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| 1 | Clinical diagnostic performance of the simultaneous amplification and testing methods for detection of the Mycobacterium tuberculosis complex for smear-negative or sputum-scarce pulmonary tuberculosis in China显示文摘 | Fan Lin Zhang Qing Cheng Liping Liu Zhibing Ji Xiaobing Cui Zhenling Ju Jingliang Xiao Heping | 2014 | Chinese Medical Journal2014，，10： | 19 |
| 2 | An efficient methodology for utilization of K-feldspar and phosphogypsum with reduced energy consumption and CO2 emissions显示文摘The issues of reducing CO_2 emissions, sustainably utilizing natural mineral resources, and dealing with industrial waste offer challenges for sustainable development in energy and the environment. We propose an efficient methodology via the co-reaction of K-feldspar and phosphogypsum for the extraction of soluble potassium salts and recovery of SO_2 with reduced CO_2 emission and energy consumption. The results of characterization and reactivity evaluation indicated that the partial melting of K-feldspar and phosphogypsum in the hightemperature co-reaction significantly facilitated the reduction of phosphogypsum to SO_2 and the exchange of K^+(K-feldspar) with Ca^(2+)(CaSO_4 in phosphogypsum). The reaction parameters were systematically investigated with the highest sulfur recovery ratio of ~ 60% and K extraction ratio of ~ 87.7%. This novel methodology possesses an energy consumption reduction of ~ 28% and CO_2 emission reduction of ~ 55% comparing with the present typical commercial technologies for utilization of K-feldspar and the treatment of phosphogypsum. | Zhixi Gan Zheng Cui Hairong Yue Siyang Tang Changjun Liu Chun Li Bin Liang Heping Xie | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 11 |
| 3 | Experimental measurement of the electrical conductivity of single crystal olivine at high temperature and high pressure under different oxygen fugacities显示文摘At 1.0-4.0 GPa and 1123-1473 K and under oxygen fugacity-controlled conditions (Ni + NiO, Fe + Fe3O4, Fe + FeO and Mo+ M0O2 buffers), a YJ-3000t Model six-anvil solid high-pressure apparatus and a Sarltron-1260 Impedance/Gain-Phase analyzer were employed to conduct an in situ measurement of the electrical conductivity of single crystal olivine. Experimental results showed that: (1) within the range of experimentally selected frequencies (103-106 Hz), the electrical conductivity of the sample is of great dependence on the frequency; (2) with the rise of temperature ( T), the electrical conductivity (σ) will increase, and the Arrenhius linear relationship is established between lgσ and 1/T; (3) under the control of oxygen buffer Fe+ Fe3O4, with the rise of pressure, the electrical conductivity tends to decrease whereas the activation enthalpy and independent-of-temperature preexponential factor tend to increase, with the activation energy and activation volume of the sample estimated at (1. 25 ± 0.08) eV and (0.105 ±0.025) cm3/mol, respectively; (4) under given pressure and temperature conditions, the electrical conductivity tends to increase whereas the activation energy tends to decrease with increasing oxygen fugacity; and ( 5) the mechanism of electrical conduction of small polarons can provide insight into the behavior of electrical conduction of olivine under high pressure and high temperature. | DAI Lidong LI Heping LIU Congqiang CUI Tongdi SHAN Shuangming YANG Changjun LIU Qingyou DENG Heming | 2006 | Progress in Natural Science:Materials International2006，16，4： | 9 |
| 4 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 5 | Experimental Study on the Electrical Conductivity of Orthopyroxene at High Temperature and High Pressure under Different Oxygen Fugacities显示文摘At presure 1.0–4.0 GPa and temperature 1073–1423 K and under oxygen partial pressure conditions, a YJ-3000t multi-anvil solid high-pressure apparatus and Sarltron-1260 Impedance/Gain-Phase analyzer were employed toconduct an in-situ measurement of the electrical conductivity of orthopyroxene. The buffering reagents consist of Ni+NiO,Fe+Fe3O4, Fe+FeO and Mo+MoO2 in order to control the environmental oxygen fugacity. Experimental results made clearthat: (1) within the measuring frequency range from 10? to 106 Hz, the complex impedance (R) is of intensive dependence 1on the frequency; (2) The electrical conductivity (σ) tends to increase along to the rise of temperature (T), and Log σ vs. 1/T fit the Arrenhius linear relations; (3) Under the control of oxygen buffer Fe+Fe3O4, with the rise of pressure, theactivation enthalpy tends to increase whereas the electrical conductivity tends to decrease. The activation energy andactivation volume of the main current carriers of orthopyroxene have been obtained, which are (1.715±0.035) eV and (0.03±0.01) cm3/mol, respectively; (4) Under given pressure and temperature, the electrical conductivity tends to increase withincreasing oxygen fugacity, while under given pressure the activation enthalpy tends to decrease with increasing oxygenfugacity; and (5) The sample’s small polarons mechanism has provided a reasonable explanations to the conductionbehavior at high temperature and high pressure. | DAI Lidong LI Heping LIU Congqiang SHAN Shuangming CUI Tongdi SU Genli | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 4 |
