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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Size and shape control of LiFePO4 nanocrystals for better lithium ion battery cathode materials显示文摘锂铁磷酸盐(LiFePO4 ) 是为锂离子电池,而是低电子电导率和单个散开隧道的潜在的高效率阴极材料因为锂离子在这材料的合成期间要求好粒子尺寸和形状控制。在这份报纸,有不同尺寸和形状的六 LiFePO4 nanocrystals 成功地在乙烯乙二醇被综合了。形成 LiFePO4 nanocrystals 与的增加顺序 Fe-PO4-Li 帮助主要 { 010 } 暴露的脸,并且增加 LiOH 的数量在粒子尺寸导致减少。六个不同 LiFePO4 粒子的电气化学的表演证明最有希望的 LiFePO4 nanocrystals 任何一个有占优势 { 010 } 脸暴露或高特定的区域,用小铁(II ) 氧化。 | Caiyun Nan Jun Lu Lihong Li Lingling Li Qing Peng Yadong Li | 2013 | Nano Research2013，6，7： | 25 |
| 3 | Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model显示文摘Objective: To develop and validate a radiomics prediction model for individualized prediction of perineural invasion(PNI) in colorectal cancer(CRC).Methods: After computed tomography(CT) radiomics features extraction, a radiomics signature was constructed in derivation cohort(346 CRC patients). A prediction model was developed to integrate the radiomics signature and clinical candidate predictors [age, sex, tumor location, and carcinoembryonic antigen(CEA) level]. Apparent prediction performance was assessed. After internal validation, independent temporal validation(separate from the cohort used to build the model) was then conducted in 217 CRC patients. The final model was converted to an easy-to-use nomogram.Results: The developed radiomics nomogram that integrated the radiomics signature and CEA level showed good calibration and discrimination performance [Harrell's concordance index(c-index): 0.817; 95% confidence interval(95% CI): 0.811–0.823]. Application of the nomogram in validation cohort gave a comparable calibration and discrimination(c-index: 0.803; 95% CI: 0.794–0.812).Conclusions: Integrating the radiomics signature and CEA level into a radiomics prediction model enables easy and effective risk assessment of PNI in CRC. This stratification of patients according to their PNI status may provide a basis for individualized auxiliary treatment. | Yanqi Huang Lan He Di Dong Caiyun Yang Cuishan Liang Xin Chen Zelan Ma Xiaomei Huang Su Yao Changhong Liang Jie Tian Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 23 |
| 4 | Numerical simulation of powder transport behavior in laser cladding with coaxial powder feeding显示文摘Laser cladding with coaxial powder feeding is one of the new processes applied to produce well bonding coating on the component to improve performance of its surface. In the process, the clad material is transported by the carrying gas through the coaxial nozzle, generating gas-powder flow. The powder feeding process in the coaxial laser cladding has important influence on the clad qualities. A 3D numerical model was developed to study the powder stream structure of a coaxial feeding nozzle. The predicted powder stream structure was well agreed with the experimental one. The validated model was used to explore the collision behavior of particles in the coaxial nozzle, as well as powder concentration distribution. It was found that the particle diameter and restitution coefficient greatly affect the velocity vector at outlet of nozzle due to the collisions, as well as the powder stream convergence characteristics below the nozzle. The results indicated a practical approach to optimize the powder stream for the coaxial laser cladding. | LIU Hao HE XiuLi YU Gang WANG Zhong Bin LI ShaoXia ZHENG CaiYun NING WeiJian | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 17 |
| 5 | Rare earth element and yttrium compositions of the Paleoproterozoic Yuanjiacun BIF in the Lüliang area and their implications for the Great Oxidation Event(GOE)显示文摘In China, most Precambrian banded iron formations(BIFs) are situated in the North China Craton. The Yuanjiacun iron deposit, located in the Lüliang area, is arguably the most representative Superior-type BIF. This iron deposit is coherent with the sedimentary rock succession of the Yuanjiacun Formation in the lower Lüliang Group, and was interpreted to be deposited at 2.3–2.1 Ga, based on ages of overlying and underlying volcanic strata. This age overlaps with the time range of the Great Oxidation Event(GOE, 2.4–2.2 Ga). The Yuanjiacun BIF consists mainly of subhedral-xenomorphic magnetite and quartz and rarely other minerals with a lower degree of metamorphism, from greenschist to lower