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| 1 | Therapeutic effect of Zijin capsule in liver fibrosis in rats显示文摘TherapeuticefectofZijincapsuleinliverfibrosisinratsCAIDaYongZHAOGang,CHENJiaChun,YEGanMei,BINGFeiHongandFANBuWuSubjecth... | CAI Da Yong, ZHAO Gang, CHEN Jia Chun, YE Gan Mei, BING Fei Hong and FAN Bu Wu | 1998 | World Journal of Gastroenterology1998，4，3： | 20 |
| 2 | Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study显示文摘Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in remission.The primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled study.This subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,respectively.The most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER trial.Teriflunomide has the potential to meet unmet medical needs for MS patients in China. | Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing Dong Hua Peng Chao-Dong Zhang Gang Zhao Yi-Ning Huang Dong Zhou Wei-Ping Wu Bao-Jun Wang Ji-Mei Li Xing-Hu Zhang Yan Cheng Hai-Feng Li Ling Li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu Wan-Li Dong Dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu | 2018 | Chinese Medical Journal2018，，23： | 10 |
| 3 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 4 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 5 | Solutions of second order degenerate integro-differential equations in vector-valued function spaces显示文摘We study the well-posedness of the second order degenerate integro-differential equations(P2):(Mu)(t)+α(Mu)(t) = Au(t)+ft-∞ a(ts)Au(s)ds + f(t),0t2π,with periodic boundary conditions M u(0)=Mu(2π),(Mu)(0) =(M u)(2π),in periodic Lebesgue-Bochner spaces Lp(T,X),periodic Besov spaces B s p,q(T,X) and periodic Triebel-Lizorkin spaces F s p,q(T,X),where A and M are closed linear operators on a Banach space X satisfying D(A) D(M),a∈L1(R+) and α is a scalar number.Using known operatorvalued Fourier multiplier theorems,we completely characterize the well-posedness of(P2) in the above three function spaces. | BU ShangQuan CAI Gang | 2013 | Science China Mathematics2013，56，5： | 4 |
| 6 | Emerging Organic Contaminants in Chinese Surface Water:Identification of Priority Pollutants显示文摘The occurrence and impacts of emerging organic contaminants(EOCs)in the aquatic environment have gained widespread attention over the past two decades.Due to large number of potential contaminants,monitoring campaigns,treatment plants,and proposed regulations should preferentially focus on specific pollutants with the highest potential for ecological and human health effects.In the present study,a multi-criteria screening approach based on hazard and exposure potentials was developed for prioritization of 405 unregulated EOCs already present in Chinese surface water.Hazard potential,exposure potential,and risk quotients for ecological and human health effects were quantitatively analyzed and used to screen contaminants.The hazard potential was defined by contaminant persistence,bioaccumulation,ecotoxicity,and human health effects;similarly,the exposure potential was a function of contaminant concentration and detection frequency.In total,123 compounds passed the preselection process,which involved a priority index equal to the normalized hazard potential multiplied by the normalized exposure potential.Based on the prioritization scheme,11 compounds were identified as top-priority,and 37 chemicals were defined as high-priority.The results obtained by the priority index were compared with four other prioritization schemes based on exposure potential,hazard potential,or risk quotients for ecological effects or human health.The priority index effectively captured and integrated the results from the more simplistic prioritization schemes.Based on identified data gaps,four uncertainty categories were classified to recommend:①regular monitoring,derivation of environmental quality standards,and development of control strategies;②increased monitoring;③fortified hazard assessment;and④increased efforts to collect occurrence and toxicity data.Overall,20 pollutants were recommended as priority EOCs.The prioritized list of contaminants provides the necessary information for authoritative regulations to monitor,control,evaluate,and manage the risks of environmentally-relevant EOCs in Chinese surface water. | Mengmeng Zhong Tielong Wang Wenxing Zhao Jun Huang Bin Wang Lee Blaney Qingwei Bu Gang Yu | 2022 | Engineering2022，8，4： | 3 |
| 7 | A Macaca mulatta model of fulminant hepatic failure显示文摘AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and endotoxin.Clinical features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal model.RESULTS:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin administration.Coagulation activity was significantly decreased.Gradually deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 h.The liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,respectively.The autopsy showed typical yellow atrophy of the liver.Hepatic encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral edema.The lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and histopathology.CONCLUSION:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies. | Ping Zhou Jie Xia Gang Guo Zi-Xing Huang Qiang Lu Li Li Hong-Xia Li Yu-Jun Shi Hong Bu | 2012 | World Journal of Gastroenterology2012，18，5： | 3 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | Simultaneous chromatographic analysis of eight fat-soluble vitamins in plasma 显示文摘 | Edvdna Sau Man Po John WHo Bu Yi Gang | 1997 | Journal of Biochemical and Biophysical Methods1997，34，2： | 1 |
