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| 1 | Hardfacing steel with nanostructured coatings of Stellite-6 by supersonic laser deposition显示文摘The ability to manufacture coatings is critical to engineering design. Many components require the application of additional layers toenhance mechanical properties and protect against hostile environments. Supersonic laser deposition (SLD) is a novel coating methodbased on cold spray (CS) principles. In this technique, the deposition velocities can be significantly lower than those required foreffective bonding in CS applications. The addition of laser heat energy permits a change in the thermodynamic experience of impactingparticles, thereby offering a greater opportunity for efficient bonding at lower velocities as compared with the CS process. The workreported in this paper demonstrates the ability of the SLD process to deliver hardfacing materials to engineering surfaces. Stellite-6 hasbeen deposited on low-carbon steel tubes over a range of process parameters to establish the appropriate target power and traversespeeds for the coating formation. The coating properties and parameters were examined to determine the primary characteristics andgrain structure size. Their morphology and performance were studied through optical microscopy, scanning electron microscope(SEM), X-ray diffraction, hardness measurements and wear testing. The results have shown that SLD is capable of depositing layers ofStellite-6, with properties that are superior to those of their conventionally manufactured counterparts. | Rocco Lupoi Andrew Cockburn Chris Bryan Martin Sparkes Fang Luo William O’Neill | 2012 | Light(Science & Applications)2012，1，1： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 3 |
| 4 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 5 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 6 | Risk factor management and depression post-stroke: The value of an integrated model of care显示文摘 | Jacques Joubert Chris Reid Lynette Joubert David Barton Denise Ruth David Jackson John O’. Sullivan Stephen M. Davis | 2005 | Journal of Clinical Neuroscience2005，，1： | 2 |
| 7 | Laboratory evaluation of the toxic properties of forest anchomanes, Anchomanes difformis against pulse beetle Callosobruchus maculatus (Coleoptera: Bruchidae)显示文摘抽象实验室实验被执行调查森林 anchomanes 的粗略的茎摘录的功效, Anchomanes difformis (P。Beauv ) 发生在韦斯特非洲人森林里的植物,对脉搏甲壳虫 Callosobruchus maculatus (赘言作家) 。在 3% 集中的粗略的茎摘录在申请以后在 24 h 以内显示出高接触毒性到成年甲壳虫,当它对甲壳虫在中等有毒时最低(1%) 集中。以最高的申请率,植物摘录提供了好保护给存储为 90 天的谷物。谷物生存能力和水吸收能力没被处理与 A 的乙醇摘录影响。difformis。这些调查结果的意义在与控制豇豆 bruchids 的 biopesticide 工具的关系被讨论。 | ROTIMI O. AKINKUROLERE CHRIS O. ADEDIRE OLUSOLA O ODEYEMI | 2006 | Insect Science2006，13，1： | 2 |
| 8 | Rapid on-site identification of hazardous organic compounds at fire scenes using person-portable gas chromatography-mass spectrometry(GC-MS)—part 2:water sampling and analysis显示文摘Building and factory fires pose a great risk to human and environmental health,due to the release of hazardous by-products of combustion.These hazardous compounds can dissipate into the environment through fire water run-off,and the impact can be immediate or chronic.Current laboratory-based methods do not report hazardous compounds released from a fire scene at the time and location of the event.Reporting of results is often delayed due to the complexities and logistics of laboratory-based sampling and analysis.These delays pose a risk to the health and wellbeing of the environment and exposed community.Recent developments in person-portable instrumentation have the potential to provide rapid analysis of samples in the field.A portable gas chromatograph-mass spectrometer(GC-MS)was evaluated for the on-site analysis of water samples for the identification of hazardous organic compounds at