amphibolite facies. The geochemical characteristics of this BIF are similar to those of Superior-type BIFs. Prominent positive La, Y, and Eu anomalies normalized by the Post Archean Australian Shale(PAAS) indicate that the primary chemical precipitate is a result of solutions that represent mixtures of seawater and high-T hydrothermal fluids. The contamination from crustal detritus found is negligible based on low abundances of Al2O3 and TiO2(<0.5%) and of trace elements such as Th, Hf, Zr, and Sc(<1.5 ppm), as well as the lack of co-variations between Al2O3 and TiO2. In particular, the Yuanjiacun BIF samples do not display significant negative Ce anomalies like those of the Archean iron formations, but rather, the Yuanjiacun BIF samples exhibit prominent positive Ce anomalies, low Y/Ho ratios, and high light to heavy REE((Pr/Yb)SN) ratios, which are essentially consistent with the late Paleoproterozoic(<2.0 Ga) BIFs around the world. These characteristics of the Yuanjiacun BIF samples imply that the ancient ocean(2.3–2.1 Ga) was redox-stratified from oxic shallow water to deeper anoxic water. The specific redox conditions of the ancient ocean may be related to the GOE, which gave rise to the oxidation of Ce and Mn in the upper water, and to the presence of a Mn oxide shuttle in the ocean, resulting in varying REE patterns due to the precipitation and dissolution of this Mn oxide shuttle under different redox states. Therefore, the Yuanjiacun BIF appears to have formed near the redoxcline and lower-level reduced marine water. | WANG ChangLe ZHANG LianChang LAN CaiYun DAI YanPei | 2014 | Science China Earth Sciences2014，57，10： | 13 |
| 6 | Recent progress in 2D materials for flexible supercapacitors显示文摘High performance supercapacitors coupled with mechanical flexibility are needed to drive flexible and wearable electronics that have anesthetic appeal and multi-functionality. Two dimensional(2D) materials have attracted attention owing to their unique physicochemical and electrochemical properties, in addition to their ability to form hetero-structures with other nanomaterials further improving mechanical and electrochemical properties. After a brief introduction of supercapacitors and 2D materials, recent progress on flexible supercapacitors using 2D materials is reviewed. Here we provide insights into the structure–property relationships of flexible electrodes, in particular free-standing films. We also present our perspectives on the development of flexible supercapacitors. | Yan Han Yu Ge Yunfeng Chao Caiyun Wang Gordon G.Wallace | 2018 | Journal of Energy Chemistry2018，27，1： | 11 |
| 7 | Porous bowl-shaped VS2 nanosheets/graphene composite for high-rate lithium-ion storage显示文摘Two-dimensional (2D) layered vanadium disulfide (VS2) is a promising anode material for lithium ion batteries (LIBs) due to the high theoretical capacity.However,it remains a challenge to synthesize monodispersed ultrathin VS2 nanosheets to realize the full potential.Herein,a novel solvothermal method has been developed to prepare the monodispersed bowl-shaped NH3-inserted VS2 nanosheets (VS2).The formation of such a unique structure is caused by the blocked growth of (001) or (002) crystal planes in combination with a ripening process driven by the thermodynamics.The annealing treatment in Ar/H2creates porous monodispersed VS2(H-VS2),which is subsequently integrated with graphene oxide to form porous monodispersed H-VS2/rGO composite coupled with a reduction process.As an anode material for LIBs,H-VS2/rGO delivers superior rate performance and longer cycle stability:a high average capacity of 868/525 mAh g^-1 at a current density of 1/10 A g^-1;a reversible capacity of 1177/889 mAh g^-1 after 150/500 cycles at 0.2/1 A g^-1.Such excellent electrochemical performance may be attributed to the increased active sites available for lithium storage,the alleviated volume variations and the shortened Li-ion diffusion induced from the porous structure with large specific surface area,as well as the protective effect from graphene nanosheets. | Daxiong Wu Caiyun Wang Mingguang Wu Yunfeng Chao Pengbin He Jianmin Ma | 2020 | Journal of Energy Chemistry2020，29，4： | 11 |