| 10 | In situ growth of mesoporous NiO nanoplates on a graphene matrix as cathode catalysts for rechargeable lithium air batteries显示文摘 | Qiu Danfeng Bu Gang Zhao Bin | 2015 | Materials Letters2015，141，2： | 1 |
| 11 | Development of a machine learning-based model for predicting risk of early postoperative recurrence of hepatocellular carcinoma显示文摘BACKGROUND Surgical resection is the primary treatment for hepatocellular carcinoma(HCC).However,studies indicate that nearly 70%of patients experience HCC recurrence within five years following hepatectomy.The earlier the recurrence,the worse the prognosis.Current studies on postoperative recurrence primarily rely on postoperative pathology and patient clinical data,which are lagging.Hence,developing a new pre-operative prediction model for postoperative recurrence is crucial for guiding individualized treatment of HCC patients and enhancing their prognosis.AIM To identify key variables in pre-operative clinical and imaging data using machine learning algorithms to construct multiple risk prediction models for early postoperative recurrence of HCC.METHODS The demographic and clinical data of 371 HCC patients were collected for this retrospective study.These data were randomly divided into training and test sets at a ratio of 8:2.The training set was analyzed,and key feature variables with predictive value for early HCC recurrence were selected to construct six different machine learning prediction models.Each model was evaluated,and the bestperforming model was selected for interpreting the importance of each variable.Finally,an online calculator based on the model was generated for daily clinical practice.RESULTS Following machine learning analysis,eight key feature variables(age,intratumoral arteries,alpha-fetoprotein,preoperative blood glucose,number of tumors,glucose-to-lymphocyte ratio,liver cirrhosis,and pre-operative platelets)were selected to construct six different prediction models.The XGBoost model outperformed other models,with the area under the receiver operating characteristic curve in the training,validation,and test datasets being 0.993(95%confidence interval:0.982-1.000),0.734(0.601-0.867),and 0.706(0.585-0.827),respectively.Calibration curve and decision curve analysis indicated that the XGBoost model also had good predictive performance and clinical application value.CONCLUSION The XGBoost model exhibits superior performance and is a reliable tool for predicting early postoperative HCC recurrence.This model may guide surgical strategies and postoperative individualized medicine. | Yu-Bo Zhang Gang Yang Yang Bu Peng Lei Wei Zhang Dan-Yang Zhang | 2023 | World Journal of Gastroenterology2023，29，43： | 1 |
| 12 | Expression of SOCS3 throughout liver regeneration is not regulated by DNA methylation显示文摘ACKGROUND:While suppressor of cytokine signaling 3(SOCS3) plays a crucial role in suppressing dysplasia and tumorigenesis,it also offers a typical instance of DNA methylation in the regulation of gene transcription,since the promoter region of the SOCS3 gene is rich in CpG islands(CGIs).During liver regeneration initiated by partial hepatectomy,SOCS3 acts as a suppressor to balance the acute-phase response and terminate the regeneration.This study aimed to determine whether the variation of SOCS3 expression throughout liver regeneration is also regulated by its DNA methylation.METHODS:We established a 70% partial hepatectomy mouse model and the animals were sacrificed at indicated times to assess the SOCS3 expression.We performed bisulfite sequencing PCR and DNA sequencing to investigate the detailed cytosine methylation in the SOCS3 gene.RESULTS:Within the promoter sequence,58 CGIs were identified and 30 were found variously methylated before or after operation;however,methylation remained at a very low level.No evidence indicated that the total methylation level or the methylation of any CpG site regularly changed throughout liver regeneration.CONCLUSION:DNA methylation or demethylation seems to be a relatively stable modification of cytosine,but not a dynamic and reversible process to regulate gene transcription in daily and acute pathophysiological events. | Gang Guo,Jie Xia,Ji Bao,Huai-Qiang Sun,Yu-Jun Shi and Hong Bu Key Laboratory of Transplant Engineering and Immunology,Ministry of Health and Department of Pathology,West China Hospital,Sichuan University,Chengdu 610041,China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 1 |
| 13 | A ruthenium complex exhibiting high catalytic efficiency for the formation of propylene carbonate from carbon dioxide显示文摘 | BU Zhan wei QIN Gang CAO Shao-kui | 2007 | Journal of Molecular Catalysis A: Chemical2007，277，： | 1 |
