
| 7 | Self-trapped exciton emission in inorganic copper(Ⅰ)metal halides显示文摘The broad emission and high photoluminescence quantum yield of self-trapped exciton(STE)radiative recombination emitters make them an ideal solution for single-substrate,white,solid-state lighting sources.Unlike impurities and defects in semiconductors,the formation of STEs requires a lattice distortion,along with strong electron–phonon coupling,in low electrondimensional materials.The photoluminescence of inorganic copper(Ⅰ)metal halides with low electron-dimensionality has been found to be the result of STEs.These materials were of significant interest because of their leadfree,all-inorganic structures,and high luminous efficiencies.In this paper,we summarize the luminescence characteristics of zero-and one-dimensional inorganic copper(I)metal halides with STEs to provide an overview of future research opportunities. | Boyu ZHANG Xian WU Shuxing ZHOU Guijie LIANG Qingsong HU | 2021 | Frontiers of Optoelectronics2021，14，4： | 1 |
| 8 | Mid-infrared active metasurface based on Si/VO_(2) hybrid meta-atoms显示文摘Active metasurfaces whose optical properties can be tuned by an external stimulus have attracted great research interest recently. Introduction of VO_(2)phase change material in all-dielectric metasurfaces has been demonstrated to modulate the resonance wavelength and amplitude in the visible to near-infrared wavelength range. In this study, we report a mid-infrared active metasurface based on Si∕VO_(2)hybrid meta-atoms. By incorporating VO_(2)thin films in different locations of Si∕VO_(2)all-dielectric nanodisks, we demonstrate different modulation amplitude of the electric or magnetic resonance scattering cross sections, leading to drastically different transmission spectrum upon VO_(2)insulator to metal phase transition. The physical mechanism is originated from the field profiles of the resonance modes, which interact with VO_(2)differently depending on its locations. Based on this mechanism, we experimentally demonstrated a large modulation of the transmittance from 82% to 28% at the 4.6 μm wavelength. Our work demonstrates a promising potential of VO_(2)-based active all-dielectric metasurface for mid-infrared photonic applications such as infrared camouflage, chemical/biomedical sensing, optical neuromorphic computing, and multispectral imaging. | Tongtong Kang Boyu Fan Jun Qin Weihao Yang Shuang Xia Zheng Peng Bo Liu Sui Peng Xiao Liang Tingting Tang Longjiang Deng Yi Luo Hanbin Wang Qiang Zhou Lei Bi | 2022 | Photonics Research2022，10，2： | 1 |
| 9 | ASTM:Developing the web service for anthrax related spatiotemporal characteristics and meteorology study显示文摘Background:Anthrax is a zoonotic infectious disease caused by Bacillus anthracis.Investigating the spatiotemporal characteristics of anthrax and the impact of meteorological factors on the incidence of anthrax is helpful for the prevention and control of anthrax.Methods:At first,we applied the Granger causality test to explore the spatiotemporal characteristics of anthrax transmission between the counties and cities of Gannan Tibetan Autonomous Prefecture,Gansu Province of China.Then,we constructed three generalized linear models to analyze the impact of meteorological factors on the monthly number of anthrax cases in Gannan Tibetan Autonomous Prefecture.Finally,we developed an easy-to-use online web server that integrates the above functions.Results:This study developed an online service website(ASTM,http://gffzz29a66330a6304158hpf0xu0cwuk5566cv.ffgz.tsg.suse.edu.cn/anthrax/index.html)for the analysis and visualization of anthrax,which not only can investigate the correlation of anthrax among different regions in Gannan Tibetan Autonomous Prefecture,but also can analyze the correlation between meteorological factors and!the number of anthrax cases.Conclusions:Our study not only explored spatiotemporal characteristics of anthrax transmission,but also analyzed the impact of seven meteorological factors on the monthly number of anthrax cases.Meanwhile,the online service website which integrates the above functions is useful for the prevention and control of anthrax. | Shiwei Fan Ming Xiao Boyu Sun Weizhong Zhou Qingrong Chen Weimin Lv Pengfei Zhang Le Zhang | 2022 | Quantitative Biology2022，10，1： | 0 |