fire scenes.The portable GC-MS was capable of detecting and identifying a range of volatile and semi-volatile organic compounds in fire water run-off,and can be used in conjunction with conventional laboratory analysis methods for a comprehensive understanding of hazardous organics released at fire scenes.Deployment of this portable instrumentation provides first responders with a rapid,on-site screening tool to appropriately manage the run-off water from firefighting activities.This ensures that environmental and human health is proactively protected. | Rylee Lam Chris Lennard Graham Kingsland Paul Johnstone Andrew Symons Laura Wythes Jeremy Fewtrell David O’Brien Val Spikmans | 2020 | Forensic Sciences Research2020，5，2： | 2 |
| 9 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome显示文摘 | Scott Russell O’Brien Richard Fulcher Greg Pardy Chris d’Emden Michael Tse Dana Taskinen Marja-Riitta Ehnholm Christian Keech Anthony | 2009 | Diabetes Care2009，，： | 2 |
| 10 | 紫硫镍矿交代镍黄铁矿的水热反应机理及动力学显示文摘本工作首次在实验室条件下对浅生区紫硫镍矿(Ni,Fe)3S4交代镍黄铁矿(Ni,Fe)9S8水热反应的机理及动力学进行了研究。起始反应矿物采用高纯自然镍黄铁矿,合成纯镍黄铁矿或合成镍黄铁矿-磁黄铁矿集合体。反应pH值采用0.2M醋酸-醋酸纳缓冲溶液控制在3~5的范围内。反应进程由X-射线衍射物相定量分析及扫描电镜观察进行跟踪。结果表明,当反应温度恒定在80℃时,交代20(4)%的镍黄铁矿需792h。相同条件下加入少量H2S可将反应速率提高一倍。当反应在125℃饱和蒸汽压水热环境下进行时,完全交代纯镍黄铁矿需约168h。此过程由于磁黄铁矿的存在而被催化,交代集合体中的镍黄铁矿仅需68h,进一步反应磁黄铁矿被交代成白铁矿。磁黄铁矿的催化作用可能源于溶解产生的微裂纹加速了流体的传质过程。当反应温度升高至145℃时,速率反而下降,不遵循Arrhenius经验规律。动力学分析得80℃速率常数介于5.8×10-8~3.0×10-7/s之间,125℃及145℃速率常数分别介于2.8×10-6~2.08×10-5/s及1×10-6~5.1×10-6/s之间,远高于同温度下固相扩散反应的速率常数,表明该反应在地质时标上为一快速反应。此外,用背散射电子显微技术对矿物表面形貌进行了分析,发现交代产物紫硫镍矿具有颗粒细小及存在微裂纹等特征,与自然界浅生矿床中的紫硫镍矿非常相似;电镜实验还表明该交代作用是一个典型的耦合溶解-再沉淀反应。其耦合机制的驱动力可能与反应界面处微空隙对流体饱和度的控制有关。 | 夏方 陈国荣 Allan PRING Joёl BRUGGER Yung NGOTHAI Brain O'NEILL Chris COLBY Christophe TENAILLEAU 王海鹏 杨云霞 | 2007 | 地质学报2007，81，10： | 2 |
| 11 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 12 | Dynamic thermal simulation of a retail shed with solar reflective coatings显示文摘 | WANG X X CHRIS K RAY O | 2008 | Applied Thermal Engi- neering2008，2，8： | 1 |
| 13 | A Prospective Study of Common Bile Duct Calculi in Patients Undergoing Laparoscopic Cholecystectomy: Natural History of Choledocholithiasis Revisited显示文摘 | Chris Collins Donal Maguire Adrian Ireland Edward Fitzgerald Gerald C. O'Sullivan | 2004 | Annals of Surgery2004，，1： | 1 |
| 14 | The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish显示文摘 | Stefan H O Maria V F Chris J H | 2011 | Dis Mod Meehan2011，4，6： | 1 |
| 15 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 16 | Reduction in Mortality as a Result of Direct Transport From the Field to a Receiving Center for Primary Percutaneous Coronary Intervention显示文摘 | Michel R. Le May George A. Wells Derek Y. So Chris A. Glover Michael Froeschl Justin Maloney Richard Dionne Jean-Fran?ois Marquis Edward R. O’Brien Alexander Dick Heather L. Sherrard John Trickett Pierre Poirier Melissa Blondeau Jordan Bernick Marino Labi | 2012 | Journal of the American College of Cardiology2012，，14： | 1 |
| 17 | Recognition of a signal peptide by the signal recognition particle显示文摘 | CY Janda L Jacle O Chris | 2010 | Nature2010，465，7297： | 1 |
| 18 | Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention显示文摘 | Sandro Cadaval Goncalves Marino Labinaz Michel Le May Chris Glover Michael Froeschl Jean-Francois Marquis Edward O’Brien Dino Shukla Peter Ruchin Dharmendra Sookur Andrew Ha Derek So | 2011 | The American Journal of Cardiology2011，，2： | 1 |
| 19 | An analysis of SEC guidelines for executing open market repurchases显示文摘 | Douglas O Cook Laurie Krigm J Chris Leach | 2003 | The Journal of Business2003，76，： | 1 |
| 20 | Application and evaluation of Pseudomonas strains for biocontrol of wheat seedling blight显示文摘 | Tahsein A Zahra O Chris W | 2008 | Crop Protection2008，27，： | 1 |
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