| 14 | A ruthenium complex exhibiting high catalytic efficiency for the formation of propylene carbonate from carbon dioxide显示文摘 | Bu Zhanwei Qin Gang Cao Shaokui | 2007 | Journal of Molecular Catalysis A: Chemical2007，277，12： | 1 |
| 15 | ,a novel bifunctional catalyst for the coupling reaction of carbon dioxide and propylene oxide显示文摘 | REN Tie Gang LI Wei Jie BU Zhan Wei | 2010 | J Chem Res S2010，7，： | 1 |
| 16 | Corrigendum to“Emerging Organic Contaminants in Chinese Surface Water:Identification of Priority Pollutants”[Engineering 11(2022)111-125]显示文摘The authors regret that the acceptable daily intake(ADI)values of 0.082 μg·kg^(-1)·d^(-1) for N,N-diethyl-3-methyl benzoyl amide(DEET),0.19 μg·kg^(-1)·d^(-1) for triclosan,and 0.83 μg·kg^(-1)·d^(-1) for acetaminophen cited from a review by Murray et al.[1],as shown in Table S4 in Appendix A of the original article,were not correct. | Mengmeng Zhong Tielong Wang Wenxing Zhao Jun Huang Bin Wang Lee Blaney Qingwei Bu Gang Yu | 2023 | Engineering2023，31，12： | 0 |
| 17 | Macroscopic superlubricity of potassium hydroxide solution achieved by incorporating in-situ released graphene from friction pairs显示文摘Graphene(G),as a typical two-dimensional material,is often used as an additive for liquid lubricants.However,graphene is mostly added to liquid lubricants in a one-time manner in friction;it mainly exists in the form of multilayer agglomerated structures due to theπ–πstacking between graphene sheets,making it unable to fully exert the synergistic lubrication function.Herein,we propose a new macroscopic superlubric system of graphene/potassium hydroxide(G/KOH)solution;and the graphene additive involved is exfoliated in-situ from graphene/epoxy(G/EP)friction pair by friction,continuously providing freshly-peeled graphene into KOH solution and minimizing the adverse effects of graphene agglomeration.Moreover,the in-situ produced graphene additive has thinner thickness and better anti-aggregation ability,which provide more graphene to accommodate OH−,form more stacked sandwich structures of OH−/graphene/OH−between friction pairs(i.e.,equivalent to a moving pulley block with more wheels),and finally realize superlubricity.This study develops a new liquid superlubric system suitable for alkaline environments,and at the same time proposes a new way to gradually release graphene additives in situ,rather than adding them all at once,deepening the understanding to liquid superlubricity mechanism,and paving the experimental foundation for the practical application of macroscopic superlubricity. | Hongyu LIANG Xinjie CHEN Yongfeng BU Meijuan XU Gang ZHENG Kaixiong GAO Xijun HUA Yonghong FU Junyan ZHANG | 2023 | Friction2023，11，4： | 0 |
| 18 | Assessing the persistence of pharmaceuticals in the aquatic environment:Challenges and needs显示文摘Chemical’s persistence is known to be an important parameter applied for decades to identify persistent organic pollutants in hazard and/or risk assessments.Nevertheless it is greatly challenged in the case of emerging contaminants such as pharmaceuticals because the persistence of these chemicals could be more affected by environmental conditions.This fact brings more challenges to the current system for evaluating the persistence of chemical contaminants.In this paper,challenges in assessing the persistence of pharmaceuticals were identified,and more importantly research needs were addressed based on the existing data and knowledge. | Qingwei Bu Xiao Shi Gang Yu Jun Huang Bin Wang | 2016 | Emerging Contaminants2016，2，3： | 0 |
| 19 | Sensor network architecture for intelligent high-speed train on-board monitoring显示文摘The China's high-speed railway is experiencing a rapid growth.Its operating mileage and the number of operating trains will exceed 45 000 km and 1500 trains by 2015,respectively.During the long range and constant high-speed operation,the high-speed trains have extremely complex and varied work conditions.Such a situation creates a huge demand for high-speed train on-board monitoring.In this paper,architecture for high-speed train on-board monitoring sensor network is proposed.This architecture is designed to achieve the goals of reliable sensing,scalable data transporting,and easy management.The three design goals are realized separately.The reliable sensing is achieved by deploying redundant sensor nodes in the same components.Then a hierarchal transporting scheme is involved to meet the second goal.Finally,an electronic-tag based addressing method is introduced to solve the management problem. | Xiao-fan WU Chun CHEN Jia-jun BU Gang CHEN | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，12： | 0 |
| 20 | Constant-Volume Heat Capacity of Mixed Supercritical Fluids and Molecular Interaction in the Systems显示文摘Constant-volume heat capacities of supercritical (SC) CO2, SC CO2-n-pentane, and SCCO2-n-heptane mixtures were determined at 308.15 K in the pressure range from 6 to 12 MPa. Itwas found that there is a maximum in each heat capacity vs pressure curve. Intermolecularinteraction in the fluids was studied. | Lei SHI Xi Feng ZHANG Xiao Gang ZHANG Bu Xing HAN Guan Ying YANG Hai Ke YAN(Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080) | 1999 | Chinese Chemical Letters1999，10，10： | 0 |
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