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| 1 | Overview of acidic deep eutectic solvents on synthesis,properties and applications显示文摘This review divides the acidic deep eutectic solvents(ADES) into Br?nsted and Lewis DES according to their diversity of acidic character.The hydrogen bond donors and halide salts for formulating an ADES are classified, the synthesis methods are described, and the physicochemical properties including freezing point, acidity, density, viscosity and conductivity are presented. Furthermore, the applications of Br?nsted acidic deep eutectic solvents(BADES) and Lewis acidic deep eutectic solvents(LADES) are overviewed, respectively, covering the fields in dissolution, extraction, organic reaction and metal electrodeposition. It is expected that the ADES has great potential to replace the pollutional mineral acid, expensive and unstable solid acid, and costly ionic liquid in many acid-employed chemical processes, thus meeting the demands of green chemistry. | Hao Qin Xutao Hu Jingwen Wang Hongye Cheng Lifang Chen Zhiwen Qi | 2020 | Green Energy & Environment2020，5，1： | 17 |
| 2 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 3 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 4 | Four outstanding young Chinese scientists received the 2013 Scholar Award from the US Chinese Anti-Cancer Association and the National Foundation for Cancer Research显示文摘To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.Since 2010,10 young Chinese researchers and physicians have received the award for their outstanding achievements in cancer research accomplished while in the | Lifang Hou Li Yan Wei Zhang Michael Yi Wang Shi-Yuan Cheng | 2013 | Chinese Journal of Cancer2013，32，12： | 3 |
| 5 | Effect of water on extractive desulfurization of fuel oils using ionic liquids: A COSMO-RS and experimental study显示文摘When evaluating ionic liquids(ILs) for extractive desulfurization(EDS) of fuel oils, the inevitable presence of water in the system may have a significant and in many cases strongly negative effect. However, few studies have considered this particular issue and a promoted water effect on EDS is scarcely reported. In this work,COSMO-RS was firstly employed to calculate the capacity and selectivity for EDS of various IL/H_2 O mixtures,which cover different IL characters and a wide water concentration range. Experiments were then conducted with a representative IL [C_4MIM][H_2PO_4], whose stable and even promoted extraction performance with a small amount of water was suggested by COSMO-RS. Through analyses of the desulfurization ratio, the crosssolubility and the water content in the desulfurized fuel, the promoted effect of water within a certain range(b 10 wt%) was experimentally demonstrated. Moreover, such effect of water was explained combining the viscosity, the solvent–solute interactions and the COSMO-RS based analysis. | Zhen Song Dian Yu Qian Zeng Jingjing Zhang Hongye Cheng Lifang Chen Zhiwen Qi | 2017 | Chinese Journal of Chemical Engineering2017，25，2： | 3 |
| 6 | Detection of Berberine Hydrochloride in Jin Weng Zhili Particle Using TLC and HPLC显示文摘[Objectives]To screen optimum conditions of HPLC and TLC for qualitative discrimination of berberine hydrochloride contained in Jin Weng Zhili Particle,thus providing basis for quality standard. [Methods]According to the method described in Chinese Veterinary Pharmacopoeia,thin layer chromatography and high performance liquid chromatography were used respectively for qualitative and quantitative identification of berberine hydrochloride contained in Jin Weng Zhili Particle by improving the conditions of extraction and purification. [Results]After optimizing TLC conditions of Jin Weng Zhili Particle,the separation effect of TLC of test samples was favorable. The spot color was clear,reproducibility was good,and precision was high. Under the conditions of mobile phase constituted by acetonitrile-water-glacial acetic acid-triethylamine( 28∶ 70∶ 1∶ 1),detection wavelength of 265 nm,flow rate of 1. 0 m L min^(-1)and column temperature of 35℃,the resolution of berberine hydrochloride was good; the injection volume in the range of 3. 15-50 μg· m L^(-1)had good linear relationship with the peak area( R^2= 0. 998); the average sample recovery rate(n=6) was 5. 672%,and RSD was 0. 864%; the content of berberine hydrochloride contained in Jin Weng Zhili Particle was 4. 023 mg. [Conclusions]The method was of good feasibility,reproducibility and specificity,and could be used for qualitative and quantitative detection of berberine hydrochloride contained in Jin Weng Zhili Particle. | Li LIU Lifang OUYANG Dengfang CHENG Juan LIU Xuehong HU Yuan LI | 2017 | Medicinal Plant2017，8，1： | 2 |
