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| 1 | Research on solar aided coal-fired power generation system and performance analysis显示文摘Integrating solar power utilization systems with coal-fired power units, the solar aided coal-fired power generation (SACPG) shows a significant prospect for the large-scale utilization of solar energy and energy saving of thermal power units. The methods and mechanism of system integration were studied. The parabolic trough solar collectors were used to collect solar energy and the integration scheme of SACPG system was determined considering the matching of working fluid flows and energy flows. The thermodynamic characteristics of solar thermal power generation and their effects on the performance of thermal power units were studied, and based on this the integration and optimization model of system structure and parameters were built up. The integration rules and coupling mecha- nism of SACPG systems were summarized in accordance with simulation results. The economic analysis of this SACPG system showed that the solar LEC of a typical SACPG system, considering CO2 avoidance, is 0.098 $/kW·h, lower than that of SEGS, 0.14 $/kW·h. | YANG YongPing CUI YingHong HOU HongJuan GUO XiYan YANG ZhiPing WANG NinLing | 2008 | Science China(Technological Sciences)2008，51，8： | 30 |
| 2 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 3 | Precision Balance Method for Cupped Wave Gyro Based on Cup-bottom Trimming显示文摘The mechanical balance process is the key process to eliminate the quadrature error and improve the performance of the cupped wave gyro.The conventional mechanical balance method for cupped wave gyro based on cup-wall trimming requires high control accuracy of trimming quantity,which increases the production cost and decreases the fabrication efficiency in large extent.However,it is hard to reach the high balance accuracy with the natural frequency split of mHz grade by using the conventional method.In this paper,the lumped mass dynamic model of the cupped wave gyro is built by discretization method,and the effects of different position trimming on the natural frequency are analyzed.It is pointed out that trimming off a tiny quantity of material from cup-wall causes large variation of the natural frequency is the main reason for the low accuracy of the conventional mechanical balance method.Then,a precision balance method for cupped wave gyro based on cup-bottom trimming is presented and the entire procedures of this method are given.The static balance process and dynamic balance process of the precision balance method are simulated by the finite element software.The simulation result shows that the precision balance method based on cup-bottom trimming brings less additional natural frequency split in the static balance process,minimizes the natural frequency split to mHz grade and rectify the angle of mode offset to 0.1° grade in the dynamic balance process,furthermore,the method decreases the requirement for control accuracy of trimming quantity evidently.The research work provides references for structure optimization design and balance process plan of the cupped wave gyro. | TAO Yi XI Xiang XIAO Dingbang TAN Yingqi CUI Hongjuan WU Xuezhong | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 9 |
| 4 | Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-L-lysine-Assisted Magnetic Iron Oxide Nanoparticles显示文摘Cell labeling with magnetic iron oxide nanoparticles(IONPs)is increasingly a routine approach in the cellbased cancer treatment.However,cell labeling with magnetic IONPs and their leading effects on the biological properties of human lung carcinoma cells remain scarcely reported.Therefore,in the present study the magnetic c-Fe2O3nanoparticles(MNPs)were firstly synthesized and surface-modified with cationic poly-L-lysine(PLL)to construct the PLL-MNPs,which were then used to magnetically label human A549 lung cancer cells.Cell viability and proliferation were evaluated with propidium iodide/fluorescein diacetate double staining and standard 