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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo显示文摘祖先 Leydig 房间从干细胞被导出。祖先 Leydig 房间的增长和区别显著地在发身期间贡献 Leydig 房间数字。然而,这些过程的规定仍然保持不清楚。现在的学习的目的是决定 luteinizing 荷尔蒙(LH ) 或雄激素是否贡献祖先 Leydig 房间的增长和区别。Fourteen-day-old 男 Sprague-Dawley 老鼠与 NalGlu 被对待 7 天,它是一个释放 gonadotropin 荷尔蒙对手,到在垂体并且这样减少 LH 的分泌物,在睾丸的雄激素。老鼠与 LH 或 7 α 被共同管理; -methyl-nortestosterone (MENT ) 是对由 5 α 的新陈代谢抵抗的雄激素, -reductase 1 在祖先 Leydig 房间,和 LH 或雄激素的随后的效果被测量。3 H-Thymidine 静脉内地也被注入老鼠在祖先 Leydig 房间学习 thymidine 加入。祖先 Leydig 房间被检验。NalGlu 管理由 83 % 减少了祖先 Leydig 房间增长;。另外, LH 或 MENT 处理恢复了 Leydig 房间 proliferative 能力到 73 %或 50 %控制,分别地。增长相关的基因的送信人 RNA 层次用即时 PCR 被测量。Igf1, Lifr, Pdgfra, Bcl2, Ccnd3 和 Pcna 的表示层次是由 MENT 的 upregulated,并且 Pdgfra, Ccnd3 和 Pcna 的那些是由 LH 的 upregulated。LH 和 MENT 在 vitro 刺激了祖先 Leydig 房间的区别。我们断定 LH 和 MENT 涉及调整祖先 Leydig 房间的发展。 | Jing-Jing Guo Xue Ma Claire Q F Wang Yu-Fei Ge Qing-Quan Lian Dianne O Hard Yu-Fei Zhang Qiang Dong Yun-Fei Xu Ren-Shan Ge | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 3 | Orius insidiosus (Say) as a predator of the soybean aphid, Aphis glycines Matsumura显示文摘 | Claire E. Rutledge Robert J. O’Neil | 2005 | Biological Control2005，，1： | 1 |
| 4 | Aggregating behavior of ovigerous female red king crabs,Paralithodes camtschaticus,in Auke Bay, Alaska显示文摘 | C E O'Clair and T C Shirley | 1993 | Can J Fish Aquat Sci1993，50，： | 1 |
| 5 | Chicken heterophil extracellular traps (HETs):Novel defense mechanism of chicken heterophils显示文摘 | Phongakorn C Jelena O Claire B A | | 0，，： | 1 |
| 6 | Transatlantic equatorial distribution of nitrous oxide and methane显示文摘 | CLAUDEL O PHILIPPE J B CLAIRE M | 2002 | DeepSea Research Ⅰ2002，49，： | 1 |
| 7 | Cellular origins and molecular mechanisms of Barrett’s esophagus and esophageal adenocarcinoma显示文摘 | Yu Fang Xiaoxin Chen Manisha Bajpai Amit Verma Kiron M. Das Rhonda F. Souza Katherine S. Garman Claire L. Donohoe Naoimh J. O’Farrell John V. Reynolds Katerina Dvorak | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 8 | Living liver donation: a survey of the attitudes of the public in Great Britain显示文摘 | James Neuberger Lauren Farber Michelle Corrado Claire O’Dell | 2003 | Transplantation2003，，8： | 1 |
| 9 | Fundamental insight on developing low dielectric constant polyimides显示文摘 | Simpson J O St Clair A K | 1997 | Thin Solid Films1997，，： | 1 |
| 10 | Becoming deliberative citizens:the moral learning process of the citizen juror 显示文摘 | SHANE Doheny CLAIRE O'neill | 2010 | Political stud- ies2010，58，： | 1 |
| 11 | Fatty acid composition of some marine microalgae 显示文摘 | Servel M O Claire C Derrien A | 1994 | Phytochemis try1994，36，： | 1 |
| 12 | Electronic trap defects in Y2O3: Eu and (Y,Gd)2O3 : Eu X-ray scintillators显示文摘 | GRESKOVICH C D O'CLAIR C R | 1994 | Mat Res Soc Symp Proc1994，348，： | 1 |
| 13 | 显示文摘 | Simpson J O St Clair A K | 1997 | Thin Solid Films1997，，： | 1 |
| 14 | Endovascular management of iliac artery occlusions: extending treatment to TransAtlantic Inter-Society Consensus class C and D patients显示文摘 | Christopher D. Leville Vikram S. Kashyap Daniel G. Clair James F. Bena Sean P. Lyden Roy K. Greenberg Patrick J. O’Hara Timur P. Sarac Kenneth Ouriel | 2006 | Journal of Vascular Surgery2006，，1： | 1 |
| 15 | Defining esophageal landmarks, gastroesophageal reflux disease, and Barrett’s esophagus显示文摘 | Kenneth DeVault Barry P. McMahon Altay Celebi Guido Costamagna Michele Marchese John O. Clarke Reza A. Hejazi Richard W. McCallum Vincenzo Savarino Patrizia Zentilin Edoardo Savarino Mike Thomson Rhonda F. Souza Claire L. Donohoe Naoimh J. O’Farrell John | 2013 | Ann. N.Y. Acad. Sci2013，，： | 1 |
| 16 | Improved glucose tolerance in aeyl CoA:diacylglycerol acyltransferase 1null mice is dependent on diet显示文摘 | Steven J Y Claire C Jacqueline O' Dowd | 2007 | Lipids in Health and Disease2007，6，1： | 1 |
| 17 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 18 | Defining esophageal landmarks, gastroesophageal reflux disease, and Barrett’s esophagus显示文摘 | Kenneth DeVault Barry P. McMahon Altay Celebi Guido Costamagna Michele Marchese John O. Clarke Reza A. Hejazi Richard W. McCallum Vincenzo Savarino Patrizia Zentilin Edoardo Savarino Mike Thomson Rhonda F. Souza Claire L. Donohoe Naoimh J. O’Farrell John | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 19 | Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors显示文摘 | Julien Maruotti Marta Mu?oz Severine A. Degrelle Enrique Gómez Claire Louet Carmen Díez Monforte Priscille Huot de Longchamp Vincent Brochard Isabelle Hue José Nestor Caama?o Alice Jouneau | 2012 | Mol Reprod Dev2012，，7： | 1 |
| 20 | New tumor suppressor found in pancreatic cancer显示文摘 | | 1996 | Science1996，271，： | 1 |
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