| 10 | A state-of-the-art review on transition between the fast fluidization and pneumatic transport of Geldart group B particles显示文摘The fluidization state in the circulating fluidized bed(CFB)boiler is crucial to its stable and safe operation.However,up to now,the research field has not reached unanimity on whether the fluidization regime that the upper furnace of the boiler operates in is the fast fluidization or pneumatic transport.To this end,this paper reviewed relevant research on the transition between the fast fluidization and pneumatic transport of Geldart group B particles,including the flow characteristics of the fast fluidization,the transition condition between the fast fluidization and pneumatic transport,the determination methods of the transport velocity utr and saturation carrying capacity G_(s)* and the influencing factors on these two parameters.Previous research findings can provide certain guidelines for the design and optimization of the CFB boiler,and result in plenty of prediction correlations for utr and G_(s)*.Nonetheless,owing to insufficient data available on Geldart group B particles,especially the ones obtained under high temperature or pressure conditions and in large-scale CFB apparatuses,the existing correlations are not well suited for the prediction of u_(tr) and G_(s)* of Geldart group B particles.Thus,further efforts are urgently demanded on the fast fluidization transition of Geldart group B particles. | Boyu Deng Yi Zhang Man Zhang Yi Ding Tuo Zhou Xinhua Yang Zhong Huang Hairui Yang Guangxi Yue | 2023 | Particuology2023，，2： | 0 |
| 11 | Spatio-temporal Variation of Water Heat Flux Using MODIS Land Surface Temperature Product over Hulun Lake,China During 2001–2018显示文摘Heat flux is important for studying interactions between atmosphere and lake.The heat exchange between air-water interfaces is one of the important ways to govern the temperature of the water surface.Heat exchange between the air-water interfaces and the surrounding environment is completed by solar radiation,conduction,and evaporation,and all these processes mainly occur at the air-water interface.Hulun Lake was the biggest lake which is also an important link and an indispensable part of the water cycle in Northeast China.This study mapped surface energy budget to better understand spatial and temporal variations in Hulun Lake in China from 2001 to 2018.Descriptive statistics were computed to build a historical time series of mean monthly heat flux at daytime and nighttime from June to September during 2001–2018.Remote sensing estimation methods we used was suitable for Hulun Lake(R2=0.81).At month scale,shortwave radiation and latent heat flux were decrease from June to September.However,the maximum sensible heat flux appeared in September.Net longwave radiation was the largest in August.The effective heat budget showed that Hulun Lake gained heat in the frost-free season with highest value in June(686.31 W/m2),and then steadily decreased to September(439.76 W/m2).At annual scale,net longwave radiation,sensible heat flux and latent heat flux all show significant growth trend from 2001 to 2018(P<0.01).Wind speed had the well correlation on sensible heat flux and latent heat flux.Water surface temperature showed the highest coefficient in sensitivity analysis. | ZHAO Boyu DU Jia SONG Kaishan Pierre-Andre JACINTHE XIANG Xiaoyun ZHOU Haohao YANG Zhichao ZHANG Liyan GUO Pingping | 2020 | Chinese Geographical Science2020，30，6： | 0 |
| 12 | A Generalized Polymer Precursor Ink Design for 3D Printing of Functional Metal Oxides显示文摘Three-dimensional-structured metal oxides have myriad applications for optoelectronic devices.Comparing to conventional lithography-based manufacturing methods which face significant challenges for 3D device architectures,additive manufacturing approaches such as direct ink writing offer convenient,on-demand manufacturing of 3D oxides with high resolutions down to sub-micrometer scales.However,the lack of a universal ink design strategy greatly limits the choices of printable oxides.Here,a universal,facile synthetic strategy is developed for direct ink writable polymer precursor inks based on metal-polymer coordination effect.Specifically,polyethyleneimine functionalized by ethylenediaminetetraacetic acid is employed as the polymer matrix for adsorbing targeted metal ions.Next,glucose is introduced as a crosslinker for endowing the polymer precursor inks with a thermosetting property required for 3D printing via the Maillard reaction.For demonstrations,binary(i.e.,ZnO,CuO,In_(2)O_(3),Ga_(2)O_(3),TiO_(2),and Y_(2)O_(3)) and ternary metal oxides(i.e.,BaTiO_(3) and SrTiO_(3)) are printed into 3D architectures with sub-micrometer resolution by extruding the inks through ultrafine nozzles.Upon thermal crosslinking and pyrolysis,the 3D microarchitectures with woodpile geometries exhibit strong light-matter coupling in the mid-infrared region.The design strategy for printable inks opens a new pathway toward 3D-printed optoelectronic devices based on functional oxides. | Hehao Chen Jizhe Wang Siying Peng Dongna Liu Wei Yan Xinggang Shang Boyu Zhang Yuan Yao Yue Hui Nanjia Zhou | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 13 | Multimaterial Embedded 3D Printing of Composite Reinforced Soft Actuators显示文摘Soft pneumatic actuators(SPAs)have attracted enormous attention in the growing field of robotics.Among different