| 8 | Phase-transfer interface promoted corrosion from PtNi10 nanoctahedra to Pt4Ni nanoframes显示文摘向 PtNi 的腐蚀的一条新奇二阶段的途径 < 潜水艇 class= “ a-plus-plus ” > 10 nanoctahedra 被开发了。在这策略,在油可溶的 PtNi 的 Ni 的活跃部件 < 潜水艇 class= “ a-plus-plus ” > 居住在上面的甲苯阶段,受不了蚀刻并且是的 10 nanoctahedra 然后由 ethylenediaminetetraacetate (EDTA ) 与协作转了进一个更低的水的阶段。由于 EDTA 支持的阶段转移接口的存在,腐蚀反应在温和条件下面以加速的率继续了。明确地,八面的磅的结果的产品 < 潜水艇 class= “ a-plus-plus ” > 4 Ni nanoframes 成功地第一次被制作,并且 PtNi < 潜水艇 class= “ a-plus-plus ” > 4 当 EDTA-2Na 的剂量被减少时,多孔的 octahedra 能被获得。在这个二阶段的系统的系统的研究以后,合作腐蚀机制被建议说明八面的磅的形成<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes ,从许多种类包含贡献(即, O <潜水艇class=“ a-plus-plus ”> 2 , H <潜水艇class=“ a-plus-plus ”> 2 O , H <啜class=“ a-plus-plus ”>+, OAm ,和 EDTA <潜水艇class=“ a-plus-plus ”> 4 )。由于磅的迷人的三维的几何学<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes 和 PtNi <潜水艇class=“ a-plus-plus ”> 4 多孔的 octahedra ,两个在太古的 PtNi 上侵蚀的 nanocrystals 显示出优异活动<潜水艇class=“ a-plus-plus ”>为在硝基苯的碱的媒介和加氢的乙醇 electrooxidation 的 10 nanoctahedra 。 | Yu Wang Yueguang Chen Caiyun Nan Lingling Li Dingsheng Wang Qing Peng Yadong Li | 2015 | Nano Research2015，8，1： | 10 |
| 9 | Lentiviral-mediated gene transfer into human adipose-derived stem cells:role of NELL1 versus BMP2 in osteogenesis and adipogenesis in vitro显示文摘(NELL1 ) 象 NEL 一样分子 1 是与 craniosynostosis 联系的一个有势力 osteogenic 因素。侵入人体气管粘膜的病菌,大多数通常为基因治疗使用了病毒的向量,有可以限制成骨的几劣势。以前的研究证明了 lentiviruses 能为骨头新生为基因治疗用作理想的向量。在这研究,编码人的 NELL1 和骨头的二 lentiviral 向量(LvNELL1 和 LvBMP2 ) 分别地,形态基因的 protein-2 (BMP2 ) 被构造。在 vitro 的人的脂肪质导出干细胞(hADSCs ) 的增长,成骨,和 adipogenesis 上的 LvNELL1 感染的效果被估计并且与 LvBMP2 的相比。结果显示出感染 LvNELL1 的那 hADSCs 能高效地并且稳定地 overexpress 目标基因。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物试金结果表明了那 LvBMP2,然而并非 LvNELL1,提高了 hADSCs 的增长。对碱的磷酸酶活动和细胞的矿化作用的评价显示 LvNELL1 感染支持了 hADSCs 的 osteogenic 区别,并且效果与 LvBMP2 的是可比较的。实时聚合酶链反应(PCR ) 在 hADSCs 揭示了那 LvNELL1 感染 upregulated OSX 表情然而并非 RUNX2 表示。另外,分析显示出的 adipogenic 标记(类脂化合物微滴, peroxisome 激活 proliferator 受体,和脂蛋白脂肪分解酵素) LvNELL1 能戏剧性地禁止 hADSCs,而是 LvBMP2 的 adipogenic 区别,这没有如此的效果。一起拿,这些调查结果建议在 hADSCs 的调停 lentiviral 的 NELL1 基因转移可以是一条新奇、有希望的途径完成有效、精确的骨头新生。 | Yajing Liu Caiyun Chen Huixia He Dongsheng Wang LingLing E Zhongyu Liu Hongchen Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 10 | Flexible SnS nanobelts: Facile synthesis, formation mechanism and application in Li-ion batteries显示文摘 | Jun Lu | 2013 | Nano Research2013，6，1： | 9 |
| 11 | Molecular, Functional, and Structural Imaging of Major Depressive Disorder显示文摘Major depressive disorder(MDD) is a significant cause of morbidity and mortality worldwide,correlating with genetic susceptibility and environmental risk factors.Molecular,functional,and structural imaging approaches have been increasingly used to detect neurobiological changes,analyze neurochemical correlates,and parse pathophysiological mechanisms underlying MDD.We reviewed recent neuroimaging publications on MDD in terms of molecular,functional,and structural alterations as detected mainly by magnetic resonance imaging(MRI) and positron emission tomography.Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated.An abnormal default mode network,as revealed by resting-state functional MRI,is likely associated with aberrant metabolicand serotonergic function revealed by radionuclide imaging.Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD. | Kai Zhang Yunqi Zhu Yuankai Zhu Shuang Wu Hao Liu Wei Zhang Caiyun Xu Hong Zhang Takuya Hayashi Mei Tian | 2016 | Neuroscience Bulletin2016，32，3： | 9 |
| 12 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 13 | Molybdenum and tungsten chalcogenides for lithium/sodium-ion batteries: Beyond MoS2显示文摘Molybdenum and tungsten chalcogenides have attracted tremendous attention in energy storage and conversion due to their outstanding physicochemical and electrochemical properties.There are intensive studies on molybdenum and tungsten chalcogenides for energy storage and conversion,however,there is no systematic review on the applications of WS2,Mo Se2and WSe2as anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs),except Mo S2.Considering the importance of these contents,it is extremely necessary to overview the recent development of novel layered WS2,Mo Se2and WSe2beyond Mo S2in energy storage.Here,we will systematically overview the recent progress of WS2,Mo Se2and WSe2as anode materials in LIBs and SIBs.This review will also discuss the opportunities,and perspectives of these materials in the energy storage fields. | Junda Huang Zengxi Wei Jiaqin Liao Wei Ni Caiyun Wang Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，6： | 7 |