3-(4,5-dimethylthiazol-2-diphenyl-tetrazolium)bromide assay,and the cytoskeleton was immunocytochemically stained.The cell cycle of the PLL-MNPlabeled A549 lung cancer cells was analyzed using flow cytometry.Apoptotic cells were fluorescently analyzed with nuclear-specific staining after the PLL-MNP labeling.The results showed that the constructed PLL-MNPs efficiently magnetically labeled A549 lung cancer cells and that,at low concentrations,labeling did not affect cellular viability,proliferation capability,cell cycle,and apoptosis.Furthermore,the cytoskeleton in the treated cells was detected intact in comparison with the untreated counterparts.However,the results also showed that at high concentration(400 lg m L-1),the PLL-MNPs would slightly impair cell viability,proliferation,cell cycle,and apoptosis and disrupt the cytoskeleton in the treated A549 lung cancer cells.Therefore,the present results indicated that the PLL-MNPs at adequate concentrations can be efficiently used for labeling A549 lung cancer cells and could be considered as a feasible approach for magnetic targeted anti-cancer drug/gene delivery,targeted diagnosis,and therapy in lung cancer treatment. | Xueqin Wang Huiru Zhang Hongjuan Jing Liuqing Cui | 2015 | Nano-Micro Letters2015，7，4： | 4 |
| 5 | Study on the interaction between engineering construction and ecosystem changes in the Longitudinal Range-Gorge Region显示文摘这份报纸拿在作为主要科学问题设计构造和生态系统变化之间的相互作用。基于 DPSIR ( Drive-Press-State-Impact-Response )框架,这研究分析在从开车,出版社,状态,影响和反应的方面设计构造和生态系统变化之间的相互作用的通匝,向前带相互作用模型,相互作用情形分析方法和相互作用索引(开车反应索引, IIDR ,开车影响索引, IIDI ,影响反应索引,红外,影响索引, IIII ),并且预付相应计算模型和相互作用索引 sy 并且也,这份报纸采用不同相互作用索引到尊重影响在上和对设计建设的反应,并且作为例子在纵的范围峡区域(LRGR ) 拿 Manwan 水力发出的电力车站和道路交通建设分析并且验证相互作用模型。由建设的结果和 Manwan 水力发出的电力的操作的系统的分析,车站是分别地 3.67, 3.92, 14.35 和 0.35。没有在相互作用系统,和利用的通匝元素的显著变化水力发出的电力车站基于想象有益于地区性的环境和社会的持续发展没有考虑环境费用,散开效果,潜在的否定效果和潜力,水力发出的电力的回答驻扎建设。通过一些案例研究,我们造了的相互作用模型在相互作用显示出很好的实际价值量的分析并且相互作用索引系统构造。 | CUI BaoShan HU Bo ZHAI HongJuan WEI GuoLiang WANG Juan School of Environment,Beijing Normal University State Key Joint Laboratory of Environmental Simulation and Pollution Contro,Beijing 100875,China | 2007 | Chinese Science Bulletin2007，52，A02： | 3 |
| 6 | Characteristics of wetland functional degradation and its ecological water requirement for restoration in Yilong Lake of Yunnan Plateau显示文摘 | CUI Baoshan ZHAI Hongjuan | 2006 | Chinese Science Bulletin2006，51，B11： | 3 |
| 7 | LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin显示文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear. | Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui | 2023 | Genes & Diseases2023，10，3： | 1 |
| 8 | Bmi-1 is essential for the tumorigenicity of neuroblastoma cells显示文摘 | bo Hu Tai Li | 2007 | Tumorigenesis and Neoplastic Progression2007，170，4： | 1 |
| 9 | Modification of Cu-based methanol synthesis catalyst for dimethyl ether synthesis from syngas in slurry phase显示文摘 | Yisheng Tan Hongjuan Xie Haitao Cui Yizhuo Han Bing Zhong | 2005 | Catalysis Today2005，，1： | 1 |
| 10 | Modification of Cu-based methanol synthesis catalyst for dimethyl ether synthesis from syngas in slurry phase显示文摘 | Tan Yisheng Xie Hongjuan Cui Haitao | 2005 | Catalysis Today2005，104，1： | 1 |
| 11 | Regional ecosystem changes under different cascade hydropower dam construction scenarios in the LRGR显示文摘生态系统上的串联水力发出的电力水坝构造的生态的效果与在纵的范围峡区域膨胀水坝发展规模从科学家获得了许多担心。在 Lancang 河区域和纵的范围峡区域(LRGR ) 的 Yuanjiang River-Red 河区域,一个索引系统因此被建立了估计当前的生态的危险并且预言可能的未来在水坝构造以后的这二个河区域的生态的危险。八种串联水力发出的电力水坝构造情形为预报在这份报纸被建立了。生态系统的突然的变化特征在计算被考虑了。象水坝构造的当前的供应,航行和旅游一样的经济好处没在计算被考虑。(1 ) 当前的生态的危险 Lancang 河区域和 Yuanjiang River-Red 河区域珍视的结果表演分别地是 0.34 和 0.43,它将在所有计划水坝的联合工作以后分别地升起到 0.900.91 和 0.860.89;(2 ) 突然的变化将在未来发生在 Lancang 河区域和 Yuanjiang River-Red 河区域身上;(3 ) 有高人的反应的间隔建设为 Lancang 河区域和 Yuanjiang River-Red 河区域,他们的多半生态的危险将分别地在以后升起到 0.560.62 和 0.420.43 被推荐。这些结果提供一个合理方法和理论参考书估计水坝建设的生态的效果,并且也把 prewarnings 给正在被计划构造串联水力发出的电力水坝的纵的范围峡区域的另外的主流。 | ZHAI HongJuan CUI BaoShan HU Bo WEI GuoLiang LIU ShiLiang | 2007 | Chinese Science Bulletin2007，52，A02： | 1 |