SPAs,composite reinforced actuators(CRAs)are widely used because of their simple structure and high controllability.However,multistep molding,a time-consuming method,is still the predominant fabrication method.Here,we propose a multimaterial embedded printing method(ME3P)to fabricate CRAs.In comparison with other 3-dimensional printing methods,our method improves fabrication flexibility greatly.Via the design and fabrication of the reinforced composites’patterns and different geometries of the soft body,we demonstrate actuators with programmable responses(elongation,contraction,twisting,bending,and helical and omnidirectional bending).Finite element analysis is employed for the prediction of pneumatic responses and the inverse design of actuators based on specific actuation needs.Lastly,we use tube-crawling robots as a model system to demonstrate our ability to fabricate complex soft robots for practical applications.This work demonstrates the versatility of ME3P for the future manufacturing of CRA-based soft robots. | Zhenhua Wang Boyu Zhang Qu He Hao Chen Jizhe Wang Yuan Yao Nanjia Zhou Weicheng Cui | 2023 | Research2023，，4： | 0 |
| 14 | A Realistic 3D Non-Stationary Channel Model for UAV-to-Vehicle Communications Incorporating Fuselage Posture显示文摘Considering the unmanned aerial vehicle(UAV) three-dimensional(3D) posture, a novel 3D non-stationary geometry-based stochastic model(GBSM) is proposed for multiple-input multipleoutput(MIMO) UAV-to-vehicle(U2V) channels. It consists of a line-of-sight(Lo S) and non-line-of-sight(NLo S) components. The factor of fuselage posture is considered by introducing a time-variant 3D posture matrix. Some important statistical properties, i.e.the temporal autocorrelation function(ACF) and spatial cross correlation function(CCF), are derived and investigated. Simulation results show that the fuselage posture has significant impact on the U2V channel characteristic and aggravate the non-stationarity. The agreements between analytical, simulated, and measured results verify the correctness of proposed model and derivations. Moreover, it is demonstrated that the proposed model is also compatible to the existing GBSM without considering fuselage posture. | Boyu Hua Tongtong Zhou Qiuming Zhu Kai Mao Junwei Bao Weizhi Zhong | 2023 | China Communications2023，20，6： | 0 |
| 15 | Icing on the cake: combining a dual PEG-functionalized pillararene and an A-D-A small molecule photosensitizer for multimodal phototherapy显示文摘The design of photosensitizers with multimodal antitumor activity and the construction of nanocarriers with specific targeting are two magic weapons to achieve highly efficient tumor phototherapy. Here we developed an A-D-A fused-ring conjugated small molecule photosensitizer DPIC and proposed a new strategy of constructing phototherapy agents, namely using supramolecular vesicles constructed by the self-assembly of a novel dual PEG-functionalized pillararene WP5-2 PEG to load DPIC. These new nanocarriers had excellent water solubility and drug encapsulation rates. The prepared DPIC NPs had a better water solubility compared with DPIC molecules and had a uniform hollow spherical morphology, which is beneficial for cell endocytosis. Under laser irradiation(808 nm), the DPIC NPs had a photothermal conversion efficiency(PTCE) of 55% and a PTCE of 49% under980-nm laser irradiation. The DPIC NPs also displayed dual type I and type II photodynamic activity. DPIC NPs had superior biocompatibility and stability and can also inhibit tumor growth in vitro and in vivo, demonstrating their potential for highly efficient cancer phototherapy. | Bing Lu Zhecheng Zhang Yangchaowei Ji Shide Zhou Boyu Jia Yuehua Zhang Jin Wang Yue Ding Yang Wang Yong Yao Xiaowei Zhan | 2022 | Science China Chemistry2022，65，6： | 0 |
| 16 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 17 | Spurious-free dynamic range improvement in a photonic time-stretched analog-to-digital converter based on third-order predistortion显示文摘Spurious-free dynamic range(SFDR)limited by intermodulation distortions is a usually accepted measure for dynamic performance of a photonic time-stretched analog-to-digital converter(ADC).In this paper,SFDR improvement in a photonic time-stretched ADC based on third-order predistortion is proposed.The third-order predistortion is achieved optically within an integrated dual-parallel Mach–Zehnder modulator(DPMZM).The mechanism of SFDR improvement with third-order predistortion in the DPMZM is theoretically analyzed.Compared with a conventional scheme without predistortion,the experimental results show that the SFDR improvement of∼26 dB in the proposed scheme is proved. | Boyu Xu Wulue Lv Jiamu Ye Jinhai Zhou Xiaofeng Jin Xianmin Zhang Hao Chi Shilie Zheng | 2014 | Photonics Research2014，2，5： | 0 |