| 14 | Experimental realization of honeycomb borophene显示文摘We report the successful preparation of a purely honeycomb,graphene-like borophene,by using an Al(11 1) surface as the substrate and molecular beam epitaxy(MBE) growth in ultrahigh vacuum.Scanning tunneling microscopy(STM) images reveal perfect monolayer borophene with planar,non-buckled honeycomb lattice similar as graphene.Theoretical calculations show that the honeycomb borophene on Al(1 1 1) is energetically stable.Remarkably,nearly one electron charge is transferred to each boron atom from the Al(1 1 1) substrate and stabilizes the honeycomb borophene structure,in contrast to the negligible charge transfer in case of borophene/Ag(1 1 1).The existence of honeycomb 2 D allotrope is important to the basic understanding of boron chemistry,and it also provides an ideal platform for fabricating boron-based materials with intriguing electronic properties such as Dirac states. | Wenbin Li Longjuan Kong Caiyun Chen Jian Gou Shaoxiang Sheng Weifeng Zhang Hui Li Lan Chen Peng Cheng Kehui Wu | 2018 | Science Bulletin2018，63，5： | 7 |
| 15 | Temporal-spatial subspaces modern combination method for 2D-DOA estimation in MIMO radar显示文摘A 2D-direction of arrival estimation(DOAE) for multiinput and multi-output(MIMO) radar using improved multiple temporal-spatial subspaces in estimating signal parameters via rotational invariance techniques method(TS-ESPRIT) is introduced. In order to realize the improved TS-ESPRIT, the proposed algorithm divides the planar array into multiple uniform sub-planar arrays with common reference point to get a unified phase shifts measurement point for all sub-arrays. The TS-ESPRIT is applied to each sub-array separately, and in the same time with the others to realize the parallelly temporal and spatial processing, so that it reduces the non-linearity effect of model and decreases the computational time. Then, the time difference of arrival(TDOA)technique is applied to combine the multiple sub-arrays in order to form the improved TS-ESPRIT. It is found that the proposed method achieves high accuracy at a low signal to noise ratio(SNR)with low computational complexity, leading to enhancement of the estimators performance. | Youssef Fayad Caiyun Wang Qunsheng Cao | 2017 | Journal of Systems Engineering and Electronics2017，28，4： | 7 |
| 16 | Electrospun CoSe@N-doped carbon nanofibers with highly capacitive Li storage显示文摘One-dimensional nano-structured materials have attracted attention due to its unique properties afforded such as the across-linked structures and large aspect ratios.In this work,one-dimensional CoSe@N-doped carbon nanofibers(CoSe@NCNFs)are successfully by combining the techniques of electrospinning and annealing.Selenium powder are directly dispersed in the polyacrylonitrile/N,N-Dimethylformamide(DMF)solution containing cobalt salt to form the product.The performance of these materials was investigated in Li-ion batteries after the annealing at different temperatures.The Co Se@NC nanofibers annealed at 550℃(CoSe@NC-550)and displayed excellent storage properties,affording a high capacity of 796 m Ah·g-1at a current density of 1 A·g^-1 for 100 cycles.Moreover,it is confirmed that the pseudocapacitive contribution of CoSe@NC-550 is up to 72.8%at the scan rate of 1 mV/s through the cyclic voltammetry analysis. | Jiandong Liu Jiaojiao Liang Caiyun Wang Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，6： | 6 |
| 17 | Learning block-structured incoherent dictionaries for sparse representation显示文摘Dictionary learning is still a challenging problem in signal and image processing. In this paper, we propose an efficient block-structured incoherent dictionary learning algorithm for sparse representations of image signals. The constrained minimization of dictionary learning is achieved by iteratively alternating between sparse coding and dictionary update. Without relying on any prior knowledge of the group structure for the input data, we develop a two-stage clustering method that identifies the underlying block structure of the dictionary under certain restricted constraints. The two-stage clustering method mainly consists of affinity propagation and agglomerative hierarchical clustering. To meet the conditions of both the upper bound and the lower bound of the mutual coherence of dictionary atoms, we introduce a regularization term for the objective function to adjust the block coherence of the overcomplete dictionary. The experiments on synthetic data and real images demonstrate that the proposed dictionary learning algorithm has lower representation error, higher visual quality and better reconstructed results than most of the state-of-the-art methods. | ZHANG YongQin XIAO JinSheng LI ShuHong SHI CaiYun XIE GuoXi | 2015 | Science China(Information Sciences)2015，58，10： | 6 |