| 7 | The US Chinese Anti-Cancer Association and the National Foundation for Cancer Research recognize five young Chinese investigators with the 2014 USCACA-NFCR Scholar Awards显示文摘To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.From 2010 to 2013,14 young | Wei Zhang Lifang Hou Li Yan Wei Zhang Michael Yi Wang Shi-Yuan Cheng | 2014 | Chinese Journal of Cancer2014，33，11： | 2 |
| 8 | Immune-adjuvant loaded Bi2Se3 nanocage for photothermal-improved PD-L1 checkpoint blockade immune-tumor metastasis therapy显示文摘Checkpoint blockade based immune therapy has shown to be effective but benefit only the minority of patients whose tumors have been pre-infiltrated by T cells. To overcome this obstacles, a PEG-modified Bi2Se3 nanocage (NC) loaded with imiquimod (R848), which could efficiently destroy the tumors thus producing enough tumor-associated antigens (TAA) and with the existence of R848, a toll-like-receptor-7 agonist, could generate strong anti-cancer immune responses is reported in this study. Moreover, immunogenic Bi2Se3 NC-PEG/R848 mediated photothermal therapy (PTT) sensitizes tumors to checkpoint inhibition mediated by a PD-L1 antibody, not only ablating cancer cells upon NIR laser but also causing strong anti-cancer immunity to suppress distant tumor growth post PTT. Both in vitro and in vivo experiments demonstrate that the Bi2Se3 NC-PEG/R848 could effectively activate a PTT-induced immune response as well as silence immune resistance based on PD-L1 checkpoint blockade to ablate the primary tumor and further inhibit the tumor metastasis. Bi2Se3 NC reported here exhibits high photothermal conversion efficiency and stability, as well as competent drug loading capacity with large hollow structures and high surface area. Our study not only provides a facial way to synthesize Bi2Se3 NC, but also offers an alternative strategy for tumor metastasis. | Yilin Song Yidan Wang Siyu Wang Yu Cheng Qianglan Lu Lifang Yang Fengping Tan Nan Li | 2019 | Nano Research2019，12，8： | 2 |
| 9 | Nonfunctional alleles of long-day suppressor genes independently regulate flowering time显示文摘Due to the remarkable adaptability to various environments, rice varieties with diverse flowering times have abeen domesticated or improved from Oryza rufipogon.Detailed knowledge of the genetic factors controlling flowering time will facilitate understanding the adaptation mechanism in cultivated rice and enable breeders to design appropriate genotypes for distinct preferences. In this study,four genes(Hd1, DTH8, Ghd7 and OsPRR37) in a rice long-day suppression pathway were collected and sequenced in 154, 74,69 and 62 varieties of cultivated rice(Oryza sativa)respectively. Under long-day conditions, varieties with nonfunctional alleles flowered significantly earlier than those with functional alleles. However, the four genes have different genetic effects in the regulation of flowering time: Hd1 and Os PRR37 are major genes that generally regulate rice flowering time for all varieties, while DTH8 and Ghd7 only regulate regional rice varieties. Geographic analysis and network studies suggested that the nonfunctional alleles of these suppression loci with regional adaptability were derived recently and independently. Alleles with regional adaptability should be taken into consideration for genetic improvement. The rich genetic variations in these four genes,which adapt rice to different environments, provide the flexibility needed for breeding rice varieties with diverse flowering times. | Xiao-Ming Zheng Li Feng Junrui Wang Weihua Qiao Lifang Zhang Yunlian Cheng Qingwen Yang | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
| 10 | Osteosarcoma metastasis: prospective role of ezrin显示文摘 | Yuanjin Zhang Ling Zhang Guofu Zhang Songbai Li Jun Duan Jie Cheng Guozhen Ding Chibing Zhou Jie Zhang Pengcheng Luo Dongbing Cai Lianghong Kuang Yichun Zhou Liqun Tong Xiangdong Yu Lifang Zhang Lijun Xu Li Yu Xiaomei Shi Aihong Ke | 2014 | Tumor Biology2014，，6： | 1 |