| 12 | Modification of Cu-based methanol synthesis catalyst for dimethyl ether synthesis from syngas in slurry phase显示文摘 | Yisheng Tan Hongjuan Xie Haitao Cui | 2005 | Catalysis Today2005，104，： | 1 |
| 13 | The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation显示文摘 | Jane Ding Tai Li Xiangwei Wang Erhu Zhao Jeong-Hyeon Choi Liqun Yang Yunhong Zha Zheng Dong Shuang Huang John M. Asara Hongjuan Cui Han-Fei Ding | 2013 | Cell Metabolism2013，，6： | 1 |
| 14 | Bombyx mori U-shaped regulates the melanization cascade and immune response via binding with the Lozenge protein显示文摘Zinc finger protein,an important transcription factor,regulates gene expression associated with various physiological and pathological processes.U-shaped,belong to the Friend of GATA(FOG)transcription factor,plays a crucial role in hematopoiesis by interacting with the GATA transcription factor as a co-factor.However,little is known about its functions in insects.In the present study,a U-shaped cDNA was identified and characterized from the silkworm Bombyx mori and its potential roles in innate immunity investigated.The predicted silkworm U-shaped amino acid sequence contained a classical nuclear localization signal(NLS)motif“GESSPKRRRR”at position 45CU459,and arginine residues at position 456 and 478 are the critical sites of the NLS.U-shaped mRNA was detected in all tested tissues of the B.mori;however,the highest levels were found in the hemocytes.U-shaped mRNA expression levels were upregulated in the hemocyte after the Escherichia coli and Staphylococcus aureus challenge.Furthermore,U-shaped knockdown significantly reduced the melanization process and suppressed the expression of melanization-associated genes,including PPO1,PPO2,PPAE and BAEE.In addition,U-shaped interacts with Lozenge protein to regulate the innate immune response of the insect.Our results revealed that U-shaped binds directly to Lozenge protein to modulate the melanization process and innate immune responses in silkworm. | Kui Zhang Juan Tan Xiangwei Hao Houyi Tang Muhammad Nadeem Abbas Jingjing Su Yongyue Su Hongjuan Cui | 2022 | Insect Science2022，29，3： | 1 |
| 15 | Methylation across the central dogma in health and diseases: new therapeutic strategies显示文摘The proper transfer of genetic information from DNA to RNA to protein is essential for cell-fate control,development,and health.Methylation of DNA,RNAs,histones,and non-histone proteins is a reversible post-synthesis modification that finetunes gene expression and function in diverse physiological processes.Aberrant methylation caused by genetic mutations or environmental stimuli promotes various diseases and accelerates aging,necessitating the development of therapies to correct the disease-driver methylation imbalance.In this Review,we summarize the operating system of methylation across the central dogma,which includes writers,erasers,readers,and reader-independent outputs.We then discuss how dysregulation of the system contributes to neurological disorders,cancer,and aging.Current small-molecule compounds that target the modifiers show modest success in certain cancers.The methylome-wide action and lack of specificity lead to undesirable biological effects and cytotoxicity,limiting their therapeutic application,especially for diseases with a monogenic cause or different directions of methylation changes.Emerging tools capable of site-specific methylation manipulation hold great promise to solve this dilemma.With the refinement of delivery vehicles,these new tools are well positioned to advance the basic research and clinical translation of the methylation field. | Ruochen Liu Erhu Zhao Huijuan Yu Chaoyu Yuan Muhammad Nadeem Abbas Hongjuan Cui | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 16 | PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of theβ-catenin pathway显示文摘Protein arginine methyltransferase 1(PRMT1),a type I PRMT,is overexpressed in gastric cancer(GC)cells.To elucidate the function of PRMT1 in GC,PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA(shRNA)or inhibited by PRMT1 inhibitors(AMI-1 or DCLX069),which resulted in inhibition of GC