| 6 | Observation and research of deep underground multi-physical fields—Huainan–848 m deep experiment显示文摘Compared with the surface,the deep environment has the advantages of allowing“super-quiet and ultra-clean”-geophysical field observation with low vibration noise and little electromagnetic interference,which are conducive to the realization of long-term and high-precision observation of multi-physical fields,thus enabling the solution of a series of geoscience problems.In the Panyidong Coal Mine,where there are extensive underground tunnels at the depth of 848 m below sea level,we carried out the first deep-underground geophysical observations,including radioactivity,gravity,magnetic,magnetotelluric,background vibration and six-component seismic observations.We concluded from these measurements that(1)the background of deep subsurface gravity noise in the long-period frequency band less than 2 Hz is nearly two orders of magnitude weaker than that in the surface observation environment;(2)the underground electric field is obviously weaker than the surface electric field,and the relatively high frequency of the underground field,greater than 1 Hz,is more than two orders of magnitude weaker than that of the surface electric field;the east-west magnetic field underground is approximately the same as that at the surface;the relatively high-frequency north-south magnetic field underground,below 10 Hz,is at least one order of magnitude lower than that at the surface,showing that the underground has a clean electromagnetic environment;(3)in addition to the highfrequency and single-frequency noises introduced by underground human activities,the deep underground space has a significantly lower background vibration noise than the surface,which is very beneficial to the detection of weak earthquake and gravity signals;and(4)the underground roadway support system built with ferromagnetic material interferes the geomagnetic field.We also found that for deep observation in the“ultra-quiet and ultra-clean”environment,the existing geophysical equipment and observation technology have problems of poor adaptability and insufficient precision as well as data cleaning problems,such as the effective separation of the signal and noise of deep observation data.It is also urgent to interpret and comprehensively utilize these high-precision multi-physics observation data. | Yun WANG Yaxin YANG Heping SUN Chengliang XIE Qisheng ZHANG Xiaoming CUI Chang CHEN Yongsheng HE Qiangqiang MIAO Chaomin MU Lianghui GUO Jiwen TENG | 2023 | Science China Earth Sciences2023，66，1： | 3 |
| 7 | Application of superconductive gravity technique on the constraints of core-mantle coupling parameters显示文摘The parameters, i.e. the Period and the Quality factor, of the Earth's free core nutation (FCN) are closely related to the dissipative coupling between the core and the mantle. Based on the FCN parameters obtained from the actual observations and theoretical simulation, significantly constrained in this study were several key parameters near the core-mantle boundary (CMB), related to the core and mantle coupling, including viscosity at the top of liquid core, conductivity at the bottom of the mantle, and dynamic ellipticity of the CMB. In order to choose high quality observations from global stations of the superconducting gravimeters (SG) on the Global Geodynamics Project (GGP) network, we adopted two criteria, the standard deviations of harmonic analysis on tidal observations and the quality of the FCN parameters calculated with the observations from single station. After the mean ocean tidal effects of the recent ocean tidal models were removed, the FCN parameters were retrieved by stacking the tidal gravity observations from the GGP network. The results were in a good agreement with those in the recent research by using the SG and/or the VLBI observations. Combined with an FCN theoretical model deduced by angular momentum method, the viscous and electromagnetic coupling parameters near the CMB were evaluated. Numerical results indicated that the viscosity at the top of the liquid core was in the range from 6.6×102 to 2.6×103 Pa·s, which was in good agreement with those obtained from the Earth's nutation, the FCN and variations in the length of day (LOD). The conductivity at the bottom of the mantle should be as large as 2.6×106-1.0×107 S m-1 to match the FCN quality factors from the actual observations. The dissipative coupling had a little influence of 1-2 sidereal days for the FCN period. | CUI XiaoMing SUN HePing XU JianQiao ZHOU JiangCun | 2012 | Science China Earth Sciences2012，55，3： | 2 |