| 11 | Expression of PI3K, PTEN and Akt in small intestinaladenocarcinoma detected by quantum dots-based immunofluorescencetechnology显示文摘 | Yi Zhang Xue Yao Congqing Jiang Junqiu Yue Jing Guan Honglei Cheng Mohammed Hajirashid Yan Wang Lifang Fan | 2013 | Cancer Biomarkers2013，，4： | 1 |
| 12 | Development of a bifurcation analysis approach based on gPROMS platform显示文摘A bifurcation analysis approach is developed based on the process simulator gPROMS platform, which can automatically trace a solution path, detect and pass the bifurcation points and check the stability of solutions. The arclength continuation algorithm is incorporated as a process entity in gPROMS to overcome the limit of turning points and get multiple solutions with respect to a user-defined parameter. The bifurcation points are detected through a bifurcation test function τ which is written in C ++ routine as a foreign object connected with gPROMS through Foreign Process Interface. The stability analysis is realized by evaluating eigenvalues of the Jacobian matrix of each steady state solution. Two reference cases of an adiabatic CSTR and a homogenous azeotropic distillation from literature are studied, which successfully validate the reliability of the proposed approach. Besides the multiple steady states and Hopf bifurcation points, a more complex homoclinic bifurcation behavior is found for the distillation case compared to literature. | Xueqing Kang Hongye Cheng Liwei Tong Lifang Chen Zhiwen Qi | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 1 |
| 13 | On properties and structure of the AOT - water - isooctane reverse micellar mieroreactor for nanoparticles显示文摘 | Cheng Guoxiang Shen Feng Yang Lifang | 1998 | Materials Chemistry and Physics1998，56，2： | 1 |
| 14 | Enhanced photoelectrochemical properties of TiO 2 nanotubes co-sensitized with CdS nanoparticles and tetrasulfonated copper phthalocyanine显示文摘 | Xiangqing Li Ying Cheng Lifang Liu Jin Mu | 2009 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2009，，2： | 1 |
| 15 | Mechanical properties of poly(butylene succinate) (PBS) biocomposites reinforced with surface modified jute fibre显示文摘 | Lifang Liu Jianyong Yu Longdi Cheng Weiwei Qu | 2009 | Composites Part A2009，，5： | 1 |
| 16 | Electrochemical reversibility of magnesium deposition-dissolution on aluminum substrates in Grignard reagent/THF solutions显示文摘The electrochemical behavior of magnesium deposition-dissolution on scratched aluminum foils in Grignard reagent/tetrahydrofuran (THF) solutions (1 mol L-1 EtMgBr/THF), which is regarded as a potential electrolyte of rechargeable magnesium batteries, was studied by using various methods such as cyclic voltammetry (CV), scanning electron microscopy (SEM), X-ray diffraction (XRD) and charge-discharge (deposition-dissolution) tests. The results present that the obtained magnesium deposits do not exhibit the morphology of dendrite and the Mg-Al alloy is not found on the surface of aluminum foils. The magnesium deposited on the aluminum substrates have excellent electrochemical cyclic performance in 1 mol L-1 EtMgBr/THF solution. The aluminum can be used as a candidate material of the negative current collector for rechargeable magnesium batteries. | CHENG Gang XU Qiang ZHANG Ming DING Fei LIU XingJiang JIAO LiFang | 2013 | Chinese Science Bulletin2013，58，27： | 1 |
| 17 | Biodegradability of poly(butylene succinate) composite reinforced with jute bre显示文摘 | Liu Lifang Yu Jianyong Cheng Longdi | 2009 | Yang Polymer Degradation and Stability2009，94，10： | 1 |
| 18 | Mechanical properties of poly(butylene succinate) (PBS) biocomposites reinforced with surface modified jute fibre显示文摘 | Liu Lifang Yu Jianyong Cheng Longdi | 2009 | Composites Part A2009，40，3： | 1 |
| 19 | Biodegradability of poly(butylene succinate)(PBS)composite reinforced with jute fibre显示文摘 | Liu Lifang Yu Jianyong Cheng Longdi | 2009 | Polymer Degradation and Stability2009，94，： | 1 |
| 20 | Effect and mechanism of AR-6 in experimental rheumatoid arthritis显示文摘 | Shi-xue Sun Yun-man Li Wei-rong Fang Peng Cheng Lifang Liu Fengwen Li | 2010 | Clinical and Experimental Medicine2010，，2： | 1 |
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