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| 1 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | Chong Cai ChangJie Xu LanLan Shan Xian Li ChunHua Zhou WangShu Zhang Ian Ferguson KunSong Chen | 2006 | Postharvest Biology and Technology2006，，3： | 2 |
| 2 | Design of a Concentration Solar Thermoelectric Generator显示文摘 | Peng Li Lanlan Cai Pengcheng Zhai Xinfeng Tang Qingjie Zhang M. Niino | 2010 | Journal of Electronic Materials2010，，9： | 1 |
| 3 | Fabrication, characterization and photocatalytic activity of Gd 3+ -doped titania nanoparticles with mesostructure显示文摘 | De Zhao Tianyou Peng Min Liu Lanlan Lu Ping Cai | 2008 | Microporous and Mesoporous Materials2008，，1： | 1 |
| 4 | Variations of temperature, precipitation, and extreme events in Heilongjiang River 显示文摘 | Yu Lanlan Xia Ziqiang Cai Tao | 2012 | ProeediaEngineering2012，28，： | 1 |
| 5 | Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients显示文摘 | Yi Li Xin Hu Bei Cai Jie Chen Yangjuan Bai Jiangtao Tang Yun Liao Lanlan Wang | 2012 | Transplant Immunology2012，，1： | 1 |
| 6 | 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection显示文摘 | Wang, Song Luo, Xiaoqin Yan, Ruoxiang Wang, Quanxin Qi, Qiuyue Chi, Xiaojuan Zhang, Lanlan Yu, Ziding Cai, Binxiang Chen, Ji-Long Liu, Hongwei | 2016 | Protein & Cell2016，7，11： | 1 |
| 7 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | Cai Chong Xu Changjie Shan Lanlan | 2006 | Postharvest Biology and Technology2006，41，3： | 1 |
| 8 | Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation显示文摘Uncontrolled and persistent inflammation is closely related to numerous acute and chronic diseases.However,effective targeting delivery systems remain to be developed for precision therapy of inflammatory diseases.Herein we report a novel strategy for engineering inflammationaccumulation nanoparticles via phenolic functionalization.Different phenol-functionalized nanoparticles were first developed,which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment.Phenolic compound-decorated poly(lactide-co-glycolide)nanoparticles,in particular tyramine(Tyr)-coated nanoparticles,showed significantly enhanced accumulation at inflammatory sites in mouse models of colitis,acute liver injury,and acute lung injury,mainly resulting from in situ cross-linking and tissue anchoring of nanoparticles triggered by local myeloperoxidase and reactive oxygen species.By combining a cyclodextrin-derived bioactive material with Tyr decoration,a multifunctional nanotherapy(TTN)was further developed,which displayed enhanced cellular uptake,antiinflammatory activities,and inflammatory tissue accumulation,thereby affording amplified therapeutic effects in mice with colitis or acute liver injury.Moreover,TTN can serve as a bioactive and inflammation-targeting nanoplatform for site-specifically delivering a therapeutic peptide to the inflamed colon post oral administration,leading to considerably potentiated in vivo efficacies.Preliminary studies also revealed good safety of orally delivered TTN.Consequently,Tyr-based functionalization is promising for inflammation targeting amplification and therapeutic potentiation of nanotherapies. | Qiang Nie Chenwen Li Yu Wang Yi Hu Wendan Pu Qixiong Zhang Jiajun Cai Yongyao Lin Gang Li Chenping Wang Lanlan Li Yin Dou Jianxiang Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 1 |
| 9 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | CAI Chong XU Changjie SHAN Lanlan | 2006 | Postharvest Biology and Technology2006，41，： | 1 |
| 10 | The smallest in the deepest:the enigmatic role of viruses in the deep biosphere显示文摘It is commonly recognized that viruses control the composition,metabolism,and evolutionary trajectories of prokaryotic communities,with resulting vital feedback on ecosystem functioning and nutrient cycling in a wide range of ecosystems.Although the deep biosphere has been estimated to be the largest reservoir for viruses and their prokaryotic hosts,the biology and ecology of viruses therein remain poorly understood.The deep virosphere is an enigmatic field of study in which many critical questions are still to be answered.Is the deep virosphere simply a repository for deeply preserved,non-functioning virus particles?Or are deep viruses infectious agents that can readily infect suitable hosts and subsequently shape microbial populations and nutrient cycling?Can the cellular content released by viral lysis,and even the organic structures of virions themselves,serve as the source of bioavailable nutrients for microbial activity in