| 18 | Identification of petroleum aromatic fraction by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry显示文摘Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry(GC×GC-TOFMS) is commercially available in the 1990s,with the characteristics of large peak capacity,high resolution,high sensitivity,etc.However,its application to the petroleum and geological analyses is just emerging in China and overseas.In this research,the analytical method for petroleum aromatic fraction using GC×GC-TOFMS is set up,via the choice of the column system and optimization of setting parameters,such as temperature programming,modulation time,hot pulse time,flow rate of carrier gas,data acquisition rate and data processing.The results indicate that different polar compounds of aromatic fraction distribute as bands on structured GC×GC chromatogram.Within each band,homologous compounds appear as a roof-tile structure based on the number of substituent residues.The aromatic compounds are identified and characterized according to the GC×GC chromatogram and mass spectra.According to the polarity and the number of rings,aromatic compounds are spatially present on one chromatogram,which directly reflects the distribution characteristics of complex compounds of aromatic hydrocarbons.In addition,quantitative analysis is favored as some overlapped peaks on traditional GC-MS chromatogram have been separated completely on GC×GC.Some heterocyclic atom aromatic compounds at trace level can be clearly identified using this method,for polarity differences from other interfered aromatic compounds.The development of this method and chromatogram recognition offer petroleum geologists a practical example for the application performance of GC×GC-TOFMS. | WANG HuiTong WENG Na ZHANG ShuiChang ZHU GuangYou CHEN JianPing WEI CaiYun | 2010 | Chinese Science Bulletin2010，55，19： | 6 |
| 19 | Expressions of apoptosis-related proteins in rats with focal cerebral ischemia after Angong Niuhuang sticker point application显示文摘In this study, we extracted and purified components in the Angong Niuhuang pill. Then we applied transdermal enhancers to Angong Niuhuang stickers by modern technology. The Angong Niuhuang sticker includes extracts from curcuma, berberine hydrochloride, baicalin, geniposide, borneol, and musk. Angong Niuhuang stickers at different point application doses (1.35, 2.7, and 5.4 g/kg) were administered to Dazhui (DU14), Qihai (RN6) and Mingmen (DU4). Rats in the different dose point application and acupuncture groups were continuously administered for 7 days. Then a middle cerebral artery occlusion model was prepared for simulating human cerebral ischemia. Twelve hours later, expressions of Bcl-2, Bax and p53 protein in hippocampal CA1 were detected with immunohistochemistry. The expression level of Bcl-2, an anti-apoptotic protein, significantly increased in the high-, medium- and low-dose point application groups and the acupuncture group, while the expression of the pro-apoptotic proteins, Bax and p53, significantly decreased compared with the middle cerebral artery occlusion rats; and the Bcl-2/Bax ratio was significantly increased. The difference was noticeable for the high-dose point application group, which showed statistical difference compared with the low-dose point application group and the acupuncture group. Our experimental findings indicate that point application with Angong Niuhuang stickers promotes the expression of Bcl-2, and inhibits the expressions of Bax and p53 in the hippocampal CA1 area of rats after focal cerebral ischemia. Thus, point application of Angong Niuhang stickers protects brain tissues from cerebral ischemia. | Dongshu Zhang Maodong Fu Chenglong Song Caiyun Wang Xiaochun Lin Yuanliang Liu | 2012 | Neural Regeneration Research2012，7，30： | 6 |
| 20 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
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