| 8 | Towards an ultimate fluidized bed stripper显示文摘 | ROSE I CUI HEPING ZHANG TIANZHU | 2005 | Pow- der Technology2005，158，： | 1 |
| 9 | Spouting of biomass particles: A review 显示文摘 | Cui Heping Grace J R | 2008 | Bioresource Technology2008，99，10： | 1 |
| 10 | Jet configuration for improved fluidized bed stripping 显示文摘 | CUI HEPING GEACE J Mc KNIGHT C | 2006 | Chemical Engineering Journal2006，125，： | 1 |
| 11 | Exogenous glutamic acid effectively involved in N-(1-deoxy-D-galulos-1-yl)-glutamic acid degradation for simultaneous improvement of both milk-like and baking flavor显示文摘This research elucidated the reason of flavor deficiency during the thermal degradation of glutamic acid(Glu)-galactose(Gal)Amadori rearrangement product(GG-ARP)and the solution.The flavor formation from GG-ARP during the thermal degradation was investigated.Compared to the volatile compounds in Glu-Gal Maillard reaction products(GG-MRP),pyrazines in the volatile compounds derived from GG-ARP were restrained.The disadvantage in evolution asynchrony and content sufficiency ofα-dicarbonyl compounds and Glu in the GG-ARP model limited the pyrazines formation.With the addition of Gal,the asynchronous effect was further exacerbated,and the furans in the GG-ARP-Gal model(956.81μg/L,120℃,60 min)were more significantly dominant among the volatile flavor compounds than in the GG-ARP model(454.98μg/L,120℃,60 min),while the pyrazines were still missing.Whereas,the extra-added Glu in the GG-ARP model could offset the deficiency of amino acids growth afterα-dicarbonyl formation and promote the formation of pyrazines(74.47μg/L,120℃,60 min).Meanwhile,the formation of diketones(92.96μg/L,120℃,60 min)was promoted.The addition of Glu enhanced both milk-like and baking flavor of the GG-ARP system simultaneously.Formulated GG-ARP-Glu mixture was proposed to promisingly achieve the controlled formation of process flavors for baked foods with both desirable milk-like and baking scent. | Caixing Pan Heping Cui Khizar Hayat Xiaoming Zhang Chi-Tang Ho | 2022 | Food Bioscience2022，47，3： | 1 |
| 12 | Spouting of biomass particles: A review显示文摘 | Cui Heping | 2008 | Bioresource Technology2008，99，10： | 1 |
| 13 | cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence显示文摘As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/TRF2/POT1 are deficient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and positions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-deficient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence. | Xiaocui Li Xiaojuan Li Chen Xie Sihui Cai Mengqiu Li Heping Jin Shu Wu Jun Cui Haiying Liu Yong Zhao | 2022 | Protein & Cell2022，13，1： | 1 |
| 14 | Random characteristics of the heterogeneous structure in gas-solid fluidization显示文摘 | Heping Cui Jinghai Li Hongzhi An Min Chen Zhiming Ma Guofu Wu | 1998 | Science in China Series B: Chemistry1998，，4： | 1 |
| 15 | Fluidization of biomass particles:A review of experimental multiphase flow aspects显示文摘 | CUI Heping GRACE J R | 2007 | Chemical Engineering Science2007，62，12： | 1 |
| 16 | Non-uniform distribution of two-phase flows through parallel identical paths显示文摘 | Grace J R Cui Heping Elnashaie S S E H | 2007 | The Canadian Journal ofChemicalEngineering2007，85，5： | 1 |
| 17 | Flow of pulp fiber suspension and slurries; A review显示文摘 | Cui Heping Gracei J R | 2007 | International Journal of Multiphase Flow2007，33，： | 1 |
| 18 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 19 | Characterization of dy- namie gas-solid distribution in fluidized beds 显示文摘 | Cui Heping Mostoufi N Chaouki J | 2000 | Chemical Engineering Journal2000，79，2： | 1 |
| 20 | A review of the 19th International Symposium on geodynamics and earth tide, Wuhan 2021显示文摘Modern geodetic technologies such as high-precision ground gravity measurements,satellite gravity measurements,the global navigation satellite system,remote sensing methods,etc.provide rich observation data for monitoring various geodynamic processes of the global Earth and its surface.The 19th International Symposium on Geodynamics and Earth Tides brought together scientific researchers from 26 countries around the world,shared the application of various measurements in different geoscience issues,covering Earth tidal deformation,oceanic and atmospheric loading effects,earthquake cycle,hydrology,Earth rotation changes,etc.,and provided a precious exchange platform for global peers. | Xiaodong Chen Heping Sun Carla Braitenberg Wei Feng Xiaoming Cui | 2023 | Geodesy and Geodynamics2023，14，1： | 0 |
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