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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 4 | The effect of rhyth-mic auditory stimulation(RAS)on physical therapy outcomesfor patients in gait training following stroke: A feasibilitystudy显示文摘 | Hayden R Clair AA Johnson G | 2009 | Int J Neurosci2009，119，12： | 1 |
| 5 | The rabbit as an ex- perimental and production animal: From genomics to pro- teomics 显示文摘 | Ingrid M Claire R G Domenico S | 2014 | Current Protein Peptide Sci2014，15，2： | 1 |
| 6 | Rough sets显示文摘 | Jackson A G Pawlak Z Le Clair S R | 1998 | Journal of Alloys and Compounds1998，279，1： | 1 |
| 7 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 8 | Genetic variation of piper- idine alkaloids in Pinus ponderosa: a common garden study 显示文摘 | Gerson E A Kelsey R G St Clair J B | 2009 | Annals of Botany2009，3，103： | 1 |
| 9 | Muscovy duck reovirusσC Protein is atypically encoded by the smallest genome segment显示文摘 | Gaelle K S Ghislaine L G R Claire D B | 2002 | Journal of General Virology2002，83，： | 1 |
| 10 | Muscovy duckreovirus σC protein is atypically encoded by the smallest genome segrnent显示文摘 | Gaelle K S Ghislaine L G R Claire B | 2002 | J Gen Virol2002，83，： | 1 |
| 11 | Long Term Toxicityof a Roundup Herbicide and a Roundup-Tolerant Genetically Mod-ified Maize显示文摘 | SéRALINI G E CLAIR E MESNAGE R | 2012 | Food and Chemical Toxicology2012，50，11： | 1 |
| 12 | Long term toxicity of a Roundup herbicide and a Roundup-tolerant ge- netically modified maize显示文摘 | SIRALINI G E CLAIR E MESNAGE R | 2012 | Food Chem Toxicol2012，50，11： | 1 |
| 13 | HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity显示文摘 | Marecki J C Cota-Gomez A Vaitaitis G M Honda J R Porntadavity S St Clair D K Flores S C | 2004 | Free Biol Med2004，37，6： | 1 |
| 14 | Observation of viruslike particles in high temperature enrichment cultures from deepsea hydrothermal vents 显示文摘 | Claire G Marc Le R Melusine G | 2003 | Research in Microbiology2003，154，： | 1 |
| 15 | Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epi- thelial cells during infection显示文摘 | LAURENCE F CLAIRE R G MARIELLE C | 2008 | BMC Genomics2008，9，： | 1 |
| 16 | AT-CHLORO,A comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins显示文摘 | MYRIAM F SABINE B DANIEL S DAPHNE S B MAGALI C LUCAS M CLAIRE R STEPHANE M MOURAD M SOPHIE L G SYLVIE K J CHRISTOPHE B JEROME G JACQUES J CHRISTOPHE B JEROME G JACQUES J CHRISTOPHE M NORBERT R | 2010 | Molecular and Cellular Proteomics2010，9，： | 1 |
| 17 | Tibial angioplasty as an alternative strategy in patients with limb-threatening ischemia 显示文摘 | Clair D G Dayal R Faries P L | 2005 | AnnVascSurg2005，19，1： | 1 |
| 18 | Molecular characterization and expression of the S3 gene of muscovy duck reovirus strain 89026 显示文摘 | Ghislaine L G R Martine C Claire A | 1999 | Journal of General Virology1999，80，： | 1 |
| 19 | High-performance liquid chrom-atographic analysis of the lactone and carboxylate forms of a topoi-somerase I inhibitor(the antitumor drug G1147211)in plasma显示文摘 | Stafford C G St Claire R L 3rd | 1995 | J Chromatogr B Biomed Appl1995，663，1： | 1 |
| 20 | Delta-opioid receptors are critical for tricyclic anti-depressant treatment of neuropathie allodynia显示文摘 | MALIKA B CLAIRE G R IPEK Y | 2008 | Biol Psychiatry2008，63，6： | 1 |
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