|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node显示文摘 | Meng Wu Siwu Peng Jialiang Yang Zhidong TU Xiaoqiang Cai Chen-Leng Cai Zhong Wang Yong Zhao | 2014 | Cell Research2014，24，10： | 6 |
| 2 | MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation显示文摘MicroRNAs are small single-stranded RNA molecules consisting of approximately 22 nucleotides (nt), and have post-transcriptional regulatory functions. By gene chip screening, we previously showed that miR-142-3p was significantly upregulated in colorectal cancer tissue and was associated with clinicopathological features, compared with matched non-tumor tissue. In this study, we confirmed significant upregulation of miR-142-3p in 60 colorectal cancer samples and three colorectal cancer cell lines by quantitative real-time PCR (qRT-PCR). Using software and network resources, we predicted TCF7 as a target of miR-142-3p, which we confirmed with dual-luciferase assays. By RT-PCR and Western blot analysis, we found miR-142-3p negatively regulates TCF7 expression post-transcriptionally. CCK8 assays and growth curves indicated that overexpression of miR-142-3p in SW480 colorectal cancer cells potently inhibited cell proliferation in vitro. The expression of TCF7 mRNA and protein was upregulated in both colorectal cancer tissues and colorectal cancer cell lines, closely correlating with its function as an oncogene in promoting tumor cell proliferation and inhibiting apoptosis. With TCF7 as a direct target, our results suggested that miR-142-3p may be involved in the regulation of cell proliferation in colorectal cancer. | ZHOU JiaLiang JIANG Zhi WANG ZhengWu ZOU ShiTao ZHANG YunXia CAI Wei WANG MingZhi XU Min SHI DongTao CHEN WeiChang | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 3 | Tailoring Bi_(2)Te_(3) edge with semiconductor and metal properties under electron beam irradiation显示文摘In pursuit of miniaturization in the semiconductor industry,two-dimensional(2D)materials are used to fabricate new electronic devices.The topological insulator(TI)material bismuth telluride(Bi_(2)Te_(3)),as an emerging 2D material,has potential applications in electronic and spintronic devices due to its unique electrical properties.It is well known that the surface-to-volume ratio increases as the thickness of the material decreases,resulting in a more prominent edge effect.Therefore,for a single-layer Bi_(2)Te_(3),the atomic structure of the edge plays a crucial role in its electrical properties.Here,combining first-principles calculations and in situ transmission electron microscopy(TEM)experimental studies,we report that there are two types of edge structures in single-layer Bi2Te3:semiconducting flat edges and metallic zigzag edges.The dynamic evolution process of the edge structure with atomic resolution shows that the proportions of these two edges change with continuous electron beam irradiation.Our findings demonstrate the viability to use electron beam as an effective tool to precisely tailor the edge of Bi_(2)Te_(3) with desired properties,which paves the way for implementation of single-layer Bi2Te3 in electronics and spintronics. | Ning Cao Peng Liu Jialiang Pan Liheng Liang Kunpeng Cai Qingguo Shao Hongwei Zhu Xiaobei Zang | 2022 | Nano Research2022，15，5： | 2 |
| 4 | Correlation of precipita- tion to temperature variation in the Huanghe river (Yellow river) basin during 1957-2006显示文摘 | HUANG Yi CAI Jialiang HE Yin | 2009 | Journal of Hydrology2009，372，： | 1 |
| 5 | Key aquatic environmental factors affecting ecosystem health of streams in the Dianchi Lake watershed,China显示文摘 | Yi Huang Hang Wen Jialiang Cai | 2010 | Procedia Environmental Sciences2010，2，： | 1 |
| 6 | Practice and Research o f Training of Marine C/EA ided by ERS显示文摘 | HUANG Jialiang CHEN Dan CAI Zhenxiong | 2004 | International Conference of Engine Room Simulator (ICERS6)2004，，9： | 1 |