the deep biosphere as in other ecosystems?In this review,we synthesize our current knowledge of viruses in the deep biosphere and seek to identify topics with the potential for substantial discoveries in the future. | Lanlan Cai Markus GWeinbauer Le Xie Rui Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 11 | A crosslinked polymer as dopant-free hole-transport material for efficient n-i-p type perovskite solar cells显示文摘A new crosslinked polymer,called P65,with appropriate photo-electrochemical,opto-electronic,and thermal properties,has been designed and synthesized as an efficient,dopant-free,hole-transport material(HTM)for n-i-p type planar perovskite solar cells(PSCs).P65 is obtained from a low-cost and easily synthesized spiro[fluorene-9,90-xanthene]-30,60-diol(SFX-OH)-based monomer X65 through a freeradical polymerization reaction.The combination of a three-dimensional(3 D)SFX core unit,holetransport methoxydiphenylamine group,and crosslinked polyvinyl network provides P65 with good solubility and excellent film-forming properties.By employing P65 as a dopant-free hole-transport layer in conventional n-i-p type PSCs,a power conversion efficiency(PCE)of up to 17.7%is achieved.To the best of our knowledge,this is the first time a 3 D,crosslinked,polymeric dopant-free HTM has been reported for use in conventional n-i-p type PSCs.This study provides a new strategy for the future development of a 3 D crosslinked polymeric dopant-free HTM with a simple synthetic route and low-cost for commercial,large-scale applications in future PSCs. | Linqin Wang Fuguo Zhang Tianqi Liu Wei Zhang Yuanyuan Li Bin Cai Lanlan He Yu Guo Xichuan Yang Bo Xu James M.Gardner Lars Kloo Licheng Sun | 2021 | Journal of Energy Chemistry2021，30，4： | 0 |
| 12 | Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells显示文摘Asthma is a serious global public health concern. Airway neutrophilic inflammation is closely related to severe asthma, for which effective and safe therapies remain to be developed. Here we report nanotherapies capable of simultaneously regulating multiple target cells relevant to the pathogenesis of neutrophilic asthma. A nanotherapy LaCD NP based on a cyclic oligosaccharide-derived bioactive material was engineered. LaCD NP effectively accumulated in the injured lungs of asthmatic mice and mainly distributed in neutrophils, macrophages, and airway epithelial cells after intravenous or inhalation delivery, thereby ameliorating asthmatic symptoms and attenuating pulmonary neutrophilic inflammation as well as reducing airway hyperresponsiveness, remodeling, and mucus production. Surface engineering via neutrophil cell membrane further enhanced targeting and therapeutic effects of LaCD NP. Mechanistically, LaCD NP can inhibit the recruitment and activation of neutrophils, especially reducing the neutrophil extracellular traps formation and NLRP3 inflammasome activation in neutrophils. Also, LaCD NP can suppress macrophage-mediated pro-inflammatory responses and prevent airway epithelial cell death and smooth muscle cell proliferation, by mitigating neutrophilic inflammation and its direct effects on relevant cells. Importantly, LaCD NP showed good safety performance. Consequently, LaCD-derived multi-bioactive nanotherapies are promising for effective treatment of neutrophilic asthma and other neutrophil-associated diseases. | Jiajun Cai Hui Tao Huan Liu Yi Hu Songling Han Wendan Pu Lanlan Li Gang Li Chenwen Li Jianxiang Zhang | 2023 | Bioactive Materials2023，，10： | 0 |
| 13 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
| 14 | Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer显示文摘Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect.Here,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping.Meanwhile,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis.This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency. | Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai | 2022 | Nano Research2022，15，5： | 0 |
| 15 | The effect of aluminum of human islet amyioid ion on the aggregation polypeptide (11-28)显示文摘 | Lanlan Su Cheng Lu Peng Yan Nan Zhang Sheng Cai Gongjun Zhang Xingfei Zhou Bin Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 0 |
| 16 | LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study显示文摘 | SHI Meiyun YIN Lei CAI Lanlan WANG Can LIU Xidong ZHAO Sen SUN Yantong FAWCETT J. Paul ZHAO Limei YANG Yan GU Jingkai | 2014 | Chemical Research in Chinese Universities2014，30，6： | 0 |
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