cell proliferation,migration,invasion,and tumorigenesis in vitro and in vivo.MLX-interacting protein(MLXIP)and Kinectin 1(KTN1)were identified as PRMT1-binding proteins.PRMT1 recruited MLXIP to the promoter ofβ-catenin,which inducedβ-catenin transcription and activated theβ-catenin signaling pathway,promoting GC cell migration and metastasis.Furthermore,KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction between TRIM48 and PRMT1.Collectively,our findings reveal a mechanism by which PRMT1 promotes cell proliferation and metastasis mediated by theβ-catenin signaling pathway. | Feng Wang Shitong Chen Shihan Peng Xujun Zhou Houyi Tang Hanghua Liang Xi Zhong He Yang Xiaoxue Ke MuHan Lü Hongjuan Cui | 2023 | Genes & Diseases2023，10，6： | 0 |
| 17 | Predicative value of urinary protein biomarkers on delayed renal involvement in children with Henoch-Sch?nlein purpura显示文摘Dear Editor,Henoch-Schonlein purpura(HSP)is one of the most common vasculitides in children with the incidence of 10-30 cases per 100,000 per year(Chen and Mao,2015)and its prognosis primarily depends on the extent of renal involvement.However,the onset of renal involvement may be delayed for weeks or months after the appearance of acute symptoms in HSP patients and easily be omitted(Mao et al.,2014).The increased urine protein biomarkers were remarkable indicators of early renal damage or early renal tubular function damage(Zulu et al.,2016)and had a great potential for early prognosis of HSP,but seldom do relationship between these biomarkers and later renal impairments of HSP were analyzed.This study aimed to investigate the relationship of several urinary protein levels during the acute stage of HSP,including N-acetyl-beta-D-glucosaminidase(NAG),p2-microglobulin(P2-MG),retinol-binding protein(RBP),transferrin(TRF),immunoglobulin G(IgG)and microalbumin(MA),with the risk of subsequent renal involvement after acute phase in HSP. | Haipeng Liu Wei Cui Hongjuan Liu Chenyu Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 0 |
| 18 | Siliconization for Wall Conditioning and Its Effect on Plasma Performance in HL-2A Tokamak显示文摘 | DUAN Xuru CAO Zeng CUI Chenghe CAI Xiao SUN Hongjuan DING Xuantong PAN Yudong WANG Mingxu YANG Qingwei SONG Xianming LIU Dequan LIU Yi JI Xiaoquan CUI Zhengying ZHOU Yan LIU Yong 无 | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 19 | CCDC25:precise navigator for neutrophil extracellular traps on the prometastatic road显示文摘The dissemination of cancer cells called metastasis accounts for the majority of deaths of cancer patients.Neutrophil extracellular traps(NETs)released by neutrophils to fight pathogens have been shown to promote metastasis in mouse models.However,the mechanism behind how NETs boost metastasis remains elusive.In a recent study in Nature,1 Yang et al reported that NETs are abundant in the liver metastases of patients with breast and colon cancers,and that the risk of liver metastasis in patients with earlystage breast cancer can be predicted by monitoring the levels of serum NETs.Furthermore,Yang et al.1 elucidated that the DNA component of NETs(NET-DNA)acts as a chemotactic factor that is recognized by coiled-coil domain containing protein 25(CCDC25),a cytoplasmic membrane-localized extracellular DNA sensor of cancer cells,which in turn activates the integrin-linked kinase(ILK)–β-parvin–RAC1–CDC42 cascade to promote metastasis(Fig.1).The clinical importance of CCDC25 was confirmed by Yang et al.,1 and targeting CCDC25 inhibits NET-mediated metastasis in mouse models,suggesting a potential therapeutic strategy to halt the metastasis. | Ruochen Liu Erhu Zhao Feng Wang Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | 转录分析显示高危险的人类神经母细胞瘤和小鼠神经母细胞瘤的球形细胞中有共同的代谢调节显示文摘高危险性的神经母细胞瘤(neuroblastoma)仍然是一种最致命的幼童癌症之一,而识别驱动或维持高危险性的神经母细胞瘤的代谢途径则可能开辟新的治疗方针。 | Mengling Liu Yingfeng Xia Jane Ding Bingwei Ye Erhu Zhao Jeong-Hyeon Choi Ahmet Alptekin Chunhong Yan Zheng Dong Shuang Huang Liqun Yang Hongjuan Cui 查运红 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
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