| 7 | Observation of magnetic droplets in magnetic tunnel junctions显示文摘Magnetic droplets,a class of highly nonlinear magnetodynamic solitons,can be nucleated and stabilized in nanocontact spintorque nano-oscillators.Here we experimentally demonstrate magnetic droplets in magnetic tunnel junctions(MTJs).The droplet nucleation is accompanied by power enhancement compared with its ferromagnetic resonance modes.The nucleation and stabilization of droplets are ascribed to the double-Co Fe B free-layer structure in the all-perpendicular MTJ,which provides a low Zhang-Li torque and a high pinning field.Our results enable better electrical sensitivity in fundamental studies of droplets and show that the droplets can be utilized in MTJ-based applications and materials science. | Kewen Shi Wenlong Cai Sheng Jiang Daoqian Zhu Kaihua Cao Zongxia Guo Jiaqi Wei Ao Du Zhi Li Yan Huang Jialiang Yin Johan Akerman Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 0 |
| 8 | Spintronics intelligent devices显示文摘Intelligent computing paradigms have become increasingly important for the efficient processing of massive amounts of data.However,using traditional electronic devices to implement these intelligent paradigms is currently mismatched and limited by their energy,area,and speed.Spintronics,which exploits the magnetic and electrical properties of electrons,could break through these limitations and bring new possibilities to electrical devices.In particular,the tunneling magnetoresistance effect,merging quantum and spintronics,enables spintronic devices to be compatible with standard integrated circuits with a magnetic tunnel junction(MTJ)design,showing great potential for implementing hardware-based intelligent frameworks.In this review,we introduce the specific capabilities of MTJs,including nonvolatility,stochasticity,plasticity,and nonlinearity,which are highly favorable in artificial intelligence algorithms.We then present how these devices could impact the development of intelligent computing,including in-memory computing,probabilistic computing,and neuromorphic computing.Finally,we discuss their challenges and perspectives in intelligent hardware implementations. | Wenlong Cai Yan Huang Xueying Zhang Shihong Wang Yuanhao Pan Jialiang Yin Kewen Shi Weisheng Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，11： | 0 |
| 9 | Thermally tunable GeSi electro-absorption modulator with a wide effective operating wavelength range显示文摘We demonstrate a GeSi electro-absorption modulator with on-chip thermal tuning for the first time,to the best of our knowledge.Theoretical simulation proves that the device temperature can be tuned and the effective operating wavelength range can be broadened.When the heater power is 4.63 mW,the temperature of the waveguide increases by about 27 K and the theoretical operating wavelength range is broadened by 23.7 nm.The experimental results show that the optical transmission line shifted to the longer wavelength by 4.8 nm by every 1 mW heater power.The effective static operating wavelength range of the device is increased from 34.4 nm to 60.1 nm,which means it is broadened by 25.7 nm.The band edge shift coefficient of 0.76 nm/K is obtained by temperature simulation and linear fitting of the measured data.The device has a 3 dB EO bandwidth of 89 GHz at 3 V reverse bias,and the eye diagram measurement shows a data rate of 80 Gbit/s for non-return-to-zero on–off keying modulation and 100 Gbit/s for 4 pulse amplitude modulation in the 1526.8 nm to 1613.2 nm wavelength range as the heater power increases from 0 mW to 10.1 mW. | YUFEI LIU JIALIANG SUN XINYU LI SHUXIAO WANG WENCHENG YUE YAN CAI MINGBIN YU | 2023 | Photonics Research2023，11，8： | 0 |
| 10 | TMEM106A transcriptionally regulated by promoter methylation is involved in invasion and metastasis of hepatocellular carcinoma显示文摘Expression of transmembrane protein 106A(TMEM106A)has been reported to be dysregulated in several types of cancers.However,the role of TMEM106A in hepatocellular carcinoma(HCC)is still unknown.In the present study,we demonstrate that TMEM106A is markedly downregulated in HCC compared with normal liver tissue.In particular,tumor-specific DNA methylation of TMEM106A is frequently observed in tumor tissues from HCC patients.Immunohistochemistry and pyrosequencing reveal a significant relationship between TMEM106A methylation and downregulation of protein expression.Receiver operating characteristic(ROC)curve analysis reveals that methylation of TMEM106A in