| 18 | Ecotourist trail-use affects the taxonomic, functional and phylogenetic diversity of mammals in a protected area: lessons for conservation management显示文摘Ecotourism,by definition,aims to engage peoples’interest in wildlife and the environment.The use of tourist roads and trails to access sites within protected areas(PAs)can detrimentally affect the behavior and distribution of species.The way mammals respond to anthropogenic pressures may differ across taxonomic,functional,and phy-logenetic groups;nevertheless,how ecotourist trail-use affects these different diversity remains under-investigated.Here,we assessed 6 metrics of taxonomic,phylogenetic,and functional diversity for a mammal community in a PA in central China,recording how Trail use(using Trail type as a proxy)and habitat variables affected sightings and signs of mammals across 60 replicate 0.5 km transects.We then examined how Trail use affected the taxonomic,functional,and phylogenetic diversity indices of species(>1 kg).Using generalized liner mixed modeling,we identified that more used trail types had a greater adverse effect on all diversity richness indices than did less used trail types.Consequently,tourist pressure was associated with a general tendency to homogenize the site’s mammal community.In contrast,the effects of Trail Types on all diversity evenness indices were non-significant.Further-more,more developed and more heavily used trail types had a greater,significant negative effect on taxonomic,functional,and phylogenetic richness,whereas these richness indices were unaffected by minor trail types,used less intensively.As a general principle,lower biodiversity indices reduce ecosystem resilience,and so it is vital to better understand these responses to balance public access against biodiversity management in PAs. | Boyu LEI Zhenfei ZHENG Jifa CUI Jin ZHAO Chris NEWMAN Youbing ZHOU | 2023 | Integrative Zoology2023，18，4： | 0 |
| 19 | Nitrogen-bridged Ni(Ⅱ)porphyrinoid trimers with a central quinodiimine unit显示文摘Buchwald-Hartwig amination of 5,15-dibromo and 5,10-dibromo Ni(Ⅱ)porphyrins with 5-amino Ni(Ⅱ)porphyrin gave linear and bent trimers 4Ni and 5Ni with a central quinodiimine-type Ni(Ⅱ)porphyrinoid.The structures of 4Ni and 5Ni have been confirmed by X-ray diffraction analysis in both cases.The formation of unusual products 4Ni and 5Ni has been ascribed to facile oxidation of 5,15-and 5,10-amino Ni(Ⅱ)porphyrin unit.Reduction of 4Ni and 5Ni under proper conditions gave NH-bridged Ni(Ⅱ)porphyrin trimers 4Ni-2H and 5Ni-2H in high yields.Trimers 4Ni and 5Ni exhibit the lowest energy band as compared with 4Ni-2H and 5Ni-2H.Especially the bent trimer 5Ni exhibits a broad absorption tail beyond 1400 nm. | Kaisheng Wang Boyu Xiao Ling Xu Mingbo Zhou Takayuki Tanaka Atsuhiro Osuka Jianxin Song | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
| 20 | A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy显示文摘Metastasis accounts for 90%of breast cancer deaths,where the lethality could be attributed to the poor drug accumulation at the metastatic loci.The tolerance to chemotherapy induced by breast cancer stem cells(BCSCs)and their particular redox microenvironment further aggravate the therapeutic dilemma.To be specific,therapy-resistant BCSCs can differentiate into heterogeneous tumor cells constantly,and simultaneously dynamic maintenance of redox homeostasis promote tumor cells to retro-differentiate into stem-like state in response to cytotoxic chemotherapy.Herein,we develop a specifically-designed biomimic platform employing neutrophil membrane as shell to inherit a neutrophil-like tumor-targeting capability,and anchored chemotherapeutic and BCSCs-differentiating reagents with nitroimidazole(NI)to yield two hypoxia-responsive prodrugs,which could be encapsulated into a polymeric nitroimidazole core.The platform can actively target the lung metastasis sites of triple negative breast cancer(TNBC),and release the escorted drugs upon being triggered by the hypoxia microenvironment.During the responsiveness,the differentiating agent could promote transferring BCSCs into non-BCSCs,and simultaneously the nitroimidazole moieties conjugated on the polymer and prodrugs could modulate the tumor microenvironment by depleting nicotinamide adenine dinucleotide phosphate hydrogen(NADPH)and amplifying intracellular oxidative stress to prevent tumor cells retro-differentiation into BCSCs.In combination,the BCSCs differentiation and tumor microenvironment modulation synergistically could enhance the chemotherapeutic cytotoxicity,and remarkably suppress tumor growth and lung metastasis.Hopefully,this work can provide a new insight in to comprehensively treat TNBC and lung metastasis using a versatile platform. | Yongchao Chu Yifan Luo Boyu Su Chao Li Qin Guo Yiwen Zhang Peixin Liu Hongyi Chen Zhenhao Zhao Zheng Zhou Yu Wang Chen Jiang Tao Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员