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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Aiming to immune elimination of ovarian cancer stem cells显示文摘Ovarian cancer accounts for only 3% of all cancers in women, but it causes more deaths than any other gynecologic cancer. Treatment with chemotherapy and cytoreductive surgery shows a good response to the therapy. However, in a large proportion of the patients the tumor grows back within a few years. Cancer stem cells, that are less responsive to these treatments, are blamed for this recurrence of disease. Immune therapy either cellular or humoral is a novel concept to treat cancer. It is based on the notice that immune cells invade the tumor. However, the tumor invest heavily to escape from immune elimination by recruiting several immune suppressive mechanisms. These processes are normally in place to limit excessive immune activation and prevent autoimmune phenomena. Here, we discuss current knowledge about the immune(suppressive)status in ovarian cancer. Moreover, we discuss the immunological targets of ovarian cancer stem cells. | Jiabo Di Tjitske Duiveman-de Boer Carl G Figdor Ruurd Torensma | 2013 | World Journal of Stem Cells2013，5，4： | 7 |
| 3 | Dirichlet Process Gaussian Mixture Models:Choice of the Base Distribution显示文摘In the Bayesian mixture modeling framework it is possible to infer the necessary number of components to model the data and therefore it is unnecessary to explicitly restrict the number of components.Nonparametric mixture models sidestep the problem of finding the'correct'number of mixture components by assuming infinitely many components.In this paper Dirichlet process mixture(DPM) models are cast as infinite mixture models and inference using Markov chain Monte Carlo is described.The specification of the priors on the model parameters is often guided by mathematical and practical convenience.The primary goal of this paper is to compare the choice of conjugate and non-conjugate base distributions on a particular class of DPM models which is widely used in applications,the Dirichlet process Gaussian mixture model (DPGMM).We compare computational efficiency and modeling performance of DPGMM defined using a conjugate and a conditionally conjugate base distribution.We show that better density models can result from using a wider class of priors with no or only a modest increase in computational effort. | Dilan Grür Carl Edward Rasmussen | 2010 | Journal of Computer Science & Technology2010，25，4： | 5 |
| 4 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 5 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 6 | Activity-Based Costing Methodology for Third-Party Logistics Companies显示文摘 | CARLES G M | 2001 | International Advances in Economic Research2001，7，1： | 1 |
| 7 | Parameter-optimized digital holographic microscope for high resolution living-cell analysis显示文摘 | Carl D Kemper B Wernicke G | 2004 | Appl Opt2004，43，6： | 1 |
| 8 | History - high Speed Network Monitoring and Analysis 显示文摘 | DRESSLER F CARLE G | 2005 | In Proceedings of the 24th IEEE Conference on Computer Communications (IEEE INFOCOM 2005)2005，，： | 1 |
| 9 | Ferrimagnetic mixed-valency and mixed-metal tris(oxalato)iron( Ⅲ ) compounds: synthesis, structure, and magnetism显示文摘 | Mathoniere C Nuttall C J Carling S G | 1996 | Inorng Chem1996，35，5： | 1 |
| 10 | Three-Dimensional Hydrofacies Modeling Based on Soil Surveys and Transition Probability Geostatistics显示文摘 | Weissmann G S Carle S F Fogg G E | 1999 | Water Resources Research1999，35，： | 1 |
| 11 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 12 | Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP- dependent protein kinase, studied using a specific and sensitive peptide assay显示文摘 | DAVIES S P CARLING D HARDIE D G | 1989 | Eur J Biochem1989，186，12： | 1 |
| 13 | Financial Strategy : Planning and Managing the Corporate Leverage Position显示文摘 | Carl M Sandberg Wilbur G Lewellen Kenneth L Stanley | 1987 | Strategic Management Journal1987，8，1： | 1 |
| 14 | The suitability of aluminum as an alternative material for car bodies显示文摘 | Carle D Blount G | 1999 | Materials and Design1999，20，4： | 1 |
| 15 | Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolyers显示文摘 | Geraldine A Carl W Elisabeth G | 2001 | Int Vitro Cell Dev Biol2001，37，： | 1 |
| 16 | PLFA Analyses of microbialcommunities associated with PAH-contaminated river-banksediment显示文摘 | Brenda P Roland R Carl J G | 2012 | Microbial Ecology2012，64，： | 1 |
| 17 | Computa- tional dam-break hydraulics over erodible sediment bed 显示文摘 | Cao Z X Pender G Wallis S Carling P | 2004 | Journal of Hydraulic Engineering ASCE2004，130，7： | 1 |
| 18 | Bio-marker responses in polar cod(Boreogadus saida)exposedto the water soluble fraction of crude oil显示文摘 | Jasmine Nahrgang Lionel Camus Mark G Carls | 2010 | Aquatic Toxi-cology2010，97，3： | 1 |
| 19 | Spray-Dried Porcine Plasma Reduces the Effects of Staphylococcal Enterotoxin B on Glucose Transport in Rat Inteaine显示文摘 | Carles G Perez-Bosque A Concepcio A | 2005 | J Nutr2005，135，： | 1 |
| 20 | N',2 -diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists Ⅱ显示文摘 | ELLIOTT J M CARLING R W CHICCHI G G | 2006 | Bioorg Med Chem Lett2006，16，22： | 1 |
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