tumor samples is different from that in non-malignant adjacent tissues of HCC patients.Moreover,HCC patients with TMEM106A hypermethylation have a poor clinical prognosis.5-Aza-2′-deoxycytidin treatment of hypermethylated TMEM106A in highly metastatic HCC cells increases the expression of TMEM106A.Functional assays reveal that overexpression of TMEM106A significantly suppresses the malignant behavior of HCC cells in vitro and decreases tumorigenicity and lung metastasis in vivo.Mechanistically,TMEM106A inhibits epithelial mesenchymal transition(EMT)of HCC cells through inactivation of the Erk1/2/Slug signaling pathway.In conclusion,our findings demonstrate that TMEM106A is an inhibitor of HCC EMT and metastasis,and TMEM106A is often transcriptionally downregulated by promoter methylation,which results in reduced levels of TMEM106A protein and predicts poor survival outcomes for HCC patients. | Shiming Shi Biao Wang Jinglei Wan Lina Song Guiqi Zhu Junxian Du Luxi Ye Qianqian Zhao Jialiang Cai Qing Chen Kun Xiao Jian He Lei Yu Zhi Dai | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 11 | Implementation of 16 Boolean logic operations based on one basic cell of spin-transfer-torque magnetic random access memory显示文摘In-memory computing(IMC)systems based on emerging nonvolatile memories(NVMs)provide a thorough solution for memory wall issues and von Neumann bottlenecks.Massive IMC schemes have been proposed by utilizing ingenious structures and additional auxiliary components.However,these schemes are not compatible with the basic cell(one memory unit and one transistor)of emerging random-access memory(RAM),which goes against low-power and high-density requirements.In this paper,we propose a logic implementation scheme based on one magnetic tunnel junction and one transistor(1MTJ-1T),which is the basic cell of spin-transfer-torque magnetic RAM(STT-MRAM).With no other assistance,complete 16 logic operations can be accomplished in two steps with their logic outputs in-situ stored in the MTJ.The area(0.2μm^(2))and energy consumption per logic operation(1.1-2.6 pJ)of the logic gates under 14 nm process node are evaluated using SPICE simulations,indicating its excellent performance.Our work exhibits a 1MTJ-1Tbased logic operation implementation,which can bridge the gap between STT-MRAM and high-performance IMC applications. | Yan HUANG Kaihua CAO Kun ZHANG Jinkai WANG Kewen SHI Zuolei HAO Wenlong CAI Ao DU Jialiang YIN Qing YANG Junfeng LI Jianfeng GAO Chao ZHAO Weisheng ZHAO | 2023 | Science China(Information Sciences)2023，66，6： | 0 |
| 12 | Mechanism of field-like torque in spin-orbit torque switching of perpendicular magnetic tunnel junction显示文摘The current-induced spin-orbit torque(SOT) is one of the most promising ways for high speed and low power spintronics devices. However, the mechanism of SOT driven magnetization reversal, especially the role of the field-like torque(FLT), is still unclear. Here, we report the observed promotion and suppression of switching by FLT, which depends on the relative direction of FLT and spin polarization. Our results reveal that the FLT could modulate the switching speed and power consumption by affecting the work done by the damping-like torque, and leads two different reversal dynamical paths during the switching.Furthermore, the origin of incubation time in SOT induced switching is clarified simultaneously. | Yudong Zhuo Wenlong Cai Daoqian Zhu Hongchao Zhang Ao Du Kaihua Cao Jialiang Yin Yan Huang Kewen Shi Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 0 |
| 13 | Cancer susceptibility genes: update and systematic perspectives显示文摘A cancer susceptibility gene(CSG)is a gene whose variants can increase the cancer risk of those bearing such variants.1 By defining an individual’s CSG profile,it may be possible to assess their cancer risk and may provide insights for future prevention and treatment of cancer.The methods used for discovery of CSGs have evolved from single candidate gene analysis to population-based next-generation sequencing. | Xiaoshun Shi Sylvia Young Kaican Cai Jialiang Yang Grant Morahan | 2022 | The Innovation2022，3，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员